Manuscripts from 2024
ARID1A-BAF Coordinates ZIC2 Genomic Occupancy for Epithelial-to-Mesenchymal Transition in Cranial Neural Crest Specification, Samantha M. Barnada, Aida Giner de Gracia, Cruz Morenilla-Palao, Maria Teresa López-Cascales, Chiara Scopa, Francis J. Waltrich, Harald M.M. Mikkers, Maria Elena Cicardi, Jonathan Karlin, Davide Trotti, Kevin A. Peterson, Samantha A. Brugmann, Gijs W.E. Santen, Steven B. McMahon, Eloísa Herrera, and Marco Trizzino
Tail-Tape-Fused Virion and Non-Virion RNA Polymerases of a Thermophilic Virus with an Extremely Long Tail, Anastasiia Chaban, Leonid Minakhin, Ekaterina Goldobina, Brain Bae, Yue Hao, Sergei Borukhov, Leena Putzeys, Maarten Boon, Florian Kabinger, Rob Lavigne, Kira Makarova, Eugene V Koonin, Satish Nair, Shunsuke Tagami, Konstantin Severinov, and Maria Sokolova
Differentially Disrupted Spinal Cord and Muscle Energy Metabolism in Spinal and Bulbar Muscular Atrophy, Danielle DeBartolo, Frederick Arnold, Y Liu, Elana Molotsky, Hsin-Yao Tang, and Diane Merry
Editorial: Pharmacology of Endocrine Related GPCRs, Francesco De Pascali, Aylin Hanyaloglu, Frederic Jean-Alphonse, Francesco Potì, and Eric Reiter
Discovery of a Small-Molecule Inhibitor that Traps Polθ on DNA and Synergizes with PARP Inhibitors, William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor Tredinnick, Mercy Ramanjulu, William Auerbacher, Marissa L Calbert, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Robert Betsch, John Krais, Yifan Wang, Umeshkumar Vekariya, John Gordon, George Morton, Tatiana Kent, Tomasz Skorski, Neil Johnson, Wayne Childers, Xiaojiang Chen, and Richard Pomerantz
Two DOT1 Enzymes Cooperatively Mediate Efficient Ubiquitin-Independent Histone H3 Lysine 76 Tri-Methylation in Kinetoplastids, Victoria Frisbie, Hideharu Hashimoto, Yixuan Xie, Francisca De Luna Vitorino, Josue Baeza, Tam Nguyen, Zhangerjiao Yuan, Janna Kiselar, Benjamin Garcia, and Erik Debler
Engineered NLS-Chimera Downregulates Expression of Aggregation-Prone Endogenous FUS, Miyuki Hayashi, Amandeep Girdhar, Ying-Hui Ko, Kevin Kim, Jacquelyn DePierro, Joseph R. Buchler, Nikhita Arunprakash, Aditya Bajaj, Gino Cingolani, and Lin Guo
Structural Basis for Substrate Binding and Selection by Human Mitochondrial RNA Polymerase, Karl Herbine, Ashok Nayak, and Dmitry Temiakov
Cryo-EM Analysis of Pseudomonas Phage Pa193 Structural Components, Stephano M. Iglesias, Chun-Feng Hou, Johnny Reid, Evan Schauer, Renae Geier, Angela Soriaga, Lucy Sim, Lucy Gao, Julian Whitelegge, Pierre Kyme, Deborah Birx, Sebastien Lemire, and Gino Cingolani
Mutant Androgen Receptor Induces Neurite Loss and Senescence Independently of ARE Binding in a Neuronal Model of SBMA, Jordyn Karliner, Y Liu, and Diane Merry
Stem-Loop and Circle-Loop TADs Generated by Directional Pairing of Boundary Elements Have Distinct Physical and Regulatory Properties, Wenfan Ke, Miki Fujioka, Paul Schedl, and James Jaynes
Inorganic Pyrophosphate Plasma Levels in Patients with GGCX-Associated PXE-Like Phenotypes, Qiaoli Li, Catherine Troutman, Mary Peckiconis, Tamara Wurst, and Sharon Terry
Blocking the Dimerization of Polyglutamine-Expanded Androgen Receptor Protects Cells from DHT-Induced Toxicity by Increasing AR Turnover, Allison Lisberg, Yuhong Liu, and Diane E. Merry
Post-Transcriptional Methylation of Mitochondrial-tRNA Differentially Contributes to Mitochondrial Pathology, Sunita Maharjan, Howard Gamper, Yuka Yamaki, Thomas W. Christian, Robert Y. Henley, Nan-Sheng Li, Takeo Suzuki, Tsutomu Suzuki, Joseph A. Piccirilli, Meni Wanunu, Erin L. Seifert, Douglas C. Wallace, and Ya-Ming Hou
Nanopore Signal Deviations from Pseudouridine Modifications in RNA are Sequence-Specific: Quantification Requires Dedicated Synthetic Controls, Amr Makhamreh, Sepideh Tavakoli, Ali Fallahi, Xinqi Kang, Howard Gamper, Mohammad Nabizadehmashhadtoroghi, Miten Jain, Ya-Ming Hou, Sara H Rouhanifard, and Meni Wanunu
A tRNA Modification Pattern That Facilitates Interpretation of the Genetic Code, Isao Masuda and Ya-Ming Hou
G12/13 Signaling in Asthma, Elizabeth L. McDuffie, Reynold A Panettieri, and Charles P. Scott
PARP2 Promotes Break Induced Replication-Mediated Telomere Fragility in Response to Replication Stress, Daniela Muoio, Natalie Laspata, Rachel L Dannenberg, Caroline Curry, Simone Darkoa-Larbi, Mark Hedglin, Shikhar Uttam, and Elise Fouquerel
The C-terminal 4CXXC-type Zinc Finger Domain of CDCA7 Recognizes Hemimethylated DNA and Modulates Activities of Chromatin Remodeling Enzyme HELLS, Akeo Shinkai, Hideharu Hashimoto, Chikako Shimura, Hiroaki Fujimoto, Kei Fukuda, Naoki Horikoshi, Masaki Okano, Hitoshi Niwa, Erik W Debler, Hitoshi Kurumizaka, and Yoichi Shinkai
Frontotemporal Dementia-Like Disease Progression Elicited by Seeded Aggregation and Spread of FUS, Sonia Vazquez-Sanchez, Britt Tilkin, Fatima Gasset-Rosa, Sitao Zhang, Diana Piol, Melissa McAlonis-Downes, Jonathan Artates, Noe Govea-Perez, Yana Verresen, Lin Guo, Don Cleveland, James Shorter, and Sandrine Da Cruz
Parg Is Essential for Polθ-Mediated Dna End-Joining by Removing Repressive Poly-Adp-Ribose Marks, Umeshkumar Vekariya, Leonid Minakhin, Gurushankar Chandramouly, Mrityunjay Tyagi, Tatiana Kent, Katherine Sullivan-Reed, Jessica Atkins, Douglas Ralph, Margaret Nieborowska-Skorska, Anna-Mariya Kukuyan, Hsin-Yao Tang, Richard T. Pomerantz, and Tomasz Skorski
Manuscripts from 2023
Disruption of the Interaction Between Mutationally Activated GαQ and Gβγ Attenuates Aberrant Signaling, Jenna L Aumiller and Philip B Wedegaertner
Fibrosis-the Tale of H3K27 Histone Methyltransferases and Demethylases, Morgan D. Basta, Svetlana Petruk, Alexander Mazo, and Janice L. Walker
Changes in Nascent Chromatin Structure Regulate Activation of the Pro-fibrotic Transcriptome and Myofibroblast Emergence in Organ Fibrosis, Morgan D. Basta, Svetlana Petruk, Ross Summer, Joel Rosenbloom, Peter J. Wermuth, Edward J. Macarak, Alex V. Levin, Alexander Mazo, and Janice L. Walker
Structural Basis for DNA Proofreading, Gina Buchel, Ashok Nayak, Karl Herbine, Azadeh Sarfallah, Viktoriia Sokolova, Angelica Zamudio-Ochoa, and Dmitry Temiakov
Candidate Variants in DNA Replication and Repair Genes in Early-Onset Renal Cell Carcinoma Patients Referred for Germline Testing, Elena V. Demidova, Ilya G. Serebriiskii, Ramilia Vlasenkova, Simon Kelow, Mark D. Andrake, Tiffiney R. Hartman, Tatiana Kent, James Virtucio, Gail L. Rosen, Richard T. Pomerantz, Roland L. Dunbrack, Erica A. Golemis, Michael J. Hall, David Y.T. Chen, Mary B. Daly, and Sanjeevani Arora
Increased SIRT3 Combined With PARP Inhibition Rescues Motor Function of SBMA Mice, David R. Garcia Castro, Joseph R. Mazuk, Erin M. Heine, Daniel Simpson, R. Seth Pinches, Caroline Lozzi, Kathryn Hoffman, Phillip Morrin, Dylan Mathis, Maria V. Lebedev, Elyse Nissley, Kang Hoo Han, Tyler Farmer, Diane E. Merry, Qiang Tong, Maria Pennuto, and Heather L. Montie
Role of Ribosome Recycling Factor in Natural Termination and Translational Coupling as A Ribosome Releasing Factor, Yoshio Inokuchi, Fabio Quaglia, Akikazu Hirashima, Yoshihiro Yamamoto, Hideko Kaji, and Akira Kaji
Identification of a β-Arrestin-Biased Negative Allosteric Modulator for the β2-Adrenergic Receptor, Michael Ippolito, Francesco De Pascali, Nathan Hopfinger, Konstantin E. Komolov, Daniela Laurinavichyute, Poli Adi Narayana Reddy, Leon A. Sakkal, Kyle Z. Rajkowski, Ajay P. Nayak, Justin Lee, Jordan Lee, Gaoyuan Cao, Preston S. Donover, Melvin Reichman, Stevens. An, Joseph M. Salvino, Raymond B. Penn, Roger S S. Armen, Charles P. Scott, and Jeffrey L. Benovic
Novel Treatments for PXE: Targeting the Systemic and Local Drivers of Ectopic Calcification, Ida Joely Jacobs and Qiaoli Li
Differentiating PC12 Cells to Evaluate Neurite Densities Through Live-Cell Imaging, Jordyn Karliner and Diane E Merry
Genetic Separation of BRCA1 Functions Reveal Mutation-Dependent Polθ Vulnerabilities, John J. Krais, David J. Glass, Ilse Chudoba, Yifan Wang, Wanjuan Feng, Dennis Simpson, Pooja Patel, Zemin Liu, Ryan Neumann-Domer, Robert G. Betsch, Andrea J. Bernhardy, Alice M. Bradbury, Jason Conger, Wei-Ting Yueh, Joseph Nacson, Richard T. Pomerantz, Gaorav P. Gupta, Joseph R. Testa, and Neil Johnson
How Carvedilol Does Not Activate β2-Adrenoceptors, Robert J. Lefkowitz, Howard A. Rockman, Paul J. Shim, Samuel Liu, Seungkirl Ahn, Biswaranjan Pani, Sudarshan Rajagopal, Sudha K. Shenoy, Michel Bouvier, Jeffrey L. Benovic, Stephen B. Liggett, Robert R. Ruffolo, Michael R. Bristow, and Milton Packer
High-Resolution Cryo-EM Structure of the Pseudomonas Bacteriophage E217, Fenglin Li, Chun-Feng Hou, Ravi K. Lokareddy, Ruoyu Yang, Francesca Forti, Federica Briani, and Gino Cingolani
Starvation Sensing by Mycobacterial RelA/SpoT Homologue Through Constitutive Surveillance of Translation, Yunlong Li, Soneya Majumdar, Ryan Treen, Manjuli R. Sharma, Jamie Corro, Howard B. Gamper, Swati R. Manjari, Jerome Prusa, Nilesh K. Banavali, Christina L. Stallings, Ya-Ming Hou, Rajendra K. Agrawal, and Anil K. Ojha
Protocol to Identify the Core Gene Supported by an Essential Gene in E. coli Bacteria Using a Genome-Wide Suppressor Screen, Isao Masuda and Ya-Ming Hou
Development of a Sensitive Microplate Assay for Characterizing RNA Methyltransferase Activity: Implications for Epitranscriptomics and Drug Development, Isaiah K. Mensah, Allison B. Norvil, Ming He, Emma Lendy, Nicole Hjortland, Hern Tan, Richard T. Pomerantz, Andrew Mesecar, and Humaira Gowher
FAN1 Removes Triplet Repeat Extrusions via a PCNA- And RFC-Dependent Mechanism, Ashutosh S. Phadte, Mayuri Bhatia, Hope Ebert, Haaris Abdullah, Essam Abed Elrazaq, Konstantin E. Komolov, and Anna Pluciennik
A Phenotypically Robust Model of Spinal and Bulbar Muscular Atrophy in Drosophila, Kristin Richardson, Medha Sengupta, Alyson Sujkowski, Kozeta Libohova, Autumn C. Harris, Robert Wessells, Diane E. Merry, and Sokol V. Todi
Semi-quantitative Detection of Pseudouridine Modifications and Type I/II I/Ii Hypermodifications in Human mRNAs Using Direct Long-Read Sequencing, Sepideh Tavakoli, Mohammad Nabizadeh, Amr Makhamreh, Howard Gamper, Caroline A McCormick, Neda K Rezapour, Ya-Ming Hou, Meni Wanunu, and Sara H Rouhanifard
Manuscripts from 2022
Genomic Features Underlie the Co-option of SVA Transposons as Cis-regulatory Elements in Human Pluripotent Stem Cells, Samantha M Barnada, Andrew Isopi, Daniela Tejada-Martinez, Clément Goubert, Sruti Patoori, Luca Pagliaroli, Mason Tracewell, and Marco Trizzino
Liquid-Liquid Phase Separation of TDP-43 and FUS in Physiology and Pathology of Neurodegenerative Diseases, Jenny L Carey and Lin Guo
Interplay between an ATP-binding cassette F protein and the ribosome from Mycobacterium tuberculosis, Zhicheng Cui, Xiaojun Li, Joonyoung Shin, Howard Gamper, Ya-Ming Hou, James C Sacchettini, and Junjie Zhang
Recognition of the TDP-43 Nuclear Localization Signal by Importin α1/β, Steven G Doll, Hamed Meshkin, Alexander J Bryer, Fenglin Li, Ying-Hui Ko, Ravi K Lokareddy, Richard E Gillilan, Kushol Gupta, Juan R Perilla, and Gino Cingolani
Mesoscale Structure-Function Relationships in Mitochondrial Transcriptional Condensates, Marina Feric, Azadeh Sarfallah, Furqan Dar, Dmitry Temiakov, Rohit V. Pappu, and Tom Misteli
Differential recognition of canonical NF-κB dimers by Importin α3, Tyler J. Florio, Ravi K Lokareddy, Daniel P Yeggoni, Rajeshwer S Sankhala, Connor A Ott, Richard E Gillilan, and Gino Cingolani
Regulating Phase Transition in Neurodegenerative Diseases by Nuclear Import Receptors, Amandeep Girdhar and Lin Guo
Structure of the Pre-mRNA Leakage 39-kDa Protein Reveals a Single Domain of Integrated zf-C3HC and Rsm1 Modules, Hideharu Hashimoto, Daniel H. Ramirez, Ophélie Lautier, Natalie Pawlak, Günter Blobel, Benoît Palancade, and Erik W. Debler
Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy, Hong Joo Kim, Payam Mohassel, Sandra Donkervoort, Lin Guo, Kevin O'Donovan, Maura Coughlin, Xaviere Lornage, Nicola Foulds, Simon R Hammans, A Reghan Foley, Charlotte M Fare, Alice F Ford, Masashi Ogasawara, Aki Sato, Aritoshi Iida, Pinki Munot, Gautam Ambegaonkar, Rahul Phadke, Dominic G O'Donovan, Rebecca Buchert, Mona Grimmel, Ana Töpf, Irina T Zaharieva, Lauren Brady, Ying Hu, Thomas E Lloyd, Andrea Klein, Maja Steinlin, Alice Kuster, Sandra Mercier, Pascale Marcorelles, Yann Péréon, Emmanuelle Fleurence, Adnan Manzur, Sarah Ennis, Rosanna Upstill-Goddard, Luca Bello, Cinzia Bertolin, Elena Pegoraro, Leonardo Salviati, Courtney E French, Andriy Shatillo, F Lucy Raymond, Tobias B Haack, Susana Quijano-Roy, Johann Böhm, Isabelle Nelson, Tanya Stojkovic, Teresinha Evangelista, Volker Straub, Norma B Romero, Jocelyn Laporte, Francesco Muntoni, Ichizo Nishino, Mark A Tarnopolsky, James Shorter, Carsten G Bönnemann, and J Paul Taylor
High-Resolution Cryo-EM Structure of the Shigella Virus Sf6 Genome Delivery Tail Machine, Fenglin Li, Chun-Feng David Hou, Ruoyu Yang, Richard Whitehead, Carolyn M. Teschke, and Gino Cingolani
Terminase Subunits from the Pseudomonas-Phage E217, Ravi K Lokareddy, Chun-Feng David Hou, Steven G Doll, Fenglin Li, Richard E Gillilan, Francesca Forti, David S Horner, Federica Briani, and Gino Cingolani
Viral Small Terminase: A Divergent Structural Framework for a Conserved Biological Function., Ravi K. Lokareddy, Chun-Feng David Hou, Fenglin Li, Ruoyu Yang, and Gino Cingolani
Structural enzymology of cholesterol biosynthesis and storage., Tao Long, Erik W Debler, and Xiaochun Li
Neuromuscular junction pathology is correlated with differential motor unit vulnerability in spinal and bulbar muscular atrophy, Elana Molotsky, Y Liu, Andrew P Lieberman, and Diane E Merry
Functions of ADP-ribose transferases in the maintenance of telomere integrity, Daniela Muoio, Natalie Laspata, and Elise Fouquerel
Evidence for Paracrine Protective Role of Exogenous αA-Crystallin in Retinal Ganglion Cells, Madhu Nath, Zachary B Sluzala, Ashutosh S Phadte, Yang Shan, Angela M Myers, and Patrice E Fort
Young Transposable Elements Rewired Gene Regulatory Networks in Human and Chimpanzee Hippocampal Intermediate Progenitors, Sruti Patoori, Samantha M Barnada, Christopher Large, John I Murray, and Marco Trizzino
Enhanced Membrane Binding of Oncogenic G Protein αqQ209L Confers Resistance to Inhibitor YM-254890, Clinita E. Randolph, Morgan B. Dwyer, Jenna L. Aumiller, Alethia J. Dixon, Asuka Inoue, Patrick Osei-Owusu, and Philip B. Wedegaertner
ISC10, an Inhibitor of the SMK1 MAPK, Prevents Activation Loop Autophosphorylation and Substrate Phosphorylation Through Separate Mechanisms, Abhimannyu Rimal, Thomas M Swayne, Zeal P Kamdar, Madison A Tewey, and Edward Winter
The Role of Ubiquitination in Spinal and Bulbar Muscular Atrophy, Medha Sengupta, Anna Pluciennik, and Diane E. Merry
In Silico Identification of a β2-Adrenoceptor Allosteric Site That Selectively Augments Canonical β2AR-Gs Signaling and Function, Sushrut D Shah, Christoffer Lind, Francesco De Pascali, Raymond B Penn, Alexander D MacKerell, and Deepak A Deshpande
Viral Ejection Proteins: Mosaically Conserved, Conformational Gymnasts, Nicholas A. Swanson, Chun-Feng Hou, and Gino Cingolani
Positive Selection and Enhancer Evolution Shaped Lifespan and Body Mass in Great Apes, Daniela Tejada-Martinez, Roberto A Avelar, Inês Lopes, Bruce Zhang, Guy Novoa, João Pedro de Magalhães, and Marco Trizzino
Positive Selection and Enhancer Evolution Shaped Lifespan and Body Mass in Great Apes., Daniela Tejada-Martinez, Roberto A Avelar, Inês Lopes, Bruce Zhang, Guy Novoa, João Pedro de Magalhães, and Marco Trizzino
G Protein-Coupled Receptor Kinase 6 (GRK6) Regulates Insulin Processing and Secretion via Effects on Proinsulin Conversion to Insulin, Matthew J Varney, Wouter Steyaert, Paul J Coucke, Joris R Delanghe, David E Uehling, Babu Joseph, Richard Marcellus, Rima Al-Awar, and Jeffrey L Benovic
Mechanisms of mitochondrial promoter recognition in humans and other mammalian species, Angelica Zamudio-Ochoa, Yaroslav I Morozov, Azadeh Sarfallah, Michael Anikin, and Dmitry Temiakov
A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis., Lei Zhang, James E Kent, Meredith Whitaker, David C Young, Dominik Herrmann, Alexander E Aleshin, Ying-Hui Ko, Gino Cingolani, Jamil S Saad, D Branch Moody, Francesca M Marassi, Sabine Ehrt, and Michael Niederweis
Manuscripts from 2021
Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation., Danique Beijer, Hong Joo Kim, Lin Guo, Kevin O'Donovan, Inès Mademan, Tine Deconinck, Kristof Van Schil, Charlotte M Fare, Lauren E Drake, Alice F Ford, Andrzej Kochański, Dagmara Kabzińska, Nicolas Dubuisson, Peter Van den Bergh, Nicol C Voermans, Richard Jlf Lemmers, Silvère M van der Maarel, Devon Bonner, Jacinda B Sampson, Matthew T Wheeler, Anahit Mehrabyan, Steven Palmer, Peter De Jonghe, James Shorter, J Paul Taylor, and Jonathan Baets
Historical Perspective of the G Protein-Coupled Receptor Kinase Family., Jeffrey L Benovic
Zebrafish Paralogs brd2a and brd2b Are Needed for Proper Circulatory, Excretory and Central Nervous System Formation and Act as Genetic Antagonists during Development, Gregory L Branigan, Kelly S Olsen, Isabella Burda, Matthew W Haemmerle, Jason Ho, Alexandra Venuto, Nicholas D D'Antonio, Ian E Briggs, and Angela J DiBenedetto
A stress-free strategy to correct point mutations in patient iPS cells, Jingli Cai, Elizabeth Kropf, Ya-Ming Hou, and Lorraine Iacovitti
Time-resolved cryo-EM visualizes ribosomal translocation with EF-G and GTP, Christine E Carbone, Anna B Loveland, Howard Gamper, Ya-Ming Hou, Gabriel Demo, and Andrei A Korostelev
Polθ promotes the repair of 5'-DNA-protein crosslinks by microhomology-mediated end-joining, Gurushankar Chandramouly, Shuren Liao, Timur Rusanov, Nikita Borisonnik, Marissa L Calbert, Tatiana Kent, Katherine Sullivan-Reed, Umeshkumar Vekariya, Ekaterina Kashkina, Tomasz Skorski, Hong Yan, and Richard T Pomerantz
Polθ reverse transcribes RNA and promotes RNA-templated DNA repair, Gurushankar Chandramouly, Jiemin Zhao, Shane McDevitt, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Taylor Treddinick, Felicia Wednesday Lopezcolorado, Tatiana Kent, Labiba Siddique, Joseph Mallon, Jacklyn Huhn, Zainab Shoda, Ekaterina Kashkina, Alessandra Brambati, Jeremy M Stark, Xiaojiang S Chen, and Richard Pomerantz
Dna polymerase θ: A cancer drug target with reverse transcriptase activity, Xiaojiang Chen and Richard T. Pomerantz
Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation., Gabriel Demo, Howard Gamper, Anna B. Loveland, Isao Masuda, Christine E. Carbone, Egor Svidritskiy, Ya-Ming Hou, and Andrei A. Korostelev
Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates., Marina Farkas, Hideharu Hashimoto, Yingtao Bi, Ramana V Davuluri, Lois Resnick-Silverman, James J. Manfredi, Erik W. Debler, and Steven B. McMahon
Learning from Nature: From a Marine Natural Product to Synthetic Cyclooxygenase-1 Inhibitors by Automated De Novo Design., Lukas Friedrich, Gino Cingolani, Ying-Hui Ko, Mariaclara Iaselli, Morena Miciaccia, Maria Grazia Perrone, Konstantin Neukirch, Veronika Bobinger, Daniel Merk, Robert Klaus Hofstetter, Oliver Werz, Andreas Koeberle, Antonio Scilimati, and Gisbert Schneider
An insulator blocks access to enhancers by an illegitimate promoter, preventing repression by transcriptional interference., Miki Fujioka, Anastasiya Nezdyur, and James B. Jaynes
Insights into genome recoding from the mechanism of a classic +1-frameshifting tRNA., Howard Gamper, Haixing Li, Isao Masuda, D. Miklos Robkis, Thomas Christian, Adam B. Conn, Gregor Blaha, E. James Petersson, Ruben L. Gonzalez, and Ya-Ming Hou
Analysis of the DNA-binding properties of Alx1, an evolutionarily conserved regulator of skeletogenesis in echinoderms, Jennifer Guerrero-Santoro, Jian Ming Khor, Ayşe Haruka Açıkbaş, James B. Jaynes, and Charles A Ettensohn
TERA-Seq: true end-to-end sequencing of native RNA molecules for transcriptome characterization, Fadia Ibrahim, Jan Oppelt, Manolis Maragkakis, and Zissimos Mourelatos
DNA Mismatch Repair and its Role in Huntington's Disease, Ravi R Iyer and Anna Pluciennik
Targeting oncogenic gαq/11 in uveal melanoma, Dominic Lapadula and Jeffrey L Benovic
Characterization of a new WHIM syndrome mutant reveals mechanistic differences in regulation of the chemokine receptor CXCR4, Jiansong Luo, Francesco De Pascali, G Wendell Richmond, Amer M Khojah, and Jeffrey L Benovic
Multiple Autonomous Cell Death Suppression Strategies Ensure Cytomegalovirus Fitness, Pratyusha Mandal, Lynsey Nagrani, Liliana Hernandez, Anita Louise McCormick, Christopher Dillon, Heather Koehler, Linda Roback, Emad S Alnemri, Douglas Green, and Edward Mocarski
Loss of N1-methylation of G37 in tRNA induces ribosome stalling and reprograms gene expression, Isao Masuda, Jae-Yeon Hwang, Thomas Christian, Sunita Maharjan, Fuad Mohammad, Howard Gamper, Allen R. Buskirk, and Ya-Ming Hou
Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis., Lindsey Mayes-Hopfinger, Aura Enache, Jian Xie, Chou-Long Huang, Robert Köchl, Victor L.J. Tybulewicz, Teresa Fernandes-Alnemri, and Emad S. Alnemri
Three-dimensional structure of human cyclooxygenase (hCOX)-1., Morena Miciaccia, Benny Danilo Belviso, Mariaclara Iaselli, Gino Cingolani, Savina Ferorelli, Marianna Cappellari, Paola Loguercio Polosa, Maria Grazia Perrone, Rocco Caliandro, and Antonio Scilimati
The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS., Joseph D Orkin, Michael J Montague, Daniela Tejada-Martinez, Marc de Manuel, Javier Del Campo, Saul Cheves Hernandez, Anthony Di Fiore, Claudia Fontsere, Jason A Hodgson, Mareike C Janiak, Lukas F K Kuderna, Esther Lizano, Maria Pia Martin, Yoshihito Niimura, George H Perry, Carmen Soto Valverde, Jia Tang, Wesley C Warren, João Pedro de Magalhães, Shoji Kawamura, Tomàs Marquès-Bonet, Roman Krawetz, and Amanda D Melin
Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders, Luca Pagliaroli, Patrizia Porazzi, Alyxandra T Curtis, Chiara Scopa, Harald M M Mikkers, Christian Freund, Lucia Daxinger, Sandra Deliard, Sarah A Welsh, Sarah Offley, Connor A Ott, Bruno Calabretta, Samantha A Brugmann, Gijs W E Santen, and Marco Trizzino
The Evolutionary Conserved SWI/SNF Subunits ARID1A and ARID1B Are Key Modulators of Pluripotency and Cell-Fate Determination, Luca Pagliaroli and Marco Trizzino
Gβγ regulates mitotic Golgi fragmentation and G2/M cell cycle progression., Kalpana Rajanala, Lauren M. Klayman, and Philip B. Wedegaertner
Expression and purification of phage T7 ejection proteins for cryo-EM analysis, Nicholas A. Swanson, Ravi K Lokareddy, Fenglin Li, Chun-Feng Hou, Mikhail Pavlenok, Michael Niederweis, and Gino Cingolani
Manuscripts from 2020
Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages., Ardeshir Ariana, Norah A Alturki, Stephanie Hajjar, Deborah J Stumpo, Christopher Tiedje, Emad S Alnemri, Matthias Gaestel, Perry J Blackshear, and Subash Sad
Purification and Use of tRNA for Enzymatic Post-translational Addition of Amino Acids to Proteins., Irem Avcilar-Kucukgoze, Howard Gamper, Ya-Ming Hou, and Anna Kashina
Lyssavirus Vaccine with a Chimeric Glycoprotein Protects across Phylogroups, Christine R Fisher, David E Lowe, Todd G Smith, Yong Yang, Christina L Hutson, Christoph Wirblich, Gino Cingolani, and Matthias J. Schnell
A Label-Free Assay for Aminoacylation of tRNA, Howard Gamper and Ya-Ming Hou
Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion, Julia A Horstmann, Michele Lunelli, Hélène Cazzola, Johannes Heidemann, Caroline Kühne, Pascal Steffen, Sandra Szefs, Claire Rossi, Ravi K Lokareddy, Chu Wang, Laurine Lemaire, Kelly T Hughes, Charlotte Uetrecht, Hartmut Schlüter, Guntram A Grassl, Theresia E B Stradal, Yannick Rossez, Michael Kolbe, and Marc Erhardt
Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion., Julia A Horstmann, Michele Lunelli, Hélène Cazzola, Johannes Heidemann, Caroline Kühne, Pascal Steffen, Sandra Szefs, Claire Rossi, Ravi K Lokareddy, Chu Wang, Laurine Lemaire, Kelly T Hughes, Charlotte Uetrecht, Hartmut Schlüter, Guntram A Grassl, Theresia E B Stradal, Yannick Rossez, Michael Kolbe, and Marc Erhardt
