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Manuscripts from 2014

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Exploring the atomic structure and conformational flexibility of a 320 Å long engineered viral fiber using X-ray crystallography., Anshul Bhardwaj, Sherwood R Casjens, and Gino Cingolani

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Multisite Phosphorylation of the Sum1 Transcriptional Repressor by S-Phase Kinases Controls Exit from Meiotic Prophase in Yeast., Daniel Corbi, Sham Sunder, Michael Weinreich, Aikaterini Skokotas, Erica S Johnson, and Edward Winter

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The p53-induced factor Ei24 inhibits nuclear import through an importin β-binding-like domain., Kim G Lieu, Eun-Hee Shim, Jinling Wang, Ravi K Lokareddy, Tao Tao, Gino Cingolani, Gerard P Zambetti, and David A Jans

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Monitoring Cancer Therapy by mRNA PET Imaging, Eric Wickstrom

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The regulator of G protein signaling (RGS) domain of G protein-coupled receptor kinase 5 (GRK5) regulates plasma membrane localization and function., Hua Xu, Xiaoshan Jiang, Ke Shen, Christopher C. Fischer, and Philip B Wedegaertner

Manuscripts from 2013

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Ash2 acts as an ecdysone receptor coactivator by stabilizing the histone methyltransferase Trr., Albert Carbonell, Alexander Mazo, Florenci Serras, and Montserrat Corominas

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The Drosophila eve Insulator Homie Promotes eve Expression and Protects the Adjacent Gene from Repression by Polycomb Spreading., Miki Fujioka, Guizhi Sun, and James B Jaynes

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Possible steps of complete disassembly of post-termination complex by yeast eEF3 deduced from inhibition by translocation inhibitors., Shinya Kurata, Ben Shen, Jun O Liu, Nono Takeuchi, Akira Kaji, and Hideko Kaji

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The tip of the tail needle affects the rate of DNA delivery by bacteriophage P22., Justin C Leavitt, Lasha Gogokhia, Eddie B Gilcrease, Anshul Bhardwaj, Gino Cingolani, and Sherwood R Casjens

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Mutant Enpp1asj mice as a model for generalized arterial calcification of infancy., Qiaoli Li, Haitao Guo, David W Chou, Annerose Berndt, John P Sundberg, and Jouni Uitto

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Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission., Matthew K Martz, Elda Grabocka, Neil Beeharry, Timothy J Yen, and Philip B Wedegaertner

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Molecular determinants of epidermal growth factor binding: a molecular dynamics study., Jeffrey M Sanders, Matthew E Wampole, Mathew L. Thakur, and Eric Wickstrom

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Disruption of Drosophila melanogaster Lipid Metabolism Genes Causes Tissue Overgrowth Associated with Altered Developmental Signaling., Takeshi Sasamura, Kenji Matsuno, and Mark E Fortini

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Dynein and dynactin leverage their bivalent character to form a high-affinity interaction., Amanda E Siglin, Shangjin Sun, Jeffrey K Moore, Sarah Tan, Martin Poenie, James D Lear, Tatyana Polenova, John A Cooper, and John C Williams

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G protein-coupled receptor kinase 2 (GRK2) is localized to centrosomes and mediates epidermal growth factor-promoted centrosomal separation., Christopher H So, Allison Michal, Konstantin E Komolov, Jiansong Luo, and Jeffrey L Benovic

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Global analysis of SUMO chain function reveals multiple roles in chromatin regulation., Tharan Srikumar, Megan C Lewicki, Michael Costanzo, Johnny M Tkach, Harm van Bakel, Kyle Tsui, Erica S Johnson, Grant W Brown, Brenda J Andrews, Charles Boone, Guri Giaever, Corey Nislow, and Brian Raught

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Structural Implications for Selective Targeting of PARPs., Jamin D Steffen, MD; Jonathan Brody, MD; Roger S Armen, MD; and John M Pascal, MD

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Consistent Surgeon Evaluations of Three-Dimensional Rendering of PET/CT Scans of the Abdomen of a Patient with a Ductal Pancreatic Mass., Matthew E Wampole, John C Kairys, Edith P Mitchell, Martha L Ankeny, Mathew L Thakur, and Eric Wickstrom

Manuscripts from 2012

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Testosterone treatment fails to accelerate disease in a transgenic mouse model of spinal and bulbar muscular atrophy., Erica S Chevalier-Larsen and Diane E Merry

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Genes adopt non-optimal codon usage to generate cell cycle-dependent oscillations in protein levels., Milana Frenkel-Morgenstern, Tamar Danon, Thomas Christian, Takao Igarashi, Lydia Cohen, Ya-Ming Hou, and Lars Juhl Jensen

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Engrailed cooperates directly with Extradenticle and Homothorax on a distinct class of homeodomain binding sites to repress sloppy paired., Miki Fujioka, Brian Gebelein, Zenobia C Cofer, Richard S Mann, and James B Jaynes

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Regulation of a duplicated locus: Drosophila sloppy paired is replete with functionally overlapping enhancers., Miki Fujioka and James B Jaynes

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Synergetic effect of recoverin and calmodulin on regulation of rhodopsin kinase., Ilya I Grigoriev, Ivan I Senin, Natalya K Tikhomirova, Konstantin E Komolov, Sergei E Permyakov, Evgeni Yu Zernii, Karl-Wilhelm Koch, and Pavel P Philippov

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Global cellular regulation including cardiac function by post-translational protein arginylation., Hideko Kaji and Akira Kaji

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Possible steps of complete disassembly of post-termination complex by yeast eEF3 deduced from inhibition by translocation inhibitors., Shinya Kurata, Ben Shen, Jun O Liu, Nono Takeuchi, Akira Kaji, and Hideko Kaji

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Mitochondrial lysyl-tRNA synthetase independent import of tRNA lysine into yeast mitochondria., Naresh Babu V Sepuri, Madhavi Gorla, and Michael P King

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Mitochondrial lysyl-tRNA synthetase independent import of tRNA lysine into yeast mitochondria., Naresh Babu V Sepuri, Madhavi Gorla, and Michael P King

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Protein synthesis factors (RF1, RF2, RF3, RRF, and tmRNA) and peptidyl-tRNA hydrolase rescue stalled ribosomes at sense codons., Serafín Vivanco-Domínguez, José Bueno-Martínez, Gloria León-Avila, Nobuhiro Iwakura, Akira Kaji, Hideko Kaji, and Gabriel Guarneros

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Structural insights into initial and intermediate steps of the ribosome-recycling process, Takeshi Yokoyama, Tanvir R. Shaikh, Nobuhiro Iwakura, Hideko Kaji, Akira Kaji, and Rajendra K. Agrawal

Manuscripts from 2011

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Structure of the ATP synthase catalytic complex (F(1)) from Escherichia coli in an autoinhibited conformation., Gino Cingolani and Thomas M Duncan

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Protein modification by arginylation, Hideko Kaji and Akira Kaji

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Potential for interdependent development of tRNA determinants for aminoacylation and ribosome decoding., Cuiping Liu, Howard Gamper, Hanqing Liu, Barry S Cooperman, and Ya-Ming Hou

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Three-dimensional structure of a viral genome-delivery portal vertex., Adam S Olia, Peter E Prevelige, John E Johnson, and Gino Cingolani

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Three Dimensional Projection Environment for Molecular Design and Surgical Simulation, Matthew Wampole, Eric Wickstrom, Chang-Po Chen, Devakumar Devadhas, Yuan-Yuan Jin, Jeffrey M. Sanders, John C. Kairys, Martha L. Ankeny, Rui Hu, Kenneth E. Barner, Karl V. Steiner, and Mathew L. Thakur

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Mitochondrial genome sequence analysis: a custom bioinformatics pipeline substantially improves Affymetrix MitoChip v2.0 call rate and accuracy., Hongbo M Xie, Juan C Perin, Theodore G Schurr, Matthew C Dulik, Sergey I Zhadanov, Joseph A Baur, Michael P King, Emily Place, Colleen Clarke, Michael Grauer, Jonathan Schug, Avni Santani, Anthony Albano, Cecilia Kim, Vincent Procaccio, Hakon Hakonarson, Xiaowu Gai, and Marni J Falk

Manuscripts from 2010

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Self-protecting bactericidal titanium alloy surface formed by covalent bonding of daptomycin bisphosphonates., Chang-Po Chen and Eric Wickstrom

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Mechanism of N-methylation by the tRNA m1G37 methyltransferase Trm5., Thomas Christian, Georges Lahoud, Cuiping Liu, Katherine Hoffmann, John J Perona, and Ya-Ming Hou

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Control of catalytic cycle by a pair of analogous tRNA modification enzymes., Thomas Christian, Georges Lahoud, Cuiping Liu, and Ya-Ming Hou

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Control of catalytic cycle by a pair of analogous tRNA modification enzymes., Thomas Christian, Georges Lahoud, Cuiping Liu, and Ya-Ming Hou

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Ribosome recycling step in yeast cytoplasmic protein synthesis is catalyzed by eEF3 and ATP., Shinya Kurata, Klaus H Nielsen, Sarah F Mitchell, Jon R Lorsch, Akira Kaji, and Hideko Kaji

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Biosynthesis: A new (old) way of hijacking tRNA., Georges Lahoud and Ya-Ming Hou

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Phosphorylation meets nuclear import: a review., Jonathan D Nardozzi, Kaylen Lott, and Gino Cingolani

Manuscripts from 2009

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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA., Teresa Fernandes-Alnemri, Je-Wook Yu, Pinaki Datta, Jianghong Wu, and Emad S Alnemri

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Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease., Kanae Iijima-Ando, Stephen A Hearn, Christopher Shenton, Anthony Gatt, Lijuan Zhao, and Koichi Iijima

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Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease., Kanae Iijima-Ando, Stephen A Hearn, Christopher Shenton, Anthony Gatt, Lijuan Zhao, and Koichi Iijima

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Regulation of energy stores and feeding by neuronal and peripheral CREB activity in Drosophila., Koichi Iijima, LiJuan Zhao, Christopher Shenton, and Kanae Iijima-Ando

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Asymmetric deactivation of HIV-1 gp41 following fusion inhibitor binding., Kristen M Kahle, H Kirby Steger, and Michael J Root

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Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development., Christine M Lightcap, Gabor Kari, Luis E Arias-Romero, Jonathan Chernoff, Ulrich Rodeck, and John C Williams

Manuscripts from 2008

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Neutralization of botulinum neurotoxin by a human monoclonal antibody specific for the catalytic light chain., Sharad P Adekar, Tsuyoshi Takahashi, R Mark Jones, Fetweh H Al-Saleem, Denise M Ancharski, Michael J Root, B P Kapadnis, Lance L Simpson, and Scott K Dessain

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The role of GTP in transient splitting of 70S ribosomes by RRF (ribosome recycling factor) and EF-G (elongation factor G)., Go Hirokawa, Nobuhiro Iwakura, Akira Kaji, and Hideko Kaji

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Abeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila., Koichi Iijima, Hsueh-Cheng Chiang, Stephen A Hearn, Inessa Hakker, Anthony Gatt, Christopher Shenton, Linda Granger, Amy Leung, Kanae Iijima-Ando, and Yi Zhong

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RecA-mediated strand invasion of DNA by oligonucleotides substituted with 2-aminoadenine and 2-thiothymine., Georges Lahoud, Khalil Arar, Ya-Ming Hou, and Howard Gamper

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Properties of pseudo-complementary DNA substituted with weakly pairing analogs of guanine or cytosine., Georges Lahoud, Victor Timoshchuk, Alexandre Lebedev, Khalil Arar, Ya-Ming Hou, and Howard Gamper

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Enzymatic synthesis of structure-free DNA with pseudo-complementary properties., Georges Lahoud, Victor Timoshchuk, Alexandre Lebedev, Miguel de Vega, Margarita Salas, Khalil Arar, Ya-Ming Hou, and Howard Gamper

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Fibulin-2 is dispensable for mouse development and elastic fiber formation, Francois-Xavier Sicot, Takeshi Tsuda, Dessislava Markova, John Klement, Machiko Arita, Rui-Zhu Zhang, Te-Cheng Pan, Robert P. Mecham, David E. Birk, and Mon-Li Chu

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A central function for perlecan in skeletal muscle and cardiovascular development, Jason J. Zoeller, Angela McQuillan, John Whitelock, Shiu-Ying Ho, and Renato V. Iozzo

Manuscripts from 2007

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Bactericidal activity of extended 9-glycyl-amido-minocyclines, Chang-po Chen, Allen R. Zeiger, and Dr. Eric Wickstrom

Novel activity of eukaryotic translocase, eEF2: Dissociation of the 80S ribosome into subunits with ATP but not with GTP, Natalia Demeshkina, Go Hirokawa, Akira Kaji, and Hideko Kaji

Caveolin-1 is required for the upregulation of fatty acid synthase (FASN), a tumor promoter, during prostate cancer progression., Dolores Di Vizio, Federica Sotgia, Terence M Williams, Ghada S Hassan, Franco Capozza, Philippe G Frank, Richard G Pestell, Massimo Loda, Michael R Freeman, and Michael P Lisanti

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Inhibition of antiassociation activity of translation initiation factor 3 by paromomycin, Go Hirokawa, Hideko Kaji, and Akira Kaji

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Ribosome recycling: An essential process of protein synthesis, Michael C. Kiel, Hideko Kaji, and Akira Kaji

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RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females, Sergey Kuznetsov, Manuela Pellegrini, Kristy Shuda, Oscar Fernandez-Capetillo, Yilun Liu, Betty K. Martin, Sandra Burkett, Eileen Southon, Debananda Pati, Lino Tessarollo, Stephen D. West, Peter J. Donovan, Andre Nussenzweig, and Shyam K. Sharan

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Trivalent vaccine against botulinum toxin serotypes A, B, and E that can be administered by the mucosal route, Easwaran Ravichandran, Fetweh H. Al-Saleem, Denise M. Ancharski, Mohammad D. Elias, Ajay K. Singh, Mohammad Shamim, Yujing Gong, and Lance L. Simpson

Manuscripts from 2006

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The ribosome-recycling step: consensus or controversy?, Go Hirokawa, Natalia Demeshkina, Nobuhiro Iwakura, Hideko Kaji, and Akira Kaji

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Antisense inhibition of cyclin D1 expression is equivalent to flavopiridol for radiosensitization of zebrafish embryos, Mary Frances McAleer, Kevin T. Duffy, William R. Davidson, Gabor Kari, Adam P. Dicker, Ulrich Rodeck, and Eric Wickstrom

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Lung development in laminin γ2 deficiency: abnormal tracheal hemidesmosomes with normal branching morphogenesis and epithelial differentiation, Nguyet M. Nguyen, Leena Pulkkinen, Jessica A. Schlueter, Guerrino Meneguzzi, Jouni Uitto, and Robert M. Senior

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Multiple domains in Siz SUMO ligases contribute to substrate selectivity., Alison Reindle, Irina Belichenko, Gwendolyn R Bylebyl, Xiaole L Chen, Nishant Gandhi, and Erica S Johnson

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Biomolecular tuning of electronic transport properties of carbon nanotubes via antibody functionalization, Kasif Teker, Dr. Eric Wickstrom, and Balaji Panchapakesan

Manuscripts from 2005

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Evaluation of glucocorticoid sensitivity in 697 pre-B acute lymphoblastic leukemia cells after overexpression or silencing of MAP Kinase Phosphotase-1, Marc T. Abrams, Noreen Robertson, Gerald Litwack, and Eric Wickstrom

The role of ribosome recycling factor in dissociation of 70S ribosomes into subunits, Go Hirakawa, Romana M. Nijman, V. Samuel Raj, Hideko Kaji, Kazuei Igarashi, and Akira Kaji

Interaction of RRF and EF-G from E. coli and T. thermophilus with ribosomes from both origins — insight into the mechanism of the ribosome recycling step, V. Samuel Raj, Hideko Kaji, and Akira Kaji

Manuscripts from 2004

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Inhibition of glucocorticoid-induced apoptosis by targeting splice variants of BIM mRNA with small interfering RNA and short hairpin RNA., Marc T. Abrams, Noreen M. Robertson, Kyonggeun Yoon, and Eric Wickstrom

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Hsp27 anti-sense oligonucleotides sensitize the microtubular cytoskeleton of Chinese hamster ovary cells grown at low pH to 42 degrees C-induced reorganization, Michael T. Hargis, C. W. Storck, Eric Wickstrom, Leonid A. Yakubov, Dennis B. Leeper, and Ronald A. Coss

Study of the early steps of the Hepatitis B Virus life cycle., Xuanyong Lu and Timothy Block

Manuscripts from 2003

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Characterization of mutations and loss of heterozygosity of p53 and K-ras2 in pancreatic cancer cell lines by immobilized polymerase chain reaction, James Butz, Eric Wickstrom, and Jeremy Edwards

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Embryonic Origins of a Motor System: Motor Dendrites Form a Myotopic Map in Drosophila, Matthias Landgraf, Victoria Jeffrey, Miki Fujioka, James B. Jaynes, and Michael Bate

Manuscripts from 2000

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Membrane cholesterol content modulates activation of volume-regulated anion current in bovine endothelial cells., I Levitan, A E Christian, T N Tulenko, and G H Rothblat

Manuscripts from 1997

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Murine transporter associated with antigen presentation (TAP) preferences influence class I-restricted T cell responses., A J Yellen-Shaw, C E Laughlin, R M Metrione, and Laurence C. Eisenlohr

Manuscripts from 1996

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Inhibition of human DNA topoisomerase II by hydroquinone and p-benzoquinone, reactive metabolites of benzene., A M Hutt and G F Kalf

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p-Benzoquinone, a reactive metabolite of benzene, prevents the processing of pre-interleukins-1 alpha and -1 beta to active cytokines by inhibition of the processing enzymes, calpain, and interleukin-1 beta converting enzyme., G F Kalf, J F Renz, and R Niculescu

Manuscripts from 1995

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Anti-human immunodeficiency virus (HIV) activities of halogenated gomisin J derivatives, new nonnucleoside inhibitors of HIV type 1 reverse transcriptase, Toshiaki Fujihashi, Hiroto Hara, Toshiya Sakata, Kazuya Mori, Hirotaka Higuchi, Akio Tanaka, Hideko Kaji, and Akira Kaji

Manuscripts from 1989

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Prevention of benzene-induced myelotoxicity by nonsteroidal anti-inflammatory drugs., G F Kalf, M J Schlosser, J F Renz, and S J Pirozzi

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Metabolism of phenol and hydroquinone to reactive products by macrophage peroxidase or purified prostaglandin H synthase., M J Schlosser, R D Shurina, and G F Kalf