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Manuscripts from 2014

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Hormone whodunit: clues for solving the case of intratumor androgen production., Karen E Knudsen

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miR-221/222 promotes S-phase entry and cellular migration in control of basal-like breast cancer., Yuan Li, Chunli Liang, Haizhong Ma, Qian Zhao, Ying Lu, Zhendong Xiang, Li Li, Jie Qin, Yihan Chen, William C Cho, Richard G Pestell, Li Liang, and Zuoren Yu

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Depletion of pre-mRNA splicing factor Cdc5L inhibits mitotic progression and triggers mitotic catastrophe., R Mu, Y-B Wang, M Wu, Y Yang, W Song, T Li, W-N Zhang, B Tan, A-L Li, N Wang, Q Xia, W-L Gong, Chenguang Wang, T Zhou, N Guo, Z-H Sang, and H-Y Li

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Single nucleotide polymorphism of SREBF-1 gene associated with an increased risk of endometrial cancer in Chinese women., Chun-Ping Qiu, Qing-Tao Lv, Samina Dongol, Chenguang Wang, and Jie Jiang

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Acetylation-defective mutant of Pparγ is associated with decreased lipid synthesis in breast cancer cells., Lifeng Tian, Chenguang Wang, Fred K Hagen, Michael Gormley, Sankar Addya, Raymond Soccio, Mathew C Casimiro, Jie Zhou, Michael J Powell, Ping Xu, Haiteng Deng, Anthony A Sauve, and Richard Pestell

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The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer., Tao Wang, Zhuo Liu, Shuiming Guo, Licheng Wu, Mingchao Li, Jun Yang, Ruibao Chen, Hua Xu, Shaoxin Cai, Hui Chen, Weiyong Li, Liang Wang, Zhiquan Hu, Qianyuan Zhuang, Shaohua Xu, Liping Wang, Jihong Liu, Zhangqun Ye, Jun-Yuan Ji, Chenguang Wang, and Ke Chen

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miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1., Zuoren Yu, Zengguang Xu, Gabriele Disante, Jennifer Wright, Min Wang, Yuan Li, Qian Zhao, Tao Ren, Xiaoming Ju, Ellen Gutman, Guangxue Wang, Sankar Addya, Tieyan Li, Zhendong Xiang, Chenguang Wang, Xiongfei Yang, Xiaolai Yang, and Richard Pestell

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Association of leukocyte mitochondrial DNA content with glioma risk: evidence from a Chinese case-control study., Jie Zhang, Deyang Li, Falin Qu, Yibing Chen, Gang Li, Hequn Jiang, Xiaojun Huang, Hushan Yang, and Jinliang Xing

Manuscripts from 2013

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Cyclin D1 determines estrogen signaling in the mammary gland in vivo., Mathew C Casimiro, Chenguang Wang, Z Li, Gabriele Disante, Nicole E Willmart, Sankar Addya, Lei Chen, Yang Liu, Michael P. Lisanti, and Richard Pestell

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Acetylation of the cell-fate factor dachshund determines p53 binding and signaling modules in breast cancer., Ke Chen, Kongming Wu, Michael Gormley, Adam Ertel, Jing Wang, Wei Zhang, Jie Zhou, Gabriele Disante, Zhiping Li, Hallgeir Rui, Andrew A Quong, Steven B McMahon, Haiteng Deng, Michael P Lisanti, Chenguang Wang, and Richard G Pestell

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Targeting cell cycle and hormone receptor pathways in cancer., C E S Comstock; M A Augello; J F Goodwin; R de Leeuw; M J Schiewer; W F Ostrander; R A Burkhart; A K McClendon; Peter McCue; Edouard J. Trabulsi; Costas D. Lallas; Leonard G Gomella, MD; M M Centenera; Jonathan Brody, MD; L M Butler; W D Tilley; and K E Knudsen, PhD

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Presence of virus neutralizing antibodies in cerebral spinal fluid correlates with non-lethal rabies in dogs., Clement W Gnanadurai, Ming Zhou, Wenqi He, Christina M Leyson, Chien-Tsun Huang, Gregory Salyards, Stephen B Harvey, Zhenhai Chen, Biao He, Yang Yang, D C Hooper, Berhnard Dietzchold, and Zhen F Fu

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A STATement on vemurafenib-resistant melanoma., Edward J Hartsough and A E Aplin

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A TH1 immune response efficiently clears rabies virus from the CNS in the absence of inflammation, Aurore Lebrun, Rhonda Kean, Jianwei Li, and Douglas Craig Hooper

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Intracellular reprogramming of expression, glycosylation, and function of a plant-derived antiviral therapeutic monoclonal antibody., Jeong-Hwan Lee, Da-Young Park, Kyung-Jin Lee, Young-Kwan Kim, Yang-Kang So, Jae-Sung Ryu, Seung-Han Oh, Yeon-Soo Han, Kinarm Ko, Young-Kug Choo, Sung-Joo Park, Robert Brodzik, Kyoung-Ki Lee, Doo-Byoung Oh, Kyung-A Hwang, Hilary Koprowski, Yong Seong Lee, and Kisung Ko

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IGF-IR Promotes Prostate Cancer Growth by Stabilizing α5β1 Integrin Protein Levels., Aejaz Sayeed, Carmine Fedele, Marco Trerotola, Kirat K Ganguly, and Lucia R Languino

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Dynamic recruitment of microRNAs to their mRNA targets in the regenerating liver., Jonathan Schug, Lindsay B McKenna, Gabriel Walton, Nicholas Hand, Sarmistha Mukherjee, Kow Essuman, Zhongjie Shi, Yan Gao, Karen Markley, Momo Nakagawa, Vasumathi Kameswaran, Anastassios Vourekas, Joshua R Friedman, Klaus H Kaestner, and Linda E Greenbaum

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Dual fluorescent molecular substrates selectively report the activation, sustainability and reversibility of cellular PKB/Akt activity., Duanwen Shen, Mingfeng Bai, Rui Tang, Baogang Xu, Xiaoming Ju, Richard Pestell, and Samuel Achilefu

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Breast cancer antiestrogen resistance 3 (BCAR3) promotes cell motility by regulating actin cytoskeletal and adhesion remodeling in invasive breast cancer cells., Ashley L Wilson, Randy S Schrecengost, Michael S Guerrero, Keena S Thomas, and Amy H Bouton

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The TWEAK receptor Fn14 is a therapeutic target in melanoma: immunotoxins targeting Fn14 receptor for malignant melanoma treatment., Hong Zhou, Suhendan Ekmekcioglu, John W Marks, Khalid A Mohamedali, Kaushal Asrani, Keeley K Phillips, Sharron A N Brown, Emily Cheng, Michele B Weiss, Walter N Hittelman, Nhan L Tran, Hideo Yagita, Jeffrey A Winkles, and Michael G Rosenblum

Manuscripts from 2012

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Adaptive upregulation of FOXD3 and resistance to PLX4032/4720-induced cell death in mutant B-RAF melanoma cells., K J Basile, E V Abel, and A E Aplin

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Genetic ablation of Cav1 differentially affects melanoma tumor growth and metastasis in mice: role of Cav1 in Shh heterotypic signaling and transendothelial migration., Franco Capozza, Casey Trimmer, Remedios Castello-Cros, Sanjay Katiyar, Diana Whitaker-Menezes, Antonia Follenzi, Marco Crosariol, Gemma Llaverias, Federica Sotgia, Richard G Pestell, and Michael P Lisanti

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Cyclin d1 induces chromosomal instability., Mathew C Casimiro and Richard Pestell

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Aleuria Aurantia Lectin (AAL)-reactive immunoglobulin G rapidly appears in sera of animals following antigen exposure., Songming Chen, Chen Lu, Hongbo Gu, Anand Mehta, Jianwei Li, Patrick B Romano, David Horn, D Craig Hooper, Carthene R Bazemore-Walker, and Timothy Block

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Aleuria Aurantia Lectin (AAL)-Reactive Immunoglobulin G Rapidly Appears in Sera of Animals following Antigen Exposure., Songming Chen, Chen Lu, Hongbo Gu, Anand Mehta, Jianwei Li, Patrick B Romano, David Horn, D Craig Hooper, Carthene R Bazemore-Walker, and Timothy Block

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Inflammatory signaling compromises cell responses to interferon alpha., W-C Huangfu, J Qian, C Liu, J Liu, A E Lokshin, D P Baker, H Rui, and S Y Fuchs

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GSK3β inhibition blocks melanoma cell/host interactions by downregulating N-cadherin expression and decreasing FAK phosphorylation., Jobin K John, Kim H T Paraiso, Vito W Rebecca, Liliana P Cantini, Ethan V Abel, Nicholas Pagano, Eric Meggers, Rahel Mathew, Clemens Krepler, Victoria Izumi, Bin Fang, John M Koomen, Jane L Messina, Meenhard Herlyn, and Keiran S M Smalley

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Initial experience with Imacor hTEE-guided management of patients following transplant and mechanical circulatory support., Christopher Kang, Hitoshi Hirose, Harold Hasting, and

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Cyclin D1 goes metabolic: dual functions of cyclin D1 in regulating lipogenesis., Karen E Knudsen

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Successful management of bleeding complications in patients supported with extracorporeal membrane oxygenation with primary respiratory failure., K Lamb, Sw Cowan, N Evans, H Pitcher, T Moritz, M Lazar, H Hirose, and Nc Cavarocchi

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Expression of cyclin D1a and D1b as predictive factors for treatment response in colorectal cancer., M P Myklebust, Z Li, T H Tran, H Rui, E S Knudsen, H Elsaleh, Ø Fluge, B Vonen, H E Myrvold, S Leh, K M Tveit, R G Pestell, and O Dahl

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Inflammation, organomegaly, and muscle wasting despite hyperphagia in a mouse model of burn cachexia., Felipe E Pedroso, Paul B Spalding, Michael C Cheung, Relin Yang, Juan C Gutierrez, Andrea Bonetto, Rui Zhan, Ho Lam Chan, Nicholas Namias, Leonidas G Koniaris, and Teresa A Zimmers

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ERK2 phosphorylation of serine 77 regulates Bmf pro-apoptotic activity., Y Shao and A E Aplin

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Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity., Trisha R Stankiewicz, F Alexandra Loucks, Emily K Schroeder, Marja T Nevalainen, Kenneth L Tyler, Klaus Aktories, Ron J Bouchard, and Daniel A Linseman

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Small non-coding RNAs govern mammary gland tumorigenesis., Zuoren Yu and Richard Pestell

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Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1., Xiaoping Zhao, Daorong Feng, Qun Wang, Arian Abdulla, Xiao-Jun Xie, Jie Zhou, Yan Sun, Ellen S Yang, Lu-Ping Liu, Bhavapriya Vaitheesvaran, Lauren Bridges, Irwin J Kurland, Randy Strich, Jian-Quan Ni, Chenguang Wang, Johan Ericsson, Jeffrey E Pessin, Jun-Yuan Ji, and Fajun Yang

Manuscripts from 2011

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Mechanisms of resistance to RAF inhibitors in melanoma., A E Aplin, Fred M Kaplan, and Yongping Shao

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Tissue-specific regulation of mouse microRNA genes in endoderm-derived tissues., Yan Gao, Jonathan Schug, Lindsay B McKenna, John Le Lay, Klaus H Kaestner, and Linda E Greenbaum

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An integrated framework to model cellular phenotype as a component of biochemical networks., Michael Gormley, Viswanadha U Akella, Judy N Quong, and Andrew A Quong

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Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease., B H Kang, M Tavecchio, H L Goel, C-C Hsieh, D S Garlick, C M Raskett, J B Lian, G S Stein, L R Languino, and D C Altieri

Manuscripts from 2010

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Bimodal gene expression and biomarker discovery., Adam Ertel

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C-jun inhibits mammary apoptosis in vivo., Sanjay Katiyar, Mathew C Casimiro, Luis Dettin, Xiaoming Ju, Erwin F Wagner, Hirokazu Tanaka, and Richard Pestell

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Differential impact of tumor suppressor pathways on DNA damage response and therapy-induced transformation in a mouse primary cell model., A Kathleen McClendon, Jeffry L Dean, Adam Ertel, and Erik S Knudsen

Manuscripts from 2009

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High adsorption rate is detrimental to bacteriophage fitness in a biofilm-like environment., Romain Gallet, Yongping Shao, and Ing-Nang Wang

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The production of antibody by invading B cells is required for the clearance of rabies virus from the central nervous system., D Craig Hooper, Timothy W Phares, Marzena J Fabis, and Anirban Roy

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Plant Vaccines: An Immunological Perspective., Douglas C. Hooper

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STAT5 regulation of BCL10 parallels constitutive NFkappaB activation in lymphoid tumor cells., Zsuzsanna S Nagy, Matthew J LeBaron, Jeremy A Ross, Abhisek Mitra, Hallgeir Rui, and Robert A Kirken

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Cyclin D1 repressor domain mediates proliferation and survival in prostate cancer., M J Schiewer, L M Morey, C J Burd, Y Liu, Diane E Merry, S-M Ho, and Karen E Knudsen

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Immunological assessment of plant-derived avian flu H5/HA1 variants., S Spitsin, V Andrianov, N Pogrebnyak, Y Smirnov, N Borisjuk, C Portocarrero, V Veguilla, H Koprowski, and M Golovkin

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Stromal Caveolin-1 Levels Predict Early Ductal Carcinoma in Situ Progression to Invasive Breast Carcinoma, A. K. Witkiewicz, A. Dasgupta, G. F. Schwartz, KH H. Nguyen, H. R. Rui, and M. P. Lisanti

Manuscripts from 2008

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Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo, Ayush Dagbadorj, Robert A. Kirken, Benjamin Leiby, James Karras, and Marja T. Nevalainen

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A novel and generalizable organotypic slice platform to evaluate stem cell potential for targeting pediatric brain tumors., Shengwen Calvin Li and William Gunter Loudon

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Alternate cyclin D1 mRNA splicing modulates P27KlP1 binding and cell migration, Zhiping Li, Chenguang Wang, Xuanmao Jiao, Sanjay Katiyar, Mathew C. Casimiro, George C. Prendergast, Michael J. Powell, and Richard G. Pestell

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Nerve Growth factor regulation of cyclin D1 in PC12 cells through a p21RAS extracellular signal-regulated kinase pathway requires cooperative interactions between Sp1 and nuclear factor-kappaB., Francesco Marampon, Mathew C Casimiro, Maofu Fu, Michael J Powell, Vladimir M Popov, Jaime Lindsay, Bianca M Zani, Carmela Ciccarelli, Genichi Watanabe, Richard J Lee, and Richard G Pestell

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Immune Evasion by Rabies Viruses through the Maintenance of Blood-Brain Barrier Integrity., Anirban Roy and Douglas C. Hooper

Manuscripts from 2007

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Plant-derived EpCAM antigen induces protective anti-cancer response., Robert Brodzik, Sergei Spitsin, Max Golovkin, Katarzyna Bandurska, Carla Portocarrero, Monika Okulicz, Zenon Steplewski, and Hilary Koprowski

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Autocrine prolactin promotes prostate cancer cell growth via Janus kinase-2-signal transducer and activator of transcription-5a/b signaling pathway., Ayush Dagvadorj, Sean Collins, Jean-Baptiste Jomain, Junaid Abdulghani, James Karras, Tobias Zellweger, Hongzhen Li, Martti Nurmi, Kalle Alanen, Tuomas Mirtti, Tapio Visakorpi, Lukas Bubendorf, Vincent Goffin, and Marja T Nevalainen

Caveolin-1 is required for the upregulation of fatty acid synthase (FASN), a tumor promoter, during prostate cancer progression., Dolores Di Vizio, Federica Sotgia, Terence M Williams, Ghada S Hassan, Franco Capozza, Philippe G Frank, Richard G Pestell, Massimo Loda, Michael R Freeman, and Michael P Lisanti

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Smallpox subunit vaccine produced in Planta confers protection in mice, Maxim Golovkin, Sergei Spitsin, Vyacheslav Andrianov, Yuriy Smirnov, Yuhong Xiao, Natalia Pogrebnyak, Karen Markley, Robert Brodzik, Yuri Gleba, Stuart N Isaacs, and Hilary Koprowski

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Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem cell factor, Sanjay Katiyar, Xuanmao Jiao, Erwin Wagner, Michael P. Lisanti, and Richard G. Pestell

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Stabilization of SMAR1 mRNA by PGA2 involves a stem loop structure in the 5' UTR, Lakshminarasimhan Pavritha, Shravanti Rampalli, Surajit Sinha, Kadreppa Sreenath, Richard G. Pestell, and Samit Chattopadhyay

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The functional significance of nuclear receptor acetylation., Vladimir M. Popov, Chenguang Wang, L . Andrew Shirley, Anne Rosenberg, Shengwen Li, Marja Nevalainen, Maofu Fu, and Richard G. Pestell

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Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells, Bin Shi, Laura Sepp-Lorenzino, Marco Prisco, Peter Linsley, Tiziana deAngelis, and Renato Baserga

DACH1 negatively regulates the human RANK ligand gene expression in stromal/preosteoblast cells, Kumaran Sundaram, Santhosh K. Mani, Kazuyuki Kitatani, Kongming Wu, Richard G. Pestell, and Sakamuri V. Reddy

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Acetylation in nuclear receptor signaling and the role of sirtuins, Chenguang Wang, Michael J. Powell, Vladimir M. Popov, and Richard G. Pestell

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Sirtuins, nuclear hormone receptor acetylation and transcriptional regulation, James R. Whittle, Michael J. Powell, Vladimir M. Popov, L. Andrew Shirley, Chenguang Wang, and Richard G. Pestell

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Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth, Kongming Wu, Manran Liu, Anping Li, Howard Donninger, Mahadev Rao, Xuanmao Jiao, Michael P. Lisanti, Ales Cvekl, Michael Birrer, and Richard G. Pestell

Manuscripts from 2006

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Role of caveolin-1 in the regulation of the vascular shear stress response, Philippe G. Frank and Michael P. Lisanti

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Epigenetics and the estrogen receptor, Jennifer E. Leader, Chenuang Wang, Vladimir M. Popov, Maofu Fu, and Richard G. Pestell

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Cyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial function., Chenguang Wang, Zhiping Li, Yinan Lu, Runlei Du, Sanjay Katiyar, Jianguo Yang, Maofu Fu, Jennifer E Leader, Andrew Quong, Phyllis M Novikoff, and Richard Pestell