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Manuscripts from 2022

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Circulating Messenger RNA Variants as a Potential Biomarker for Surveillance of Hepatocellular Carcinoma, Timothy Block, Daniel Zezulinski, David E. Kaplan, Jingqiao Lu, Samantha Zanine, Tingting Zhan, Cataldo Doria, and Aejaz Sayeed

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A Genome-Wide Screen Identifies PDPK1 as a Target to Enhance the Efficacy of MEK1/2 Inhibitors, Weijia Cai, Nicole A. Wilski, Timothy J. Purwin, Megane Vernon, Manoela Tiago, and Andrew E. Aplin

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The future of targeted kinase inhibitors in melanoma, Signe Caksa, Usman Baqai, and A E Aplin

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Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma, Claudia Capparelli; Timothy J. Purwin; McKenna Glasheen; Signe Caksa; Manoela Tiago; Nicole A. Wilski; Danielle Pomante; Sheera Rosenbaum; Mai Q Nguyen; Weijia Cai; Janusz Franco-Barraza; R. Zheng, MD; Gaurav Kumar; I Chervoneva; Ayako Shimada; Vito W Rebecca; Adam E. Snook; Kim Hookim; Xiaowei Xu; Edna Cukierman; Meenhard Herlyn; and A E Aplin

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Guanylyl cyclase C as a Diagnostic and Therapeutic Target in Colorectal Cancer, Adi Caspi, Ariana A. Entezari, Madison Crutcher, Adam E. Snook, and Scott A. Waldman

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Pharmacologic Ascorbic Acid as Early Therapy for Hospitalized Patients with COVID-19: A Randomized Clinical Trial, Dagan Coppock, Pierre-Christian Violet, Gustavo Vasquez, Katherine Belden, Michael Foster, Bret Mullin, Devon Magee, Isabelle Mikell, Lokesh Shah, Victoria Powers, Brian Curcio, Daniel A. Monti, and Mark Levine

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DNA-PKcs: A Targetable Protumorigenic Protein Kinase., Emanuela Dylgjeri and Karen E Knudsen

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T-Cell Responses to Immunodominant Listeria Epitopes Limit Vaccine-Directed Responses to the Colorectal Cancer Antigen, Guanylyl Cyclase C, John C. Flickinger, Jagmohan Singh, Yanki Yarman, Robert D Carlson, Joshua Barton, Scott A Waldman, and Adam E. Snook

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Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability, Jagadish C Ghosh, Michela Perego, Ekta Agarwal, Irene Bertolini, Yuan Wang, Aaron R Goldman, Hsin-Yao Tang, Andrew V Kossenkov, Catherine J Libby, Lucia R Languino, Edward F Plow, Annamaria Morotti, Luisa Ottobrini, Marco Locatelli, David W Speicher, M Cecilia Caino, Joel Cassel, Joseph M Salvino, Marie E Robert, Valentina Vaira, and Dario C Altieri

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Stabilized COre Gene and Pathway Election Uncovers Pan-Cancer Shared Pathways and a Cancer-Specific Driver, Pathum Kossinna, Weijia Cai, Xuewen Lu, Carrie S Shemanko, and Qingrun Zhang

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Functional Assessment of Missense Variants in the ABCC6 Gene Implicated in Pseudoxanthoma Elasticum, a Heritable Ectopic Mineralization Disorder., Luke Kowal, Jianhe Huang, Hongbin Luo, Jagmohan Singh, Adam E Snook, Jouni Uitto, and Qiaoli Li

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Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells, Shiv Ram Krishn, Vaughn Garcia, Nicole M Naranjo, Fabio Quaglia, Christopher D Shields, Maisha A Harris, Andrew V Kossenkov, Qin Liu, Eva Corey, Dario C Altieri, and Lucia R Languino

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Lysine Methyltransferase NSD1 and Cancers: Any Role in Melanoma?, Imène Krossa, Thomas Strub, Andrew E Aplin, Robert Ballotti, and Corine Bertolotto

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CTpathway: A Crosstalk-Based Pathway Enrichment Analysis Method for Cancer Research, Haizhou Liu, Mengqin Yuan, Ramkrishna Mitra, Xu Zhou, Min Long, Wanyue Lei, Shunheng Zhou, Yu-E Huang, Fei Hou, Christine M. Eischen, and Wei Jiang

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Spatial Metrics of Interaction between CD163-Positive Macrophages and Cancer Cells and Progression-Free Survival in Chemo-Treated Breast Cancer, Brenton Maisel, Misung Yi, Amy R Peck, Yunguang Sun, Jeffrey A Hooke, Albert J Kovatich, Craig D Shriver, Hai Hu, Marja T Nevalainen, Takemi Tanaka, Nicole L Simone, Li Lily Wang, Hallgeir Rui, and I Chervoneva

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Novel Oncogenic Transcription Factor Cooperation in RB-Deficient Cancer, Amy C. Mandigo, Ayesha A Shafi, Jennifer J McCann, Wei Yuan, Talya Laufer, Denisa Bogdan, Lewis Gallagher, Emanuela Dylgjeri, Galina Semenova, Irina A Vasilevskaya, M J Schiewer, Chris M McNair, Johann S de Bono, and Karen E Knudsen

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A Prospective Cohort Study of the Clinical Predictors of Bacteremia in Under-Five Children With Acute Undifferentiated Fever Attending a Secondary Health Facility in Northwestern Nigeria, Taofik Oluwaseun Ogunkunle, Timothy Olanrewaju Adedoyin, Samuel Kolade Ernest, Fatimah Hassan-Hanga, Abdulazeez Imam, Rasaq Olaosebikan, and Stephen K Obaro

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HOXA9 Overexpression Contributes to Stem Cell Overpopulation That Drives Development and Growth of Colorectal Cancer, Brian Osmond, Caroline O.B. Facey, Chi Zhang, and Bruce M. Boman

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Ondansetron to Reduce Neonatal Opioid Withdrawal Severity: A Randomized Clinical Trial, Gary Peltz, Lauren M. Jansson, Susan Adeniyi-Jones, Carol Cohane, David Drover, Steven Shafer, Meiyue Wang, Manhong Wu, Balaji Govindaswami, Priya Jegatheesan, Cynthia Argani, Salwa Kahn, and Walter K. Kraft

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The NOGO Receptor NgR2, A Novel αVβ3 Integrin Effector, Induces Neuroendocrine Differentiation in Prostate Cancer, Fabio Quaglia, Shiv Ram Krishn, Khalid Sossey-Alaoui, Priyanka Shailendra Rana, Elzbieta Pluskota, Pyung Hun Park, Christopher D. Shields, Stephen Lin, Peter McCue, Andrew V. Kossenkov, Yanqing Wang, David W. Goodrich, Sheng-Yu Ku, Himisha Beltran, William K. Kelly, Eva Corey, Maja Klose, Christine Bandtlow, Qin Liu, Dario C. Altieri, Edward F. Plow, and Lucia R. Languino

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RAS-mediated tumor stress adaptation and the targeting opportunities it presents, Alexandra Redding, A E Aplin, and Elda Grabocka

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Development and Preclinical Investigation of Physically Cross-Linked and pH-Sensitive Polymeric Gels as Potential Vaginal Contraceptives, Ankit K. Rochani, Vivek Agrahari, Neelima Chandra, Onkar N Singh, Timothy J McCormick, Gustavo F Doncel, Meredith R Clark, and Gagan Kaushal

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Targeting gastrointestinal cancers with chimeric antigen receptor (CAR)-T cell therapy, Ross E Staudt, Robert D Carlson, and Adam E. Snook

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Age Moderates the Effect of Injury Severity on Functional Trajectories in Traumatic Brain Injury: A Study Using the NIDILRR Traumatic Brain Injury Model Systems National Dataset., Laraine Winter, Janell L Mensinger, Helene J Moriarty, Keith M Robinson, Michelle McKay, and Benjamin E Leiby

Manuscripts from 2021

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A cancer ubiquitome landscape identifies metabolic reprogramming as target of Parkin tumor suppression, Ekta Agarwal, Aaron R Goldman, Hsin-Yao Tang, Andrew V Kossenkov, Jagadish C Ghosh, Lucia Languino, Valentina Vaira, David W Speicher, and Dario C Altieri

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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors, Stephen PH Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Annie Beuve, Peter Brouckaert, Clare Bryant, John C Burnett, Richard W Farndale, Andreas Friebe, John Garthwaite, Adrian J Hobbs, Gavin E Jarvis, Michaela Kuhn, David MacEwan, Tom P Monie, Andreas Papapetropoulos, Lincoln R Potter, Harald H H W Schmidt, Csaba Szabo, and Scott A Waldman

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Choline-Sigma-1R as an Additional Mechanism for Potentiation of Orexin by Cocaine, Jeffrey Barr, Pingwei Zhao, G Cristina Brailoiu, and Eugen Brailoiu

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Seeking Similarities Rather Than Differences With Adults to Aid in Therapeutic Advancement for Children., Mara L. Becker and Walter K. Kraft

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Longitudinal evaluation of azithromycin and cytokine concentrations in amniotic fluid following one-time oral dosing in pregnancy., Rupsa C. Boelig, Edwin Lam, Ankit Rochani, Gagan Kaushal, Amanda Roman, and Walter K. Kraft

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Emerging targets for the diagnosis of Parkinson's disease: examination of systemic biomarkers., Lara Cheslow, Adam E. Snook, and Scott A. Waldman

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Printing the Pathway Forward in Bone Metastatic Cancer Research: Applications of 3D Engineered Models and Bioprinted Scaffolds to Recapitulate the Bone-Tumor Niche., Anne M. Hughes, Alexus D. Kolb, Alison B. Shupp, Kristy M. Shine, and Karen M. Bussard

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Retinoids as Chemo-Preventive and Molecular-Targeted Anti-Cancer Therapies., Victoria O. Hunsu, Caroline O.B. Facey, Jeremy Z. Fields, and Bruce M. Boman

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Association of Dietary Total Antioxidant Capacity with Bone Mass and Osteoporosis Risk in Korean Women: Analysis of the Korea National Health and Nutrition Examination Survey 2008-2011, Donghyun Kim, Anna Han, and Yongsoon Park

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'Educated' Osteoblasts Reduce Osteoclastogenesis in a Bone-Tumor Mimetic Microenvironment., Alexus D. Kolb, Jinlu Dai, Evan T. Keller, and Karen M. Bussard

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A Randomized Trial to Improve Adherence to Follow-up Eye Examinations Among People With Glaucoma, Benjamin E Leiby, Sarah E. Hegarty, Tingting Zhan, Jonathan S Myers, L Jay Katz, Julia A Haller, Michael Waisbourd, Christine Burns, Meskerem Divers, Jeanne Molineaux, Jeffrey Henderer, Charles Brodowski, and Lisa A Hark

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The Quandary of DNA-Based Treatment Assessment in De Novo Metastatic Prostate Cancer in the Era of Precision Oncology., Sigve Nakken, Wolfgang Lilleby, Marta D. Switlyk, Karen E Knudsen, Oscar Lilleby, Sen Zhao, Fatemeh Kaveh, Per O. Ekstrøm, Alfonso Urbanucci, and Eivind Hovig

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IFIT3 (interferon induced protein with tetratricopeptide repeats 3) modulates STAT1 expression in small extracellular vesicles., Nicole M Naranjo, Israa Salem, Maisha A Harris, and Lucia R Languino

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Correlations between Coffee Consumption and Metabolic Phenotypes, Plasma Folate, and Vitamin B12: NHANES 2003 to 2006., Pratibha V Nerurkar, Krupa Gandhi, and John J Chen

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Level of utilization and provider-related barriers to the use of hydroxyurea in the treatment of sickle cell disease patients in Jos, North-Central Nigeria, Akinyemi O.D. Ofakunrin, Edache S. Okpe, Tolulope O. Afolaranmi, Rasaq Olaosebikan, Patience U. Kanhu, Kehinde Adekola, Nantok Dami, and Atiene S. Sagay

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Redefining cancer of unknown primary: Is precision medicine really shifting the paradigm?, Timothée Olivier, Eugenio Fernandez, Intidhar Labidi-Galy, Pierre-Yves Dietrich, Veronica Rodriguez-Bravo, Giulia Baciarello, Karim Fizazi, and Anna Patrikidou

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MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor-1., Tessa M. Popay, Jing Wang, Clare M. Adams, Gregory Caleb Howard, Simona G. Codreanu, Stacy D. Sherrod, John A. McLean, Lance R. Thomas, Shelly L. Lorey, Yuichi J. Machida, April M. Weissmiller, Christine M. Eischen, Qi Liu, and William P. Tansey

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Targeting the cdk6 dependence of ph+ acute lymphoblastic leukemia, Patrizia Porazzi, Marco De Dominici, Joseph Salvino, and Bruno Calabretta

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Differential expression of αVβ3 and αVβ6 integrins in prostate cancer progression, Fabio Quaglia, Shiv Ram Krishn, Yanqing Wang, David W Goodrich, Peter McCue, Andrew Kossenkov, Amy C Mandigo, Karen Knudsen, Paul H Weinreb, Eva Corey, William Kevin Kelly, and Lucia R Languino

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SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects, Sheera Rosenbaum, Manoela Tiago, Signe Caksa, Claudia Capparelli, Timothy J. Purwin, Gaurav Kumar, McKenna Glasheen, Danielle Pomante, Daniel Kotas, I Chervoneva, and A E Aplin

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The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair., Ayesha A Shafi, Chris M McNair, Jennifer J McCann, Mohammed Alshalalfa, Anton Shostak, Tesa M Severson, Yanyun Zhu, Andre Bergman, Nicolas Gordon, Amy C Mandigo, Saswati N Chand, Peter Gallagher, Emanuela Dylgjeri, Talya S Laufer, Irina A Vasilevskaya, Matthew J Schiewer, Michael Brunner, Felix Y Feng, Wilbert Zwart, and Karen E Knudsen

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Review article: diagnosis, management and patient perspectives of the spectrum of constipation disorders., Amol Sharma, Satish S C Rao, Kimberly Kearns, Kimberly D Orleck, and Scott A Waldman

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The Role of miRNAs, miRNA Clusters, and isomiRs in Development of Cancer Stem Cell Populations in Colorectal Cancer., Victoria A Stark, Caroline O B Facey, Vignesh Viswanathan, and Bruce M Boman

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Targeted Treatment of Head and Neck (Pre)Cancer: Preclinical Target Identification and Development of Novel Therapeutic Applications, Anne van Harten and Ruud H. Brakenhoff

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Point-of-Care Lung Ultrasound for COVID-19: Findings and Prognostic Implications From 105 Consecutive Patients, Kosuke Yasukawa, Taro Minami, David R Boulware, Ayako Shimada, and Ernest A Fischer

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miRcorrNet: machine learning-based integration of miRNA and mRNA expression profiles, combined with feature grouping and ranking., Malik Yousef, Gokhan Goy, Ramkrishna Mitra, Christine M. Eischen, Amhar Jabeer, and Burcu Bakir-Gungor

Manuscripts from 2020

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Unexpected cell type-dependent effects of autophagy on polyglutamine aggregation revealed by natural genetic variation in C. elegans., J Alexander-Floyd, S Haroon, M Ying, A A Entezari, C Jaeger, M Vermulst, and T Gidalevitz

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APC-β-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis., Erik S Blomain, Jeffrey A Rappaport, Amanda M Pattison, Babar Bashir, Ellen Caparosa, Jonathan Stem, Adam E Snook, and Scott A Waldman

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Autocatalytic Tissue Polymerization Reaction Mechanism in Colorectal Cancer Development and Growth., Bruce M Boman, Arthur Guetter, Ryan M Boman, and Olaf A Runquist

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The membrane-associated form of cyclin D1 enhances cellular invasion, Ke Chen, Xuanmao Jiao, Anthony Ashton, Agnese Di Rocco, Timothy G Pestell, Yunguang Sun, Jun Zhao, Mathew C Casimiro, Zhiping Li, Michael P Lisanti, Peter McCue, Duanwen Shen, Samuel Achilefu, Hallgeir Rui, and Richard G Pestell

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Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation., Ke Chen, Xuanmao Jiao, Agnese Di Rocco, Duanwen Shen, Shaohua Xu, Adam Ertel, Zuoren Yu, Gabriele Di Sante, Min Wang, Zhiping Li, Timothy G Pestell, Mathew C Casimiro, Emmanuel Skordalakes, Samuel Achilefu, and Richard G Pestell

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Development of an abbreviated symptom score for the neonatal abstinence syndrome., I. Chervoneva, S. C. Adeniyi-Jones, F. Blanco, and W. K. Kraft

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Chimeric Ad5.F35 vector evades anti-adenovirus serotype 5 neutralization opposing GUCY2C-targeted antitumor immunity, John C. Flickinger, Jagmohan Singh, Robert D Carlson, Elinor Leong, Trevor R. Baybutt, Joshua Barton, Ellen M. Caparosa, Amanda M. Pattison, Jeff A. Rappaport, Jamin Roh, Tingting Zhan, Babar Bashir, Scott A Waldman, and Adam E. Snook

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Epidemiology of COVID-19 and Predictors of Outcome in Nigeria: A Single-Center Study., Olayinka Rasheed Ibrahim, Bello Muhammed Suleiman, Suleiman Bello Abdullahi, Taofeek Oloyede, Abdallah Sanda, Maruf Sanusi Gbadamosi, Bashir Olajide Yusuf, Rabilu Yandoma Iliyasu, Lawal Magaji Ibrahim, Adamu Danladi Dawud, Sulaiman Saidu Bashir, Nwawueze Efam Okonta, Wasinda Francis Umar, Abiodun Gbenga Tekobo, Muhammadu Sani Abubakar, Bashir Taiye Aminu, Shuaibu Onoruoyiza Ibrahim, Rasaq Olaosebikan, and Olugbenga Ayodeji Mokuolu

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Mobilizing Toxins for Cancer Treatment: Historical Perspectives and Current Strategies., Jessica Kopenhaver, Robert D Carlson, and Adam E Snook

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Artificial Intelligence-Powered Search Tools and Resources in the Fight Against COVID-19., Larry J Kricka, Sergei Polevikov, Jason Y Park, Paolo Fortina, Sergio Bernardini, Daniel Satchkov, Valentin Kolesov, and Maxim Grishkov

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The αvβ6 integrin in cancer cell-derived small extracellular vesicles enhances angiogenesis., Shiv Ram Krishn, Israa Salem, Fabio Quaglia, Nicole M Naranjo, Ekta Agarwal, Qin Liu, Srawasti Sarker, Jessica Kopenhaver, Peter A McCue, Paul H Weinreb, Shelia M Violette, Dario C Altieri, and Lucia R Languino

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iSeqQC: a tool for expression-based quality control in RNA sequencing., Gaurav Kumar, Adam Ertel, George Feldman, Joan Kupper, and Paolo Fortina

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Vancomycin in peritoneal dialysis: Clinical pharmacology considerations in therapy., Edwin Lam, Yi Ting Kayla Lien, Walter K. Kraft, Beth Piraino, Valvanera Vozmediano, Stephan Schmidt, and Jingjing Zhang

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Twice-Daily Doravirine Overcomes the Interaction Effect from Once-Weekly Rifapentine and Isoniazid in Healthy Volunteers., Edwin Lam, Joseph Schaefer, Richard Zheng, Tingting Zhan, and Walter K. Kraft

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Simulation-based mastery learning compared to standard education for discussing diagnostic uncertainty with patients in the emergency department: a randomized controlled trial., Danielle M. McCarthy, Rhea E. Powell, Kenzie A. Cameron, David H. Salzman, Dimitrios Papanagnou, Amanda Doty, Benjamin E. Leiby, Katherine Piserchia, Matthew R. Klein, Xiao C. Zhang, William C. McGaghie, and Kristin L. Rising

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Pan-cancer analysis reveals cooperativity of both strands of microRNA that regulate tumorigenesis and patient survival, Ramkrishna Mitra, Clare M. Adams, Wei Jiang, Evan J. Greenawalt, and Christine M. Eischen

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Functional Blockade of E-Selectin in Tumor-Associated Vessels Enhances Anti-Tumor Effect of Doxorubicin in Breast Cancer, Yoshihiro Morita, Macall Leslie, Hiroyasu Kameyama, Ganesh L R Lokesh, Norihisa Ichimura, Rachel Davis, Natalie Hills, Nafis Hasan, Roy Zhang, Yuji Kondo, David G Gorenstein, David E Volk, Inna Chervoneva, Hallgeir Rui, and Takemi Tanaka

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Hitting the Bullseye: Are extracellular vesicles on target?, Nicole Noren Hooten, María Yáñez-Mó, Rachel M. DeRita, Ashley Russell, Peter Quesenberry, Bharat Ramratnam, Paul D Robbins, Dolores Di Vizio, Sicheng Wen, Kenneth W Witwer, and Lucia R Languino

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Fatal case of newborn Lassa fever virus infection mimicking late onset neonatal sepsis: a case report from northern Nigeria, Taofik Oluwaseun Ogunkunle, Surajudeen Oyeleke Bello, Chinwe Immaculata Anderson, Rashida Musa, Rasaq Olaosebikan, and Abdulazeez Imam

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MicroRNA and transcription factor co-regulatory networks and subtype classification of seminoma and non-seminoma in testicular germ cell tumors, Guimin Qin, Saurav Mallik, Ramkrishna Mitra, Aimin Li, Peilin Jia, Christine M. Eischen, and Zhongming Zhao

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MicroRNA and transcription factor co-regulatory networks and subtype classification of seminoma and non-seminoma in testicular germ cell tumors., Guimin Qin, Saurav Mallik, Ramkrishna Mitra, Aimin Li, Peilin Jia, Christine M. Eischen, and Zhongming Zhao

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FOXD3 Regulates VISTA Expression in Melanoma., Sheera R. Rosenbaum, Meghan Knecht, Mehri Mollaee, Zhijiu Zhong, Dan A. Erkes, Peter A. McCue, Chervoneva, Adam C. Berger, Jennifer A. Lo, David E. Fisher, Jeffrey E. Gershenwald, Michael A. Davies, Timothy J. Purwin, and Andrew E. Aplin

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Profiling the circulating mRNA transcriptome in human liver disease, Aejaz Sayeed, Brielle E Dalvano, David E Kaplan, Usha Viswanathan, John Kulp, Alhaji H Janneh, Lu-Yu Hwang, Adam Ertel, Cataldo Doria, and Timothy Block

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MicroRNA Expression Profiling of Normal and Malignant Human Colonic Stem Cells Identifies, Vignesh Viswanathan, Lynn Opdenaker, Shirin Modarai, Jeremy Z Fields, Gregory Gonye, and Bruce M Boman

Manuscripts from 2019

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Myc-mediated transcriptional regulation of the mitochondrial chaperone TRAP1 controls primary and metastatic tumor growth., Ekta Agarwal, Brian J. Altman, Jae Ho Seo, Jagadish C. Ghosh, Andrew V Kossenkov, Hsin-Yao Tang, Shiv Ram Krishn, Lucia R. Languino, Dmitry I. Gabrilovich, David W. Speicher, Chi V. Dang, and Dario C. Altieri

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No meaningful drug interactions with doravirine, lamivudine and tenofovir disoproxil fumarate co-administration., Matt S. Anderson, Jocelyn Gilmartin, Li Fan, Ka Lai Yee, Walter K. Kraft, Ilias Triantafyllou, Christina Reitmann, Ying Guo, Rachael Liu, and Marian Iwamoto

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Silencing the GUCA2A-GUCY2C tumor suppressor axis in CIN, serrated, and MSI colorectal neoplasia., Babar Bashir, Dante J. Merlino, Jeff A. Rappaport, Esteban Gnass, Juan P. Palazzo, Ying Feng, Eric R R. Fearon, Adam E. Snook, and Scott A. Waldman

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Advances in Chimeric Antigen Receptor T-Cell Therapies for Solid Tumors., Trevor R. Baybutt, John C. Flickinger, Ellen M. Caparosa, and Adam E. Snook

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Tumor-Derived Extracellular Vesicles Require β1 Integrins to Promote Anchorage-Independent Growth., Rachel M. DeRita, Aejaz Sayeed, Vaughn Garcia, Shiv Ram Krishn, Christopher D. Shields, Srawasti Sarker, Andrea Friedman, Peter McCue, Sudheer Kumar Molugu, Ulrich Rodeck, Adam P. Dicker, and Lucia R. Languino

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Sighting acute myocardial infarction through platelet gene expression., Giuliana Gobbi, Cecilia Carubbi, Guidantonio Malagoli Tagliazucchi, Elena Masselli, Prisco Mirandola, Filippo Pigazzani, Antonio Crocamo, Maria Francesca Notarangelo, Sergio Suma, Elvezia Paraboschi, Giuseppe Maglietta, Srikanth Nagalla, Giulia Pozzi, Daniela Galli, Mauro Vaccarezza, Paolo Fortina, Sankar Addya, Adam Ertel, Paul Bray, Stefano Duga, Carlo Berzuini, Marco Vitale, and Diego Ardissino

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CADM1 is a TWIST1-regulated suppressor of invasion and survival., Edward J. Hartsough, Michele B. Weiss, Shea A. Heilman, Timothy J. Purwin, Curtis H Kugel, Sheera R. Rosenbaum, Dan A. Erkes, Manoela Tiago, Kim Hookim, Inna Chervoneva, and Andrew E. Aplin

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Non-Thermal Plasma-Induced Immunogenic Cell Death in Cancer: A Topical Review., Marian Khalili, Lynsey Daniels, Abraham Lin, Fred C. Krebs, Adam E. Snook, Sander Bekeschus, Wilbur B. Bowne, and Vandana Miller

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The Bone Extracellular Matrix as an Ideal Milieu for Cancer Cell Metastases., Alexus D. Kolb and Karen M. Bussard

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Osteoblasts are "educated" by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment., Alexus D. Kolb, Alison B. Shupp, Dimpi Mukhopadhyay, Frank C. Marini, and Karen M. Bussard

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Drug interactions between direct-acting oral anticoagulants and calcineurin inhibitors during solid organ transplantation: considerations for therapy, Edwin Lam, Babar Bashir, Mark Chaballa, and Walter K. Kraft

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Pharmacokinetics of Ketamine at Dissociative Doses in an Adult Patient With Refractory Status Asthmaticus Receiving Extracorporeal Membrane Oxygenation Therapy., Edwin Lam, Ankit K. Rochani, Gagan Kaushal, Brandi N. Thoma, Julian Tanjuakio, Frances Mae West, and Hitoshi Hirose

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Cyclin D1 integrates G9a-mediated histone methylation., Zhiping Li, Xuanmao Jiao, Gabriele Di Sante, Adam Ertel, Mathew C. Casimiro, Min Wang, Sanjay Katiyar, Xiaoming Ju, D. V. Klopfenstein, Aydin Tozeren, William Dampier, Iouri Chepelev, Albert Jeltsch, and Richard G. Pestell

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Pharmacological and non-pharmacological treatments for the Neonatal Abstinence Syndrome (NAS)., A. K. Mangat, G. M. Schmölzer, and W. K. Kraft

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Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs., Jérôme Mastio, Thomas Condamine, George Dominguez, Andrew V Kossenkov, Laxminarasimha Donthireddy, Filippo Veglia, Cindy Lin, Fang Wang, Shuyu Fu, Jie Zhou, Patrick Viatour, Sergio Lavilla-Alonso, Alexander T. Polo, Evgenii N. Tcyganov, Charles Mulligan, Brian Nam, Joseph Bennett, Gregory Masters, Michael Guarino, Amit Kumar, Yulia Nefedova, Robert H. Vonderheide, Lucia R. Languino, Scott I. Abrams, and Dmitry I. Gabrilovich

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Quantitative sensory testing in children with sickle cell disease: additional insights and future possibilities., Robin E. Miller, Dawn S. Brown, Scott W. Keith, Sarah E. Hegarty, Yamaja Setty, Claudia M. Campbell, Suzanne M. McCahan, Suhita Gayen-Betal, Hal Byck, and Marie Stuart

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Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients., Adam E. Snook, Trevor R. Baybutt, Bo Xiang, Tara S. Abraham, John C. Flickinger, Terry Hyslop, Tingting Zhan, Walter K. Kraft, Takami Sato, and Scott A. Waldman

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Transcriptional activation of the miR-17-92 cluster is involved in the growth-promoting effects of MYB in human Ph-positive leukemia cells., Manuela Spagnuolo, Giulia Regazzo, Marco De Dominici, Andrea Sacconi, Andrea Pelosi, Etleva Korita, Francesco Marchesi, Francesco Pisani, Alessandra Magenta, Valentina Lulli, Iole Cordone, Andrea Mengarelli, Sabrina Strano, Giovanni Blandino, Maria G. Rizzo, and Bruno Calabretta

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Efficacy and safety of intravenous golimumab plus methotrexate in patients with rheumatoid arthritis aged < 65 years and those ≥ 65 years of age., John Tesser, Shelly Kafka, Raphael J. DeHoratius, Stephen Xu, Elizabeth C Hsia, and Anthony Turkiewicz

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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines, Clotilde Théry; Kenneth W. Witwer; Elena Aikawa; Maria Jose Alcaraz; Johnathon D. Anderson; Ramaroson Andriantsitohaina; Anna Antoniou; Tanina Arab; Fabienne Archer; Georgia K. Atkiin-Smith; D. Craig Ayre; Jean-Marie Bach; Daniel Bachurski; Hossein Baharvand; Leonora Balaj; Shawn Baldacchino; Natalie N. Bauer; Amy A. Baxter; Mary Bebawy; Carla Beckham; Apolonija Bedina Zavec; Abderrahim Benmoussa; Anna C. Berardi; Paolo Bergese; Ewa Bielska; Cherie Blenkiron; Sylwia Bobis-Wozowicz; Eric Boilard; Wilfrid Boireau; Antonella Bongiovanni; Francesc E. Borràs; Steffi Bosch; Chantal M. Boulanger; Xandra Breakefield; Andrew M. Breglio; Meadhbh Á. Brennan; David R. Brigstock; Alain Brisson; Marike L.D. Broekman; Jacqueline F. Bromberg; Paulina Bryl-Górecka; Shilpa Buch; Amy H. Buck; Dylan Burger; Sara Busatto; Dominik Buschmann; Benedetta Bussolati; Edit I. Buzás; James Bryan Byrd; Giovanni Camussi; David R.F. Carter; Sarah Caruso; Lawrence W. Chamley; Yu-Ting Chang; Chichen Chen; Shuai Chen; Lesley Cheng; Andrew R. Chin; Aled Clayton; Stefano P. Clerici; Alex Cocks; Emanuele Cocucci; Robert J. Coffey; Anabela Cordeiro-da-Silva; Yvonne Couch; Frank A.W. Coumans; Beth Coyle; Rossella Crescitelli; Miria Ferreira Criado; Crislyn D’ Souza-Schorey; Saumya Das; Amrita Datta Chaudhuri; Paola de Candia; Eliezer F. De Santana Junior; Olivier De Wever; Hernando A. del Portillo; Tanguy Demaret; Sarah Deville; Andrew Devitt; Bert Dhondt; Dolores Di Vizio; Lothar C. Dieterich; Vincenza Dolo; Ana Paula Dominguez Rubio; Massimo Dominici; Mauricio R. Dourado; Tom A.P Driedonks; Filipe V. Duarte; Heather M. Duncan; Ramon M. Eichenberger; Karin Ekström; Samir El Andaloussi; Celine Elie-Caille; Uta Erdbrügger; Juan M. Falcón-Pérez; Farah Fatima; Jason E. Fish; Miguel Flores-Bellver; András Försönits; Annie Frelet-Barrand; Fabia Fricke; Gregor Fuhrmann; Susanne Gabrielsson; Ana Gámez-Valero; Chris Gardiner; Kathrin Gärtner; Raphael Gaudin; Yong Song Gho; Bernd Giebel; Caroline Gilbert; Mario Gimona; Ilaria Giusti; Deborah C.I. Goberdhan; André Görgens; Sharon M. Gorski; David W. Greening; Julia Christina Gross; Alice Gualerzi; Gopal N. Gupta; Dakota Gustafson; Aase Handberg; Reka A. Haraszti; Paul Harrison; Hargita Hegyesi; An Hendrix; Andrew F. Hill; Fred H. Hochberg; Karl F. Hoffmann; Beth Holder; Harry Holthofer; Baharak Hosseinkhani; Guoku Hu; Yiyao Huang; Veronica Huber; Stuart Hunt; Ahmed Gamal-Eldin Ibrahim; Tsuneya Ikezu; Jameel M. Inal; Mustafa Isin; Alena Ivanova; Hannah K. Jackson; Soren Jacobsen; Steven M. Jay; Muthuvel Jayachandran; Guido Jenster; Lanzhou Jiang; Suzanne M. Johnson; Jennifer C. Jones; Ambrose Jong; Tijana Jovanovic-Talisman; Stephanie Jung; Raghu Kalluri; Shin-ichi Kano; Sukhbir Kaur; Yumi Kawamura; Evan T. Keller; Delaram Khamari; Elena Khomyakova; Anastasia Khvorova; Peter Kierulf; Kwang Pyo Kim; Thomas Kislinger; Mikael Klingeborn; David J. Klinke II; Miroslaw Kornek; Maja M. Kosanović; Árpád Ferenc Kovács; Eva-Maria Krämer-Albers; Susanne Krasemann; Mirja Krause; Igor V. Kurochkin; Gina D. Kusuma; Sören Kuypers; Saara Laitinen; Scott M. Langevin; Lucia R. Languino; Joanne Lannigan; Cecilia Lässer; Louise C. Laurent; Gregory Lavieu; Elisa Lázaro-Ibáñez; Soazig Le Lay; Myung-Shin Lee; Yi Xin Fiona Lee; Debora S. Lemos; Metka Lenassi; Aleksandra Leszczynska; Isaac T.S. Li; Ke Liao; Sten F. Libregts; Erzsebet Ligeti; Rebecca Lim; Sai Kiang Lim; Aija Linē; Karen Linnemannstöns; Alicia Llorente; Catherine A. Lombard; Magdalena J. Lorenowicz; Ákos M. Lörincz; Jan Lötvall; Jason Lovett; Michelle C. Lowry; Xavier Loyer; Quan Lu; Barbara Lukomska; Taral R. Lunavat; Sybren L.N. Maas; Harmeet Malhi; Antonio Marcilla; Jacopo Mariani; Javier Mariscal; Elena S. Martens-Uzunova; Lorena Martin-Jaular; M. Carmen Martinez; Vilma Regina Martins; Mathilde Mathieu; Suresh Mathivanan; Marco Maugeri; Lynda K. McGinnis; Mark J. McVey; David G. Meckes, Jr.; Katie L. Meehan; Inge Mertens; Valentina R. Minciacchi; Andreas Möller; Malene Møller Jørgensen; Aizea Morales-Kastresana; Jess Morhayim; François Mullier; Maurizio Muraca; Luca Musante; Veronika Mussack; Dillon C. Muth; Kathryn H. Myburgh; Tanbir Najrana; Muhammad Nawaz; Irina Nazarenko; Peter Nejsum; Christian Neri; Tommaso Neri; Rienk Nieuwland; Leonardo Nimrichter; John P. Nolan; Esther N.M. Nolte-’ t Hoen; Nicole Noren Hooten; Lorraine O’Driscoll; Tina O’Grady; Ana O’Loghlen; Takahiro Ochiya; Martin Olivier; Alberto Ortiz; Luis A. Ortiz; Xabier Osteikoetxea; Ole Ostegaard; Matias Ostrowski; Jaesung Park; D. Michiel Pegtel; Hector Peinado; Francesca Perut; Michael W. Pfaffl; Donald G. Phinney; Bartijn C.H. Pieters; Ryan C. Pink; David S. Pisetsky; Elke Pogge von Strandmann; Iva Polakovicova; Ivan K.H. Poon; Bonita H. Powell; Ilaria Prada; Lynn Pulliam; Peter Quesenberry; Annalisa Radeghieri; Robert L. Raffai; Stefania Raimondo; Janusz Rak; Marcel I. Ramirez; Graça Raposo; Morsi S. Rayyan; Neta Regev-Rudzki; Fran L. Ricklefs; Paul D. Robbins; David D. Roberts; Silvia C. Rodrigues; Eva Rohde; Sophie Rome; Kasper M.A. Rouschop; Aurelia Rughetti; Ashley E. Russell; Paula Saá; Susmita Sahoo; Edison Salas-Huenuleo; Catherine Sánchez; Julie A. Saugstad; Meike J. Saul; Raymond M. Schiffelers; Raphael Schneider; Tine Hiorth Schøyen; Aaron Scott; Eriomina Shahaj; Shivani Sharma; Olga Shatnyeva; Faezeh Shekari; Ganesh Vilas Shelke; Ashok K. Shetty; Kiyotaka Shiba; Pia R-M Siljander; Andreia M. Silva; Agata Skowronek; Orman L. Snyder II; Rodrigo Pedro Soares; Barbara W. Sódar; Carolina Soekmadji; Javier Sotillo; Philip D. Stahl; Willem Stoorvogel; Shannon L. Stott; Erwin F. Strasser; Simon Swift; Hidetoshi Tahara; Muneesh Tewari; Kate Timms; Swasti Tiwari; Rochelle Tixeira; Mercedes Tkach; Wei Seong Toh; Richard Tomasini; Ana Claudia Torrecilhas; Juan Pablo Tosar; Vasilis Toxavidis; Lorena Urbanelli; Pieter Vader; Bas W.M. van Balkom; Susanne G. van der Grein; Jan Van Deun; Martijn J.C. van Herwijnen; Kendall van Keuren-Jensen; Guillaume van Niel; Martin E. van Royen; Andre J. van Wijnen; M. Helena Vasconcelos; Ivan J. Vechetti Jr.; Tiago D. Veit; Laura J. Vella; Émilie Velot; Frederik J. Verweij; Beate Vestad; Jose L. Viñas; Tamás Visnovitz; Krisztina V. Vukman; Jessica Wahlgren; Dionysios C. Watson; Marca H.M. Wauben; Alissa Weaver; Jason P. Webber; Viktoria Weber; Ann M. Wehman; Daniel J. Weiss; Joshua A. Welsh; Sebastian Wendt; Asa M. Wheelock; Zoltán Wiener; Leonie Witte; Joy Wolfram; Angeliki Xagorari; Patricia Xander; Jing Xu; Xiaomei Yan; María Yáñez-Mó; Hang Yin; Yuana Yuana; Valentina Zappulli; Jana Zarubova; Vytautas Žėkas; Jian-ye Zhang; Zezhou Zhao; Lei Zheng; Alexander R. Zheutlin; Antje M. Zickler; Pascale Zimmermann; Angela M. Zivkovic; Davide Zocco; and Ewa K. Zuba-Surma

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Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance., Lance R. Thomas, Clare M. Adams, Jing Wang, April M. Weissmiller, Joy Creighton, Shelly L. Lorey, Qi Liu, Stephen W. Fesik, Christine M. Eischen, and William P. Tansey

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Blunted Evoked Prouroguanylin Endocrine Secretion in Chronic Constipation., Scott A. Waldman, Renata Tenenbaum, Henry C. Foehl, Peter Winkle, and Patrick Griffin

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Health Care Evolves From Reactive to Proactive., Scott A. Waldman and Andre Terzic

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m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade, Seungwon Yang, Jiangbo Wei, Yan-Hong Cui, Gayoung Park, Palak Shah, Yu Deng, Andrew E. Aplin, Zhike Lu, Seungmin Hwang, Chuan He, and Yu-Ying He

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SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors., Akihiro Yoshida, Yiwen Bu, Shuo Qie, John Wrangle, E. Ramsay Camp, E. Starr Hazard, Gary Hardiman, Renée de Leeuw, Karen E. Knudsen, and J. Alan Diehl

Manuscripts from 2018

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Neonatal Safety Information Reported to the FDA During Drug Development Studies., Debbie Avant, Gerri Baer, Jason N. Moore, Panli Zheng, Alfred Sorbello, Ron Ariagno, Lynne Yao, Gilbert J. Burckart, and Jian Wang