Document Type
Article
Publication Date
11-30-2021
Abstract
The complex and adaptive nature of malignant neoplasm constitute a major challenge for the development of effective anti-oncogenic therapies. Emerging evidence has uncovered the pivotal functions exerted by the small leucine-rich proteoglycans, decorin and biglycan, in affecting tumor growth and progression. In their soluble forms, decorin and biglycan act as powerful signaling molecules. By receptor-mediated signal transduction, both proteoglycans modulate key processes vital for tumor initiation and progression, such as autophagy, inflammation, cell-cycle, apoptosis, and angiogenesis. Despite of their structural homology, these two proteoglycans interact with distinct cell surface receptors and thus modulate distinct signaling pathways that ultimately affect cancer development. In this review, we summarize growing evidence for the complex roles of decorin and biglycan signaling in tumor biology and address potential novel therapeutic implications.
Recommended Citation
Diehl, Valentina; Huber, Lisa Sophie; Trebicka, Jonel; Wygrecka, Malgorzata; Iozzo, Renato V.; and Schaefer, Liliana, "The Role of Decorin and Biglycan Signaling in Tumorigenesis" (2021). Department of Pathology, Anatomy, and Cell Biology Faculty Papers. Paper 337.
https://jdc.jefferson.edu/pacbfp/337
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
34917515
Language
English
Comments
This article is the author’s final published version in Frontiers in Oncology, Volume 11, November 2021, Article number 801801.
The published version is available at https://doi.org/10.3389/fonc.2021.801801. Copyright © Diehl et al.