Document Type
Article
Publication Date
7-23-2025
Abstract
DNA resection is a universal process in genome maintenance by which one strand of DNA is degraded, leaving the other strand intact. This sometimes highly processive process is critical for many forms of DNA damage repair, replication-coupled repair, meiotic recombination, and telomere maintenance. Therefore, resection must be tightly regulated to prevent genome instability and promote faithful and accurate repair. Here, we review what is known about how resection functions and how it is controlled, using DNA double-strand break repair and telomere maintenance as examples. We address how resection is regulated in three independent steps: resection initiation, long-range processing, and termination. By addressing these mechanisms in the context of both pathways, we attempt to provide an overview of the similarities as well as the outstanding questions regarding how this robust process is regulated.
Recommended Citation
Soniat, Michael M, and Myler, Logan R., "Using the Safety Scissors: DNA Resection Regulation at DNA Double-Strand Breaks and Telomeres" (2025). Department of Biochemistry and Molecular Biology Faculty Papers. Paper 285.
https://jdc.jefferson.edu/bmpfp/285
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
40716322
Language
English
Comments
This article is the author’s final published version in DNA Repair, Volume 152, 2025, Article number 103876.
The published version is available at https://doi.org/10.1016/j.dnarep.2025.103876. Copyright © © 2025 The Authors.