Manuscripts from 2012
Blood-Brain Barrier Abnormalities Caused by HIV-1 gp120: Mechanistic and Therapeutic Implications., Jean-Pierre Louboutin and David S Strayer
Kaempferol nanoparticles achieve strong and selective inhibition of ovarian cancer cell viability., Haitao Luo, Bingbing Jiang, Bingyun Li, Zhaoliang Li, Bing-Hua Jiang, and Yi Charlie Chen
Loss of Retinoblastoma (RB) Tumor Suppressor Expression in Breast Cancer Correlates with Better Response to Neoadjuvant Chemotherapy, Jeanne McFalls, MD; Jessica Kline, BA; Gordon Schwartz, MD, MBA, FACS; and Angieszka Witkiewicz, MD
The metastasis suppressor KISS1 lacks antimetastatic activity in the C8161.9 xenograft model of melanoma., Jean-Marc Navenot, Barry Evans, Shinya Oishi, Shohei Setsuda, Nobutaka Fujii, and Stephen C Peiper
Decorin antagonizes the angiogenic network: Concurrent inhibition of met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of thrombospondin-1 and tiMP3, Thomas Neill, Hannah Painter, Simone Buraschi, Rick T. Owens, Michael P. Lisanti, Liliana Schaefer, and Renato V. Iozzo
Mini-Review: Decorin, a Guardian from the Matrix, Thomas Neill, Liliana Schaefer, and Renato V. Iozzo
Knockdown of ki-67 by dicer-substrate small interfering RNA sensitizes bladder cancer cells to curcumin-induced tumor inhibition., Sivakamasundari Pichu, Swapna Krishnamoorthy, Andrei Shishkov, Bi Zhang, Peter McCue, and Biddanda C Ponnappa
Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models., N Takahashi, L Duprez, S Grootjans, A Cauwels, W Nerinckx, J B DuHadaway, V Goossens, R Roelandt, F Van Hauwermeiren, C Libert, W Declercq, N Callewaert, G C Prendergast, A Degterev, J Yuan, and P Vandenabeele
P16/Rb Correlations in Oropharyngeal Squamous Cell Carcinoma (OSCC), Madalina Tuluc, Voichita Bar-Ad, and David Cognetti
P53 Expression in Oropharyngeal Squamous Cell Carcinoma in Increased in HPV Positive Smokers, Madalina Tuluc, Voichita Bar-Ad, Zi-Xuan Wang, and Joseph Curry
Uterine Dysfunction in Biglycan and Decorin Deficient Mice Leads to Dystocia during Parturition., Zhiping Wu, Abraham W Aron, Elyse E Macksoud, Renato V Iozzo, Chi-Ming Hai, and Beatrice E Lechner
MiR-145 directly targets p70S6K1 in cancer cells to inhibit tumor growth and angiogenesis., Qing Xu, Ling-Zhi Liu, Xu Qian, Qi Chen, Yue Jiang, Dan Li, Lihui Lai, and Bing-Hua Jiang
Graft Versus Host Disease of the Brain Following Allogeneic Stem Cell Transplant for Myelodysplastic Syndrome, Janet Yoo; Lindsay Simon; Zi-Xuan Wang, PhD; and Lawrence C. Kenyon
Lung carcinoma in the era of personalized medicine: the role of cytology., Maureen F Zakowski and Marluce Bibbo
Integrative gene regulatory network analysis reveals light-induced regional gene expression phase shift programs in the mouse suprachiasmatic nucleus., Haisun Zhu, Rajanikanth Vadigepalli, Rachel Rafferty, Gregory E Gonye, David R Weaver, and James S Schwaber
Manuscripts from 2011
Protein surface characterization using an invariant descriptor., Zainab Abu Deeb, Donald A Adjeroh, and Bing-Hua Jiang
Evidence-based genomic diagnosis characterized chromosomal and cryptic imbalances in 30 elderly patients with myelodysplastic syndrome and acute myeloid leukemia., Renu Bajaj, Fang Xu, Bixia Xiang, Katherine Wilcox, Autumn J Diadamo, Rachana Kumar, Alexandra Pietraszkiewicz, Stephanie Halene, and Peining Li
Expression of Cancer Stem Cell Biomarkers in Male Breast Cancer, Ping Gong, MD and Juan P. Palazzo, MD
The variable presentations of anaplastic spindle cell squamous carcinoma associated with tall cell variant of papillary thyroid carcinoma., Pallavi P Gopal, Kathleen T Montone, Zubair Baloch, Madalina Tuluc, and Virginia LiVolsi
Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats, Cao Huang, Jianbin Tong, Fangfang Bi, Hongxia Zhou, and Xu-Gang Xia
FUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degeneration., Cao Huang, Hongxia Zhou, Jianbin Tong, Han Chen, Yong-Jian Liu, Dian Wang, Xiaotao Wei, and Xu-Gang Xia
Perfluorochemical liquid-adenovirus suspensions enhance gene delivery to the distal lung., Jeffrey A Kazzaz, Marlene S Strayer, Jichuan Wu, Daniel J Malone, Hshi-Chi Koo, Thomas H Shaffer, Jonathan M Davis, David S Strayer, and Marla R Wolfson
Role and mechanism of arsenic in regulating angiogenesis., Ling-Zhi Liu, Yue Jiang, Richard L Carpenter, Yi Jing, Stephen C Peiper, and Bing-Hua Jiang
MiR-21 induced angiogenesis through AKT and ERK activation and HIF-1α expression., Ling-Zhi Liu, Chongyong Li, Qi Chen, Yi Jing, Richard Carpenter, Yue Jiang, Hsiang-Fu Kung, Lihui Lai, and Bing-Hua Jiang
Switches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination system., Lan K Nguyen, Javier Muñoz-García, Helene Maccario, Aaron Ciechanover, Walter Kolch, and Boris N Kholodenko
Switches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination system., Lan K Nguyen, Javier Muñoz-García, Helene Maccario, Aaron Ciechanover, Walter Kolch, and Boris N Kholodenko
TDP-43 potentiates alpha-synuclein toxicity to dopaminergic neurons in transgenic mice., Tian Tian, Cao Huang, Jianbin Tong, Ming Yang, Hongxia Zhou, and Xugang Xia
Expression of Aldehyde Dehydrogenase in Dysplastic Lesions Arising from Inflammatory Bowel Disease, Adam D. Toll, Bruce M. Boman, and Juan P. Palazzo
Prognostic significance of high-grade dysplasia in colorectal adenomas., A D Toll, D Fabius, T Hyslop, E Pequignot, A J Dimarino, A Infantolino, and J P Palazzo
MiR-148a inhibits angiogenesis by targeting ERBB3., Jing Yu, Qi Li, Qing Xu, Lingzhi Liu, and Bing-Hua Jiang
Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake., Hongxia Zhou, Cao Huang, Jianbin Tong, Weimin C Hong, Yong-Jian Liu, and Xugang Xia
Early exposure to paraquat sensitizes dopaminergic neurons to subsequent silencing of PINK1 gene expression in mice., Hongxia Zhou, Cao Huang, Jianbin Tong, and XuGang Xia
Manuscripts from 2010
Azi-isoflurane, a Photolabel Analog of the Commonly Used Inhaled General Anesthetic Isoflurane., Roderic G Eckenhoff, Jin Xi, Motomu Shimaoka, Aditya Bhattacharji, Manuel Covarrubias, and William P Dailey
Sarcoidosis Cannot Be Reliably Distinguished from Other Causes of Hepatic Granulomas in a Liver Biopsy Alone, Phililp A. Grieshaber, MD; Whitney Jackson, MD; and John L. Farber, MD
S-glutathionylation activates STIM1 and alters mitochondrial homeostasis., Brian J Hawkins, Krishna M Irrinki, Karthik Mallilankaraman, Yu-Chin Lien, Youjun Wang, Cunnigaiper D Bhanumathy, Ramasamy Subbiah, Michael F Ritchie, Jonathan Soboloff, Yoshihiro Baba, Tomohiro Kurosaki, Suresh K Joseph, Donald L Gill, and Muniswamy Madesh
Autoimmunity in transfusion babesiosis: a spectrum of clinical presentations., Jay H Herman, Saleh Ayache, and Danuta Olkowska
Sustained expression of TDP-43 and FUS in motor neurons in rodent's lifetime., Cao Huang, Pedro Yuxing Xia, and Hongxia Zhou
Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans., Renato V. Iozzo and Liliana Schaefer
Robust dynamic balance of AP-1 transcription factors in a neuronal gene regulatory network., Gregory M Miller, Babatunde A Ogunnaike, James S Schwaber, and Rajanikanth Vadigepalli
Interesting Case Presentation: Placental Site Trophoblastic Tumor, Nicole Qualtieri, MS, PA (ASCP) and Andrea Gadue, MHS, PA (ASCP)
The Added Value of Molecular Testing in Small Pancreatic Cysts, Adam D. Toll, MD and Marluce Bibbo, MD
Loss of Stromal Caveolin-1 Independently Predicts Poor Disease-Free Survival and Time to Recurrence in Patients with Prostate Cancer, M. Wagner, A. Dasgupta, F. Sotgia, R. B. West, M. P. Lisanti, and A. K. Witkiewicz
Transgenic rat model of neurodegeneration caused by mutation in the TDP gene., Hongxia Zhou, Cao Huang, Han Chen, Dian Wang, Carlisle P Landel, Pedro Yuxing Xia, Robert Bowser, Yong-Jian Liu, and Xu Gang Xia
Manuscripts from 2009
Teratology, Transplantation and the impact of Jefferson Mentors, Vincent Armenti
Graft-versus-Host Disease-Like Pattern in Mycophenolate Mofetil Related Colon Mucosal Injury: Role of FISH in Establishing the Diagnosis., Kathryn C Behling, Dorothy M J Foster, Tina B Edmonston, and Agnieszka K Witkiewicz
Systems-level interactions between insulin-EGF networks amplify mitogenic signaling., Nikolay Borisov, Edita Aksamitiene, Anatoly Kiyatkin, Stefan Legewie, Jan Berkhout, Thomas Maiwald, Nikolai P Kaimachnikov, Jens Timmer, Jan B Hoek, and Boris N Kholodenko
The significance of GATA3 expression in breast cancer: a 10-year follow-up study., Vincenzo Ciocca, Constantine Daskalakis, Robin M. Ciocca, Alejandra Ruiz-Orrico, and Juan P. Palazzo
Decorin is a novel antagonistic ligand of the Met receptor., Silvia Goldoni, Ashley Humphries, Alexander Nyström, Sampurna Sattar, Rick T Owens, David J McQuillan, Keith Ireton, and Renato V Iozzo
Establishing the Purity of Mononuclear Cell Preparations Using Morphology and Flow Cytometry, Adam Holtz, BS; Adam D. Toll, MD; Susan W. Burkholder, MD; Alicia M. Carlin, BA; Linda F. Blumstein, BS; Kathleen A. Schroeder, BS; Eric M. Behling, MD; and Tina B. Edmonston, MD
Basement membrane proteoglycans: modulators Par Excellence of cancer growth and angiogenesis., Renato V. Iozzo, Jason J. Zoeller, and Alexander Nyström
N-glycosylation status of E-cadherin controls cytoskeletal dynamics through the organization of distinct β-catenin- and γ-catenin-containing AJs., Basem T Jamal, Mihai Nita-Lazar, Zhennan Gao, Bakr Amin, Janice Walker, and Maria A Kukuruzinska
Revealing genes associated with vitellogenesis in the liver of the zebrafish (Danio rerio) by transcriptome profiling., Liraz Levi, Irena Pekarski, Ellen Gutman, Paolo Fortina, Terry Hyslop, Jakob Biran, Berta Levavi-Sivan, and Esther Lubzens
Positional information generated by spatially distributed signaling cascades., Javier Muñoz-García, Zoltan Neufeld, and Boris N Kholodenko
The elucidation of metabolic pathways and their improvements using stable optimization of large-scale kinetic models of cellular systems, Evgeni V. Nikolaev
Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis, Leonardo Sorci, Dariusz Martynowski, Dmitry A. Rodionov, Yvonne Eyobo, Xhavit Zogaj, Karl E. Klose, Evgeni V. Nikolaev, Giulio Magni, Hong Zhang, and Andrei L. Osterman
Identification of Gastrointestinal Contamination in Pancreatic FNA, A. D. Toll and M. Bibbo
Repression of E-Cadherin by the Polycomb Group Protein EZH2 in Pancreatic Cancer, A. D. Toll, A. Dasgupta, M. Potoczek, C. G. Kleer, J. R. Brody, and A. K. Witkiewicz
FoxP3-Expressing T Regulatory Cells (T-regs) Increase with the Severity of Active Disease in Chronic Hepatitis C, Adam D. Toll, MD and John L. Farber, MD
Intra-tumor heterogeneity of MLH1 promoter methylation revealed by deep single molecule bisulfite sequencing., Katherine E Varley, David G Mutch, Tina B Edmonston, Paul J Goodfellow, and Robi D Mitra
Detection of Merkel Cell Carcinoma Polyomavirus in Mucosal Merkel Cell Carcinoma, Karen N. Wu, MD; Peter A. McCue, MD; Zi-Xuan Wang, PhD; and Agnieszka K. Witkiewicz, MD
CD34 and Alpha-Smooth Muscle Actin Distinguish Cryptogenic Organizing Pneumonia from Secondary Bronchiolitis Obliterans-Organizing Pneumonia, Karen N. Wu, MD; Tajender S. Vasu, MD; and John L. Farber, MD
Nerve injection of viral vectors efficiently transfers transgenes into motor neurons and delivers RNAi therapy against ALS., Rui Wu, Hongyan Wang, Xugang Xia, Hongxia Zhou, Chunyan Liu, Maria Castro, and Zuoshang Xu
Developing tTA transgenic rats for inducible and reversible gene expression., Hongxia Zhou, Cao Huang, Min Yang, Carlisle P Landel, Pedro Yuxing Xia, Yong-Jian Liu, and Xu Gang Xia
Manuscripts from 2008
Domain-Oriented Reduction of Rule-Based Network Models, Nikolay M. Borisov, Alexander S. Chistopolsky, James R. Faeder, and Boris N. Kholodenko
Prolonged hemophagocytic lymphohistiocytosis syndrome as an initial presentation of Hodgkin lymphoma: a case report., Kathryn Chan, Eric Behling, David S Strayer, William S Kocher, and Scott K Dessain
Demyelinating and nondemyelinating strains of mouse hepatitis virus differ in their neural cell tropism., Jayasri Das Sarma, Kathryn Iacono, Lilli Gard, Ryan Marek, Lawrence C. Kenyon, Michael Koval, and Susan R. Weiss
Gating charge immobilization in Kv4.2 channels: the basis of closed-state inactivation., Kevin Dougherty, Jose A De Santiago-Castillo, and Manuel Covarrubias
Transcriptional regulation network analysis of the hypertension-perturbed nucleus tractus solitarius, Gregory E. Gonye, Rajanikanth Vadigepalli, Haiping Hao, and James S. Schwaber
Temporal and functional profile of the transcriptional regulatory network in the early regenerative response to partial hepatectomy in the rat., Egle Juskeviciute, Rajanikanth Vadigepalli, and Jan B Hoek
A new model for hemoglobin ingestion and transport by the human malaria parasite Plasmodium falciparum., Michelle D Lazarus, Timothy G Schneider, and Theodore F Taraschi
Presence of endometrial adenocarcinoma in situ in complex atypical endometrial hyperplasia is associated with increased incidence of endometrial carcinoma in subsequent hysterectomy., Khush Mittal, Matjaz Sebenik, Cybil Irwin, Zhijije Yan, Dorota Popiolek, John Curtin, and Juan Palazzo
Transcriptional regulatory network analysis during epithelial-mesenchymal transformation of retinal pigment epithelium., Craig H Pratt, Rajanikanth Vadigepalli, Praveen Chakravarthula, Gregory E Gonye, Nancy J Philp, and Gerald B Grunwald
A construct with fluorescent indicators for conditional expression of miRNA., Linghua Qiu, Hongyan Wang, Xugang Xia, Hongxia Zhou, and Zuoshang Xu
The Value of Intraoperative Examination of Axillary Sentinel Nodes in Carcinoma of the Breast., Gordon F. Schwartz, Lauren S. Krill, Juan P. Palazzo, and Abhijit Dasgupta
Fibulin-2 is dispensable for mouse development and elastic fiber formation, Francois-Xavier Sicot, Takeshi Tsuda, Dessislava Markova, John Klement, Machiko Arita, Rui-Zhu Zhang, Te-Cheng Pan, Robert P. Mecham, David E. Birk, and Mon-Li Chu
Multi-scale modeling of angiotensin II induced neuronal regulatory mechanisms in the brain, Rajanikanth Vadigepalli
Multiple forms of atypical rearrangements generating supernumerary derivative chromosome 15., Nicholas J Wang, Alexander S Parokonny, Karen N Thatcher, Jennette Driscoll, Barbara M Malone, Naghmeh Dorrani, Marian Sigman, Janine M LaSalle, and N Carolyn Schanen
Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts., Hua Zhang, Sudipto Das, Quan-Zhen Li, Ioannis Dragatsis, Joyce Repa, Scott Zeitlin, György Hajnóczky, and Ilya Bezprozvanny
Proteomic profiling of endorepellin angiostatic activity on human endothelial cells., Jason J Zoeller and Renato V Iozzo
A central function for perlecan in skeletal muscle and cardiovascular development, Jason J. Zoeller, Angela McQuillan, John Whitelock, Shiu-Ying Ho, and Renato V. Iozzo
Manuscripts from 2007
Renal cell carcinoma metastatic to the duodenum: Treatment by classic pancreaticoduodenectomy and review of the literature, Robert Adamo, Patrick J. Greaney Jr., Agnieszka Witkiewicz, Eugene P. Kennedy, and Charles J. Yeo
Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses., Marc R Birtwistle; Mariko Hatakeyama; Noriko Yumoto; Babatunde A Ogunnaike; Jan B. Hoek; and Boris N. Kholodenko PhD, DSci
A dipeptidyl aminopeptidase-like protein remodels gating charge dynamics in Kv4.2 channels, Kevin Dougherty and Manuel Covarrubias
Department of Pathology, Thomas Jefferson University, Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors., Jason I Herschkowitz, Karl Simin, Victor J Weigman, Igor Mikaelian, Jerry Usary, Zhiyuan Hu, Karen E Rasmussen, Laundette P Jones, Shahin Assefnia, Subhashini Chandrasekharan, Michael G Backlund, Yuzhi Yin, Andrey I Khramtsov, Roy Bastein, John Quackenbush, Robert I Glazer, Powel H Brown, Jeffrey E Green, Levy Kopelovich, Priscilla A Furth, Juan P Palazzo, Olufunmilayo I Olopade, Philip S Bernard, Gary A Churchill, Terry Van Dyke, and Charles M Perou
Untangling the signalling wires, Boris N. Kholodenko PhD, DSci
The enigma of struma ovarii, Lawrence M. Roth and Aleksander Talerman
Bladder inflammatory transcriptome in response to tachykinins: Neurokinin 1 receptor-dependent genes and transcription regulatory elements, Ricardo Saban, Cindy Simpson, Rajanikanth Vadigepalli, Sylvie Memet, Igor Dozmorov, and Marcia R. Saban
Gangliocytic paraganglioma: case report and review of the literature, Agnes Witkiewicz, Avi Galler, and Charles Yeo
Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice., Hongxia Zhou, Björn H Falkenburger, Jörg B Schulz, Kim Tieu, Zuoshang Xu, and Xu Gang Xia
Manuscripts from 2006
Antioxidant enzyme gene delivery to protect from HIV-1 gp120-induced neuronal apoptosis, Lokesh Agrawal, Jean-Pierre Louboutin, Beverly A.S. Reyes, Elisabeth J. Van Bockstaele, and David S. Strayer
Scientific issues related to the cytology proficiency testing regulations, George Birdsong, Lydia Howell, Karen Atkinson, R. Marshall Austin, Marluce Bibbo, Thomas A. Bonfiglio, Diane D. Davey, Catherine Keebler, Dina Mody, Lynnette Savaloja, Jacalyn Papillo, Marianne Prey, Stephen Raab, Brenda L. Schultz, and Diane Solomon
Trading the micro-world of combinatorial complexity for the macro-world of protein interaction domains, Nikolay M. Borisov, Nick I. Markevitch, Jan B. Hoek, and Boris N. Kholodenko
A domain-oriented approach to the reduction of combinatorial complexity in signal transduction networks, Holger Conzelmann; Julio Saez-Rodriguez; Thomas Sauter; Boris N. Kholodenko PhD, DSci; and Ernst D. Gilles
Structural and functional features and significance of the physical linkage between ER and mitochondria., György Csordás, Christian Renken, Péter Várnai, Ludivine Walter, David Weaver, Karolyn F Buttle, Tamás Balla, Carmen A Mannella, and György Hajnóczky
SMC3 knockdown triggers genomic instability and p53-dependent apoptosis in human and zebrafish cells., Giancarlo Ghiselli
The molecular portraits of breast tumors are conserved acress microarray platforms, Zhiyuan Hu, Cheng Fan, Daniel S. Oh, J. S. Marron, Xiaping He, Bahjat F. Qaqish, Chad Livasy, Lisa A. Carey, Evangeline Reynolds, Lynn Dressler, Andrew Nobel, Joel Parker, Matthew G. Ewend, Lynda R. Sawyer, Junyuan Wu, Yudong Liu, Rita Nanda, Maria Tretiakova, Alejandra Ruiz Orrico, Donna Dreher, Juan P. Palazzo, Laurent Perreard, Edward Nelson, Mary Mone, Heidi Hansen, Michael Mullins, John F. Quackenbush, Matthew J. Ellis, Olufunmilayo I. Olopade, Philip S. Bernard, and Charles M. Perou
Chronic-alcohol exposure alters IGF1 signaling in H9c2 cells via changes in PKC delta, Richard Ila and Michele Solem
Combined effects of aldehyde dehydrogenase variants and maternal mitochondrial genes on alcohol consumption, Yedy Israel, Maria E. Quintanilla, Amalia Sapag, and Lutske Tampier
A universal reference sample derived from clone vector for improved detection of differential gene expression, Rishi L. Khan, Gregory E. Gonye, Guang Gao, and James S. Schwaber
Cell-signalling dynamics in time and space, Boris N. Kholodenko PhD, DSci
