A comparison of the WHO 2004 and 2010 classification systems in pancreatic neuroendocrine tumors (Pancreatic NET)

Authors

James P. Casey, MD, Thomas Jefferson UniversityFollow
Aakanksha Asija, MD, Thomas Jefferson UniversityFollow
Anthony J. Prestipino, M.D., Department of Pathology, Anatomy, & Cell Biology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PAFollow
Jocelyn A. Sendecki, MD, Thomas Jefferson UniversityFollow
Jonathan Brody, MD, Thomas Jefferson UniversityFollow
Harish Lavu, MD, Thomas Jefferson UniversityFollow
Jordan M. Winter, MD, Thomas Jefferson UniversityFollow
Charles Yeo, MD, Thomas Jefferson UniversityFollow
Ashwin R. Sama, MD, Thomas Jefferson UniversityFollow
Madhaven V. Pillai, MD, Thomas Jefferson UniversityFollow

Document Type

Poster

Publication Date

9-8-2014

Comments

Presented at College of American Pathologists in Chicago Illinois.

Abstract

Pancreatic NETs are rare tumors with multiple classification systems. Previous classification systems included tumor size, histologic grade, mitoses, Ki67, and metastases. The current WHO 2010 system utilizes mitotic rate and Ki67% to assign a grade. We compared the WHO 2004 and 2010 classification systems in predicting mortality and metastasis.

Pathologic parameters were used to classify 50 cases of Pancreatic NET according to the WHO 2004 and WHO 2010 systems. The relationship between the WHO 2004 and WHO 2010 grading was investigated using an exact Chi squared test. WHO grade categorization was next explored by vital status, by the exact method, in order to determine if there was a difference in survivorship and metastasis by grading system. Associations between death and categorical variables were tested using exact methods and between death and continuous variables by the Wilcoxon test. Survival was explored using Cox Proportional Hazards regression (Cox).

The WHO grades were significantly associated with one another (p

Recommended Citation

Casey, MD, James P.; Asija, MD, Aakanksha; Prestipino, M.D., Anthony J.; Sendecki, MD, Jocelyn A.; Brody, MD, Jonathan; Lavu, MD, Harish; Winter, MD, Jordan M.; Yeo, MD, Charles; Sama, MD, Ashwin R.; and Pillai, MD, Madhaven V., "A comparison of the WHO 2004 and 2010 classification systems in pancreatic neuroendocrine tumors (Pancreatic NET)" (2014). Department of Pathology, Anatomy, and Cell Biology Faculty Papers. Paper 153.
https://jdc.jefferson.edu/pacbfp/153