Manuscripts from 2019
Osteoblasts are "educated" by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment., Alexus D. Kolb, Alison B. Shupp, Dimpi Mukhopadhyay, Frank C. Marini, and Karen M. Bussard
Drug interactions between direct-acting oral anticoagulants and calcineurin inhibitors during solid organ transplantation: considerations for therapy, Edwin Lam, Babar Bashir, Mark Chaballa, and Walter K. Kraft
Pharmacokinetics of Ketamine at Dissociative Doses in an Adult Patient With Refractory Status Asthmaticus Receiving Extracorporeal Membrane Oxygenation Therapy., Edwin Lam, Ankit K. Rochani, Gagan Kaushal, Brandi N. Thoma, Julian Tanjuakio, Frances Mae West, and Hitoshi Hirose
Cyclin D1 integrates G9a-mediated histone methylation., Zhiping Li, Xuanmao Jiao, Gabriele Di Sante, Adam Ertel, Mathew C. Casimiro, Min Wang, Sanjay Katiyar, Xiaoming Ju, D. V. Klopfenstein, Aydin Tozeren, William Dampier, Iouri Chepelev, Albert Jeltsch, and Richard G. Pestell
Pharmacological and non-pharmacological treatments for the Neonatal Abstinence Syndrome (NAS)., A. K. Mangat, G. M. Schmölzer, and W. K. Kraft
Identification of monocyte-like precursors of granulocytes in cancer as a mechanism for accumulation of PMN-MDSCs., Jérôme Mastio, Thomas Condamine, George Dominguez, Andrew V Kossenkov, Laxminarasimha Donthireddy, Filippo Veglia, Cindy Lin, Fang Wang, Shuyu Fu, Jie Zhou, Patrick Viatour, Sergio Lavilla-Alonso, Alexander T. Polo, Evgenii N. Tcyganov, Charles Mulligan, Brian Nam, Joseph Bennett, Gregory Masters, Michael Guarino, Amit Kumar, Yulia Nefedova, Robert H. Vonderheide, Lucia R. Languino, Scott I. Abrams, and Dmitry I. Gabrilovich
Quantitative sensory testing in children with sickle cell disease: additional insights and future possibilities., Robin E. Miller, Dawn S. Brown, Scott W. Keith, Sarah E. Hegarty, Yamaja Setty, Claudia M. Campbell, Suzanne M. McCahan, Suhita Gayen-Betal, Hal Byck, and Marie Stuart
Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients., Adam E. Snook, Trevor R. Baybutt, Bo Xiang, Tara S. Abraham, John C. Flickinger, Terry Hyslop, Tingting Zhan, Walter K. Kraft, Takami Sato, and Scott A. Waldman
Transcriptional activation of the miR-17-92 cluster is involved in the growth-promoting effects of MYB in human Ph-positive leukemia cells., Manuela Spagnuolo, Giulia Regazzo, Marco De Dominici, Andrea Sacconi, Andrea Pelosi, Etleva Korita, Francesco Marchesi, Francesco Pisani, Alessandra Magenta, Valentina Lulli, Iole Cordone, Andrea Mengarelli, Sabrina Strano, Giovanni Blandino, Maria G. Rizzo, and Bruno Calabretta
Efficacy and safety of intravenous golimumab plus methotrexate in patients with rheumatoid arthritis aged < 65 years and those ≥ 65 years of age., John Tesser, Shelly Kafka, Raphael J. DeHoratius, Stephen Xu, Elizabeth C Hsia, and Anthony Turkiewicz
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines, Clotilde Théry; Kenneth W. Witwer; Elena Aikawa; Maria Jose Alcaraz; Johnathon D. Anderson; Ramaroson Andriantsitohaina; Anna Antoniou; Tanina Arab; Fabienne Archer; Georgia K. Atkiin-Smith; D. Craig Ayre; Jean-Marie Bach; Daniel Bachurski; Hossein Baharvand; Leonora Balaj; Shawn Baldacchino; Natalie N. Bauer; Amy A. Baxter; Mary Bebawy; Carla Beckham; Apolonija Bedina Zavec; Abderrahim Benmoussa; Anna C. Berardi; Paolo Bergese; Ewa Bielska; Cherie Blenkiron; Sylwia Bobis-Wozowicz; Eric Boilard; Wilfrid Boireau; Antonella Bongiovanni; Francesc E. Borràs; Steffi Bosch; Chantal M. Boulanger; Xandra Breakefield; Andrew M. Breglio; Meadhbh Á. Brennan; David R. Brigstock; Alain Brisson; Marike L.D. Broekman; Jacqueline F. Bromberg; Paulina Bryl-Górecka; Shilpa Buch; Amy H. Buck; Dylan Burger; Sara Busatto; Dominik Buschmann; Benedetta Bussolati; Edit I. Buzás; James Bryan Byrd; Giovanni Camussi; David R.F. Carter; Sarah Caruso; Lawrence W. Chamley; Yu-Ting Chang; Chichen Chen; Shuai Chen; Lesley Cheng; Andrew R. Chin; Aled Clayton; Stefano P. Clerici; Alex Cocks; Emanuele Cocucci; Robert J. Coffey; Anabela Cordeiro-da-Silva; Yvonne Couch; Frank A.W. Coumans; Beth Coyle; Rossella Crescitelli; Miria Ferreira Criado; Crislyn D’ Souza-Schorey; Saumya Das; Amrita Datta Chaudhuri; Paola de Candia; Eliezer F. De Santana Junior; Olivier De Wever; Hernando A. del Portillo; Tanguy Demaret; Sarah Deville; Andrew Devitt; Bert Dhondt; Dolores Di Vizio; Lothar C. Dieterich; Vincenza Dolo; Ana Paula Dominguez Rubio; Massimo Dominici; Mauricio R. Dourado; Tom A.P Driedonks; Filipe V. Duarte; Heather M. Duncan; Ramon M. Eichenberger; Karin Ekström; Samir El Andaloussi; Celine Elie-Caille; Uta Erdbrügger; Juan M. Falcón-Pérez; Farah Fatima; Jason E. Fish; Miguel Flores-Bellver; András Försönits; Annie Frelet-Barrand; Fabia Fricke; Gregor Fuhrmann; Susanne Gabrielsson; Ana Gámez-Valero; Chris Gardiner; Kathrin Gärtner; Raphael Gaudin; Yong Song Gho; Bernd Giebel; Caroline Gilbert; Mario Gimona; Ilaria Giusti; Deborah C.I. Goberdhan; André Görgens; Sharon M. Gorski; David W. Greening; Julia Christina Gross; Alice Gualerzi; Gopal N. Gupta; Dakota Gustafson; Aase Handberg; Reka A. Haraszti; Paul Harrison; Hargita Hegyesi; An Hendrix; Andrew F. Hill; Fred H. Hochberg; Karl F. Hoffmann; Beth Holder; Harry Holthofer; Baharak Hosseinkhani; Guoku Hu; Yiyao Huang; Veronica Huber; Stuart Hunt; Ahmed Gamal-Eldin Ibrahim; Tsuneya Ikezu; Jameel M. Inal; Mustafa Isin; Alena Ivanova; Hannah K. Jackson; Soren Jacobsen; Steven M. Jay; Muthuvel Jayachandran; Guido Jenster; Lanzhou Jiang; Suzanne M. Johnson; Jennifer C. Jones; Ambrose Jong; Tijana Jovanovic-Talisman; Stephanie Jung; Raghu Kalluri; Shin-ichi Kano; Sukhbir Kaur; Yumi Kawamura; Evan T. Keller; Delaram Khamari; Elena Khomyakova; Anastasia Khvorova; Peter Kierulf; Kwang Pyo Kim; Thomas Kislinger; Mikael Klingeborn; David J. Klinke II; Miroslaw Kornek; Maja M. Kosanović; Árpád Ferenc Kovács; Eva-Maria Krämer-Albers; Susanne Krasemann; Mirja Krause; Igor V. Kurochkin; Gina D. Kusuma; Sören Kuypers; Saara Laitinen; Scott M. Langevin; Lucia R. Languino; Joanne Lannigan; Cecilia Lässer; Louise C. Laurent; Gregory Lavieu; Elisa Lázaro-Ibáñez; Soazig Le Lay; Myung-Shin Lee; Yi Xin Fiona Lee; Debora S. Lemos; Metka Lenassi; Aleksandra Leszczynska; Isaac T.S. Li; Ke Liao; Sten F. Libregts; Erzsebet Ligeti; Rebecca Lim; Sai Kiang Lim; Aija Linē; Karen Linnemannstöns; Alicia Llorente; Catherine A. Lombard; Magdalena J. Lorenowicz; Ákos M. Lörincz; Jan Lötvall; Jason Lovett; Michelle C. Lowry; Xavier Loyer; Quan Lu; Barbara Lukomska; Taral R. Lunavat; Sybren L.N. Maas; Harmeet Malhi; Antonio Marcilla; Jacopo Mariani; Javier Mariscal; Elena S. Martens-Uzunova; Lorena Martin-Jaular; M. Carmen Martinez; Vilma Regina Martins; Mathilde Mathieu; Suresh Mathivanan; Marco Maugeri; Lynda K. McGinnis; Mark J. McVey; David G. Meckes, Jr.; Katie L. Meehan; Inge Mertens; Valentina R. Minciacchi; Andreas Möller; Malene Møller Jørgensen; Aizea Morales-Kastresana; Jess Morhayim; François Mullier; Maurizio Muraca; Luca Musante; Veronika Mussack; Dillon C. Muth; Kathryn H. Myburgh; Tanbir Najrana; Muhammad Nawaz; Irina Nazarenko; Peter Nejsum; Christian Neri; Tommaso Neri; Rienk Nieuwland; Leonardo Nimrichter; John P. Nolan; Esther N.M. Nolte-’ t Hoen; Nicole Noren Hooten; Lorraine O’Driscoll; Tina O’Grady; Ana O’Loghlen; Takahiro Ochiya; Martin Olivier; Alberto Ortiz; Luis A. Ortiz; Xabier Osteikoetxea; Ole Ostegaard; Matias Ostrowski; Jaesung Park; D. Michiel Pegtel; Hector Peinado; Francesca Perut; Michael W. Pfaffl; Donald G. Phinney; Bartijn C.H. Pieters; Ryan C. Pink; David S. Pisetsky; Elke Pogge von Strandmann; Iva Polakovicova; Ivan K.H. Poon; Bonita H. Powell; Ilaria Prada; Lynn Pulliam; Peter Quesenberry; Annalisa Radeghieri; Robert L. Raffai; Stefania Raimondo; Janusz Rak; Marcel I. Ramirez; Graça Raposo; Morsi S. Rayyan; Neta Regev-Rudzki; Fran L. Ricklefs; Paul D. Robbins; David D. Roberts; Silvia C. Rodrigues; Eva Rohde; Sophie Rome; Kasper M.A. Rouschop; Aurelia Rughetti; Ashley E. Russell; Paula Saá; Susmita Sahoo; Edison Salas-Huenuleo; Catherine Sánchez; Julie A. Saugstad; Meike J. Saul; Raymond M. Schiffelers; Raphael Schneider; Tine Hiorth Schøyen; Aaron Scott; Eriomina Shahaj; Shivani Sharma; Olga Shatnyeva; Faezeh Shekari; Ganesh Vilas Shelke; Ashok K. Shetty; Kiyotaka Shiba; Pia R-M Siljander; Andreia M. Silva; Agata Skowronek; Orman L. Snyder II; Rodrigo Pedro Soares; Barbara W. Sódar; Carolina Soekmadji; Javier Sotillo; Philip D. Stahl; Willem Stoorvogel; Shannon L. Stott; Erwin F. Strasser; Simon Swift; Hidetoshi Tahara; Muneesh Tewari; Kate Timms; Swasti Tiwari; Rochelle Tixeira; Mercedes Tkach; Wei Seong Toh; Richard Tomasini; Ana Claudia Torrecilhas; Juan Pablo Tosar; Vasilis Toxavidis; Lorena Urbanelli; Pieter Vader; Bas W.M. van Balkom; Susanne G. van der Grein; Jan Van Deun; Martijn J.C. van Herwijnen; Kendall van Keuren-Jensen; Guillaume van Niel; Martin E. van Royen; Andre J. van Wijnen; M. Helena Vasconcelos; Ivan J. Vechetti Jr.; Tiago D. Veit; Laura J. Vella; Émilie Velot; Frederik J. Verweij; Beate Vestad; Jose L. Viñas; Tamás Visnovitz; Krisztina V. Vukman; Jessica Wahlgren; Dionysios C. Watson; Marca H.M. Wauben; Alissa Weaver; Jason P. Webber; Viktoria Weber; Ann M. Wehman; Daniel J. Weiss; Joshua A. Welsh; Sebastian Wendt; Asa M. Wheelock; Zoltán Wiener; Leonie Witte; Joy Wolfram; Angeliki Xagorari; Patricia Xander; Jing Xu; Xiaomei Yan; María Yáñez-Mó; Hang Yin; Yuana Yuana; Valentina Zappulli; Jana Zarubova; Vytautas Žėkas; Jian-ye Zhang; Zezhou Zhao; Lei Zheng; Alexander R. Zheutlin; Antje M. Zickler; Pascale Zimmermann; Angela M. Zivkovic; Davide Zocco; and Ewa K. Zuba-Surma
Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance., Lance R. Thomas, Clare M. Adams, Jing Wang, April M. Weissmiller, Joy Creighton, Shelly L. Lorey, Qi Liu, Stephen W. Fesik, Christine M. Eischen, and William P. Tansey
Blunted Evoked Prouroguanylin Endocrine Secretion in Chronic Constipation., Scott A. Waldman, Renata Tenenbaum, Henry C. Foehl, Peter Winkle, and Patrick Griffin
Health Care Evolves From Reactive to Proactive., Scott A. Waldman and Andre Terzic
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade, Seungwon Yang, Jiangbo Wei, Yan-Hong Cui, Gayoung Park, Palak Shah, Yu Deng, Andrew E. Aplin, Zhike Lu, Seungmin Hwang, Chuan He, and Yu-Ying He
SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors., Akihiro Yoshida, Yiwen Bu, Shuo Qie, John Wrangle, E. Ramsay Camp, E. Starr Hazard, Gary Hardiman, Renée de Leeuw, Karen E. Knudsen, and J. Alan Diehl
Manuscripts from 2018
Neonatal Safety Information Reported to the FDA During Drug Development Studies., Debbie Avant, Gerri Baer, Jason N. Moore, Panli Zheng, Alfred Sorbello, Ron Ariagno, Lynne Yao, Gilbert J. Burckart, and Jian Wang
Semaphorin 5A drives melanoma progression: role of Bcl-2, miR-204 and c-Myb., Simona D'Aguanno, Elisabetta Valentini, Maria Grazia Tupone, Marianna Desideri, Marta Di Martile, Manuela Spagnuolo, Simonetta Buglioni, Cristiana Ercolani, Italia Falcone, Marco De Dominici, Michele Milella, Maria Giulia Rizzo, Bruno Calabretta, Carlo Cota, Andrea Anichini, Daniela Trisciuoglio, and Donatella Del Bufalo
Evaluating comfort measures for commonly performed painful procedures in pediatric patients., Sana Dastgheyb, Keith Fishlock, Constantine Daskalakis, Jami Kessel, and Paul Rosen
Targeting CDK6 and BCL2 Exploits the "MYB Addiction" of Ph+ Acute Lymphoblastic Leukemia, Marco De Dominici, Patrizia Porazzi, Angela Rachele Soliera, Samanta A. Mariani, Sankar Addya, Paolo Fortina, Luke F. Peterson, Orietta Spinelli, Alessandro Rambaldi, Giovanni Martinelli, Anna Ferrari, Ilaria Iacobucci, and Bruno Calabretta
MAPK Reliance via Acquired CDK4/6 Inhibitor Resistance in Cancer., Renée de Leeuw, Christopher McNair, Matthew J. Schiewer, Neermala Poudel Neupane, Lucas J. Brand, Michael A. Augello, Zhen Li, Larry C. Cheng, Akihiro Yoshida, Sean M. Courtney, E. Starr Hazard, Gary Hardiman, Maha H. Hussain, J. Alan Diehl, Justin M. Drake, William Kevin Kelly, and Karen E. Knudsen
Listeria monocytogenes as a vector for cancer immunotherapy: Current understanding and progress, John C. Flickinger, Ulrich Rodeck, and Adam E. Snook
ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma., Shujun Han, Yibo Ren, Wangxiao He, Huadong Liu, Zhe Zhi, Xinliang Zhu, Tielin Yang, Yu Rong, Bohan Ma, Timothy J. Purwin, Zhenlin Ouyang, Caixia Li, Xun Wang, Xueqiang Wang, Huizi Yang, Yan Zheng, Andrew E. Aplin, Jiankang Liu, and Yongping Shao
Response and Resistance to Paradox-Breaking BRAF Inhibitor in Melanomas, Edward J. Hartsough, Curtis H. Kugel, Michael J. Vido, Adam C. Berger, Timothy J. Purwin, Allison F. Goldberg, Michael A. Davies, Matthew J. Schiewer, Karen E. Knudsen, Gideon Bollag, and Andrew E. Aplin
Buprenorphine in Neonatal Abstinence Syndrome., Walter K. Kraft
Visual field changes in professional wind versus non-wind musical instrument players in the Philadelphia orchestra, Shuai‑Chun Lin, Cindy X. Zheng, Michael Waisbourd, Jeanne Molineaux, Lichuan Zeng, Tingting Zhan, Kamran Rahmatnejad, Arthur Resende, Anand V. Mantravadi, Lisa A. Hark, Marlene R. Moster, Joseph I. Markoff, George L. Spaeth, and L. Jay Katz
Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrate-resistant prostate cancer by a well-defined polyherbal mixture with anticancer properties., Amber F. MacDonald, Ahmed Bettaieb, Dallas R. Donohoe, Dina S. Alani, Anna Han, Yi Zhao, and Jay Whelan
Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases., Michael S. Magee, Tara S. Abraham, Trevor R. Baybutt, John C. Flickinger, Natalie A. Ridge, Glen P Marszalowicz, Priyanka Prajapati, Adam R. Hersperger, Scott A. Waldman, and Adam E. Snook
Differential impact of RB status on E2F1 reprogramming in human cancer., Christopher McNair, Kexin Xu, Amy C. Mandigo, Matteo Benelli, Benjamin E. Leiby, Daniel Rodrigues, Johan Lindberg, Henrik Gronberg, Mateus Crespo, Bram De Laere, Luc Dirix, Tapio Visakorpi, Fugen Li, Felix Y. Feng, Johann de Bono, Francesca Demichelis, Mark A. Rubin, Myles Brown, and Karen E. Knudsen
miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential., Sara E. Meyer, David E. Muench, Andrew M. Rogers, Tess J. Newkold, Emily Orr, Eric O'Brien, John P. Perentesis, John G. Doench, Ashish Lal, Patrick J. Morris, Craig J. Thomas, Judy Lieberman, Edwina McGlinn, Bruce J. Aronow, Nathan Salomonis, and H. Leighton Grimes
Targeting the STAT5 pathway in Ph+ acute lymphoblastic leukemia, Valentina Minieri, Marco De Dominici, Marja T. Nevalainen, and Bruno Calabretta
The anti-cancer effect of retinoic acid signaling in CRC occurs via decreased growth of ALDH+ colon cancer stem cells and increased differentiation of stem cells, Shirin R. Modarai, Anindita Gupta, Lynn M. Opdenaker, Ryan Kowash, Gabriel Masters, Vignesh Viswanathan, Tao Zhang, Jeremy Z. Fields, and Bruce M. Boman
The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia., Jeffrey A. Rappaport and Scott A. Waldman
A preexisting rare PIK3CA e545k subpopulation confers clinical resistance to MEK plus CDK4/6 inhibition in NRAS melanoma and is dependent on S6K1 signaling, Gabriele Romano, Pei-Ling Chen, Ping Song, Jennifer L. McQuade, Roger J. Liang, Mingguang Liu, Whijae Roh, Dzifa Y. Duose, Fernando C.L. Carapeto, Jun Li, Jessica L.F. Teh, Andrew A. Aplin, Merry Chen, Jianhua Zhang, Alexander J. Lazar, Michael A. Davies, P. Andrew Futreal, Rodabe N. Amaria, David Y. Zhang, Jennifer A. Wargo, and Lawrence N. Kwong
PARP-1 regulates DNA repair factor availability., M J Schiewer; Amy C. Mandigo; Nicolas Gordon; Fangjin Huang; Sanchaika Gaur; Renée de Leeuw; Shuang G Zhao; Joseph Evans; Sumin Han; Theodore Parsons; Ruth Birbe; Peter McCue; Christopher McNair; Saswati N. Chand; Ylenia Cendon-Florez; Peter Gallagher; Jennifer J McCann; Neermala Poudel Neupane; Ayesha A Shafi; Emanuela Dylgjeri; Lucas J Brand; Tapio Visakorpi; Ganesh V Raj; Costas D. Lallas; Edouard J Trabulsi; Leonard G Gomella; Adam Dicker MD, PhD; William Kevin Kelly; Benjamin E Leiby; Beatrice Knudsen; Felix Y Feng; and Karen E Knudsen
Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements., Jae Ho Seo, Ekta Agarwal, Kelly G. Bryant, M. Cecilia Caino, Eui Tae Kim, Andrew V. Kossenkov, Hsin-Yao Tang, Lucia R. Languino, Dmitry I. Gabrilovich, Andrew R. Cohen, David W. Speicher, and Dario C. Altieri
Process Improvement for Maximized Therapeutic Innovation Outcome., Scott A. Waldman and Andre Terzic
Cyclin D1-mediated microRNA expression signature predicts breast cancer outcome, Guangxue Wang, Michael Gormley, Jing Qiao, Qian Zhao, Min Wang, Gabriele DiSante, Shengqiong Deng, Lin Dong, Timothy G. Pestell, Xiaoming Ju, Mathew C. Casimiro, Sankar Addya, Adam Ertel, Ayden Tozeren, Qinchuan Li, Zuoren Yu, and Richard G. Pestell
EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer., Li Wang, Abdel Saci, Peter M. Szabo, Scott D. Chasalow, Mireia Castillo-Martin, Josep Domingo-Domenech, Arlene Siefker-Radtke, Padmanee Sharma, John P. Sfakianos, Yixuan Gong, Ana Dominguez-Andres, William K. Oh, David Mulholland, Alex Azrilevich, Liangyuan Hu, Carlos Cordon-Cardo, Hélène Salmon, Nina Bhardwaj, Jun Zhu, and Matthew D. Galsky
Manuscripts from 2017
BCL-W has a fundamental role in B cell survival and lymphomagenesis., Clare M. Adams, Annette S. Kim, Ramkrishna Mitra, John K Choi, Jerald Z. Gong, and Christine M. Eischen
Non-Hodgkin and Hodgkin Lymphomas Select for Overexpression of BCLW., Clare M. Adams; Ramkrishna Mitra; Jerald Z. Gong, MD; and Christine M. Eischen
Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer., Allison A. Aka, Jeff A. Rappaport, Amanda M. Pattison, Takami Sato, Adam E. Snook, and Scott A. Waldman
The Heat-Stable Enterotoxin Receptor, Guanylyl Cyclase C, as a Pharmacological Target in Colorectal Cancer Immunotherapy: A Bench-to-Bedside Current Report., Trevor R. Baybutt, Allison A. Aka, and Adam E. Snook
Inhibition of Age-Related Therapy Resistance in Melanoma by Rosiglitazone-Mediated Induction of Klotho., Reeti Behera, Amanpreet Kaur, Marie R. Webster, Suyeon Kim, Abibatou Ndoye, Curtis H. Kugel, Gretchen M. Alicea, Joshua Wang, Kanad Ghosh, Phil Cheng, Sofia Lisanti, Katie Marchbank, Vanessa Dang, Mitchell Levesque, Reinhard Dummer, Xiaowei Xu, Meenhard Herlyn, Andrew E. Aplin, Alexander Roesch, Cecilia Caino, Dario C. Altieri, and Ashani T. Weeraratna
CKS1 expression in melanocytic nevi and melanoma, Anna A. Brożyna, Andrew Aplin, Cynthia Cohen, Grant Carlson, Andrew Joseph Page, Michael Murphy, Andrzej T. Slominski, and J. Andrew Carlson
Syntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer., M Cecilia Caino, Jae Ho Seo, Yuan Wang, Dayana B. Rivadeneira, Dmitry I. Gabrilovich, Eui Tae Kim, Ashani T Weeraratna, Lucia R. Languino, and Dario C. Altieri
Cyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis., Mathew C. Casimiro, Gabriele Disante, Agnese Di Rocco, Emanuele Loro, Claudia Pupo, Timothy G. Pestell, Sara Bisetto, Marco A. Velasco-Velázquez, Xuanmao Jiao, Zhiping Li, Christine M. Kusminski, Erin L. Seifert, Chenguang Wang, Daniel Ly, Bin Zheng, Che-Hung Shen, Philipp E. Scherer, and Richard Pestell
Co-targeting HGF/cMET Signaling with MEK Inhibitors in Metastatic Uveal Melanoma., Hanyin Cheng, Vivian Chua, Connie Liao, Timothy J. Purwin, Mizue Terai, Ken Kageyama, Michael A. Davies, Takami Sato, and Andrew E. Aplin
Diversity and plasticity in signaling pathways that regulate smooth muscle responsiveness: Paradigms and paradoxes for the myosin phosphatase, the master regulator of smooth muscle contraction., Masumi Eto and Toshio Kitazawa
Mdm2 Is Required for Survival and Growth of p53-Deficient Cancer Cells., Kyle P Feeley, Clare M. Adams, Ramkrishna Mitra, and Christine M. Eischen
Unfair competition governs the interaction of pCPI-17 with myosin phosphatase (PP1-MYPT1)., Joshua J. Filter, Byron C. Williams, Masumi Eto, David Shalloway, and Michael L. Goldberg
Different Effects of Maternal Low-Isoflavone Soy Protein and Genistein Consumption on Hepatic Lipid Metabolism of 21-Day-Old Male Rat Offspring., Anna Han, Sae Bom Won, and Young Hye Kwon
GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress, Crystal Kraft, Jeff A. Rappaport, Adam E. Snook, Amanda M. Pattison, John P. Lynch, and Scott A. Waldman
ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice., Peng Li, Jieru E. Lin, Adam E. Snook, and Scott A. Waldman
GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome., Peng Li, Evan Wuthrick, Jeff A. Rappaport, Crystal Kraft, Jieru E. Lin, Glen Marszalowicz, Adam E. Snook, Tingting Zhan, Terry M. Hyslop, and Scott A. Waldman
Extensions of D-optimal Minimal Designs for Symmetric Mixture Models., Yanyan Li, Damaraju Raghavarao, and Inna Chervoneva
Tumor necrosis factor inhibitors in psoriatic arthritis., Santhi Mantravadi, Alexis Ogdie, and Walter K. Kraft
Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells., Lingyu Meng, Cuicui Liu, Jinhui Lü, Qian Zhao, Shengqiong Deng, Guangxue Wang, Jing Qiao, Chuyi Zhang, Lixiao Zhen, Ying Lu, Wenshu Li, Yuzhen Zhang, Richard G. Pestell, Huiming Fan, Yi-Han Chen, Zhongmin Liu, and Zuoren Yu
From EMT to HSC to AML: ZEB2 is a cell fate switch., Sara E. Meyer
Decoding critical long non-coding RNA in ovarian cancer epithelial-to-mesenchymal transition., Ramkrishna Mitra, Xi Chen, Evan J. Greenawalt, Ujjwal Maulik, Wei Jiang, Zhongming Zhao, and Christine M. Eischen
Pathologic evaluation of tumor-associated macrophage density and vessel inflammation in invasive breast carcinomas, Yoshihiro Morita, Roy Zhang, Macall Leslie, Smita Adhikari, Nafis Hasan, Inna Chervoneva, Hallgeir Rui, and Takemi Tanaka
Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis., Erika M. Palmieri, Alessio Menga, Rosa Martín-Pérez, Annamaria Quinto, Carla Riera-Domingo, Giacoma De Tullio, D Craig Hooper, Wouter H. Lamers, Bart Ghesquière, Daniel W. McVicar, Attilio Guarini, Massimiliano Mazzone, and Alessandra Castegna
Detection of activating estrogen receptor gene (ESR1) mutations in single circulating tumor cells, Carmela Paolillo, Zhaomei Mu, Giovanna Rossi, Matthew J. Schiewer, Thomas Nguyen, Laura Austin, Ettore Capoluongo, Karen E. Knudsen, Massimo Cristofanilli, and Paolo Fortina
Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth, Timothy G. Pestell, Xuanmao Jiao, Mukesh Kumar, Amy R. Peck, Marco Prisco, Shengqiong Deng, Zhiping Li, Adam Ertel, Matthew C. Casimiro, Xiaoming Ju, Agnese Di Rocco, Gabriele Di Sante, Sanjay Katiyar, Alison Shupp, Michael P. Lisanti, Pooja Jain, Kongming Wu, Hallgeir Rui, Douglas Craig Hooper, Zuoren Yu, Aaron R. Goldman, David W. Speicher, Lisa Laury-Kleintop, and Richard G. Pestell
Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification., Svetlana Petruk, Samanta A. Mariani, Marco De Dominici, Patrizia Porazzi, Valentina Minieri, Jingli Cai, Lorraine Iacovitti, Neal Flomenberg, Bruno Calabretta, and Alexander Mazo
Not So Fast: Cultivating miRs as Kinks in the Chain of the Cell Cycle., Matthew J. Schiewer and Karen E. Knudsen
Biological functions of CDK5 and potential CDK5 targeted clinical treatments., Alison Shupp, Mathew C. Casimiro, and Richard G. Pestell
Sigma1 Targeting to Suppress Aberrant Androgen Receptor Signaling in Prostate Cancer., Jeffrey D. Thomas, Charles G. Longen, Halley M. Oyer, Nan Chen, Christina M. Maher, Joseph M. Salvino, Blase Kania, Kelsey N. Anderson, William F. Ostrander, Karen E. Knudsen, and Felix J. Kim
Clinical Pharmacology & Therapeutics: Past, Present, and Future., Scott A. Waldman and Andre Terzic
Peer Review Certifies Quality and Innovation in Clinical Pharmacology & Therapeutics., Scott A. Waldman and Andre M. Terzic
Bioactivity of Oral Linaclotide in Human Colorectum for Cancer Chemoprevention., David S. Weinberg, Jieru E. Lin, Nathan R. Foster, Gary Della'Zanna, Asad Umar, Drew Seisler, walter K. Kraft, David M. Kastenberg, Leo C. Katz, Paul J. Limburg, and Scott A. Waldman
DACH1 suppresses breast cancer as a negative regulator of CD44., Hanxiao Xu, Shengnan Yu, Xun Yuan, Jing Xiong, Dong Kuang, Richard Pestell, and Kongming Wu
Manuscripts from 2016
Editorial: Ferid murad, at 80: A legacy of science, medicine, and mentorship, Atta-Ur-Rahman
The transcription factor RUNX2 regulates receptor tyrosine kinase expression in melanoma., Rajeev K Boregowda, Daniel J Medina, Elke Markert, Michael A Bryan, Wenjin Chen, Suzie Chen, Anna Rabkin, Michael J Vido, Samuel I Gunderson, Marina Chekmareva, David J Foran, Ahmed Lasfar, James S Goydos, and Karine A Cohen-Solal
Tumor-associated stromal cells as key contributors to the tumor microenvironment., Karen M. Bussard, Lysette Mutkus, Kristina Stumpf, Candelaria Gomez-Manzano, and Frank C. Marini
A neuronal network of mitochondrial dynamics regulates metastasis., M. Cecilia Caino, Jae Ho Seo, Angeline Aguinaldo, Eric Wait, Kelly G. Bryant, Andrew V. Kossenkov, James E. Hayden, Valentina Vaira, Annamaria Morotti, Stefano Ferrero, Silvano Bosari, Dmitry I. Gabrilovich, Lucia R. Languino, Andrew R. Cohen, and Dario C. Altieri
Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming., Young Chan Chae, Valentina Vaira, M. Cecilia Caino, Hsin-Yao Tang, Jae Ho Seo, Andrew V. Kossenkov, Luisa Ottobrini, Cristina Martelli, Giovanni Lucignani, Irene Bertolini, Marco Locatelli, Kelly G. Bryant, Jagadish C. Ghosh, Sofia Lisanti, Bonsu Ku, Silvano Bosari, Lucia R. Languino, David W. Speicher, and Dario C. Altieri
The landscape of pancreatic cancer therapeutic resistance mechanisms, Saswati N. Chand; Kevin O’Hayer; Fernando F. Blanco; Jordan M Winter; and Jonathan Brody, MD
A microRNA/Runx1/Runx2 network regulates prostate tumor progression from onset to adenocarcinoma in TRAMP mice., Nicholas H Farina, Areg Zingiryan, Jacqueline A Akech, Cody J Callahan, Huimin Lu, Janet L Stein, Lucia R Languino, Gary S Stein, and Jane B Lian
Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice., Brian C. Grieb, Kelli Boyd, Ramkrishna Mitra, and Christine M. Eischen
v-Src Oncogene Induces Trop2 Proteolytic Activation via Cyclin D1., Xiaoming Ju, Xuanmao Jiao, Adam Ertel, Mathew C. Casimiro, Gabriele Disante, Shengqiong Deng, Zhiping Li, Agnese Di Rocco, Tingting Zhan, Adam Hawkins, Tanya Stoyanova, Sebastiano Andò, Alessandro Fatatis, Michael P. Lisanti, Leonard G. Gomella, Lucia R. Languino, and Richard G. Pestell
Effect of Vorapaxar Alone and in Combination with Aspirin on Bleeding Time and Platelet Aggregation in Healthy Adult Subjects., Walter K. Kraft, J H Gilmartin, D L Chappell, F Gheyas, B M Walker, S Nagalla, U P Naik, J C Horrow, R E Wrishko, S Zhang, and M S Anderson
Neonatal abstinence syndrome: Pharmacologic strategies for the mother and infant., Walter K. Kraft, Megan W. Stover, and Jonathan M. Davis
Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis., Jieru E. Lin, Francheska Colon-Gonzalez, Erik S. Blomain, Gilbert W. Kim, Amanda Aing, Brian Stoecker, Justin Rock, Adam E. Snook, Tingting Zhan, Terry M. Hyslop, Michal Tomczak, Richard S. Blumberg, and Scott A. Waldman
The Potential Roles of Long Noncoding RNAs (lncRNA) in Glioblastoma Development, Shuang Liu, Ramkrishna Mitra, Ming-Ming Zhao, Wenhong Fan, Christine M. Eischen, Feng Yin, and Zhongming Zhao
Genome-wide redistribution of MeCP2 in dorsal root ganglia after peripheral nerve injury., Melissa T. Manners, Adam Ertel, Yuzhen Tian, and Seena K. Ajit
Role of a plausible nuisance contributor in the declining obesity-mortality risks over time., Tapan Mehta, Nicholas m. Pajewski, Scott W. Keith, Kevin Fontaine, and David B. Allison
Expression of μ-protocadherin is negatively regulated by the activation of the β-catenin signaling pathway in normal and cancer colorectal enterocytes., Lucia Montorsi, Sandra Parenti, Lorena Losi, Fabrizio Ferrarini, Claudia Gemelli, A Rossi, Gianrocco Manco, Stefano Ferrari, Bruno Calabretta, Enrico Tagliafico, Tommaso Zanocco-Marani, and Alexis Grande
Pharmacologic and clinical evaluation of posaconazole., Jason N. Moore, Jason R. Healy, and Walter K. Kraft
Impossibility to eliminate observer effect in the assessment of adherence in clinical trials., Jonathan S. Myers, Scott J. Fudemberg, Robert E. Fintelmann, Lisa A. Hark, Nitasha Khanna, Benjamin E. Leiby, and Michael Waisbourd
A survey of physician receptivity to molecular diagnostic testing and readiness to act on results for early-stage colon cancer patients., Ronald E. Myers, Thomas Wolf, Phillip Shwae, Sarah E. Hegarty, Stephen C. Peiper, and Scott A. Waldman
Reversibility of Apixaban Anticoagulation with a Four-Factor Prothrombin Complex Concentrate in Healthy Volunteers., S Nagalla, Lynda Thomson, Y Oppong, B Bachman, I Chervoneva, and walter k. Kraft
Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer., Amanda R. Oran, Clare M. Adams, Xiao-Yong Zhang, Victoria J. Gennaro, Harla K. Pfeiffer, Hestia S. Mellert, Hans E. Seidel, Kirsten Mascioli, Jordan Kaplan, Mahmoud R. Gaballa, Chen Shen, Isidore Rigoutsos, Michael P. King, Justin L Cotney, Jamie J. Arnold, Suresh D. Sharma, Ubaldo E. Martinez-Outshoorn, Christopher R. Vakoc, Lewis A. Chodosh, James E. Thompson, James E. Bradner, Craig E. Cameron, Gerald S. Shadel, Christine M. Eischen, and Steven B. McMahon
β1 integrin- and JNK-dependent tumor growth upon hypofractionated radiation., Aejaz Sayeed, Huimin Lu, Qin Liu, David Deming, Alexander Duffy, Peter McCue, Adam P. Dicker, Roger J. Davis, Dmitry Gabrilovich, Ulrich Rodeck, Dario C. Altieri, and Lucia R. Languino
The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis., Jae Ho Seo, Dayana B. Rivadeneira, M. Cecilia Caino, Young Chan Chae, David W. Speicher, Hsin-Yao Tang, Valentina Vaira, Silvano Bosari, Alessandro Palleschi, Paolo Rampini, Andrew V. Kossenkov, Lucia R. Languino, and Dario C. Altieri
Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype., Amrita Singh, Carmine Fedele, Huimin Lu, Marja T. Nevalainen, James H. Keen, and Lucia R. Languino
Big Data Transforms Discovery-Utilization Therapeutics Continuum., Scott A. Waldman and Andre Terzic
Bioinnovation Enterprise: An engine driving breakthrough therapies., Scott A. Waldman and Andre Terzic
A direct quantification method for measuring plasma MicroRNAs identified potential biomarkers for detecting metastatic breast cancer., Qian Zhao, Shengqiong Deng, Guangxue Wang, Cuicui Liu, Lingyu Meng, Shanshan Qiao, Lei Shen, Yue Zhang, Jinhui Lü, Yuzhen Zhang, Min Wang, Richard Pestell, Chunli Liang, Zuoren Yu, and Wenshu Li
