Document Type
Article
Publication Date
1-1-2020
Abstract
Prostate cancer (PrCa) cells crosstalk with the tumour microenvironment by releasing small extracellular vesicles (sEVs). sEVs, as well as large extracellular vesicles (LEVs), isolated via iodixanol density gradients from PrCa cell culture media, express the epithelial-specific αvβ6 integrin, which is known to be induced in cancer. In this study, we show sEV-mediated protein transfer of αvβ6 integrin to microvascular endothelial cells (human microvascular endothelial cells 1 - HMEC1) and demonstrate that
Recommended Citation
Krishn, Shiv Ram; Salem, Israa; Quaglia, Fabio; Naranjo, Nicole M; Agarwal, Ekta; Liu, Qin; Sarker, Srawasti; Kopenhaver, Jessica; McCue, Peter A; Weinreb, Paul H; Violette, Shelia M; Altieri, Dario C; and Languino, Lucia R, "The αvβ6 integrin in cancer cell-derived small extracellular vesicles enhances angiogenesis." (2020). Department of Cancer Biology Faculty Papers. Paper 167.
https://jdc.jefferson.edu/cbfp/167
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
PubMed ID
32595914
Language
English
Comments
This is the final published version the article from Journal of Extracellular Vesicles, 2020, Vol. 9, 1763594
The published version of the article can be found at https://doi.org/10.1080/20013078.2020.1763594
Copyright Krishn et.al.