Manuscripts from 2022
A Genome-Wide Screen Identifies PDPK1 as a Target to Enhance the Efficacy of MEK1/2 Inhibitors, Weijia Cai, Nicole A. Wilski, Timothy J. Purwin, Megane Vernon, Manoela Tiago, and Andrew E. Aplin
The future of targeted kinase inhibitors in melanoma, Signe Caksa, Usman Baqai, and A E Aplin
Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma, Claudia Capparelli; Timothy J. Purwin; McKenna Glasheen; Signe Caksa; Manoela Tiago; Nicole A. Wilski; Danielle Pomante; Sheera Rosenbaum; Mai Q Nguyen; Weijia Cai; Janusz Franco-Barraza; R. Zheng, MD; Gaurav Kumar; I Chervoneva; Ayako Shimada; Vito W Rebecca; Adam E. Snook; Kim Hookim; Xiaowei Xu; Edna Cukierman; Meenhard Herlyn; and A E Aplin
DNA-PKcs: A Targetable Protumorigenic Protein Kinase., Emanuela Dylgjeri and Karen E Knudsen
Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability, Jagadish C Ghosh, Michela Perego, Ekta Agarwal, Irene Bertolini, Yuan Wang, Aaron R Goldman, Hsin-Yao Tang, Andrew V Kossenkov, Catherine J Libby, Lucia R Languino, Edward F Plow, Annamaria Morotti, Luisa Ottobrini, Marco Locatelli, David W Speicher, M Cecilia Caino, Joel Cassel, Joseph M Salvino, Marie E Robert, Valentina Vaira, and Dario C Altieri
Stabilized COre Gene and Pathway Election Uncovers Pan-Cancer Shared Pathways and a Cancer-Specific Driver, Pathum Kossinna, Weijia Cai, Xuewen Lu, Carrie S Shemanko, and Qingrun Zhang
Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cells, Shiv Ram Krishn, Vaughn Garcia, Nicole M Naranjo, Fabio Quaglia, Christopher D Shields, Maisha A Harris, Andrew V Kossenkov, Qin Liu, Eva Corey, Dario C Altieri, and Lucia R Languino
Lysine Methyltransferase NSD1 and Cancers: Any Role in Melanoma?, Imène Krossa, Thomas Strub, Andrew E Aplin, Robert Ballotti, and Corine Bertolotto
CTpathway: A Crosstalk-Based Pathway Enrichment Analysis Method for Cancer Research, Haizhou Liu, Mengqin Yuan, Ramkrishna Mitra, Xu Zhou, Min Long, Wanyue Lei, Shunheng Zhou, Yu-E Huang, Fei Hou, Christine M. Eischen, and Wei Jiang
Novel Oncogenic Transcription Factor Cooperation in RB-Deficient Cancer, Amy C. Mandigo, Ayesha A Shafi, Jennifer J McCann, Wei Yuan, Talya Laufer, Denisa Bogdan, Lewis Gallagher, Emanuela Dylgjeri, Galina Semenova, Irina A Vasilevskaya, M J Schiewer, Chris M McNair, Johann S de Bono, and Karen E Knudsen
The NOGO Receptor NgR2, A Novel αVβ3 Integrin Effector, Induces Neuroendocrine Differentiation in Prostate Cancer, Fabio Quaglia, Shiv Ram Krishn, Khalid Sossey-Alaoui, Priyanka Shailendra Rana, Elzbieta Pluskota, Pyung Hun Park, Christopher D. Shields, Stephen Lin, Peter McCue, Andrew V. Kossenkov, Yanqing Wang, David W. Goodrich, Sheng-Yu Ku, Himisha Beltran, William K. Kelly, Eva Corey, Maja Klose, Christine Bandtlow, Qin Liu, Dario C. Altieri, Edward F. Plow, and Lucia R. Languino
RAS-mediated tumor stress adaptation and the targeting opportunities it presents, Alexandra Redding, A E Aplin, and Elda Grabocka
Manuscripts from 2021
A cancer ubiquitome landscape identifies metabolic reprogramming as target of Parkin tumor suppression, Ekta Agarwal, Aaron R Goldman, Hsin-Yao Tang, Andrew V Kossenkov, Jagadish C Ghosh, Lucia Languino, Valentina Vaira, David W Speicher, and Dario C Altieri
Printing the Pathway Forward in Bone Metastatic Cancer Research: Applications of 3D Engineered Models and Bioprinted Scaffolds to Recapitulate the Bone-Tumor Niche., Anne M. Hughes, Alexus D. Kolb, Alison B. Shupp, Kristy M. Shine, and Karen M. Bussard
Association of Dietary Total Antioxidant Capacity with Bone Mass and Osteoporosis Risk in Korean Women: Analysis of the Korea National Health and Nutrition Examination Survey 2008-2011, Donghyun Kim, Anna Han, and Yongsoon Park
'Educated' Osteoblasts Reduce Osteoclastogenesis in a Bone-Tumor Mimetic Microenvironment., Alexus D. Kolb, Jinlu Dai, Evan T. Keller, and Karen M. Bussard
The Quandary of DNA-Based Treatment Assessment in De Novo Metastatic Prostate Cancer in the Era of Precision Oncology., Sigve Nakken, Wolfgang Lilleby, Marta D. Switlyk, Karen E Knudsen, Oscar Lilleby, Sen Zhao, Fatemeh Kaveh, Per O. Ekstrøm, Alfonso Urbanucci, and Eivind Hovig
Redefining cancer of unknown primary: Is precision medicine really shifting the paradigm?, Timothée Olivier, Eugenio Fernandez, Intidhar Labidi-Galy, Pierre-Yves Dietrich, Veronica Rodriguez-Bravo, Giulia Baciarello, Karim Fizazi, and Anna Patrikidou
MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor-1., Tessa M. Popay, Jing Wang, Clare M. Adams, Gregory Caleb Howard, Simona G. Codreanu, Stacy D. Sherrod, John A. McLean, Lance R. Thomas, Shelly L. Lorey, Yuichi J. Machida, April M. Weissmiller, Christine M. Eischen, Qi Liu, and William P. Tansey
Targeting the cdk6 dependence of ph+ acute lymphoblastic leukemia, Patrizia Porazzi, Marco De Dominici, Joseph Salvino, and Bruno Calabretta
Differential expression of αVβ3 and αVβ6 integrins in prostate cancer progression, Fabio Quaglia, Shiv Ram Krishn, Yanqing Wang, David W Goodrich, Peter McCue, Andrew Kossenkov, Amy C Mandigo, Karen Knudsen, Paul H Weinreb, Eva Corey, William Kevin Kelly, and Lucia R Languino
SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects, Sheera Rosenbaum, Manoela Tiago, Signe Caksa, Claudia Capparelli, Timothy J. Purwin, Gaurav Kumar, McKenna Glasheen, Danielle Pomante, Daniel Kotas, I Chervoneva, and A E Aplin
The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair., Ayesha A Shafi, Chris M McNair, Jennifer J McCann, Mohammed Alshalalfa, Anton Shostak, Tesa M Severson, Yanyun Zhu, Andre Bergman, Nicolas Gordon, Amy C Mandigo, Saswati N Chand, Peter Gallagher, Emanuela Dylgjeri, Talya S Laufer, Irina A Vasilevskaya, Matthew J Schiewer, Michael Brunner, Felix Y Feng, Wilbert Zwart, and Karen E Knudsen
Targeted Treatment of Head and Neck (Pre)Cancer: Preclinical Target Identification and Development of Novel Therapeutic Applications, Anne van Harten and Ruud H. Brakenhoff
miRcorrNet: machine learning-based integration of miRNA and mRNA expression profiles, combined with feature grouping and ranking., Malik Yousef, Gokhan Goy, Ramkrishna Mitra, Christine M. Eischen, Amhar Jabeer, and Burcu Bakir-Gungor
Manuscripts from 2020
The membrane-associated form of cyclin D1 enhances cellular invasion, Ke Chen, Xuanmao Jiao, Anthony Ashton, Agnese Di Rocco, Timothy G Pestell, Yunguang Sun, Jun Zhao, Mathew C Casimiro, Zhiping Li, Michael P Lisanti, Peter McCue, Duanwen Shen, Samuel Achilefu, Hallgeir Rui, and Richard G Pestell
Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation., Ke Chen, Xuanmao Jiao, Agnese Di Rocco, Duanwen Shen, Shaohua Xu, Adam Ertel, Zuoren Yu, Gabriele Di Sante, Min Wang, Zhiping Li, Timothy G Pestell, Mathew C Casimiro, Emmanuel Skordalakes, Samuel Achilefu, and Richard G Pestell
Artificial Intelligence-Powered Search Tools and Resources in the Fight Against COVID-19., Larry J Kricka, Sergei Polevikov, Jason Y Park, Paolo Fortina, Sergio Bernardini, Daniel Satchkov, Valentin Kolesov, and Maxim Grishkov
The αvβ6 integrin in cancer cell-derived small extracellular vesicles enhances angiogenesis., Shiv Ram Krishn, Israa Salem, Fabio Quaglia, Nicole M Naranjo, Ekta Agarwal, Qin Liu, Srawasti Sarker, Jessica Kopenhaver, Peter A McCue, Paul H Weinreb, Shelia M Violette, Dario C Altieri, and Lucia R Languino
iSeqQC: a tool for expression-based quality control in RNA sequencing., Gaurav Kumar, Adam Ertel, George Feldman, Joan Kupper, and Paolo Fortina
Pan-cancer analysis reveals cooperativity of both strands of microRNA that regulate tumorigenesis and patient survival, Ramkrishna Mitra, Clare M. Adams, Wei Jiang, Evan J. Greenawalt, and Christine M. Eischen
Hitting the Bullseye: Are extracellular vesicles on target?, Nicole Noren Hooten, María Yáñez-Mó, Rachel M. DeRita, Ashley Russell, Peter Quesenberry, Bharat Ramratnam, Paul D Robbins, Dolores Di Vizio, Sicheng Wen, Kenneth W Witwer, and Lucia R Languino
MicroRNA and transcription factor co-regulatory networks and subtype classification of seminoma and non-seminoma in testicular germ cell tumors, Guimin Qin, Saurav Mallik, Ramkrishna Mitra, Aimin Li, Peilin Jia, Christine M. Eischen, and Zhongming Zhao
MicroRNA and transcription factor co-regulatory networks and subtype classification of seminoma and non-seminoma in testicular germ cell tumors., Guimin Qin, Saurav Mallik, Ramkrishna Mitra, Aimin Li, Peilin Jia, Christine M. Eischen, and Zhongming Zhao
FOXD3 Regulates VISTA Expression in Melanoma., Sheera R. Rosenbaum, Meghan Knecht, Mehri Mollaee, Zhijiu Zhong, Dan A. Erkes, Peter A. McCue, Chervoneva, Adam C. Berger, Jennifer A. Lo, David E. Fisher, Jeffrey E. Gershenwald, Michael A. Davies, Timothy J. Purwin, and Andrew E. Aplin
Profiling the circulating mRNA transcriptome in human liver disease, Aejaz Sayeed, Brielle E Dalvano, David E Kaplan, Usha Viswanathan, John Kulp, Alhaji H Janneh, Lu-Yu Hwang, Adam Ertel, Cataldo Doria, and Timothy Block
Manuscripts from 2019
Myc-mediated transcriptional regulation of the mitochondrial chaperone TRAP1 controls primary and metastatic tumor growth., Ekta Agarwal, Brian J. Altman, Jae Ho Seo, Jagadish C. Ghosh, Andrew V Kossenkov, Hsin-Yao Tang, Shiv Ram Krishn, Lucia R. Languino, Dmitry I. Gabrilovich, David W. Speicher, Chi V. Dang, and Dario C. Altieri
Tumor-Derived Extracellular Vesicles Require β1 Integrins to Promote Anchorage-Independent Growth., Rachel M. DeRita, Aejaz Sayeed, Vaughn Garcia, Shiv Ram Krishn, Christopher D. Shields, Srawasti Sarker, Andrea Friedman, Peter McCue, Sudheer Kumar Molugu, Ulrich Rodeck, Adam P. Dicker, and Lucia R. Languino
Sighting acute myocardial infarction through platelet gene expression., Giuliana Gobbi, Cecilia Carubbi, Guidantonio Malagoli Tagliazucchi, Elena Masselli, Prisco Mirandola, Filippo Pigazzani, Antonio Crocamo, Maria Francesca Notarangelo, Sergio Suma, Elvezia Paraboschi, Giuseppe Maglietta, Srikanth Nagalla, Giulia Pozzi, Daniela Galli, Mauro Vaccarezza, Paolo Fortina, Sankar Addya, Adam Ertel, Paul Bray, Stefano Duga, Carlo Berzuini, Marco Vitale, and Diego Ardissino
CADM1 is a TWIST1-regulated suppressor of invasion and survival., Edward J. Hartsough, Michele B. Weiss, Shea A. Heilman, Timothy J. Purwin, Curtis H Kugel, Sheera R. Rosenbaum, Dan A. Erkes, Manoela Tiago, Kim Hookim, Inna Chervoneva, and Andrew E. Aplin
The Bone Extracellular Matrix as an Ideal Milieu for Cancer Cell Metastases., Alexus D. Kolb and Karen M. Bussard
Osteoblasts are "educated" by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment., Alexus D. Kolb, Alison B. Shupp, Dimpi Mukhopadhyay, Frank C. Marini, and Karen M. Bussard
Cyclin D1 integrates G9a-mediated histone methylation., Zhiping Li, Xuanmao Jiao, Gabriele Di Sante, Adam Ertel, Mathew C. Casimiro, Min Wang, Sanjay Katiyar, Xiaoming Ju, D. V. Klopfenstein, Aydin Tozeren, William Dampier, Iouri Chepelev, Albert Jeltsch, and Richard G. Pestell
Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs., Jérôme Mastio, Thomas Condamine, George Dominguez, Andrew V Kossenkov, Laxminarasimha Donthireddy, Filippo Veglia, Cindy Lin, Fang Wang, Shuyu Fu, Jie Zhou, Patrick Viatour, Sergio Lavilla-Alonso, Alexander T. Polo, Evgenii N. Tcyganov, Charles Mulligan, Brian Nam, Joseph Bennett, Gregory Masters, Michael Guarino, Amit Kumar, Yulia Nefedova, Robert H. Vonderheide, Lucia R. Languino, Scott I. Abrams, and Dmitry I. Gabrilovich
Validation of a Miniaturized Permeability Assay Compatible with CRISPR-Mediated Genome-Wide Screen., Claire Simonneau, Junning Yang, Xianguo Kong, Robert Kilker, Leonard Edelstein, Paolo Fortina, Eric R. Londin, and Arie Horowitz
Transcriptional activation of the miR-17-92 cluster is involved in the growth-promoting effects of MYB in human Ph-positive leukemia cells., Manuela Spagnuolo, Giulia Regazzo, Marco De Dominici, Andrea Sacconi, Andrea Pelosi, Etleva Korita, Francesco Marchesi, Francesco Pisani, Alessandra Magenta, Valentina Lulli, Iole Cordone, Andrea Mengarelli, Sabrina Strano, Giovanni Blandino, Maria G. Rizzo, and Bruno Calabretta
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines, Clotilde Théry; Kenneth W. Witwer; Elena Aikawa; Maria Jose Alcaraz; Johnathon D. Anderson; Ramaroson Andriantsitohaina; Anna Antoniou; Tanina Arab; Fabienne Archer; Georgia K. Atkiin-Smith; D. Craig Ayre; Jean-Marie Bach; Daniel Bachurski; Hossein Baharvand; Leonora Balaj; Shawn Baldacchino; Natalie N. Bauer; Amy A. Baxter; Mary Bebawy; Carla Beckham; Apolonija Bedina Zavec; Abderrahim Benmoussa; Anna C. Berardi; Paolo Bergese; Ewa Bielska; Cherie Blenkiron; Sylwia Bobis-Wozowicz; Eric Boilard; Wilfrid Boireau; Antonella Bongiovanni; Francesc E. Borràs; Steffi Bosch; Chantal M. Boulanger; Xandra Breakefield; Andrew M. Breglio; Meadhbh Á. Brennan; David R. Brigstock; Alain Brisson; Marike L.D. Broekman; Jacqueline F. Bromberg; Paulina Bryl-Górecka; Shilpa Buch; Amy H. Buck; Dylan Burger; Sara Busatto; Dominik Buschmann; Benedetta Bussolati; Edit I. Buzás; James Bryan Byrd; Giovanni Camussi; David R.F. Carter; Sarah Caruso; Lawrence W. Chamley; Yu-Ting Chang; Chichen Chen; Shuai Chen; Lesley Cheng; Andrew R. Chin; Aled Clayton; Stefano P. Clerici; Alex Cocks; Emanuele Cocucci; Robert J. Coffey; Anabela Cordeiro-da-Silva; Yvonne Couch; Frank A.W. Coumans; Beth Coyle; Rossella Crescitelli; Miria Ferreira Criado; Crislyn D’ Souza-Schorey; Saumya Das; Amrita Datta Chaudhuri; Paola de Candia; Eliezer F. De Santana Junior; Olivier De Wever; Hernando A. del Portillo; Tanguy Demaret; Sarah Deville; Andrew Devitt; Bert Dhondt; Dolores Di Vizio; Lothar C. Dieterich; Vincenza Dolo; Ana Paula Dominguez Rubio; Massimo Dominici; Mauricio R. Dourado; Tom A.P Driedonks; Filipe V. Duarte; Heather M. Duncan; Ramon M. Eichenberger; Karin Ekström; Samir El Andaloussi; Celine Elie-Caille; Uta Erdbrügger; Juan M. Falcón-Pérez; Farah Fatima; Jason E. Fish; Miguel Flores-Bellver; András Försönits; Annie Frelet-Barrand; Fabia Fricke; Gregor Fuhrmann; Susanne Gabrielsson; Ana Gámez-Valero; Chris Gardiner; Kathrin Gärtner; Raphael Gaudin; Yong Song Gho; Bernd Giebel; Caroline Gilbert; Mario Gimona; Ilaria Giusti; Deborah C.I. Goberdhan; André Görgens; Sharon M. Gorski; David W. Greening; Julia Christina Gross; Alice Gualerzi; Gopal N. Gupta; Dakota Gustafson; Aase Handberg; Reka A. Haraszti; Paul Harrison; Hargita Hegyesi; An Hendrix; Andrew F. Hill; Fred H. Hochberg; Karl F. Hoffmann; Beth Holder; Harry Holthofer; Baharak Hosseinkhani; Guoku Hu; Yiyao Huang; Veronica Huber; Stuart Hunt; Ahmed Gamal-Eldin Ibrahim; Tsuneya Ikezu; Jameel M. Inal; Mustafa Isin; Alena Ivanova; Hannah K. Jackson; Soren Jacobsen; Steven M. Jay; Muthuvel Jayachandran; Guido Jenster; Lanzhou Jiang; Suzanne M. Johnson; Jennifer C. Jones; Ambrose Jong; Tijana Jovanovic-Talisman; Stephanie Jung; Raghu Kalluri; Shin-ichi Kano; Sukhbir Kaur; Yumi Kawamura; Evan T. Keller; Delaram Khamari; Elena Khomyakova; Anastasia Khvorova; Peter Kierulf; Kwang Pyo Kim; Thomas Kislinger; Mikael Klingeborn; David J. Klinke II; Miroslaw Kornek; Maja M. Kosanović; Árpád Ferenc Kovács; Eva-Maria Krämer-Albers; Susanne Krasemann; Mirja Krause; Igor V. Kurochkin; Gina D. Kusuma; Sören Kuypers; Saara Laitinen; Scott M. Langevin; Lucia R. Languino; Joanne Lannigan; Cecilia Lässer; Louise C. Laurent; Gregory Lavieu; Elisa Lázaro-Ibáñez; Soazig Le Lay; Myung-Shin Lee; Yi Xin Fiona Lee; Debora S. Lemos; Metka Lenassi; Aleksandra Leszczynska; Isaac T.S. Li; Ke Liao; Sten F. Libregts; Erzsebet Ligeti; Rebecca Lim; Sai Kiang Lim; Aija Linē; Karen Linnemannstöns; Alicia Llorente; Catherine A. Lombard; Magdalena J. Lorenowicz; Ákos M. Lörincz; Jan Lötvall; Jason Lovett; Michelle C. Lowry; Xavier Loyer; Quan Lu; Barbara Lukomska; Taral R. Lunavat; Sybren L.N. Maas; Harmeet Malhi; Antonio Marcilla; Jacopo Mariani; Javier Mariscal; Elena S. Martens-Uzunova; Lorena Martin-Jaular; M. Carmen Martinez; Vilma Regina Martins; Mathilde Mathieu; Suresh Mathivanan; Marco Maugeri; Lynda K. McGinnis; Mark J. McVey; David G. Meckes, Jr.; Katie L. Meehan; Inge Mertens; Valentina R. Minciacchi; Andreas Möller; Malene Møller Jørgensen; Aizea Morales-Kastresana; Jess Morhayim; François Mullier; Maurizio Muraca; Luca Musante; Veronika Mussack; Dillon C. Muth; Kathryn H. Myburgh; Tanbir Najrana; Muhammad Nawaz; Irina Nazarenko; Peter Nejsum; Christian Neri; Tommaso Neri; Rienk Nieuwland; Leonardo Nimrichter; John P. Nolan; Esther N.M. Nolte-’ t Hoen; Nicole Noren Hooten; Lorraine O’Driscoll; Tina O’Grady; Ana O’Loghlen; Takahiro Ochiya; Martin Olivier; Alberto Ortiz; Luis A. Ortiz; Xabier Osteikoetxea; Ole Ostegaard; Matias Ostrowski; Jaesung Park; D. Michiel Pegtel; Hector Peinado; Francesca Perut; Michael W. Pfaffl; Donald G. Phinney; Bartijn C.H. Pieters; Ryan C. Pink; David S. Pisetsky; Elke Pogge von Strandmann; Iva Polakovicova; Ivan K.H. Poon; Bonita H. Powell; Ilaria Prada; Lynn Pulliam; Peter Quesenberry; Annalisa Radeghieri; Robert L. Raffai; Stefania Raimondo; Janusz Rak; Marcel I. Ramirez; Graça Raposo; Morsi S. Rayyan; Neta Regev-Rudzki; Fran L. Ricklefs; Paul D. Robbins; David D. Roberts; Silvia C. Rodrigues; Eva Rohde; Sophie Rome; Kasper M.A. Rouschop; Aurelia Rughetti; Ashley E. Russell; Paula Saá; Susmita Sahoo; Edison Salas-Huenuleo; Catherine Sánchez; Julie A. Saugstad; Meike J. Saul; Raymond M. Schiffelers; Raphael Schneider; Tine Hiorth Schøyen; Aaron Scott; Eriomina Shahaj; Shivani Sharma; Olga Shatnyeva; Faezeh Shekari; Ganesh Vilas Shelke; Ashok K. Shetty; Kiyotaka Shiba; Pia R-M Siljander; Andreia M. Silva; Agata Skowronek; Orman L. Snyder II; Rodrigo Pedro Soares; Barbara W. Sódar; Carolina Soekmadji; Javier Sotillo; Philip D. Stahl; Willem Stoorvogel; Shannon L. Stott; Erwin F. Strasser; Simon Swift; Hidetoshi Tahara; Muneesh Tewari; Kate Timms; Swasti Tiwari; Rochelle Tixeira; Mercedes Tkach; Wei Seong Toh; Richard Tomasini; Ana Claudia Torrecilhas; Juan Pablo Tosar; Vasilis Toxavidis; Lorena Urbanelli; Pieter Vader; Bas W.M. van Balkom; Susanne G. van der Grein; Jan Van Deun; Martijn J.C. van Herwijnen; Kendall van Keuren-Jensen; Guillaume van Niel; Martin E. van Royen; Andre J. van Wijnen; M. Helena Vasconcelos; Ivan J. Vechetti Jr.; Tiago D. Veit; Laura J. Vella; Émilie Velot; Frederik J. Verweij; Beate Vestad; Jose L. Viñas; Tamás Visnovitz; Krisztina V. Vukman; Jessica Wahlgren; Dionysios C. Watson; Marca H.M. Wauben; Alissa Weaver; Jason P. Webber; Viktoria Weber; Ann M. Wehman; Daniel J. Weiss; Joshua A. Welsh; Sebastian Wendt; Asa M. Wheelock; Zoltán Wiener; Leonie Witte; Joy Wolfram; Angeliki Xagorari; Patricia Xander; Jing Xu; Xiaomei Yan; María Yáñez-Mó; Hang Yin; Yuana Yuana; Valentina Zappulli; Jana Zarubova; Vytautas Žėkas; Jian-ye Zhang; Zezhou Zhao; Lei Zheng; Alexander R. Zheutlin; Antje M. Zickler; Pascale Zimmermann; Angela M. Zivkovic; Davide Zocco; and Ewa K. Zuba-Surma
Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance., Lance R. Thomas, Clare M. Adams, Jing Wang, April M. Weissmiller, Joy Creighton, Shelly L. Lorey, Qi Liu, Stephen W. Fesik, Christine M. Eischen, and William P. Tansey
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade, Seungwon Yang, Jiangbo Wei, Yan-Hong Cui, Gayoung Park, Palak Shah, Yu Deng, Andrew E. Aplin, Zhike Lu, Seungmin Hwang, Chuan He, and Yu-Ying He
SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors., Akihiro Yoshida, Yiwen Bu, Shuo Qie, John Wrangle, E. Ramsay Camp, E. Starr Hazard, Gary Hardiman, Renée de Leeuw, Karen E. Knudsen, and J. Alan Diehl
Manuscripts from 2018
Semaphorin 5A drives melanoma progression: role of Bcl-2, miR-204 and c-Myb., Simona D'Aguanno, Elisabetta Valentini, Maria Grazia Tupone, Marianna Desideri, Marta Di Martile, Manuela Spagnuolo, Simonetta Buglioni, Cristiana Ercolani, Italia Falcone, Marco De Dominici, Michele Milella, Maria Giulia Rizzo, Bruno Calabretta, Carlo Cota, Andrea Anichini, Daniela Trisciuoglio, and Donatella Del Bufalo
Targeting CDK6 and BCL2 Exploits the "MYB Addiction" of Ph+ Acute Lymphoblastic Leukemia, Marco De Dominici, Patrizia Porazzi, Angela Rachele Soliera, Samanta A. Mariani, Sankar Addya, Paolo Fortina, Luke F. Peterson, Orietta Spinelli, Alessandro Rambaldi, Giovanni Martinelli, Anna Ferrari, Ilaria Iacobucci, and Bruno Calabretta
MAPK Reliance via Acquired CDK4/6 Inhibitor Resistance in Cancer., Renée de Leeuw, Christopher McNair, Matthew J. Schiewer, Neermala Poudel Neupane, Lucas J. Brand, Michael A. Augello, Zhen Li, Larry C. Cheng, Akihiro Yoshida, Sean M. Courtney, E. Starr Hazard, Gary Hardiman, Maha H. Hussain, J. Alan Diehl, Justin M. Drake, William Kevin Kelly, and Karen E. Knudsen
ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma., Shujun Han, Yibo Ren, Wangxiao He, Huadong Liu, Zhe Zhi, Xinliang Zhu, Tielin Yang, Yu Rong, Bohan Ma, Timothy J. Purwin, Zhenlin Ouyang, Caixia Li, Xun Wang, Xueqiang Wang, Huizi Yang, Yan Zheng, Andrew E. Aplin, Jiankang Liu, and Yongping Shao
Response and Resistance to Paradox-Breaking BRAF Inhibitor in Melanomas, Edward J. Hartsough, Curtis H. Kugel, Michael J. Vido, Adam C. Berger, Timothy J. Purwin, Allison F. Goldberg, Michael A. Davies, Matthew J. Schiewer, Karen E. Knudsen, Gideon Bollag, and Andrew E. Aplin
Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrate-resistant prostate cancer by a well-defined polyherbal mixture with anticancer properties., Amber F. MacDonald, Ahmed Bettaieb, Dallas R. Donohoe, Dina S. Alani, Anna Han, Yi Zhao, and Jay Whelan
Differential impact of RB status on E2F1 reprogramming in human cancer., Christopher McNair, Kexin Xu, Amy C. Mandigo, Matteo Benelli, Benjamin E. Leiby, Daniel Rodrigues, Johan Lindberg, Henrik Gronberg, Mateus Crespo, Bram De Laere, Luc Dirix, Tapio Visakorpi, Fugen Li, Felix Y. Feng, Johann de Bono, Francesca Demichelis, Mark A. Rubin, Myles Brown, and Karen E. Knudsen
miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential., Sara E. Meyer, David E. Muench, Andrew M. Rogers, Tess J. Newkold, Emily Orr, Eric O'Brien, John P. Perentesis, John G. Doench, Ashish Lal, Patrick J. Morris, Craig J. Thomas, Judy Lieberman, Edwina McGlinn, Bruce J. Aronow, Nathan Salomonis, and H. Leighton Grimes
Targeting the STAT5 pathway in Ph+ acute lymphoblastic leukemia, Valentina Minieri, Marco De Dominici, Marja T. Nevalainen, and Bruno Calabretta
A preexisting rare PIK3CA e545k subpopulation confers clinical resistance to MEK plus CDK4/6 inhibition in NRAS melanoma and is dependent on S6K1 signaling, Gabriele Romano, Pei-Ling Chen, Ping Song, Jennifer L. McQuade, Roger J. Liang, Mingguang Liu, Whijae Roh, Dzifa Y. Duose, Fernando C.L. Carapeto, Jun Li, Jessica L.F. Teh, Andrew A. Aplin, Merry Chen, Jianhua Zhang, Alexander J. Lazar, Michael A. Davies, P. Andrew Futreal, Rodabe N. Amaria, David Y. Zhang, Jennifer A. Wargo, and Lawrence N. Kwong
PARP-1 regulates DNA repair factor availability., M J Schiewer; Amy C. Mandigo; Nicolas Gordon; Fangjin Huang; Sanchaika Gaur; Renée de Leeuw; Shuang G Zhao; Joseph Evans; Sumin Han; Theodore Parsons; Ruth Birbe; Peter McCue; Christopher McNair; Saswati N. Chand; Ylenia Cendon-Florez; Peter Gallagher; Jennifer J McCann; Neermala Poudel Neupane; Ayesha A Shafi; Emanuela Dylgjeri; Lucas J Brand; Tapio Visakorpi; Ganesh V Raj; Costas D. Lallas; Edouard J Trabulsi; Leonard G Gomella; Adam Dicker MD, PhD; William Kevin Kelly; Benjamin E Leiby; Beatrice Knudsen; Felix Y Feng; and Karen E Knudsen
Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements., Jae Ho Seo, Ekta Agarwal, Kelly G. Bryant, M. Cecilia Caino, Eui Tae Kim, Andrew V. Kossenkov, Hsin-Yao Tang, Lucia R. Languino, Dmitry I. Gabrilovich, Andrew R. Cohen, David W. Speicher, and Dario C. Altieri
Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome, Guangxue Wang, Michael Gormley, Jing Qiao, Qian Zhao, Min Wang, Gabriele DiSante, Shengqiong Deng, Lin Dong, Timothy G. Pestell, Xiaoming Ju, Mathew C. Casimiro, Sankar Addya, Adam Ertel, Ayden Tozeren, Qinchuan Li, Zuoren Yu, and Richard G. Pestell
EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer., Li Wang, Abdel Saci, Peter M. Szabo, Scott D. Chasalow, Mireia Castillo-Martin, Josep Domingo-Domenech, Arlene Siefker-Radtke, Padmanee Sharma, John P. Sfakianos, Yixuan Gong, Ana Dominguez-Andres, William K. Oh, David Mulholland, Alex Azrilevich, Liangyuan Hu, Carlos Cordon-Cardo, Hélène Salmon, Nina Bhardwaj, Jun Zhu, and Matthew D. Galsky
Manuscripts from 2017
BCL-W has a fundamental role in B cell survival and lymphomagenesis., Clare M. Adams, Annette S. Kim, Ramkrishna Mitra, John K Choi, Jerald Z. Gong, and Christine M. Eischen
Non-Hodgkin and Hodgkin Lymphomas Select for Overexpression of BCLW., Clare M. Adams; Ramkrishna Mitra; Jerald Z. Gong, MD; and Christine M. Eischen
Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho., Reeti Behera, Amanpreet Kaur, Marie R. Webster, Suyeon Kim, Abibatou Ndoye, Curtis H. Kugel, Gretchen M. Alicea, Joshua Wang, Kanad Ghosh, Phil Cheng, Sofia Lisanti, Katie Marchbank, Vanessa Dang, Mitchell Levesque, Reinhard Dummer, Xiaowei Xu, Meenhard Herlyn, Andrew E. Aplin, Alexander Roesch, Cecilia Caino, Dario C. Altieri, and Ashani T. Weeraratna
CKS1 expression in melanocytic nevi and melanoma, Anna A. Brożyna, Andrew Aplin, Cynthia Cohen, Grant Carlson, Andrew Joseph Page, Michael Murphy, Andrzej T. Slominski, and J. Andrew Carlson
Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer., M Cecilia Caino, Jae Ho Seo, Yuan Wang, Dayana B. Rivadeneira, Dmitry I. Gabrilovich, Eui Tae Kim, Ashani T Weeraratna, Lucia R. Languino, and Dario C. Altieri
Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis., Mathew C. Casimiro, Gabriele Disante, Agnese Di Rocco, Emanuele Loro, Claudia Pupo, Timothy G. Pestell, Sara Bisetto, Marco A. Velasco-Velázquez, Xuanmao Jiao, Zhiping Li, Christine M. Kusminski, Erin L. Seifert, Chenguang Wang, Daniel Ly, Bin Zheng, Che-Hung Shen, Philipp E. Scherer, and Richard Pestell
Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma., Hanyin Cheng, Vivian Chua, Connie Liao, Timothy J. Purwin, Mizue Terai, Ken Kageyama, Michael A. Davies, Takami Sato, and Andrew E. Aplin
Mdm2 Is Required for Survival and Growth of p53-Deficient Cancer Cells., Kyle P Feeley, Clare M. Adams, Ramkrishna Mitra, and Christine M. Eischen
Different Effects of Maternal Low-Isoflavone Soy Protein and Genistein Consumption on Hepatic Lipid Metabolism of 21-Day-Old Male Rat Offspring., Anna Han, Sae Bom Won, and Young Hye Kwon
Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells., Lingyu Meng, Cuicui Liu, Jinhui Lü, Qian Zhao, Shengqiong Deng, Guangxue Wang, Jing Qiao, Chuyi Zhang, Lixiao Zhen, Ying Lu, Wenshu Li, Yuzhen Zhang, Richard G. Pestell, Huiming Fan, Yi-Han Chen, Zhongmin Liu, and Zuoren Yu
From EMT to HSC to AML: ZEB2 is a cell fate switch., Sara E. Meyer
Decoding critical long non-coding RNA in ovarian cancer epithelial-to-mesenchymal transition., Ramkrishna Mitra, Xi Chen, Evan J. Greenawalt, Ujjwal Maulik, Wei Jiang, Zhongming Zhao, and Christine M. Eischen
Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis., Erika M. Palmieri, Alessio Menga, Rosa Martín-Pérez, Annamaria Quinto, Carla Riera-Domingo, Giacoma De Tullio, D Craig Hooper, Wouter H. Lamers, Bart Ghesquière, Daniel W. McVicar, Attilio Guarini, Massimiliano Mazzone, and Alessandra Castegna
Detection of activating estrogen receptor gene (ESR1) mutations in single circulating tumor cells, Carmela Paolillo, Zhaomei Mu, Giovanna Rossi, Matthew J. Schiewer, Thomas Nguyen, Laura Austin, Ettore Capoluongo, Karen E. Knudsen, Massimo Cristofanilli, and Paolo Fortina
Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth, Timothy G. Pestell, Xuanmao Jiao, Mukesh Kumar, Amy R. Peck, Marco Prisco, Shengqiong Deng, Zhiping Li, Adam Ertel, Matthew C. Casimiro, Xiaoming Ju, Agnese Di Rocco, Gabriele Di Sante, Sanjay Katiyar, Alison Shupp, Michael P. Lisanti, Pooja Jain, Kongming Wu, Hallgeir Rui, Douglas Craig Hooper, Zuoren Yu, Aaron R. Goldman, David W. Speicher, Lisa Laury-Kleintop, and Richard G. Pestell
Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification., Svetlana Petruk, Samanta A. Mariani, Marco De Dominici, Patrizia Porazzi, Valentina Minieri, Jingli Cai, Lorraine Iacovitti, Neal Flomenberg, Bruno Calabretta, and Alexander Mazo
Not So Fast: Cultivating miRs as Kinks in the Chain of the Cell Cycle., Matthew J. Schiewer and Karen E. Knudsen
Biological functions of CDK5 and potential CDK5 targeted clinical treatments., Alison Shupp, Mathew C. Casimiro, and Richard G. Pestell
Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer., Jeffrey D. Thomas, Charles G. Longen, Halley M. Oyer, Nan Chen, Christina M. Maher, Joseph M. Salvino, Blase Kania, Kelsey N. Anderson, William F. Ostrander, Karen E. Knudsen, and Felix J. Kim
DACH1 suppresses breast cancer as a negative regulator of CD44., Hanxiao Xu, Shengnan Yu, Xun Yuan, Jing Xiong, Dong Kuang, Richard Pestell, and Kongming Wu
Manuscripts from 2016
The transcription factor RUNX2 regulates receptor tyrosine kinase expression in melanoma., Rajeev K Boregowda, Daniel J Medina, Elke Markert, Michael A Bryan, Wenjin Chen, Suzie Chen, Anna Rabkin, Michael J Vido, Samuel I Gunderson, Marina Chekmareva, David J Foran, Ahmed Lasfar, James S Goydos, and Karine A Cohen-Solal
Tumor-associated stromal cells as key contributors to the tumor microenvironment., Karen M. Bussard, Lysette Mutkus, Kristina Stumpf, Candelaria Gomez-Manzano, and Frank C. Marini
A neuronal network of mitochondrial dynamics regulates metastasis., M. Cecilia Caino, Jae Ho Seo, Angeline Aguinaldo, Eric Wait, Kelly G. Bryant, Andrew V. Kossenkov, James E. Hayden, Valentina Vaira, Annamaria Morotti, Stefano Ferrero, Silvano Bosari, Dmitry I. Gabrilovich, Lucia R. Languino, Andrew R. Cohen, and Dario C. Altieri
Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming., Young Chan Chae, Valentina Vaira, M. Cecilia Caino, Hsin-Yao Tang, Jae Ho Seo, Andrew V. Kossenkov, Luisa Ottobrini, Cristina Martelli, Giovanni Lucignani, Irene Bertolini, Marco Locatelli, Kelly G. Bryant, Jagadish C. Ghosh, Sofia Lisanti, Bonsu Ku, Silvano Bosari, Lucia R. Languino, David W. Speicher, and Dario C. Altieri
A microRNA/Runx1/Runx2 network regulates prostate tumor progression from onset to adenocarcinoma in TRAMP mice., Nicholas H Farina, Areg Zingiryan, Jacqueline A Akech, Cody J Callahan, Huimin Lu, Janet L Stein, Lucia R Languino, Gary S Stein, and Jane B Lian
Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice., Brian C. Grieb, Kelli Boyd, Ramkrishna Mitra, and Christine M. Eischen
v-Src Oncogene Induces Trop2 Proteolytic Activation via Cyclin D1., Xiaoming Ju, Xuanmao Jiao, Adam Ertel, Mathew C. Casimiro, Gabriele Disante, Shengqiong Deng, Zhiping Li, Agnese Di Rocco, Tingting Zhan, Adam Hawkins, Tanya Stoyanova, Sebastiano Andò, Alessandro Fatatis, Michael P. Lisanti, Leonard G. Gomella, Lucia R. Languino, and Richard G. Pestell
The Potential Roles of Long Noncoding RNAs (lncRNA) in Glioblastoma Development, Shuang Liu, Ramkrishna Mitra, Ming-Ming Zhao, Wenhong Fan, Christine M. Eischen, Feng Yin, and Zhongming Zhao
Genome-wide redistribution of MeCP2 in dorsal root ganglia after peripheral nerve injury., Melissa T. Manners, Adam Ertel, Yuzhen Tian, and Seena K. Ajit
Expression of μ-protocadherin is negatively regulated by the activation of the β-catenin signaling pathway in normal and cancer colorectal enterocytes., Lucia Montorsi, Sandra Parenti, Lorena Losi, Fabrizio Ferrarini, Claudia Gemelli, A Rossi, Gianrocco Manco, Stefano Ferrari, Bruno Calabretta, Enrico Tagliafico, Tommaso Zanocco-Marani, and Alexis Grande
Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer., Amanda R. Oran, Clare M. Adams, Xiao-Yong Zhang, Victoria J. Gennaro, Harla K. Pfeiffer, Hestia S. Mellert, Hans E. Seidel, Kirsten Mascioli, Jordan Kaplan, Mahmoud R. Gaballa, Chen Shen, Isidore Rigoutsos, Michael P. King, Justin L Cotney, Jamie J. Arnold, Suresh D. Sharma, Ubaldo E. Martinez-Outshoorn, Christopher R. Vakoc, Lewis A. Chodosh, James E. Thompson, James E. Bradner, Craig E. Cameron, Gerald S. Shadel, Christine M. Eischen, and Steven B. McMahon
β1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation., Aejaz Sayeed, Huimin Lu, Qin Liu, David Deming, Alexander Duffy, Peter McCue, Adam P. Dicker, Roger J. Davis, Dmitry Gabrilovich, Ulrich Rodeck, Dario C. Altieri, and Lucia R. Languino
The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis., Jae Ho Seo, Dayana B. Rivadeneira, M. Cecilia Caino, Young Chan Chae, David W. Speicher, Hsin-Yao Tang, Valentina Vaira, Silvano Bosari, Alessandro Palleschi, Paolo Rampini, Andrew V. Kossenkov, Lucia R. Languino, and Dario C. Altieri
Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype., Amrita Singh, Carmine Fedele, Huimin Lu, Marja T. Nevalainen, James H. Keen, and Lucia R. Languino
A direct quantification method for measuring plasma MicroRNAs identified potential biomarkers for detecting metastatic breast cancer., Qian Zhao, Shengqiong Deng, Guangxue Wang, Cuicui Liu, Lingyu Meng, Shanshan Qiao, Lei Shen, Yue Zhang, Jinhui Lü, Yuzhen Zhang, Min Wang, Richard Pestell, Chunli Liang, Zuoren Yu, and Wenshu Li
