Structural enzymology of cholesterol biosynthesis and storage.

Authors

Tao Long, University of Texas Southwestern Medical Center
Erik W Debler, Thomas Jefferson UniversityFollow
Xiaochun Li, University of Texas Southwestern Medical Cente

Document Type

Article

Publication Date

4-7-2022

Comments

This is the accepted manuscript version of the article form the journal Current Opinion in Structural Biology, Apr 7;74:102369.

The final published manuscript can be found on the journals website: https://doi.org/10.1016/j.sbi.2022.102369

Abstract

Cholesterol biosynthesis occurs in the endoplasmic reticulum (ER). Its lego-like construction from water-soluble small metabolites via intermediates of increasing complexity to water-insoluble cholesterol requires numerous distinct enzymes. Dysfunction of the involved enzymes can cause several human inborn defects and diseases. Here, we review recent structures of three key cholesterol biosynthetic enzymes: Squalene epoxidase (SQLE), NAD(P)-dependent steroid dehydrogenase-like (NSDHL), and 3β-hydroxysteroid Δ

Recommended Citation

Long, Tao; Debler, Erik W; and Li, Xiaochun, "Structural enzymology of cholesterol biosynthesis and storage." (2022). Department of Biochemistry and Molecular Biology Faculty Papers. Paper 214.
https://jdc.jefferson.edu/bmpfp/214

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

PubMed ID

35398802

Language

English