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Manuscripts from 2020

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Unexpected cell type-dependent effects of autophagy on polyglutamine aggregation revealed by natural genetic variation in C. elegans., J Alexander-Floyd, S Haroon, M Ying, A A Entezari, C Jaeger, M Vermulst, and T Gidalevitz

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APC-β-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis., Erik S Blomain, Jeffrey A Rappaport, Amanda M Pattison, Babar Bashir, Ellen Caparosa, Jonathan Stem, Adam E Snook, and Scott A Waldman

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Autocatalytic Tissue Polymerization Reaction Mechanism in Colorectal Cancer Development and Growth., Bruce M Boman, Arthur Guetter, Ryan M Boman, and Olaf A Runquist

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Chimeric Ad5.F35 vector evades anti-adenovirus serotype 5 neutralization opposing GUCY2C-targeted antitumor immunity, John C. Flickinger, Jagmohan Singh, Robert D Carlson, Elinor Leong, Trevor R. Baybutt, Joshua Barton, Ellen M. Caparosa, Amanda M. Pattison, Jeff A. Rappaport, Jamin Roh, Tingting Zhan, Babar Bashir, Scott A Waldman, and Adam E. Snook

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Mobilizing Toxins for Cancer Treatment: Historical Perspectives and Current Strategies., Jessica Kopenhaver, Robert D Carlson, and Adam E Snook

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Vancomycin in peritoneal dialysis: Clinical pharmacology considerations in therapy., Edwin Lam, Yi Ting Kayla Lien, Walter K. Kraft, Beth Piraino, Valvanera Vozmediano, Stephan Schmidt, and Jingjing Zhang

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Twice-Daily Doravirine Overcomes the Interaction Effect from Once-Weekly Rifapentine and Isoniazid in Healthy Volunteers., Edwin Lam, Joseph Schaefer, Richard Zheng, Tingting Zhan, and Walter K. Kraft

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Simulation-based mastery learning compared to standard education for discussing diagnostic uncertainty with patients in the emergency department: a randomized controlled trial., Danielle M. McCarthy, Rhea E. Powell, Kenzie A. Cameron, David H. Salzman, Dimitrios Papanagnou, Amanda Doty, Benjamin E. Leiby, Katherine Piserchia, Matthew R. Klein, Xiao C. Zhang, William C. McGaghie, and Kristin L. Rising

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Functional Blockade of E-Selectin in Tumor-Associated Vessels Enhances Anti-Tumor Effect of Doxorubicin in Breast Cancer, Yoshihiro Morita, Macall Leslie, Hiroyasu Kameyama, Ganesh L R Lokesh, Norihisa Ichimura, Rachel Davis, Natalie Hills, Nafis Hasan, Roy Zhang, Yuji Kondo, David G Gorenstein, David E Volk, Inna Chervoneva, Hallgeir Rui, and Takemi Tanaka

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Fatal case of newborn Lassa fever virus infection mimicking late onset neonatal sepsis: a case report from northern Nigeria, Taofik Oluwaseun Ogunkunle, Surajudeen Oyeleke Bello, Chinwe Immaculata Anderson, Rashida Musa, Rasaq Olaosebikan, and Abdulazeez Imam

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MicroRNA Expression Profiling of Normal and Malignant Human Colonic Stem Cells Identifies, Vignesh Viswanathan, Lynn Opdenaker, Shirin Modarai, Jeremy Z Fields, Gregory Gonye, and Bruce M Boman

Manuscripts from 2019

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No meaningful drug interactions with doravirine, lamivudine and tenofovir disoproxil fumarate co-administration., Matt S. Anderson, Jocelyn Gilmartin, Li Fan, Ka Lai Yee, Walter K. Kraft, Ilias Triantafyllou, Christina Reitmann, Ying Guo, Rachael Liu, and Marian Iwamoto

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Silencing the GUCA2A-GUCY2C tumor suppressor axis in CIN, serrated, and MSI colorectal neoplasia., Babar Bashir, Dante J. Merlino, Jeff A. Rappaport, Esteban Gnass, Juan P. Palazzo, Ying Feng, Eric R R. Fearon, Adam E. Snook, and Scott A. Waldman

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Advances in Chimeric Antigen Receptor T-Cell Therapies for Solid Tumors., Trevor R. Baybutt, John C. Flickinger, Ellen M. Caparosa, and Adam E. Snook

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Antibody responses against the vaccine antigens Ov-103 and Ov-RAL-2 are associated with protective immunity to Onchocerca volvulus infection in both mice and humans., Parakkal Jovvian George, Jessica A. Hess, Sonia Jain, John B. Patton, Tingting Zhan, Nancy Tricoche, Bin Zhan, Maria Elena Bottazzi, Peter J. Hotez, David Abraham, and Sara Lustigman

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Non-Thermal Plasma-Induced Immunogenic Cell Death in Cancer: A Topical Review., Marian Khalili, Lynsey Daniels, Abraham Lin, Fred C. Krebs, Adam E. Snook, Sander Bekeschus, Wilbur B. Bowne, and Vandana Miller

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Drug interactions between direct-acting oral anticoagulants and calcineurin inhibitors during solid organ transplantation: considerations for therapy, Edwin Lam, Babar Bashir, Mark Chaballa, and Walter K. Kraft

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Pharmacokinetics of Ketamine at Dissociative Doses in an Adult Patient With Refractory Status Asthmaticus Receiving Extracorporeal Membrane Oxygenation Therapy., Edwin Lam, Ankit K. Rochani, Gagan Kaushal, Brandi N. Thoma, Julian Tanjuakio, Frances Mae West, and Hitoshi Hirose

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Pharmacological and non-pharmacological treatments for the Neonatal Abstinence Syndrome (NAS)., A. K. Mangat, G. M. Schmölzer, and W. K. Kraft

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Quantitative sensory testing in children with sickle cell disease: additional insights and future possibilities., Robin E. Miller, Dawn S. Brown, Scott W. Keith, Sarah E. Hegarty, Yamaja Setty, Claudia M. Campbell, Suzanne M. McCahan, Suhita Gayen-Betal, Hal Byck, and Marie Stuart

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Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients., Adam E. Snook, Trevor R. Baybutt, Bo Xiang, Tara S. Abraham, John C. Flickinger, Terry Hyslop, Tingting Zhan, Walter K. Kraft, Takami Sato, and Scott A. Waldman

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Efficacy and safety of intravenous golimumab plus methotrexate in patients with rheumatoid arthritis aged < 65 years and those ≥ 65 years of age., John Tesser, Shelly Kafka, Raphael J. DeHoratius, Stephen Xu, Elizabeth C Hsia, and Anthony Turkiewicz

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Blunted Evoked Prouroguanylin Endocrine Secretion in Chronic Constipation., Scott A. Waldman, Renata Tenenbaum, Henry C. Foehl, Peter Winkle, and Patrick Griffin

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Health Care Evolves From Reactive to Proactive., Scott A. Waldman and Andre Terzic

Manuscripts from 2018

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Neonatal Safety Information Reported to the FDA During Drug Development Studies., Debbie Avant, Gerri Baer, Jason N. Moore, Panli Zheng, Alfred Sorbello, Ron Ariagno, Lynne Yao, Gilbert J. Burckart, and Jian Wang

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Evaluating comfort measures for commonly performed painful procedures in pediatric patients., Sana Dastgheyb, Keith Fishlock, Constantine Daskalakis, Jami Kessel, and Paul Rosen

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Listeria monocytogenes as a vector for cancer immunotherapy: Current understanding and progress, John C. Flickinger, Ulrich Rodeck, and Adam E. Snook

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Buprenorphine in Neonatal Abstinence Syndrome., Walter K. Kraft

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Visual field changes in professional wind versus non-wind musical instrument players in the Philadelphia orchestra, Shuai‑Chun Lin, Cindy X. Zheng, Michael Waisbourd, Jeanne Molineaux, Lichuan Zeng, Tingting Zhan, Kamran Rahmatnejad, Arthur Resende, Anand V. Mantravadi, Lisa A. Hark, Marlene R. Moster, Joseph I. Markoff, George L. Spaeth, and L. Jay Katz

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Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases., Michael S. Magee, Tara S. Abraham, Trevor R. Baybutt, John C. Flickinger, Natalie A. Ridge, Glen P Marszalowicz, Priyanka Prajapati, Adam R. Hersperger, Scott A. Waldman, and Adam E. Snook

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The anti-cancer effect of retinoic acid signaling in CRC occurs via decreased growth of ALDH+ colon cancer stem cells and increased differentiation of stem cells, Shirin R. Modarai, Anindita Gupta, Lynn M. Opdenaker, Ryan Kowash, Gabriel Masters, Vignesh Viswanathan, Tao Zhang, Jeremy Z. Fields, and Bruce M. Boman

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The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia., Jeffrey A. Rappaport and Scott A. Waldman

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Process Improvement for Maximized Therapeutic Innovation Outcome., Scott A. Waldman and Andre Terzic

Manuscripts from 2017

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Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer., Allison A. Aka, Jeff A. Rappaport, Amanda M. Pattison, Takami Sato, Adam E. Snook, and Scott A. Waldman

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The Heat-Stable Enterotoxin Receptor, Guanylyl Cyclase C, as a Pharmacological Target in Colorectal Cancer Immunotherapy: A Bench-to-Bedside Current Report., Trevor R. Baybutt, Allison A. Aka, and Adam E. Snook

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GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress, Crystal Kraft, Jeff A. Rappaport, Adam E. Snook, Amanda M. Pattison, John P. Lynch, and Scott A. Waldman

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ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice., Peng Li, Jieru E. Lin, Adam E. Snook, and Scott A. Waldman

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GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome., Peng Li, Evan Wuthrick, Jeff A. Rappaport, Crystal Kraft, Jieru E. Lin, Glen Marszalowicz, Adam E. Snook, Tingting Zhan, Terry M. Hyslop, and Scott A. Waldman

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Extensions of D-optimal Minimal Designs for Symmetric Mixture Models., Yanyan Li, Damaraju Raghavarao, and Inna Chervoneva

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Tumor necrosis factor inhibitors in psoriatic arthritis., Santhi Mantravadi, Alexis Ogdie, and Walter K. Kraft

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Pathologic evaluation of tumor-associated macrophage density and vessel inflammation in invasive breast carcinomas, Yoshihiro Morita, Roy Zhang, Macall Leslie, Smita Adhikari, Nafis Hasan, Inna Chervoneva, Hallgeir Rui, and Takemi Tanaka

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Clinical Pharmacology & Therapeutics: Past, Present, and Future., Scott A. Waldman and Andre Terzic

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Peer Review Certifies Quality and Innovation in Clinical Pharmacology & Therapeutics., Scott A. Waldman and Andre M. Terzic

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Bioactivity of Oral Linaclotide in Human Colorectum for Cancer Chemoprevention., David S. Weinberg, Jieru E. Lin, Nathan R. Foster, Gary Della'Zanna, Asad Umar, Drew Seisler, walter K. Kraft, David M. Kastenberg, Leo C. Katz, Paul J. Limburg, and Scott A. Waldman

Manuscripts from 2016

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Editorial: Ferid murad, at 80: A legacy of science, medicine, and mentorship, Atta-Ur-Rahman

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The landscape of pancreatic cancer therapeutic resistance mechanisms, Saswati N. Chand; Kevin O’Hayer; Fernando F. Blanco; Jordan M Winter; and Jonathan Brody, MD

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Effect of Vorapaxar Alone and in Combination with Aspirin on Bleeding Time and Platelet Aggregation in Healthy Adult Subjects., Walter K. Kraft, J H Gilmartin, D L Chappell, F Gheyas, B M Walker, S Nagalla, U P Naik, J C Horrow, R E Wrishko, S Zhang, and M S Anderson

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Neonatal abstinence syndrome: Pharmacologic strategies for the mother and infant., Walter K. Kraft, Megan W. Stover, and Jonathan M. Davis

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Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis., Jieru E. Lin, Francheska Colon-Gonzalez, Erik S. Blomain, Gilbert W. Kim, Amanda Aing, Brian Stoecker, Justin Rock, Adam E. Snook, Tingting Zhan, Terry M. Hyslop, Michal Tomczak, Richard S. Blumberg, and Scott A. Waldman

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Role of a plausible nuisance contributor in the declining obesity-mortality risks over time., Tapan Mehta, Nicholas m. Pajewski, Scott W. Keith, Kevin Fontaine, and David B. Allison

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Pharmacologic and clinical evaluation of posaconazole., Jason N. Moore, Jason R. Healy, and Walter K. Kraft

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Impossibility to eliminate observer effect in the assessment of adherence in clinical trials., Jonathan S. Myers, Scott J. Fudemberg, Robert E. Fintelmann, Lisa A. Hark, Nitasha Khanna, Benjamin E. Leiby, and Michael Waisbourd

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A survey of physician receptivity to molecular diagnostic testing and readiness to act on results for early-stage colon cancer patients., Ronald E. Myers, Thomas Wolf, Phillip Shwae, Sarah E. Hegarty, Stephen C. Peiper, and Scott A. Waldman

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Reversibility of Apixaban Anticoagulation with a Four-Factor Prothrombin Complex Concentrate in Healthy Volunteers., S Nagalla, Lynda Thomson, Y Oppong, B Bachman, I Chervoneva, and walter k. Kraft

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Big Data Transforms Discovery-Utilization Therapeutics Continuum., Scott A. Waldman and Andre Terzic

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Bioinnovation Enterprise: An engine driving breakthrough therapies., Scott A. Waldman and Andre Terzic

Manuscripts from 2015

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Association of Adipokines with Insulin Resistance, Microvascular Dysfunction, and Endothelial Dysfunction in Healthy Young Adults., Cindy Cheng, MD, PhD and Constantine Daskalakis

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Adolescent and adult African Americans have similar metabolic dyslipidemia., Samuel S. Gidding, Scott W. Keith, and Bonita Falkner

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Ketamine for the treatment of depression in patients receiving hospice care: a retrospective medical record review of thirty-one cases., Alana Iglewicz, Katherine Morrison, Richard A. Nelesen, Tingting Zhan, Boris Iglewicz, Nathan Fairman, Jeremy M. Hirst, and Scott A. Irwin

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No Evidence of a Drug-Drug Interaction Between Letermovir (MK-8228) and Mycophenolate Mofetil, WL Marshall; C. Badshah; F. Liu; Walter K. Kraft, MD; F. Colon-Gonzalez; A. van Schanke; CR. Cho; E. Hulskotte; JR Butterton; and EE Marcantonio

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GM1 ganglioside in Parkinson's disease: Pilot study of effects on dopamine transporter binding., Jay S. Schneider, Franca Cambi, Stephen M. Gollomp, Hiroto Kuwabara, James R. Brašić, Benjamin E. Leiby, Stephanie Sendek, and Dean F. Wong

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Companion diagnostics at the intersection of personalized medicine and healthcare delivery., Scott A Waldman and Andre Terzic

Manuscripts from 2014

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Evidence for role of acid-sensing ion channels in nucleus ambiguus neurons: essential differences in anesthetized versus awake rats., G Cristina Brailoiu, Elena Deliu, Joseph Altmann, Vineet Chitravanshi, and Eugen Brailoiu

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ASA Section on Teaching of Statistics in the Health Sciences: 25 Years Later, Constantine Daskalakis, ScD

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Posaconazole Tablet Pharmacokinetics: Lack of Effect of Concomitant Medications Altering Gastric pH and Gastric Motility in Healthy Subjects., Walter K. Kraft, Peter S. Chang, Marlou L P S van Iersel, Hetty Waskin, Gopal Krishna, and Wendy M Kersemaekers

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Ethanol Pharmacokinetics in Neonates and Infants, Elizabeth Marek, PharmD. and Walter K. Kraft, MD

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GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer., Glen P Marszalowicz, Adam E. Snook, Michael Sullivan Magee, Dante Merlino, Lisa D Berman-Booty, and Scott A Waldman

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Obesity and mortality: are the risks declining? Evidence from multiple prospective studies in the United States., Tapan S. Mehta, Kevin R. Fontaine, Scott W. Keith, Sripal S. Bangalore, Gustavo de los Campos, Alfred Bartolucci, Nicholas M. Pajewski, and David B. Allison

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Impact of Preadmission Beta-blocker Use on Cardiac Abnormalities and In-hospital Mortality in Patients with Aneurysmal Subarachnoid Hemorrhage, Toshimasa Okabe, MD; Anushya Jeyabalan, MD; Benjamin E. Leiby, PhD; Fred Rincon, MD; and Walter K. Kraft, MD

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Current Therapeutic Research is Now Indexed on PubMed., John N van den Anker, Karel Allegaert, and Walter K. Kraft

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Managing the innovation supply chain to maximize personalized medicine., Scott A. Waldman and Andre Terzic

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Tumor radiation therapy creates therapeutic vaccine responses to the colorectal cancer antigen GUCY2C., Matthew Witek, Erik S Blomain, Michael Sullivan Magee, Bo Xiang, Scott A Waldman, and Adam E. Snook

Manuscripts from 2013

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Mechanisms of Weight Regain following Weight Loss, Erik Scott Blomain, Dara Anne Dirhan, Michael Anthony Valentino, Gilbert Won Kim, and Scott A Waldman

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The Impact of Community Use of Novel Oral Anticoagulants on an Academic Medical Center, Luis Eraso, MD; Taki Galanis, MD; Kristina Kipp, Pharm.D.; Walter K. Kraft, MD; Michael Palladino, Pharm.D., CACP; Alejandro Perez, MD; Kimberle Ferebee-Spruill, CRNP; Geno Merli, MD; Brian G. Swift, Pharm.D., MBA; Lynda Thomson; and Brittany Vining

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Intestinal GUCY2C prevents TGF-β secretion coordinating desmoplasia and hyperproliferation in colorectal cancer., Ahmara V Gibbons, Jieru Egeria Lin, Gilbert Won Kim, Glen P Marszalowicz, Peng Li, Brian Arthur Stoecker, Erik S Blomain, Satish Rattan, Adam E. Snook, Stephanie Schulz, and Scott A Waldman

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Molecular staging of node negative patients with colorectal cancer., Terry Hyslop and Scott A Waldman

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Increased levels of plasma soluble Sema4D in patients with heart failure., Qiongyu Lu, Ningzheng Dong, Qi Wang, Wenxiu Yi, Yuxin Wang, Shengjie Zhang, Haibo Gu, Xin Zhao, Xiaorong Tang, Boquan Jin, Qingyu Wu, Lawrence F Brass, and Li Zhu

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Management of intracranial bleeding associated with dabigatran use in a neuroscience hospital, Alejandro Perez, MD; Lynda Thomson; and Geno J. Merli, MD

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Pharmacology and clinical potential of guanylyl cyclase C agonists in the treatment of ulcerative colitis., Giovanni M Pitari

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Poor Positive Predictive Value of McConnell’s Sign on Transthoracic Echocardiography for the Diagnosis of Acute Pulmonary Embolism, Urvashi Vaid, MD, MS; Esme Singer, MD; Gregary D. Marhefka, MD; Walter K. Kraft, MD; and Michael Baram, MD, FCCM

Manuscripts from 2012

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Dysregulation of miR-31 and miR-21 Induced by Zinc Deficiency Promotes Esophageal Cancer, Hansjuerg Alder, Cristian Taccioli, Hongping Chen, Yubao Jiang, Karl Smalley, Paolo Fadda, Hatice G. Ozer, Kay Huebner, John Farber, Carlo M. Croce, and Louise Fong

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Analytic lymph node number establishes staging accuracy by occult tumor burden in colorectal cancer., Terry Hyslop, David S. Weinberg, Stephanie Schulz, Alan Barkun, and Scott A. Waldman

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Effect of Concomitant Medications Affecting Gastric pH and Motility on Posaconazole Tablet Pharmacokinetics, Walter K. Kraft, P. Chang, MLPS Van Iersel, H. Waskin, G. Krishna, and W. Kersemaekers

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Pharmacologic management of the opioid neonatal abstinence syndrome., Walter K. Kraft and John N van den Anker

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Healthy Volunteer Registries and Ethical Research Principles, Erine A. Kupetsky-Rincon and Walter K. Kraft

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GUCY2C Opposes Systemic Genotoxic Tumorigenesis by Regulating AKT-Dependent Intestinal Barrier Integrity, Jieru Egeria Lin, Adam Eugene Snook, Peng Li, Brian Arthur Stoecker, Gilbert Won Kim, Michael Sullivan Magee, Alex Vladimir Mejia Garcia, Michael Anthony Valentino, Terry Hyslop, Stephanie Schulz, and Scott Arthur Waldman

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Molecular staging individualizing cancer management, Alex Mejia, Stephanie Schulz, Terry Hyslop, David S. Weinberg, and Scott A. Waldman

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MK-0448, a Specific Kv1.5 Inhibitor: Safety, Pharmacokinetics and Pharmacodynamic Electrophysiology in Experimental Animal Models and in Humans., Behzad B. Pavri, Howard E Greenberg, Walter K. Kraft, Nicole Lazarus, Joseph J Lynch, Joseph J Salata, Mark T Bilodeau, Christopher P Regan, Gary Stump, Li Fan, Anish Mehta, John A Wagner, David E Gutstein, and Daniel Bloomfield

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Advancing pharmacometrics and systems pharmacology., Scott A. Waldman and Andre Terzic

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The value proposition of molecular medicine., Scott A. Waldman and Andre Terzic

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Phosphorylation of vasodilator-stimulated phosphoprotein Ser239 suppresses filopodia and invadopodia in colon cancer., David S Zuzga, Joshua Pelta-Heller, Peng Li, Alessandro Bombonati, Scott A Waldman, and Giovanni Mario Pitari

Manuscripts from 2011

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Analysis of the proteome of human airway epithelial secretions., Mehboob Ali, Erik P Lillehoj, Yongsung Park, Yoshiyuki Kyo, and K Chul Kim

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Formulation of buprenorphine for sublingual use in neonates., Ellena A Anagnostis, Rania E Sadaka, Linda A Sailor, David E Moody, Kevin C Dysart, and Walter k. Kraft

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The effects of laropiprant, a selective prostaglandin D₂ receptor 1 antagonist, on the antiplatelet activity of clopidogrel or aspirin., Aimee Dallob, Wen-Lin Luo, Julie Mabalot Luk, Lisa Ratcliffe, Amy O Johnson-Levonas, Jules I Schwartz, Victor Dishy, Walter K. Kraft, Jan N De Hoon, Anne Van Hecken, Inge De Lepeleire, Waldemar Radziszewski, John A Wagner, and Eseng Lai

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The incidence of deep vein thrombosis detected by routine surveillance ultrasound in neurosurgery patients receiving dual modality prophylaxis., Patricia C Henwood, Thomas M Kennedy, Lynda Thomson, Taki Galanis, George L Tzanis, Geno J Merli, and Walter K. Kraft

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Revised dose schema of sublingual buprenorphine in the treatment of the neonatal opioid abstinence syndrome., Walter K Kraft, Kevin Dysart, Jay S Greenspan, Eric Gibson, Karol Kaltenbach, and Michelle E Ehrlich

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Chronic diseases: the emerging pandemic., Andre Terzic and Scott A. Waldman

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A uroguanylin-GUCY2C endocrine axis regulates feeding in mice., Michael A Valentino, Jieru E Lin, Adam E Snook, Peng Li, Gilbert W Kim, Glen Marszalowicz, Michael S Magee, Terry Hyslop, Stephanie Schulz, and Scott A Waldman

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Bionic Technologies Transforming the Science of Healthcare Delivery, Scott A. Waldman , M.D., Ph.D and Andre Terzic , M.D., Ph.D

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Clinical pharmacology as a foundation for translational science., Scott A. Waldman, R J. Hohl, G L. Kearns, S J. Swan, and A Terzic