Manuscripts from 2012
Analytic lymph node number establishes staging accuracy by occult tumor burden in colorectal cancer., Terry Hyslop, David S. Weinberg, Stephanie Schulz, Alan Barkun, and Scott A. Waldman
GSK3β inhibition blocks melanoma cell/host interactions by downregulating N-cadherin expression and decreasing FAK phosphorylation., Jobin K John, Kim H T Paraiso, Vito W Rebecca, Liliana P Cantini, Ethan V Abel, Nicholas Pagano, Eric Meggers, Rahel Mathew, Clemens Krepler, Victoria Izumi, Bin Fang, John M Koomen, Jane L Messina, Meenhard Herlyn, and Keiran S M Smalley
Initial experience with Imacor hTEE-guided management of patients following transplant and mechanical circulatory support., Christopher Kang, Hitoshi Hirose, Harold Hasting, and
Cyclin D1 goes metabolic: dual functions of cyclin D1 in regulating lipogenesis., Karen E Knudsen
Effect of Concomitant Medications Affecting Gastric pH and Motility on Posaconazole Tablet Pharmacokinetics, Walter K. Kraft, P. Chang, MLPS Van Iersel, H. Waskin, G. Krishna, and W. Kersemaekers
Pharmacologic management of the opioid neonatal abstinence syndrome., Walter K. Kraft and John N van den Anker
Healthy Volunteer Registries and Ethical Research Principles, Erine A. Kupetsky-Rincon and Walter K. Kraft
Successful management of bleeding complications in patients supported with extracorporeal membrane oxygenation with primary respiratory failure., K Lamb, Sw Cowan, N Evans, H Pitcher, T Moritz, M Lazar, H Hirose, and Nc Cavarocchi
GUCY2C Opposes Systemic Genotoxic Tumorigenesis by Regulating AKT-Dependent Intestinal Barrier Integrity, Jieru Egeria Lin, Adam Eugene Snook, Peng Li, Brian Arthur Stoecker, Gilbert Won Kim, Michael Sullivan Magee, Alex Vladimir Mejia Garcia, Michael Anthony Valentino, Terry Hyslop, Stephanie Schulz, and Scott Arthur Waldman
Molecular staging individualizing cancer management, Alex Mejia, Stephanie Schulz, Terry Hyslop, David S. Weinberg, and Scott A. Waldman
Expression of cyclin D1a and D1b as predictive factors for treatment response in colorectal cancer., M P Myklebust, Z Li, T H Tran, H Rui, E S Knudsen, H Elsaleh, Ø Fluge, B Vonen, H E Myrvold, S Leh, K M Tveit, R G Pestell, and O Dahl
MK-0448, a Specific Kv1.5 Inhibitor: Safety, Pharmacokinetics and Pharmacodynamic Electrophysiology in Experimental Animal Models and in Humans., Behzad B. Pavri, Howard E Greenberg, Walter K. Kraft, Nicole Lazarus, Joseph J Lynch, Joseph J Salata, Mark T Bilodeau, Christopher P Regan, Gary Stump, Li Fan, Anish Mehta, John A Wagner, David E Gutstein, and Daniel Bloomfield
Inflammation, organomegaly, and muscle wasting despite hyperphagia in a mouse model of burn cachexia., Felipe E Pedroso, Paul B Spalding, Michael C Cheung, Relin Yang, Juan C Gutierrez, Andrea Bonetto, Rui Zhan, Ho Lam Chan, Nicholas Namias, Leonidas G Koniaris, and Teresa A Zimmers
ERK2 phosphorylation of serine 77 regulates Bmf pro-apoptotic activity., Y Shao and A E Aplin
Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity., Trisha R Stankiewicz, F Alexandra Loucks, Emily K Schroeder, Marja T Nevalainen, Kenneth L Tyler, Klaus Aktories, Ron J Bouchard, and Daniel A Linseman
Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the β1 integrin-RACK1 axis., Marco Trerotola, Jing Li, Saverio Alberti, and Lucia R. Languino
Advancing pharmacometrics and systems pharmacology., Scott A. Waldman and Andre Terzic
The value proposition of molecular medicine., Scott A. Waldman and Andre Terzic
Small non-coding RNAs govern mammary gland tumorigenesis., Zuoren Yu and Richard Pestell
Identification of the functional binding pocket for compounds targeting small-conductance Ca²⁺-activated potassium channels., Miao Zhang, John M Pascal, Marcel Schumann, Roger S Armen, and Ji-Fang Zhang
Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1., Xiaoping Zhao, Daorong Feng, Qun Wang, Arian Abdulla, Xiao-Jun Xie, Jie Zhou, Yan Sun, Ellen S Yang, Lu-Ping Liu, Bhavapriya Vaitheesvaran, Lauren Bridges, Irwin J Kurland, Randy Strich, Jian-Quan Ni, Chenguang Wang, Johan Ericsson, Jeffrey E Pessin, Jun-Yuan Ji, and Fajun Yang
Phosphorylation of vasodilator-stimulated phosphoprotein Ser239 suppresses filopodia and invadopodia in colon cancer., David S Zuzga, Joshua Pelta-Heller, Peng Li, Alessandro Bombonati, Scott A Waldman, and Giovanni Mario Pitari
Manuscripts from 2011
Analysis of the proteome of human airway epithelial secretions., Mehboob Ali, Erik P Lillehoj, Yongsung Park, Yoshiyuki Kyo, and K Chul Kim
Formulation of buprenorphine for sublingual use in neonates., Ellena A Anagnostis, Rania E Sadaka, Linda A Sailor, David E Moody, Kevin C Dysart, and Walter k. Kraft
Mechanisms of resistance to RAF inhibitors in melanoma., A E Aplin, Fred M Kaplan, and Yongping Shao
The effects of laropiprant, a selective prostaglandin D₂ receptor 1 antagonist, on the antiplatelet activity of clopidogrel or aspirin., Aimee Dallob, Wen-Lin Luo, Julie Mabalot Luk, Lisa Ratcliffe, Amy O Johnson-Levonas, Jules I Schwartz, Victor Dishy, Walter K. Kraft, Jan N De Hoon, Anne Van Hecken, Inge De Lepeleire, Waldemar Radziszewski, John A Wagner, and Eseng Lai
Tissue-specific regulation of mouse microRNA genes in endoderm-derived tissues., Yan Gao, Jonathan Schug, Lindsay B McKenna, John Le Lay, Klaus H Kaestner, and Linda E Greenbaum
An integrated framework to model cellular phenotype as a component of biochemical networks., Michael Gormley, Viswanadha U Akella, Judy N Quong, and Andrew A Quong
The incidence of deep vein thrombosis detected by routine surveillance ultrasound in neurosurgery patients receiving dual modality prophylaxis., Patricia C Henwood, Thomas M Kennedy, Lynda Thomson, Taki Galanis, George L Tzanis, Geno J Merli, and Walter K. Kraft
Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease., B H Kang, M Tavecchio, H L Goel, C-C Hsieh, D S Garlick, C M Raskett, J B Lian, G S Stein, L R Languino, and D C Altieri
Revised dose schema of sublingual buprenorphine in the treatment of the neonatal opioid abstinence syndrome., Walter K Kraft, Kevin Dysart, Jay S Greenspan, Eric Gibson, Karol Kaltenbach, and Michelle E Ehrlich
Chronic diseases: the emerging pandemic., Andre Terzic and Scott A. Waldman
A uroguanylin-GUCY2C endocrine axis regulates feeding in mice., Michael A Valentino, Jieru E Lin, Adam E Snook, Peng Li, Gilbert W Kim, Glen Marszalowicz, Michael S Magee, Terry Hyslop, Stephanie Schulz, and Scott A Waldman
Bionic Technologies Transforming the Science of Healthcare Delivery, Scott A. Waldman , M.D., Ph.D and Andre Terzic , M.D., Ph.D
Clinical pharmacology as a foundation for translational science., Scott A. Waldman, R J. Hohl, G L. Kearns, S J. Swan, and A Terzic
Clinical Translational Science 2020: Disruptive Innovation Redefines the Discovery-Application Enterprise, Scott A. Waldman and Andre Terzic
Year in Review, Scott A. Waldman and Andre Terzic
Manuscripts from 2010
Mechanism of catch force: tethering of thick and thin filaments by twitchin., Thomas M Butler and Marion J Siegman
Selection of optimal reference genes for normalization in quantitative RT-PCR., Inna Chervoneva, Yanyan Li, Stephanie Schulz, Sean Croker, Chantell Wilson, Scott A Waldman, and Terry Hyslop
Bimodal gene expression and biomarker discovery., Adam Ertel
C-jun inhibits mammary apoptosis in vivo., Sanjay Katiyar, Mathew C Casimiro, Luis Dettin, Xiaoming Ju, Erwin F Wagner, Hirokazu Tanaka, and Richard Pestell
Bacterial heat-stable enterotoxins: translation of pathogenic peptides into novel targeted diagnostics and therapeutics., Jieru E Lin, Michael A. Valentino, Glen Marszalowicz, Michael S Magee, Peng Li, Adam E. Snook, Brian Arthur Stoecker, Chang Chang, and Scott A Waldman
Survival associated pathway identification with group Lp penalized global AUC maximization., Zhenqiu Liu, Laurence S Magder, Terry Hyslop, and Li Mao
Identification of thioaptamer ligand against E-selectin: potential application for inflamed vasculature targeting., Aman P Mann, Anoma Somasunderam, René Nieves-Alicea, Xin Li, Austin Hu, Anil K Sood, Mauro Ferrari, David G Gorenstein, and Takemi Tanaka
Differential impact of tumor suppressor pathways on DNA damage response and therapy-induced transformation in a mouse primary cell model., A Kathleen McClendon, Jeffry L Dean, Adam Ertel, and Erik S Knudsen
Molecular staging estimates occult tumor burden in colorectal cancer, Alex Mejia, Stephanie Schulz, Terry Hyslop, David S. Weinberg, and Scott A. Waldman
Sizing up pharmacotherapy for obesity., Michael A. Valentino, Andre Terzic, and Scott A. Waldman
Expression of the intestinal biomarkers Guanylyl cyclase C and CDX2 in poorly differentiated colorectal carcinomas., Brody Winn, Rosemarie Tavares, Andres Matoso, Lelia Noble, Jacqueline Fanion, Scott A Waldman, and Murray B Resnick
Manuscripts from 2009
Y27632, a Rho-activated kinase inhibitor, normalizes dysregulation in alpha1-adrenergic receptor-induced contraction of Lyon hypertensive rat artery smooth muscle., Maria Regina Freitas, Masumi Eto, Jason A Kirkbride, Christa Schott, Jean Sassard, and Jean-Claude Stoclet
High adsorption rate is detrimental to bacteriophage fitness in a biofilm-like environment., Romain Gallet, Yongping Shao, and Ing-Nang Wang
The production of antibody by invading B cells is required for the clearance of rabies virus from the central nervous system., D Craig Hooper, Timothy W Phares, Marzena J Fabis, and Anirban Roy
Plant Vaccines: An Immunological Perspective., Douglas C. Hooper
Expression of CPI-17 in smooth muscle during embryonic development and in neointimal lesion formation., Jee In Kim, Garbo D Young, Li Jin, Avril V Somlyo, and Masumi Eto
Solution structure of the inhibitory phosphorylation domain of myosin phosphatase targeting subunit 1., Shunsuke Mori, Ryou Iwaoka, Masumi Eto, and Shin-ya Ohki
STAT5 regulation of BCL10 parallels constitutive NFkappaB activation in lymphoid tumor cells., Zsuzsanna S Nagy, Matthew J LeBaron, Jeremy A Ross, Abhisek Mitra, Hallgeir Rui, and Robert A Kirken
Targeting the cGMP Pathway to Treat Colorectal Cancer, Giovanni Mario Pitari
Cyclin D1 repressor domain mediates proliferation and survival in prostate cancer., M J Schiewer, L M Morey, C J Burd, Y Liu, Diane E Merry, S-M Ho, and Karen E Knudsen
Lineage-specific T-cell responses to cancer mucosa antigen oppose systemic metastases without mucosal inflammatory disease., Adam E. Snook, Peng Li, Benjamin J Stafford, Elizabeth J Faul, Lan Huang, Ruth C Birbe, Alessandro Bombonati, Stephanie Schulz, Matthias J. Schnell, Laurence C. Eisenlohr, and Scott A. Waldman
Immunological assessment of plant-derived avian flu H5/HA1 variants., S Spitsin, V Andrianov, N Pogrebnyak, Y Smirnov, N Borisjuk, C Portocarrero, V Veguilla, H Koprowski, and M Golovkin
A glycosylated recombinant human granulocyte colony stimulating factor produced in a novel protein production system (AVI-014) in healthy subjects: a first-in human, single dose, controlled study., Roslyn Varki, Ed Pequignot, Mark C Leavitt, Andres Ferber, and Walter K Kraft
Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancer., Scott A Waldman, Terry Hyslop, Stephanie Schulz, Alan Barkun, Karl Nielsen, Janis Haaf, Christine Bonaccorso, Yanyan Li, and David S Weinberg
A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer., Scott A Waldman and Andre Terzic
Stromal Caveolin-1 Levels Predict Early Ductal Carcinoma in Situ Progression to Invasive Breast Carcinoma, A. K. Witkiewicz, A. Dasgupta, G. F. Schwartz, KH H. Nguyen, H. R. Rui, and M. P. Lisanti
Prediction of Sublingual Bioavailability of Buprenorphine in Newborns with Neonatal Abstinence Syndrome—a case study on physiological and developmental changes using NONMEM and SIMCYP, Di Wu, Walter K. Kraft, Michelle E. Ehrlick, and Jeffrey S. Barnett
Manuscripts from 2008
Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo, Ayush Dagbadorj, Robert A. Kirken, Benjamin Leiby, James Karras, and Marja T. Nevalainen
Tumor Epithelial Cell Matrix Metalloproteinase 9 (MMP-9) is a Prognostic Marker in Colorectal Cancer, DS Zuzga, AV Gibbons, P Li, WJ Lubbe, I Chervoneva, and Giovanni Mario Pitari
A novel and generalizable organotypic slice platform to evaluate stem cell potential for targeting pediatric brain tumors., Shengwen Calvin Li and William Gunter Loudon
Alternate cyclin D1 mRNA splicing modulates P27KlP1 binding and cell migration, Zhiping Li, Chenguang Wang, Xuanmao Jiao, Sanjay Katiyar, Mathew C. Casimiro, George C. Prendergast, Michael J. Powell, and Richard G. Pestell
Nerve Growth factor regulation of cyclin D1 in PC12 cells through a p21RAS extracellular signal-regulated kinase pathway requires cooperative interactions between Sp1 and nuclear factor-kappaB., Francesco Marampon, Mathew C Casimiro, Maofu Fu, Michael J Powell, Vladimir M Popov, Jaime Lindsay, Bianca M Zani, Carmela Ciccarelli, Genichi Watanabe, Richard J Lee, and Richard G Pestell
Enterotoxin preconditioning restores calcium-sensing receptor-mediated cytostasis in colon cancer cells, Giovanni Mario Pitari, Jieru E. Lin, Fawad J. Shah, Wilhelm J. Lubbe, David Zuzga, Peng Li, Stephanie Schulz, and Scott A Waldman
uPA is upregulated by high dose celecoxib in women at increased risk of developing breast cancer., Wenyi Qin, Weizhu Zhu, John E Hewett, George Rottinghaus, Yin-Chieh Chen, John T Flynn, Beth Kliethermes, Ferdinando Mannello, and Edward R Sauter
Immune Evasion by Rabies Viruses through the Maintenance of Blood-Brain Barrier Integrity., Anirban Roy and Douglas C. Hooper
Celecoxib concentration predicts decrease in prostaglandin E2 concentrations in nipple aspirate fluid from high risk women, Edward R. Sauter, Wenyi Qin, John E. Hewett, Rachel L. Ruhlen, John T. Flynn, George Rottinghaus, and Yin-Chieh Chen
Overexpression of matrix metalloproteinase 9 in tumor epithelial cells correlates with colorectal cancer metastasis., David S Zuzga, Ahmara Vivian Gibbons, Peng Li, Wilhelm Johannes Lubbe, Inna Chervoneva, and Giovanni Mario Pitari
Manuscripts from 2007
Plant-derived EpCAM antigen induces protective anti-cancer response., Robert Brodzik, Sergei Spitsin, Max Golovkin, Katarzyna Bandurska, Carla Portocarrero, Monika Okulicz, Zenon Steplewski, and Hilary Koprowski
Autocrine prolactin promotes prostate cancer cell growth via Janus kinase-2-signal transducer and activator of transcription-5a/b signaling pathway., Ayush Dagvadorj, Sean Collins, Jean-Baptiste Jomain, Junaid Abdulghani, James Karras, Tobias Zellweger, Hongzhen Li, Martti Nurmi, Kalle Alanen, Tuomas Mirtti, Tapio Visakorpi, Lukas Bubendorf, Vincent Goffin, and Marja T Nevalainen
Caveolin-1 is required for the upregulation of fatty acid synthase (FASN), a tumor promoter, during prostate cancer progression., Dolores Di Vizio, Federica Sotgia, Terence M Williams, Ghada S Hassan, Franco Capozza, Philippe G Frank, Richard G Pestell, Massimo Loda, Michael R Freeman, and Michael P Lisanti
Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase-1 in focal adhesions, Masumi Eto, Jason Kirkbride, Elizabeth Elliott, Su Hao Lo, and David L. Brautigan
Phosphorylation-induced conformational switching of CPI-17 produces a potent myosin phosphatase inhibitor, Masumi Eto, Toshio Kitazawa, Fumiko Matsuzawa, Sei-ichi Aikawa, Jason A. Kirkbride, Noriyoshi Isozumi, Yumi Nishimura, David L. Brautigan, and Shin-ya Ohki
Smallpox subunit vaccine produced in Planta confers protection in mice, Maxim Golovkin, Sergei Spitsin, Vyacheslav Andrianov, Yuriy Smirnov, Yuhong Xiao, Natalia Pogrebnyak, Karen Markley, Robert Brodzik, Yuri Gleba, Stuart N Isaacs, and Hilary Koprowski
The pharmacokinetics of taurolidine metabolites in healthy volunteers., Li Gong, Howard E Greenberg, James L Perhach, Scott A Waldman, and Walter K. Kraft
Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem cell factor, Sanjay Katiyar, Xuanmao Jiao, Erwin Wagner, Michael P. Lisanti, and Richard G. Pestell
Transgenic avian-derived recombinant human interferon-alpha2b (AVI-005) in healthy subjects: an open-label, single-dose, controlled study., T B Patel, E Pequignot, S H Parker, M C Leavitt, H E Greenberg, and Walter K. Kraft
Stabilization of SMAR1 mRNA by PGA2 involves a stem loop structure in the 5' UTR, Lakshminarasimhan Pavritha, Shravanti Rampalli, Surajit Sinha, Kadreppa Sreenath, Richard G. Pestell, and Samit Chattopadhyay
The functional significance of nuclear receptor acetylation., Vladimir M. Popov, Chenguang Wang, L . Andrew Shirley, Anne Rosenberg, Shengwen Li, Marja Nevalainen, Maofu Fu, and Richard G. Pestell
Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells, Bin Shi, Laura Sepp-Lorenzino, Marco Prisco, Peter Linsley, Tiziana deAngelis, and Renato Baserga
DACH1 negatively regulates the human RANK ligand gene expression in stromal/preosteoblast cells, Kumaran Sundaram, Santhosh K. Mani, Kazuyuki Kitatani, Kongming Wu, Richard G. Pestell, and Sakamuri V. Reddy
Acetylation in nuclear receptor signaling and the role of sirtuins, Chenguang Wang, Michael J. Powell, Vladimir M. Popov, and Richard G. Pestell
Sirtuins, nuclear hormone receptor acetylation and transcriptional regulation, James R. Whittle, Michael J. Powell, Vladimir M. Popov, L. Andrew Shirley, Chenguang Wang, and Richard G. Pestell
Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth, Kongming Wu, Manran Liu, Anping Li, Howard Donninger, Mahadev Rao, Xuanmao Jiao, Michael P. Lisanti, Ales Cvekl, Michael Birrer, and Richard G. Pestell
Manuscripts from 2006
Role of caveolin-1 in the regulation of the vascular shear stress response, Philippe G. Frank and Michael P. Lisanti
Epigenetics and the estrogen receptor, Jennifer E. Leader, Chenuang Wang, Vladimir M. Popov, Maofu Fu, and Richard G. Pestell
Celecoxib decreases prostaglandin E2 concentrations in nipple aspirate fluid from high risk postmenopausal women and women with breast cancer, Edward R. Sauter, Wenyi Quin, Lisa Schlatter, John E. Hewett, and John T. Flynn
Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function., Chenguang Wang, Zhiping Li, Yinan Lu, Runlei Du, Sanjay Katiyar, Jianguo Yang, Maofu Fu, Jennifer E Leader, Andrew Quong, Phyllis M Novikoff, and Richard Pestell
Manuscripts from 2004
Nuovi Approcci Terapeutici contro il Cancro del Colon, Giovanni Mario Pitari
Manuscripts from 2001
Guanylyl Cyclase C (GC-C) Inhibits Human Colon Carcinoma Cell Growth, Giovanni Mario Pitari
Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells., Giovanni Mario Pitari, M D Di Guglielmo, J Park, S Schulz, and Scott A Waldman
Submissions from 1999
Essential role of P-selectin in the initiation of the inflammatory response induced by hemorrhage and reinfusion., R Scalia, V E Armstead, A G Minchenko, and A M Lefer
Manuscripts from 1979
A scale for assessing the severity of diseases and adverse drug reactions: Application to drug benefit and risk, Ronald J. Tallarida, Rodney B. Murray, and Carl Eiben
