Document Type
Article
Publication Date
8-1-2016
Abstract
The effect of the protease-activated receptor-1 (PAR-1) antagonist vorapaxar on human bleeding time is not known. This was a randomized, two-period, open-label trial in healthy men (n = 31) and women (n = 5). In period 1, subjects received 81 mg aspirin q.d. or a vorapaxar regimen achieving steady-state plasma concentrations equivalent to chronic 2.5 mg q.d. doses, for 7 days. In period 2, each group added 7 days of the therapy alternate to that of period 1 without washout. Bleeding time and platelet aggregation using arachidonic acid, ADP, and TRAP agonists were assessed. Bleeding time geometric mean ratio (90% CI) for vorapaxar/baseline was 1.01 (0.88-1.15), aspirin/baseline was 1.32 (1.15-1.51), vorapaxar + aspirin/vorapaxar was 1.47 (1.26-1.70), and vorapaxar + aspirin/aspirin was 1.12 (0.96-1.30). Unlike aspirin, vorapaxar did not prolong bleeding time compared with baseline. Bleeding time following administration of vorapaxar with aspirin was similar to that following aspirin alone.
Recommended Citation
Kraft, Walter K.; Gilmartin, J H; Chappell, D L; Gheyas, F; Walker, B M; Nagalla, S; Naik, U P; Horrow, J C; Wrishko, R E; Zhang, S; and Anderson, M S, "Effect of Vorapaxar Alone and in Combination with Aspirin on Bleeding Time and Platelet Aggregation in Healthy Adult Subjects." (2016). Department of Pharmacology and Experimental Therapeutics Faculty Papers. Paper 73.
https://jdc.jefferson.edu/petfp/73
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
PubMed ID
27304196
Comments
This article has been peer reviewed. It is the author’s final published version in Clinical and Translational Science
Volume 9, Issue 4, August 2016, Pages 221-227.
The published version is available at DOI: 10.1111/cts.12405. Copyright © Kraft et al.