"Untangling the signalling wires" by Boris N. Kholodenko PhD, DSci
 

Document Type

Response or Comment

Publication Date

March 2007

Comments

This article has been peer reviewed. It is the author's final version prior to publication in Nature Cell Biology 9(3):247-249, March 2007. The published version is available at http://dx.doi.org/10.1038/ncb0307-247, copyright © 2007 by Nature Publishing Group.

It is a comment on Santos SD, Verveer PJ, Bastiaens PI. Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nature Cell Biology 9(3):324-30, March 2007.

Abstract

Mitogen-activated protein kinase (MAPK) cascades process myriads of stimuli, generating receptor-specific cellular outcomes. New work exploits emergent mathematics of network inference to reveal distinct feedback designs of the RAF/MEK/ERK cascade induced by two different growth factors. It shows that response specificity can arise from differential signal-induced wiring of overlapping protein networks.

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