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Manuscripts from 2021

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Characterization and Clinical Significance of EIF1AX Mutations and Co-Mutations in Cytologically Indeterminate Thyroid Nodules: A 5-Year Retrospective Analysis., Stacey Gargano; Nitika Badjatia; Yanina Nikolaus; Stephen C Peiper; and Zi-Xuan Wang, PhD

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Genetic Variants and Tumor Immune Microenvironment: Clues for Targeted Therapies in Inflammatory Breast Cancer (IBC), Yulan Gong, Rajeswari Nagarathinam, Maria F. Arisi, Lorenzo Gerratana, Jennifer S Winn, Michael Slifker, Jianming Pei, Kathy Q Cai, Zachary Hasse, Elias Obeid, Julio Noriega, Christopher Sebastiano, Eric Ross, Katherine Alpaugh, Massimo Cristofanilli, and Sandra V Fernandez

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Clinical Performance of the Point-of-Care cobas Liat for Detection of SARS-CoV-2 in 20 Minutes: a Multicenter Study., Glen Hansen, Jamie Marino, Zi-Xuan Wang, Kathleen G Beavis, John Rodrigo, Kylie Labog, Lars F Westblade, Run Jin, Nedra Love, Karen Ding, Sachin Garg, Alan Huang, Joanna Sickler, and Nam K Tran

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3D single cell scale anatomical map of sex-dependent variability of the rat intrinsic cardiac nervous system., Clara Leung, Shaina Robbins, Alison Moss, Maci Heal, Mahyar Osanlouy, Richard Christie, Navid Farahani, Corey Monteith, Jin Chen, Peter Hunter, Susan Tappan, Rajanikanth Vadigepalli, Zixi Jack Cheng, and James S. Schwaber

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NOX4 Signaling Mediates Cancer Development and Therapeutic Resistance through HER3 in Ovarian Cancer Cells., Wen-Jing Liu, Ying-Xue Huang, Wei Wang, Ye Zhang, Bing-Jie Liu, Jian-Ge Qiu, Bing-Hua Jiang, and Ling-Zhi Liu

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Resident immune cells of the avascular lens: Mediators of the injury and fibrotic response of the lens., A. Menko, JodiRae DeDreu, Caitlin M. Logan, Heather Paulson, Alex V Levin, and Janice L Walker

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A single cell transcriptomics map of paracrine networks in the intrinsic cardiac nervous system., Alison Moss, Shaina Robbins, Sirisha Achanta, Lakshmi Kuttippurathu, Scott Turick, Sean Nieves, Peter Hanna, Elizabeth H. Smith, Donald B. Hoover, Jin Chen, Zixi Jack Cheng, Jeffrey L. Ardell, Kalyanam Shivkumar, James S. Schwaber, and Rajanikanth Vadigepalli

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Plasma Adenosine Deaminase (ADA)-1 and -2 Demonstrate Robust Ontogeny Across the First Four Months of Human Life., Oludare A. Odumade, Alec L. Plotkin, Jensen Pak, Olubukola T. Idoko, Matthew A. Pettengill, Tobias R. Kollmann, Al Ozonoff, Beate Kampmann, Ofer Levy, and Kinga K. Smolen

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A rare fatal case of adenovirus serotype 4 associated acute disseminated encephalomyelitis in an adult: A case report, Zahra Qamar, Catherine Tucker, Lawrence C. Kenyon, and Tricia. Royer

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The Mitochondrial Permeability Transition: Nexus of Aging, Disease and Longevity., Hagai Rottenberg and Jan B. Hoek

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TMEM67, TMEM237, and Embigin in Complex With Monocarboxylate Transporter MCT1 Are Unique Components of the Photoreceptor Outer Segment Plasma Membrane., Nikolai P. Skiba, Martha A. Cady, Laurie Molday, John Y.S. Han, Tylor R. Lewis, William J. Spencer, Will J. Thompson, Sarah Hiles, Nancy J. Philp, Robert S. Molday, and Vadim Y. Arshavsky

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Mapping the little brain at the heart by an interdisciplinary systems biology team., Rajanikanth Vadigepalli and James S. Schwaber

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Immune cells in lens injury repair and fibrosis, Janice L Walker and A. Sue Menko

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Specification of the patterning of a ductal tree during branching morphogenesis of the submandibular gland., Janice L Walker, Weihao Wang, Edith Lin, Alison Romisher, Meghan P Bouchie, Brigid Bleaken, A Sue Menko, and Maria A Kukuruzinska

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Discovery of a New CDK4/6 and PI3K/AKT Multiple Kinase Inhibitor Aminoquinol for the Treatment of Hepatocellular Carcinoma., Zhong-Kun Xia, Wei Wang, Jian-Ge Qiu, Xi-Nan Shi, Hong-Jian Li, Rong Chen, Kun-Bin Ke, Chao Dong, Ying Zhu, Shi-Guo Wu, Rong-Ping Zhang, Zhuo-Ran Meng, Hui Zhao, Peng Gu, Kwong-Sak Leung, Man-Hon Wong, Xiao-Dong Liu, Feng-Mei Zhou, Jian-Ying Zhang, Ya-Ting Yao, Si-Jia Wang, Chun-Yang Zhang, Yan-Ru Qin, Marie Chia-Mi Lin, and Bing-Hua Jiang

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Impaired 26S Proteasome Assembly Precedes Neuronal Loss in Mutant UBQLN2 Rats., Wenjuan Zhang, Bo Huang, Limo Gao, and Cao Huang

Manuscripts from 2020

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A Comprehensive Integrated Anatomical and Molecular Atlas of Rat Intrinsic Cardiac Nervous System., Sirisha Achanta, Jonathan Gorky, Clara Leung, Alison Moss, Shaina Robbins, Leonard Eisenman, Jin Chen, Susan Tappan, Maci Heal, Navid Farahani, Todd Huffman, Steve England, Zixi Jack Cheng, Rajanikanth Vadigepalli, and James S Schwaber

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Discoidin Domain Receptor 1 functionally interacts with the IGF-I system in bladder cancer, Simone Buraschi, Alaide Morcavallo, Thomas Neill, Manuela Stefanello, Chiara Palladino, Shi-Qiong Xu, Antonino Belfiore, Renato V. Iozzo, and Andrea Morrione

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CD4 Deficiency Causes Poliomyelitis and Axonal Blebbing in Murine Coronavirus-Induced Neuroinflammation., Debanjana Chakravarty, Fareeha Saadi, Soumya Kundu, Abhishek Bose, Reas Khan, Kimberly Dine, Lawrence C Kenyon, Kenneth S Shindler, and Jayasri Das Sarma

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Hepatic lipocalin 2 promotes liver fibrosis and portal hypertension, Jiegen Chen, Josepmaria Argemi, Gemma Odena, Ming-Jiang Xu, Yan Cai, Veronica Massey, Austin Parrish, Rajanikanth Vadigepalli, Jose Altamirano, Joaquin Cabezas, Pere Gines, Juan Caballeria, Natasha Snider, Pau Sancho-Bru, Shizuo Akira, Ivan Rusyn, Bin Gao, and Ramon Bataller

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Just how many holes…?, Gyorgy Csordas and Stephen Hurst

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Educational Case: A Case of Transfusion-Transmitted Babesiosis: Diagnostic Perspectives Across the Clinical Laboratory., Kaitlyn Dykes and Alexis R. Peedin

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Credible practice of modeling and simulation in healthcare: ten rules from a multidisciplinary perspective, Ahmet Erdemir, Lealem Mulugeta, Joy P Ku, Andrew Drach, Marc Horner, Tina M Morrison, Grace C Y Peng, Rajanikanth Vadigepalli, William W Lytton, and Jerry G Myers

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Abrogation of esophageal carcinoma development in miR-31 knockout rats., Louise Y Fong, Cristian Taccioli, Alexey Palamarchuk, Guidantonio Malagoli Tagliazucchi, Ruiyan Jing, Karl J Smalley, Sili Fan, Joseph Altemus, Oliver Fiehn, Kay Huebner, John L Farber, and Carlo M Croce

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Endorepellin evokes an angiostatic stress signaling cascade in endothelial cells., Aastha Kapoor, Carolyn G Chen, and Renato V Iozzo

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Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Modulates Aggressiveness of Ewing Sarcoma by Regulating the CD164-CXCR4 Axis, Caterina Mancarella, Giulia Caldoni, Irene Ribolsi, Alessandro Parra, Maria Cristina Manara, Arthur M Mercurio, Andrea Morrione, and Katia Scotlandi

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Computational Modeling Analysis of Generation of Reactive Oxygen Species by Mitochondrial Assembled and Disintegrated Complex II., Nikolay I. Markevich, Lubov N. Markevich, and Jan B. Hoek

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Genomic characterization of malignant progression in neoplastic pancreatic cysts, Michaël Noë, Noushin Niknafs, Catherine G Fischer, Wenzel M Hackeng, Violeta Beleva Guthrie, Waki Hosoda, Marija Debeljak, Eniko Papp, Vilmos Adleff, James R White, Claudio Luchini, Antonio Pea, Aldo Scarpa, Giovanni Butturini, Giuseppe Zamboni, Paola Castelli, Seung-Mo Hong, Shinichi Yachida, Nobuyoshi Hiraoka, Anthony J Gill, Jaswinder S Samra, G Johan A Offerhaus, Anne Hoorens, Joanne Verheij, Casper Jansen, N Volkan Adsay, Wei Jiang, Jordan Winter, Jorge Albores-Saavedra, Benoit Terris, Elizabeth D Thompson, Nicholas J Roberts, Ralph H Hruban, Rachel Karchin, Robert B Scharpf, Lodewijk A A Brosens, Victor E Velculescu, and Laura D Wood

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Investigating the Effects of Brainstem Neuronal Adaptation on Cardiovascular Homeostasis., James H Park, Jonathan Gorky, Babatunde Ogunnaike, Rajanikanth Vadigepalli, and James S Schwaber

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Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling, Anindya Roy Chowdhury, Satish Srinivasan, György Csordás, György Hajnóczky, and Narayan G Avadhani

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Diurnal Patterns of Gene Expression in the Dorsal Vagal Complex and the Central Nucleus of the Amygdala - Non-rhythm-generating Brain Regions, Mary M Staehle, Sean O'Sullivan, Rajanikanth Vadigepalli, Kate F Kernan, Gregory E Gonye, Babatunde A Ogunnaike, and James S. Schwaber

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Quantification of lactoyl-CoA (lactyl-CoA) by liquid chromatography mass spectrometry in mammalian cells and tissues., Erika L Varner, Sophie Trefely, David Bartee, Eliana von Krusenstiern, Luke Izzo, Carmen Bekeova, Roddy S O'Connor, Erin L Seifert, Kathryn E Wellen, Jordan L Meier, and Nathaniel W Snyder

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Regulation of MicroRNA-497-Targeting AKT2 Influences Tumor Growth and Chemoresistance to Cisplatin in Lung Cancer., Lin Wang, Xiang-Bo Ji, Li-Hong Wang, Jian-Ge Qiu, Feng-Mei Zhou, Wen-Jing Liu, Di-di Wan, Marie Chai-Mi Lin, Ling-Zhi Liu, Jian-Ying Zhang, and Bing-Hua Jiang

Manuscripts from 2019

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Single-Cell Gene Expression Analysis Identifies Chronic Alcohol-Mediated Shift in Hepatocyte Molecular States After Partial Hepatectomy., Sirisha Achanta, Aalap Verma, Ankita Srivastava, Harshavardhan Nilakantan, Jan B. Hoek, and Rajanikanth Vadigepalli

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IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer, Adam Bartok, David Weaver, Tünde Golenár, Zuzana Nichtova, Máté Katona, Száva Bánsághi, Kamil J. Alzayady, V. Kaye Thomas, Hideaki Ando, Katsuhiko Mikoshiba, Suresh K. Joseph, David I. Yule, György Csordás, and György Hajnóczky

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Multiple mitochondrial thioesterases have distinct tissue and substrate specificity and CoA regulation, suggesting unique functional roles., Carmen Bekeova, Lauren Anderson-Pullinger, Kevin Boye, Felix Boos, Yana Sharpadskaya, Johannes M Herrmann, and Erin L. Seifert

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New Insights into the Lactate Shuttle: Role of MCT4 in the Modulation of the Exercise Capacity., Sara Bisetto, Megan C Wright, Romana A Nowak, Angelo C Lepore, Tejvir S Khurana, Emanuele Loro, and Nancy J Philp

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Comparison of Two Commercial Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) Systems for Identification of Nontuberculous Mycobacteria., Barbara A. Brown-Elliott, Thomas R. Fritsche, Brooke J. Olson, Sruthi Vasireddy, Ravikiran Vasireddy, Elena Iakhiaeva, Diana Alame, Richard J. Wallace, and John A. Branda

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PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth., Weijia Cai, Liya Su, Lili Liao, Zongzhi Z Liu, Lauren Langbein, Essel Dulaimi, Joseph R Testa, Robert G Uzzo, Zhijiu Zhong, Wei Jiang, Qin Yan, Qing Zhang, and Haifeng Yang

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Second-harmonic generation microscopy analysis reveals proteoglycan decorin is necessary for proper collagen organization in prostate., Kirby R. Campbell, Rajeev Chaudhary, Monica Montano, Renato V. Iozzo, Wade A. Bushman, and Paul J. Campagnola

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Methods for Monitoring Matrix-Induced Autophagy., Carolyn Chen, Aastha Kapoor, and Renato V. Iozzo

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Dysregulation of Mitochondrial Ca2+ Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1, Valentina Debattisti, Adam Horn, Raghavendra Singh, Erin L. Seifert, Marshall W. Hogarth, Davi A. Mazala, Kai Ting Huang, Rita Horvath, Jyoti K. Jaiswal, and György Hajnóczky

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A Physiologically-Based Pharmacokinetic Model for Targeting Calcitriol-Conjugated Quantum Dots to Inflammatory Breast Cancer Cells., James Forder, Mallory Smith, Margot Wagner, Rachel J. Schaefer, Jonathan Gorky, Kenneth L. van Golen, Anja Nohe, and Prasad Dhurjati

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Conceptualization of a Parasympathetic Endocrine System., Jonathan Gorky and James Schwaber

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Assessing the utilization of high-resolution 2-field HLA typing in solid organ transplantation., Yanping Huang, Anh Dinh, Steven Heron, Allison Gasiewski, Carolina Kneib, Hilary Mehler, Michael T. Mignogno, Ryan Morlen, Larissa Slavich, Ethan Kentzel, Edward C. Frackelton, Jamie L. Duke, Deborah Ferriola, Timothy Mosbruger, Olga A. Timofeeva, Steven S. Geier, and Dimitri Monos

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Dynamic molecular changes during the first week of human life follow a robust developmental trajectory., Amy H. Lee, Casey P. Shannon, Nelly Amenyogbe, Tue B. Bennike, Joann Diray-Arce, Olubukola T. Idoko, Erin E. Gill, Rym Ben-Othman, William S. Pomat, Simon D. van Haren, Kim-Anh Lê Cao, Momoudou Cox, Alansana Darboe, Reza Falsafi, Davide Ferrari, Daniel J. Harbeson, Daniel He, Cai Bing, Samuel J. Hinshaw, Jorjoh Ndure, Jainaba Njie-Jobe, Matthew A. Pettengill, Peter C. Richmond, Rebecca Ford, Gerard Saleu, Geraldine Masiria, John Paul Matlam, Wendy Kirarock, Elishia Roberts, Mehrnoush Malek, Guzmán Sanchez-Schmitz, Amrit Singh, Asimenia Angelidou, Kinga K. Smolen, Diana Vo, Ken Kraft, Kerry McEnaney, Sofia Vignolo, Arnaud Marchant, Ryan R. Brinkman, Al Ozonoff, Robert E.W. Hancock, Anita H.J. van den Biggelaar, Hanno Steen, Scott J. Tebbutt, Beate Kampmann, Ofer Levy, and Tobias R. Kollmann

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Is Retinal Metabolic Dysfunction at the Center of the Pathogenesis of Age-related Macular Degeneration?, Thierry Léveillard, Nancy J. Philp, and Florian Sennlaub

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Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation., Alyssa A. Lombardi, Andrew A. Gibb, Ehtesham Arif, Devin W. Kolmetzky, Dhanendra Tomar, Timothy S. Luongo, Pooja Jadiya, Emma K. Murray, Pawel K. Lorkiewicz, György Hajnóczky, Elizabeth Murphy, Zoltan P. Arany, Daniel P. Kelly, Kenneth B. Margulies, Bradford G. Hill, and John W. Elrod

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Gangliosides: Treatment Avenues in Neurodegenerative Disease., Pierre J. Magistretti, Fred H. Geisler, Jay S. Schneider, P. Andy Li, Hubert Fiumelli, and Simonetta Sipione

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Perturbed mitochondria-ER contacts in live neurons that model the amyloid pathology of Alzheimer's disease., Pamela V. Martino Adami, Zuzana Nichtova, David B. Weaver, Adam Bartok Dr., Thomas Wisniewski, Drew R. Jones, Sonia Do Carmo, Eduardo M. Castaño, A. Claudio Cuello, György Hajnóczky, and Laura Morelli

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Single-Cell Glia and Neuron Gene Expression in the Central Amygdala in Opioid Withdrawal Suggests Inflammation With Correlated Gut Dysbiosis, Sean J. O'Sullivan, Evangelia Malahias, James Park, Ankita Srivastava, Beverly A.S. Reyes, Jonathan Gorky, Rajanikanth Vadigepalli, Elisabeth J. Van Bockstaele, and James S. Schwaber

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The top 10 things to know about transfusion medicine before intern year: an evidence-based course for graduating medical students., Alexis R. Peedin, Irina Perjar, Marshall A. Mazepa, Marian A. Rollins-Raval, Yara A. Park, and Jay S. Raval

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Probable Donor-Derived Human Adenovirus Type 34 Infection in 2 Kidney Transplant Recipients From the Same Donor., Matthew A. Pettengill, Tara M. Babu, Paritosh Prasad, Sally Chuang, Michael G. Drage, Marilyn Menegus, Daryl M. Lamson, Xiaoyan Lu, Dean Erdman, and Nicole Pecora

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GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson's Disease., Jay S. Schneider, Radha Aras, Courtney K. Williams, James B. Koprich, Jonathan M. Brotchie, and Vikrant Singh

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Coming together to define membrane contact sites., Luca Scorrano, Maria Antonietta De Matteis, Scott Emr, Francesca Giordano, György Hajnóczky, Benoît Kornmann, Laura L. Lackner, Tim P. Levine, Luca Pellegrini, Karin Reinisch, Rosario Rizzuto, Thomas Simmen, Harald Stenmark, Christian Ungermann, and Maya Schuldiner

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A proline insertion-deletion in the spike glycoprotein fusion peptide of mouse hepatitis virus strongly alters neuropathology., Manmeet Singh, Abhinoy Kishore, Dibyajyoti Maity, Punnepalli Sunanda, Bankala Krishnarjuna, Sreeparna Vappala, Srinivasarao Raghothama, Lawrence C. Kenyon, Debnath Pal, and Jayasri Das Sarma

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Model-based virtual patient analysis of human liver regeneration predicts critical perioperative factors controlling the dynamic mode of response to resection., Babita Verma, Pushpavanam Subramaniam, and Rajanikanth Vadigepalli

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Case-Based Asynchronous Interactive Modules in Undergraduate Medical Education., Tatiana Villatoro, Katherine Lackritz, and Joanna S Y Chan

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Clinical, Cytogenetic, and Molecular Findings in Two Cases of Variant t(8;21) Acute Myeloid Leukemia (AML)., Lindsay Wilde, Jillian Cooper, Zi-Xuan Wang, and Jinglan Liu

Manuscripts from 2018

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SPSNet: subpopulation-sensitive network-based analysis of heterogeneous gene expression data., Abha Belorkar, Rajanikanth Vadigepalli, and Limsoon Wong

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Monocarboxylate Transporter 4 (MCT4) Knockout Mice Have Attenuated 4NQO Induced Carcinogenesis; A Role for MCT4 in Driving Oral Squamous Cell Cancer., Sara Bisetto, Diana Whitaker Menezes, Nicole A. Wilski, Madalina Tuluc, Joseph Curry, Tingting Zhan, Christopher M. Snyder, Ubaldo E. Martinez-Outshoorn, and Nancy J. Philp

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Mutant UBQLN2P497H in motor neurons leads to ALS-like phenotypes and defective autophagy in rats, Tianhong Chen, Bo Huang, Xinglong Shi, Limo Gao, and Cao Huang

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Cellular network modeling and single cell gene expression analysis reveals novel hepatic stellate cell phenotypes controlling liver regeneration dynamics, Daniel Cook, Sirisha Achanta, Jan B. Hoek, Babatunde A. Ogunnaike, and Rajanikanth Vadigepalli

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Metformin Clinical Trial in HPV+ and HPV- Head and Neck Squamous Cell Carcinoma: Impact on Cancer Cell Apoptosis and Immune Infiltrate., Joseph M. Curry; Jennifer Johnson; Mehri Mollaee; Patrick Tassone; Dev Amin; Alexander Knops; Diana Whitaker Menezes; My Mahoney; Andrew P. South; Ulrich Rodeck; Tingting Zhan; Larry A. Harshyne; Nancy Philp; Adam J. Luginbuhl; David Cognetti; Madalina Tuluc; and Ubaldo E. Martinez-Outshoorn, MD

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Microtubule-Associated Protein 1 Light Chain 3B, (LC3B) Is Necessary to Maintain Lipid-Mediated Homeostasis in the Retinal Pigment Epithelium., Anuradha Dhingra, Brent A Bell, Neal S. Peachey, Lauren L. Daniele, Juan Reyes-Reveles, Rachel C. Sharp, Bokkyoo Jun, Nicolas G. Bazan, Janet R. Sparrow, Hye Jin Kim, Nancy J. Philp, and Kathleen Boesze-Battaglia

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Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats., Louise Y. Fong, Ruiyan Jing, Karl J. Smalley, Zi-Xuan Wang, Cristian Taccioli, Sili Fan, Hongping Chen, Hansjuerg Alder, Kay Huebner, John L. Farber, Oliver Fiehn, and Carlo M. Croce

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Potential role of CSF cytokine profiles in discriminating infectious from non-infectious CNS disorders., Danielle Fortuna, D. Craig Hooper, Amity L. Roberts, Larry A. Harshyne, Michelle Nagurney, and Mark T. curtis

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Hypoxia-mediated mitochondria apoptosis inhibition induces temozolomide treatment resistance through miR-26a/Bad/Bax axis., Xin Ge, Min-Hong Pan, Lin Wang, Wei Li, Chengfei Jiang, Jun He, Khaled Abouzid, Ling-Zhi Liu, Zhumei Shi, and Bing-Hua Jiang

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Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas., Felipe C. Geyer, Anqi Li, Anastasios D. Papanastasiou, Alison Smith, Pier Selenica, Kathleen A. Burke, Marcia Edelweiss, Huei-Chi Wen, Salvatore Piscuoglio, Anne M. Schultheis, Luciano G. Martelotto, Fresia Pareja, Rahul Kumar, Alissa Brandes, Dan Fan, Thais Basili, Arnaud Da Cruz Paula, John R. Lozada, Pedro Blecua, Simone Muenst, Achim A. Jungbluth, Maria P. Foschini, Hannah Y. Wen, Edi Brogi, Juan P. Palazzo, Brian P. Rubin, Charlotte K.Y. Ng, Larry Norton, Zsuzsanna Varga, Ian O. Ellis, Emad A. Rakha, Sarat Chandarlapaty, Britta Weigelt, and Jorge S. Reis-Filho

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Metabolic reprogramming of murine cardiomyocytes during autophagy requires the extracellular nutrient sensor decorin., Maria A. Gubbiotti, Erin L. Seifert, Ulrich Rodeck, Jan B. Hoek, and Renato V. Iozzo

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Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells., Suresh K. Joseph, Michael P. Young, Kamil Alzayady, David I. Yule, Mehboob Ali, David M. Booth, and György Hajnóczky

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Phosphaturic mesenchymal tumor of the nasal cavity: Clinicopathologic correlation is essential for diagnosis, Aidan Kerr, Ryan Rimmer, Marc Rosen, James J. Evans, Madalina Tuluc, and Stacey K. Mardekian

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Bacterial contamination of platelets for transfusion: strategies for prevention., Jerrold H. Levy, Matthew D. Neal, and Jay H. Herman

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High affinity binding of H3K14ac through collaboration of bromodomains 2, 4 and 5 is critical for the molecular and tumor suppressor functions of PBRM1., Lili Liao, Nilda L. Alicea-Velázquez, Lauren Langbein, Xiaohua Niu, Weijia Cai, Eun-Ah Cho, Meiling Zhang, Celeste B. Greer, Qin Yan, Michael S. Cosgrove, and Haifeng Yang

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Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer., Lili Liao, Zongzhi Z. Liu, Lauren Langbein, Weijia Cai, Eun-Ah Cho, Jie Na, Xiaohua Niu, Wei Jiang, Zhijiu Zhong, Wesley L. Cai, Geetha Jagannathan, Essel Dulaimi, Joseph R. Testa, Robert G. Uzzo, Yuxin Wang, George R. Stark, Jianxin Sun, Stephen C. Peiper, Yaomin Xu, Qin Yan, and Haifeng Yang

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Credibility, Replicability, and Reproducibility in Simulation for Biomedicine and Clinical Applications in Neuroscience., Lealem Mulugeta, Andrew Drach, Ahmet Erdemir, C A Hunt, Marc Horner, Joy P. Ku, Jerry G Myers, Rajanikanth Vadigepalli, and William W. Lytton

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Mitochondrial fusion and Bid-mediated mitochondrial apoptosis are perturbed by alcohol with distinct dependence on its metabolism, Shamim Naghdi, William S. Slovinsky, Muniswamy Madesh, Emanual Rubin, and György Hajnóczky

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Endorepellin remodels the endothelial transcriptome toward a pro-autophagic and pro-mitophagic gene signature., Thomas Neill, Eva Andreuzzi, Zi-Xuan Wang, Stephen C. Peiper, Maurizo Mongiat, and Renato V. Iozzo

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MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca2+ Flux and Sensitivity to Ru360, Melanie Paillard, György Csordás, Kai-Ting Huang, Peter Várnai, Suresh K. Joseph, and György Hajnóczky

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Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors., Fresia Pareja, Alissa H. Brandes, Thais Basili, Pier Selenica, Felipe C. Geyer, Dan Fan, Arnaud Da Cruz Paula, Rahul Kumar, David N. Brown, Rodrigo Gularte-Mérida, Barbara Alemar, Rui Bi, Raymond S. Lim, Ino de Bruijn, Sho Fujisawa, Rui Gardner, Elvin Feng, Anqi Li, Edaise M. da Silva, John R. Lozada, Pedro Blecua, Leona Cohen-Gould, Achim A. Jungbluth, Emad A. Rakha, Ian O. Ellis, Maria I.A. Edelweiss, Juan P. Palazzo, Larry Norton, Travis Hollmann, Marcia Edelweiss, Brian P. Rubin, Britta Weigelt, and Jorge S. Reis-Filho

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Antimicrobial peptide LL-37 and recombinant human mannose-binding lectin express distinct age- and pathogen-specific antimicrobial activity in human newborn cord blood in vitro, Annette Scheid, Ning Li, Carleen Jeffers, Francesco Borriello, Sweta Joshi, Al Ozonoff, Matthew Pettengill, and Ofer Levy

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Altered expression of genes involved in ganglioside biosynthesis in substantia nigra neurons in Parkinson's disease., Jay S. Schneider

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Sex-dependent effects of developmental lead exposure on the brain, Garima Singh, Vikrant Singh, Marissa Sobolewski, Deborah A. Cory-Slechta, and Jay S. Schneider

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Different Behavioral Experiences Produce Distinctive Parallel Changes in, and Correlate With, Frontal Cortex and Hippocampal Global Post-translational Histone Levels., Marissa Sobolewski, Garima Singh, Jay S. Schneider, and Deborah A. Cory-Slechta

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Synchronous gastric and duodenal metastases from head and neck squamous cell carcinoma: a unique presentation of upper gastrointestinal bleeding., Nicholas P. Tarangelo, Charles Andrew Kistler, Zachary Daitch, Wei Jiang, and Daniel M. Quirk

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Neuroprotective Role of Phytochemicals., Bharath Kumar Velmurugan, Baskaran Rathinasamy, Bharathi Priya Lohanathan, Varadharajan Thiyagarajan, and Ching-Feng Weng

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Causality Analysis and Cell Network Modeling of Spatial Calcium Signaling Patterns in Liver Lobules., Aalap Verma, Anil Noronha Antony, Babatunde A. Ogunnaike, Jan B. Hoek, and Rajanikanth Vadigepalli

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Modeling the dynamics of human liver failure post liver resection, Babita Verma, Pushpavanam Subramaniam, and Rajanikanth Vadigepalli

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In wound repair vimentin mediates the transition of mesenchymal leader cells to a myofibroblast phenotype., J. L. Walker, B. M. Bleaken, A. R. Romisher, A. A. Alnwibit, and A. S. Menko

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Developing a Backup Plan: Implementing a Career-Planning Course for Undergraduate Biology Majors., Julianne M. Winters, Haizhi Wang, Laura E. Duwel, Elizabeth A. Spudich, and Jennifer S. Stanford

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Epidemiology of moderate alcohol consumption and breast cancer: Association or causation?, Samir Zakhari and Jan B. Hoek

Manuscripts from 2017

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How Should Clinicians Weigh the Benefits and Harms of Discussing Politicized Topics that Influence Their Individual Patients' Health?, Diana Alame and Robert D. Truog

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Novel Influences of IL-10 on CNS Inflammation Revealed by Integrated Analyses of Cytokine Networks and Microglial Morphology., Warren D. Anderson, Andrew D. Greenhalgh, Aditya Takwale, Samuel David, and Rajanikanth Vadigepalli

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Intracellular Ca 2+ sensing: role in calcium homeostasis and signaling, Rafaela Bagur and György Hajnóczky

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Life After Being a Pathology Department Chair II: Lessons Learned., David N. Bailey, Mary F. Lipscomb, Fred Gorstein, David Wilkinson, and Fred Sanfilippo

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A simple and accurate rule-based modeling framework for simulation of autocrine/paracrine stimulation of glioblastoma cell motility and proliferation by L1CAM in 2-D culture., Justin Caccavale, David Fiumara, Michael Stapf, Liedeke Sweitzer, Hannah J. Anderson, Jonathan Gorky, Prasad Dhurjati, and Deni S. Galileo

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Microscopic Examination of Findings Encountered during Cadaver Dissection: Malignant, Benign or Anatomic Variation?, Maria Cicioni, Vandi Ly, Guiyun Zhang, and Bruce Fenderson

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Developmental Lead and/or Prenatal Stress Exposures Followed by Different Types of Behavioral Experience Result in the Divergence of Brain Epigenetic Profiles in a Sex, Brain Region, and Time-Dependent Manner: Implications for Neurotoxicology., Deborah A. Cory-Slechta, Marissa Sobolewski, Garima Varma, and Jay S. Schneider

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ROS Control Mitochondrial Motility through p38 and the Motor Adaptor Miro/Trak., Valentina Debattisti, Akos A. Gerencser, Masao Saotome, Sudipto Das, and György Hajnóczky

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Integration of metabolomics, transcriptomics, and microRNA expression profiling reveals a miR-143-HK2-glucose network underlying zinc-deficiency-associated esophageal neoplasia, Louise Y. Fong, Ruiyan Jing, Karl Smalley, Cristian Taccioli, Johannes Fahrmann, Dinesh K. Barupal, Hansjuerg Alder, John L. Farber, Oliver Fiehn, and Carlo M. Croce