Not So Fast: Cultivating miRs as Kinks in the Chain of the Cell Cycle.

Authors

Matthew J. Schiewer, Thomas Jefferson UniversityFollow
Karen E. Knudsen, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

4-10-2017

Comments

This article has been peer reviewed. It is the authors' final version prior to publication in Cancer Cell, Volume 31, Issue 4, April 2017, Pages 471-473.

The published version is available at https://doi.org/10.1016/j.ccell.2017.03.012. Copyright © Cell Press

Abstract

In this issue of Cancer Cell, Hydbring and colleagues define a novel class of microRNAs (miRNAs), deemed "cell-cycle-targeting miRNAs," that target several cyclins/CDKs, reduce tumor cell growth, and induce apoptosis. These miRNAs effectively suppressed chemoresistant patient-derived xenograft growth in vivo, and efficacy could be prospectively predicted with an expression-based algorithm.

Recommended Citation

Schiewer, Matthew J. and Knudsen, Karen E., "Not So Fast: Cultivating miRs as Kinks in the Chain of the Cell Cycle." (2017). Department of Cancer Biology Faculty Papers. Paper 132.
https://jdc.jefferson.edu/cbfp/132

PubMed ID

28399406

Language

English