Document Type

Article

Publication Date

6-2012

Comments

This article is peer reviewed. It is the author's final version prior to publication in Clinical Pharmacology and Therapeutics; 2012 Jun;91(6):965-8. ©Nature Publishing Group.

Abstract

The dual enrolling of phase I volunteers is a potential risk to subjects. It can also distort study results, threaten study validity, and possibly cause harm to future patients. Existing subject registries differ in structure, funding, and governance. Although the choice of the ideal system is driven by the scope of the risk and the funding mechanism, and is ultimately a value judgment of freedom versus paternalism, none of the registries significantly impinges on the tenets of ethically based research.

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