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Manuscripts from 2023

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Longitudinal Ultrasound Imaging and Network Modeling in Rats Reveal Sex-Dependent Suppression of Liver Regeneration After Resection in Alcoholic Liver Disease, Benjamin K. Barnhart, Toshiki Kan, Ankita Srivastava, Corinne E. Wessner, John Waters, Manju Ambelil, John R. Eisenbrey, Jan B. Hoek, and Rajanikanth Vadigepalli

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Autophagy Requirements for Eye Lens Differentiation and Transparency, Lisa Brennan, M Joseph Costello, J Fielding Hejtmancik, A. Menko, S Amer Riazuddin, Alan Shiels, and Marc Kantorow

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OPA1 Disease-Causing Mutants Have Domain-Specific Effects on Mitochondrial Ultrastructure and Fusion, Benjamín Cartes-Saavedra, Daniel Lagos, Josefa Macuada, Duxan Arancibia, Florence Burté, Marcela K. Sjöberg-Herrera, María Estela Andrés, Rita Horvath, Patrick Yu-Wai-Man, György Hajnóczky, and Verónica Eisner

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Sexual Dimorphism in Bidirectional Sr-Mitochondria Crosstalk in Ventricular Cardiomyocytes, Richard T Clements, Radmila Terentyeva, Shanna Hamilton, Paul M L Janssen, Karim Roder, Benjamin Y Martin, Fruzsina Perger, Timothy G Schneider, Zuzana Nichtova, Anindhya S Das, Roland Veress, Beth S Lee, Do-Gyoon Kim, Gideon Koren, Matthew S Stratton, György Csordás, Federica Accornero, Andriy E Belevych, Sandor Gyorke, and Dmitry Terentyev

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Transcriptomic Changes Predict Metabolic Alterations in LC3 Associated Phagocytosis in Aged Mice, Anuradha Dhingra, John W. Tobias, Nancy J. Philp, and Kathleen Boesze-Battaglia

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Closed-Loop Modeling of Central and Intrinsic Cardiac Nervous System Circuits Underlying Cardiovascular Control, Michelle M. Gee, Abraham M. Lenhoff, James S. Schwaber, Babatunde A. Ogunnaike, and Rajanikanth Vadigepalli

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Corneal Injury Is Associated With Stromal and Vascular Alterations Within Cranial Dura Mater, Olga V. Glinskii, Vladislav V. Glinsky, Leike Xie, Filiz Bunyak, Vladimir V. Glinskii, Sunilima Sinha, Suneel Gupta, Renato V. Iozzo, and Rajiv R. Mohan

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Acute ACAT1/SOAT1 Blockade Increases MAM Cholesterol and Strengthens ER-Mitochondria Connectivity., Taylor C Harned, Radu V Stan, Ze Cao, Rajarshi Chakrabarti, Henry N Higgs, Catherine C Y Chang, and Ta Yuan Chang

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Undergraduate Medical Student Perspectives on the Role of Autopsy in Medical Education, Patrick Hearle, Wing Fei Wong, and Joanna Chan

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Experiential Exposure as the Key to Recruiting Medical Students Into Pathology, Ashley M. Holloman, Mary P. Berg, Bronwyn Bryant, Lisa Ross Dixson, Melissa R. George, Julie Katz Karp, Barbara E.C. Knollmann-Ritschel, Victor Gerardo Prieto, Charles F. Timmons, John Michael Childs, Amanda Lofgreen, Kristen Johnson, and Cindy B. McCloskey

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How Influential Are Medical School Curriculum and Other Medical School Characteristics in Students’ Selecting Pathology as a Specialty?, Cindy B. McCloskey, Mark Brissette, John Michael Childs, Amanda Lofgreen, Kristen Johnson, Melissa R. George, Ashley M. Holloman, Bronwyn Bryant, Mary P. Berg, Lisa Ross Dixon, Julie Katz Karp, Barbara E.C. Knollmann-Ritschel, Victor Gerardo Prieto, Charles F. Timmons, and Robert D. Hoffman

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High expression of Talin-1 is associated with tumor progression and recurrence in melanoma skin cancer patients., Yasaman Rezaie, Fahimeh Fattahi, Baharnaz Mashinchi, Kambiz Kamyab Hesari, Sahar Montazeri, Elham Kalantari, Zahra Madjd, and Leili Saeednejad Zanjani

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MICU1 Occludes the Mitochondrial Calcium Uniporter in Divalent-Free Conditions, Macarena Rodríguez-Prados, Elena Berezhnaya, Maria Teresa Castromonte, Sergio L. Menezes-Filho, Melanie Paillard, and György Hajnóczky

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Estimated Impact of Low Isolate Numbers on the Reliability of Cumulative Antibiogram Data, Christian Tran, John Hargy, Bryan Hess, and Matthew Pettengill

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Supporting a Culture of Patient Safety: Resident-Led Patient Safety Event Reviews in a Pathology Residency Training Program, Catherine Tucker; Rebecca C. Jaffe,; and Allison F Goldberg

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Educational Case: Ovarian Neoplasms: A Series of Educational Cases to Review Malignancies of Epithelial, Stromal, and Germ Cell Origin, Jordyn B. Tumas and Joanna Chan

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Progranulin Oncogenic Network in Solid Tumors, Elisa Ventura, Giacomo Ducci, Reyes Benot Dominguez, Valentina Ruggiero, Antonino Belfiore, Elena Sacco, Marco Vanoni, Renato V. Iozzo, Antonio Giordano, and Andrea Morrione

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Exploring the Past, Present, and Future of Anti-Angiogenic Therapy in Glioblastoma., Ashley B. Zhang, Khashayar Mozaffari, Brian Aguirre, Victor Li, Rohan Kubba, Nilay C Desai, Darren Wei, Isaac Yang, and Madhuri Wadehra

Manuscripts from 2022

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A mathematical model of GLUT1 modulation in rods and RPE and its differential impact in cell metabolism, Andrea Aparicio, Erika T Camacho, Nancy J. Philp, and Stephen A Wirkus

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Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors, Vikas Arige, Lara E. Terry, Larry E. Wagner, Sundeep Malik, Mariah R. Baker, Guizhen Fan, Suresh K. Joseph, Irina I Serysheva, and David I. Yule

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PI3K Isoform-Specific Regulation of Leader and Follower Cell Function for Collective Migration and Proliferation in Response to Injury, Morgan D Basta, A. Menko, and Janice L Walker

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Fluorescence imaging detection of nanodomain redox signaling events at organellar contacts, David M. Booth, Péter Várnai, Suresh K Joseph, and György Hajnóczky

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OPA1 Modulates Mitochondrial Ca 2+ Uptake Through ER-Mitochondria Coupling, Benjamín Cartes-Saavedra, Josefa Macuada, Daniel Lagos, Duxan Arancibia, María E Andrés, Patrick Yu-Wai-Man, György Hajnóczky, and Verónica Eisner

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Extracellular matrix guidance of autophagy: a mechanism regulating cancer growth, Carolyn Chen and Renato V. Iozzo

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Reduced ER-mitochondria connectivity promotes neuroblastoma multidrug resistance., Jorida Çoku, David M. Booth, Jan Skoda, Madison C Pedrotty, Jennifer Vogel, Kangning Liu, Annette Vu, Erica L Carpenter, Jamie C Ye, Michelle A Chen, Peter Dunbar, Elizabeth Scadden, Taekyung D Yun, Eiko Nakamaru-Ogiso, Estela Area-Gomez, Yimei Li, Kelly C Goldsmith, C Patrick Reynolds, György Hajnóczky, and Michael D Hogarty

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Interferon Gamma Release Assay Mitogen Responses in COVID-19, Dagan Coppock, Claire E. Zurlo, Jenna M. Meloni, Sara L. Goss, John J. Zurlo, and Matthew A. Pettengill

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Glucose Uptake by GLUT1 in Photoreceptors is Essential for Outer Segment Renewal and rod Photoreceptor Survival, Lauren L. Daniele, John Y.S. Han, Ivy S Samuels, Ravikiran Komirisetty, Nikhil Mehta, Jessica L McCord, Minzhong Yu, Yekai Wang, Kathleen Boesze-Battaglia, Brent A Bell, Jianhai Du, Neal S Peachey, and Nancy J. Philp

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Uveitis-mediated immune cell invasion through the extracellular matrix of the lens capsule, JodiRae DeDreu, Sonali Pal-Ghosh, Mary J Mattapallil, Rachel R Caspi, Mary Ann Stepp, and A Sue Menko

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Uveitis-mediated immune cell invasion through the extracellular matrix of the lens capsule., JodiRae DeDreu, Sonali Pal-Ghosh, Mary J Mattapallil, Rachel R Caspi, Mary Ann Stepp, and A Sue Menko

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Bacille Calmette-Guérin vaccine reprograms human neonatal lipid metabolism in vivo and in vitro, Joann Diray-Arce, Asimenia Angelidou, Kristoffer Jarlov Jensen, Maria Giulia Conti, Rachel S Kelly, Matthew Pettengill, Mark Liu, Simon D van Haren, Scott D McCulloch, Greg Michelloti, Olubukola Idoko, Tobias R Kollmann, Beate Kampmann, Hanno Steen, Al Ozonoff, Jessica Lasky-Su, Christine S Benn, and Ofer Levy

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Human Dectin-1 Deficiency Impairs Macrophage-Mediated Defense Against Phaeohyphomycosis, Rebecca A. Drummond, Jigar V. Desai, Amy P. Hsu, Vasileios Oikonomou, Donald C. Vinh, Joshua A. Acklin, Michael S. Abers, Magdalena A. Walkiewicz, Sarah L. Anzick, Muthulekha Swamydas, Simon Vautier, Mukil Natarajan, Andrew J. Oler, Daisuke Yamanaka, Katrin D. Mayer-Barber, Yoichiro Iwakura, David Bianchi, Brian Driscoll, Ken Hauck, Ahnika Kline, Nicholas S.P. Viall, Christa S. Zerbe, Elise M.N. Ferré, Monica M. Schmitt, Tom DiMaggio, Stefania Pittaluga, John A. Butman, Adrian M. Zelazny, Yvonne R. Shea, Cesar A. Arias, Cameron Ashbaugh, Maryam Mahmood, Zelalem Temesgen, Alexander G. Theofiles, Masayuki Nigo, Varsha Moudgal, Karen C. Bloch, Sean G. Kelly, M. Suzanne Whitworth, Ganesh Rao, Cindy J. Whitener, Neema Mafi, Juan Gea-Banacloche, Lawrence C. Kenyon, William R. Miller, Katia Boggian, Andrea Gilbert, Matthew Sincock, Alexandra F. Freeman, John E. Bennett, Rodrigo Hasbun, Constantinos M. Mikelis, Kyung J. Kwon-Chung, Yasmine Belkaid, Gordon D. Brown, Jean K. Lim, Douglas B. Kuhns, Steven M. Holland, and Michail S. Lionakis

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Suppression of PI3K signaling is linked to autophagy activation and the spatiotemporal induction of the lens organelle free zone, Rifah Gheyas, Ramon Ortega-Alvarez, Daniel Chauss, Marc Kantorow, and A. Menko

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Unreliable Automated Complete Blood Count Results: Causes, Recognition, and Resolution, Gene Gulati, Guldeep Uppal, and Jerald Z. Gong

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Microbial Cell Factory of Baccatin III Preparation in Escherichia coli by Increasing DBAT Thermostability and in vivo Acetyl-CoA Supply, Jia-Jun Huang, Tao Wei, Zhi-Wei Ye, Qian-Wang Zheng, Bing-Hua Jiang, Wen-Feng Han, An-Qi Ye, Pei-Yun Han, Li-Qiong Guo, and Jun-Fang Lin

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Capture at the ER-Mitochondrial Contacts Licenses IP, Máté Katona, Ádám Bartók, Zuzana Nichtova, György Csordás, Elena Berezhnaya, David Weaver, Arijita Ghosh, Péter Várnai, David I. Yule, and György Hajnóczky

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68-year old man with progressive weakness and ventilator dependent respiratory failure: a case report of sporadic late onset nemaline myopathy, P. Kirupaharan, Daniel Kramer, Alan Gandler, Lawrence C. Kenyon, and Ross Summer

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BAP1 Maintains Hif-Dependent Interferon Beta Induction to Suppress Tumor Growth in Clear Cell Renal Cell Carcinoma., Lauren Langbein, Rayan El Hajjar, Shen He, Eleonora Sementino, Zhijiu Zhong, Wei Jiang, Benjamin E Leiby, Li Li, Robert G Uzzo, Joseph R Testa, and Haifeng Yang

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Data Supporting the Roles of BAP1, Sting, and IFN-β in ISGF3 Activation in ccRCC, Lauren E Langbein, Eleonora Sementino, Zhijiu Zhong, Wei Jiang, Li Li, Joseph R Testa, and Haifeng Yang

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Patient with Multiple Genetically Distinct Thyroid Nodules Including Papillary Thyroid Carcinoma Harboring Novel YWHAG-BRAF Fusion, Ruihe Lin, Zi-Xuan Wang, Elizabeth Cottrill, Nitika Badjatia, and Stacey Gargano

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miR-196a Upregulation Contributes to Gefitinib Resistance through Inhibiting GLTP Expression, Bing-Jie Liu, Fang-Fang Li, Yun-Xia Xie, Chong-Yuan Fan, Wen-Jing Liu, Jian-Ge Qiu, and Bing-Hua Jiang

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Reactive oxygen species reprogram macrophages to suppress antitumor immune response through the exosomal miR-155-5p/PD-L1 pathway, Xiang Li, Shaomin Wang, Wei Mu, Jennifer Barry, Anna Han, Richard L Carpenter, Bing-Hua Jiang, Stephen C Peiper, M G Mahoney, A E Aplin, Hong Ren, and Jun He

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Genome-Scale Metabolic Modeling Reveals Sequential Dysregulation of Glutathione Metabolism in Livers from Patients with Alcoholic Hepatitis, Alexandra Manchel, Radhakrishnan Mahadevan, Ramon Bataller, Jan B. Hoek, and Rajanikanth Vadigepalli

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Patterns of Crystallin Gene Expression in Differentiation State Specific Regions of the Embryonic Chicken Lens, Zhiwei Ma, Daniel Chauss, Joshua Disatham, Xiaodong Jiao, Lisa Ann Brennan, A Sue Menko, Marc Kantorow, and J Fielding Hejtmancik

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The Pro-fibrotic Response of Mesenchymal Leader Cells to Lens Wounding Involves Hyaluronic Acid, Its Receptor RHAMM, and Vimentin, A. Sue Menko, Alison Romisher, and Janice L Walker

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The Pro-Fibrotic Response to Lens Injury is Signaled in a PI3K Isoform-Specific Manner, A. Sue Menko and Janice L. Walker

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The Role of Decorin Proteoglycan in Mitophagy., Thomas Neill and Renato V. Iozzo

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Single-cell systems neuroscience: A growing frontier in mental illness, Sean O'Sullivan

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Germline Polymorphisms in MGMT Associated With Temozolomide-Related Myelotoxicity Risk in Patients With Glioblastoma Treated on NRG Oncology/RTOG 0825, Michael E Scheurer, Renke Zhou, Mark R Gilbert, Melissa L Bondy, Erik P Sulman, Ying Yuan, Yanhong Liu, Elizabeth Vera, Merideth M Wendland, Emad F Youssef, Volker W Stieber, Ritsuko R Komaki, John C Flickinger, Lawrence C. Kenyon, H Ian Robins, Grant K Hunter, Ian R Crocker, Samuel T Chao, Stephanie L Pugh, and Terri S Armstrong

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Altered Expression of Glycobiology-Related Genes in Parkinson’s Disease Brain, Jay S Schneider and Garima Singh

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GM1 ganglioside modifies microglial and neuroinflammatory responses to α-synuclein in the rat AAV-A53T α-synuclein model of Parkinson's disease, Jay S Schneider, Garima Singh, Courtney K. Williams, and Vikrant Singh

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Altered Genome-wide Hippocampal Gene Expression Profiles Following Early Life Lead Exposure and Their Potential for Reversal by Environmental Enrichment, Garima Singh, V Singh, T Kim, A Ertel, W Fu, and J S Schneider

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Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of neurodegeneration in MICU1-deficient mice and patients, Raghavendra Singh, Adam Bartok, Melanie Paillard, Ashley L. Tyburski, Melanie B Elliott, and György Hajnóczky

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Complexity of Progranulin Mechanisms of Action in Mesothelioma, Elisa Ventura, Christopher Xie, Simone Buraschi, Antonino Belfiore, Renato V. Iozzo, Antonio Giordano, and Andrea Morrione

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Oncosuppressive roles of decorin through regulation of multiple receptors and diverse signaling pathways., Christopher Xie, Dipon K Mondal, Mikdat Ulas, Thomas Neill, and Renato V Iozzo

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Human endothelial cells promote arsenic-transformed lung epithelial cells to induce tumor growth and angiogenesis through interleukin-8 induction, Lei Zhao, Yi-Fang Wang, Jie Liu, Bing-Hua Jiang, and Ling-Zhi Liu

Manuscripts from 2021

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Dabigatran reduces thrombin-induced neuroinflammation and AD markers in vitro: Therapeutic relevance for Alzheimer's disease, Syed Waseem Bihaqi, Haripriya Vittal Rao, Abhik Sen, and Paula Grammas

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The Role of Decorin and Biglycan Signaling in Tumorigenesis, Valentina Diehl, Lisa Sophie Huber, Jonel Trebicka, Malgorzata Wygrecka, Renato V. Iozzo, and Liliana Schaefer

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Simultaneous brain and intramedullary spinal abscesses in a patient with Streptococcus intermedius infection, David P. Friedman, Joseph DeSimone Jr, Aaron Christensen, and Matthew Pettengill

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Characterization and Clinical Significance of EIF1AX Mutations and Co-Mutations in Cytologically Indeterminate Thyroid Nodules: A 5-Year Retrospective Analysis., Stacey Gargano; Nitika Badjatia; Yanina Nikolaus; Stephen C Peiper; and Zi-Xuan Wang, PhD

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Genetic Variants and Tumor Immune Microenvironment: Clues for Targeted Therapies in Inflammatory Breast Cancer (IBC), Yulan Gong, Rajeswari Nagarathinam, Maria F. Arisi, Lorenzo Gerratana, Jennifer S Winn, Michael Slifker, Jianming Pei, Kathy Q Cai, Zachary Hasse, Elias Obeid, Julio Noriega, Christopher Sebastiano, Eric Ross, Katherine Alpaugh, Massimo Cristofanilli, and Sandra V Fernandez

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Clinical Performance of the Point-of-Care cobas Liat for Detection of SARS-CoV-2 in 20 Minutes: a Multicenter Study., Glen Hansen, Jamie Marino, Zi-Xuan Wang, Kathleen G Beavis, John Rodrigo, Kylie Labog, Lars F Westblade, Run Jin, Nedra Love, Karen Ding, Sachin Garg, Alan Huang, Joanna Sickler, and Nam K Tran

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3D single cell scale anatomical map of sex-dependent variability of the rat intrinsic cardiac nervous system., Clara Leung, Shaina Robbins, Alison Moss, Maci Heal, Mahyar Osanlouy, Richard Christie, Navid Farahani, Corey Monteith, Jin Chen, Peter Hunter, Susan Tappan, Rajanikanth Vadigepalli, Zixi Jack Cheng, and James S. Schwaber

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The immunotherapy candidate TNFSF4 may help the induction of a promising immunological response in breast carcinomas., Kai Li, Lei Ma, Ye Sun, Xiang Li, Hong Ren, Shou-Ching Tang, and Xin Sun

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M6A associated TSUC7 inhibition contributed to Erlotinib resistance in lung adenocarcinoma through a notch signaling activation dependent way, Kai Li, Zi-Yang Peng, Shan Gao, Qing-Shi Wang, Rui Wang, Xiang Li, Guo-Dong Xiao, Jing Zhang, Hong Ren, Shou-Ching Tang, and Xin Sun

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NOX4 Signaling Mediates Cancer Development and Therapeutic Resistance through HER3 in Ovarian Cancer Cells., Wen-Jing Liu, Ying-Xue Huang, Wei Wang, Ye Zhang, Bing-Jie Liu, Jian-Ge Qiu, Bing-Hua Jiang, and Ling-Zhi Liu

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Resident immune cells of the avascular lens: Mediators of the injury and fibrotic response of the lens., A. Menko, JodiRae DeDreu, Caitlin M. Logan, Heather Paulson, Alex V Levin, and Janice L Walker

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A single cell transcriptomics map of paracrine networks in the intrinsic cardiac nervous system., Alison Moss, Shaina Robbins, Sirisha Achanta, Lakshmi Kuttippurathu, Scott Turick, Sean Nieves, Peter Hanna, Elizabeth H. Smith, Donald B. Hoover, Jin Chen, Zixi Jack Cheng, Jeffrey L. Ardell, Kalyanam Shivkumar, James S. Schwaber, and Rajanikanth Vadigepalli

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Plasma Adenosine Deaminase (ADA)-1 and -2 Demonstrate Robust Ontogeny Across the First Four Months of Human Life., Oludare A. Odumade, Alec L. Plotkin, Jensen Pak, Olubukola T. Idoko, Matthew A. Pettengill, Tobias R. Kollmann, Al Ozonoff, Beate Kampmann, Ofer Levy, and Kinga K. Smolen

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Retinoic Acid Fluctuation Activates an Uneven, Direction-Dependent Network-Wide Robustness Response in Early Embryogenesis, Madhur Parihar, Liat Bendelac-Kapon, Michal Gur, Tali Abbou, Abha Belorkar, Sirisha Achanta, Keren Kinberg, Rajanikanth Vadigepalli, and Abraham Fainsod

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Dysregulation of miR-21-associated miRNA regulatory networks by chronic ethanol consumption impairs liver regeneration., Austin Parrish, Ankita Srivastava, Egle Juskeviciute, Jan B Hoek, and Rajanikanth Vadigepalli

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Stem signatures associating SOX2 antibody helps to define diagnosis and prognosis prediction with esophageal cancer, Zi-Yang Peng, Qing-Shi Wang, Kai Li, Si-Si Chen, Xiang Li, Guo-Dong Xiao, Shou-Ching Tang, Hong Ren, Zhe Wang, and Xin Sun

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A rare fatal case of adenovirus serotype 4 associated acute disseminated encephalomyelitis in an adult: A case report, Zahra Qamar, Catherine Tucker, Lawrence C. Kenyon, and Tricia. Royer

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The Mitochondrial Permeability Transition: Nexus of Aging, Disease and Longevity., Hagai Rottenberg and Jan B. Hoek

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TMEM67, TMEM237, and Embigin in Complex With Monocarboxylate Transporter MCT1 Are Unique Components of the Photoreceptor Outer Segment Plasma Membrane., Nikolai P. Skiba, Martha A. Cady, Laurie Molday, John Y.S. Han, Tylor R. Lewis, William J. Spencer, Will J. Thompson, Sarah Hiles, Nancy J. Philp, Robert S. Molday, and Vadim Y. Arshavsky

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Immune responses to injury and their links to eye disease., Mary Ann Stepp and A Sue Menko

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Mapping the little brain at the heart by an interdisciplinary systems biology team., Rajanikanth Vadigepalli and James S. Schwaber

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A Spatial Model of Hepatic Calcium Signaling and Glucose Metabolism Under Autonomic Control Reveals Functional Consequences of Varying Liver Innervation Patterns Across Species, Aalap Verma, Alexandra Manchel, Rahul Narayanan, Jan B. Hoek, Babatunde A Ogunnaike, and Rajanikanth Vadigepalli

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Immune cells in lens injury repair and fibrosis, Janice L Walker and A. Sue Menko

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Specification of the patterning of a ductal tree during branching morphogenesis of the submandibular gland., Janice L Walker, Weihao Wang, Edith Lin, Alison Romisher, Meghan P Bouchie, Brigid Bleaken, A Sue Menko, and Maria A Kukuruzinska

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MiRNA-30e downregulation increases cancer cell proliferation, invasion and tumor growth through targeting RPS6KB1, Lin Wang, Xiang-Bo Ji, Li-Hong Wang, Zhong-Kun Xia, Yun-Xia Xie, Wen-Jing Liu, Jian-Ge Qiu, Bing-Hua Jiang, and Ling-Zhi Liu

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Discovery of a New CDK4/6 and PI3K/AKT Multiple Kinase Inhibitor Aminoquinol for the Treatment of Hepatocellular Carcinoma., Zhong-Kun Xia, Wei Wang, Jian-Ge Qiu, Xi-Nan Shi, Hong-Jian Li, Rong Chen, Kun-Bin Ke, Chao Dong, Ying Zhu, Shi-Guo Wu, Rong-Ping Zhang, Zhuo-Ran Meng, Hui Zhao, Peng Gu, Kwong-Sak Leung, Man-Hon Wong, Xiao-Dong Liu, Feng-Mei Zhou, Jian-Ying Zhang, Ya-Ting Yao, Si-Jia Wang, Chun-Yang Zhang, Yan-Ru Qin, Marie Chia-Mi Lin, and Bing-Hua Jiang

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Metabolic adaptation to the chronic loss of Ca 2+ signaling induced by KO of IP 3 receptors or the mitochondrial Ca 2+ uniporter, Michael P. Young, Zachary T Schug, David M. Booth, David I Yule, Katsuhiko Mikoshiba, György Hajnóczky, and Suresh K Joseph

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Impaired 26S Proteasome Assembly Precedes Neuronal Loss in Mutant UBQLN2 Rats., Wenjuan Zhang, Bo Huang, Limo Gao, and Cao Huang

Manuscripts from 2020

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A Comprehensive Integrated Anatomical and Molecular Atlas of Rat Intrinsic Cardiac Nervous System., Sirisha Achanta, Jonathan Gorky, Clara Leung, Alison Moss, Shaina Robbins, Leonard Eisenman, Jin Chen, Susan Tappan, Maci Heal, Navid Farahani, Todd Huffman, Steve England, Zixi Jack Cheng, Rajanikanth Vadigepalli, and James S Schwaber

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Discoidin Domain Receptor 1 functionally interacts with the IGF-I system in bladder cancer, Simone Buraschi, Alaide Morcavallo, Thomas Neill, Manuela Stefanello, Chiara Palladino, Shi-Qiong Xu, Antonino Belfiore, Renato V. Iozzo, and Andrea Morrione

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CD4 Deficiency Causes Poliomyelitis and Axonal Blebbing in Murine Coronavirus-Induced Neuroinflammation., Debanjana Chakravarty, Fareeha Saadi, Soumya Kundu, Abhishek Bose, Reas Khan, Kimberly Dine, Lawrence C Kenyon, Kenneth S Shindler, and Jayasri Das Sarma

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Hepatic lipocalin 2 promotes liver fibrosis and portal hypertension, Jiegen Chen, Josepmaria Argemi, Gemma Odena, Ming-Jiang Xu, Yan Cai, Veronica Massey, Austin Parrish, Rajanikanth Vadigepalli, Jose Altamirano, Joaquin Cabezas, Pere Gines, Juan Caballeria, Natasha Snider, Pau Sancho-Bru, Shizuo Akira, Ivan Rusyn, Bin Gao, and Ramon Bataller

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Just how many holes…?, Gyorgy Csordas and Stephen Hurst

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An immune response to the avascular lens following wounding of the cornea involves ciliary zonule fibrils., JodiRae DeDreu, Caitlin J Bowen, Caitlin M Logan, Sonali Pal-Ghosh, Paola Parlanti, Mary Ann Stepp, and A Sue Menko

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Educational Case: A Case of Transfusion-Transmitted Babesiosis: Diagnostic Perspectives Across the Clinical Laboratory., Kaitlyn Dykes and Alexis R. Peedin

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Credible practice of modeling and simulation in healthcare: ten rules from a multidisciplinary perspective, Ahmet Erdemir, Lealem Mulugeta, Joy P Ku, Andrew Drach, Marc Horner, Tina M Morrison, Grace C Y Peng, Rajanikanth Vadigepalli, William W Lytton, and Jerry G Myers

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Abrogation of esophageal carcinoma development in miR-31 knockout rats., Louise Y Fong, Cristian Taccioli, Alexey Palamarchuk, Guidantonio Malagoli Tagliazucchi, Ruiyan Jing, Karl J Smalley, Sili Fan, Joseph Altemus, Oliver Fiehn, Kay Huebner, John L Farber, and Carlo M Croce

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Endorepellin evokes an angiostatic stress signaling cascade in endothelial cells., Aastha Kapoor, Carolyn G Chen, and Renato V Iozzo

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Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 Modulates Aggressiveness of Ewing Sarcoma by Regulating the CD164-CXCR4 Axis, Caterina Mancarella, Giulia Caldoni, Irene Ribolsi, Alessandro Parra, Maria Cristina Manara, Arthur M Mercurio, Andrea Morrione, and Katia Scotlandi

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Computational Modeling Analysis of Generation of Reactive Oxygen Species by Mitochondrial Assembled and Disintegrated Complex II., Nikolay I. Markevich, Lubov N. Markevich, and Jan B. Hoek

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Catabolic degradation of endothelial VEGFA via autophagy, Thomas Neill, Carolyn Chen, Simone Buraschi, and Renato V. Iozzo

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Genomic characterization of malignant progression in neoplastic pancreatic cysts, Michaël Noë, Noushin Niknafs, Catherine G Fischer, Wenzel M Hackeng, Violeta Beleva Guthrie, Waki Hosoda, Marija Debeljak, Eniko Papp, Vilmos Adleff, James R White, Claudio Luchini, Antonio Pea, Aldo Scarpa, Giovanni Butturini, Giuseppe Zamboni, Paola Castelli, Seung-Mo Hong, Shinichi Yachida, Nobuyoshi Hiraoka, Anthony J Gill, Jaswinder S Samra, G Johan A Offerhaus, Anne Hoorens, Joanne Verheij, Casper Jansen, N Volkan Adsay, Wei Jiang, Jordan Winter, Jorge Albores-Saavedra, Benoit Terris, Elizabeth D Thompson, Nicholas J Roberts, Ralph H Hruban, Rachel Karchin, Robert B Scharpf, Lodewijk A A Brosens, Victor E Velculescu, and Laura D Wood

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Investigating the Effects of Brainstem Neuronal Adaptation on Cardiovascular Homeostasis., James H Park, Jonathan Gorky, Babatunde Ogunnaike, Rajanikanth Vadigepalli, and James S Schwaber

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Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling, Anindya Roy Chowdhury, Satish Srinivasan, György Csordás, György Hajnóczky, and Narayan G Avadhani

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Diurnal Patterns of Gene Expression in the Dorsal Vagal Complex and the Central Nucleus of the Amygdala - Non-rhythm-generating Brain Regions, Mary M Staehle, Sean O'Sullivan, Rajanikanth Vadigepalli, Kate F Kernan, Gregory E Gonye, Babatunde A Ogunnaike, and James S. Schwaber