Submissions from 2024
Reaching the Unheard: Overcoming Challenges in Health Research With Hard-To-Reach Populations, Venera Bekteshi, Munjireen Sifat, and Darla Kendzor
Computational Analysis of Cas Proteins Unlocks New Potential in HIV-1 Targeted Gene Therapy, Will Dampier, Rachel Berman, Michael Nonnemacher, and Brian Wigdahl
Immunotherapy Resistance in Solid Tumors: Mechanisms and Potential Solutions, Daniel Lefler, Steven Manobianco, and Babar Bashir
Submissions from 2023
AKT/mTOR Signaling Modulates Resistance to Endocrine Therapy and CDK4/6 Inhibition in Metastatic Breast Cancers, Maysa M. Abu-Khalaf, K. Alex Hodge, Christos Hatzis, Elisa Baldelli, Emna El Gazzah, Frances Valdes, William M. Sikov, Monica M. Mita, Neelima Denduluri, Rita Murphy, Daniel Zelterman, and Lance Liotta
Assessment of anti-HIV-1 Guide RNA Efficacy in Cells Containing the Viral Target Sequence, Corresponding gRNA, and CRISPR/Cas9., Alexander G Allen, Cheng-Han Chung, Stephen D. Worrell, Glad Nwaozo, Rebekah Madrid, Anthony R. Mele, Will Dampier, Michael R. Nonnemacher, and Brian Wigdahl
The v8-10 Variant Isoform of CD44 is Selectively Expressed in the Normal Human Colonic Stem Cell Niche and Frequently is Overexpressed in Colon Carcinomas During Tumor Development, Bruce M. Boman, Vignesh Viswanathan, Caroline O B Facey, Jeremy Z Fields, and James W Stave
Tumor Biology and Immune Infiltration Define Primary Liver Cancer Subsets Linked to Overall Survival After Immunotherapy, Anuradha Budhu, Erica C Pehrsson, Aiwu He, Lipika Goyal, Robin Kate Kelley, Hien Dang, Changqing Xie, Cecilia Monge, Mayank Tandon, Lichun Ma, Mahler Revsine, Laura Kuhlman, Karen Zhang, Islam Baiev, Ryan Lamm, Keyur Patel, David E Kleiner, Stephen M Hewitt, Bao Tran, Jyoti Shetty, Xiaolin Wu, Yongmei Zhao, Tsai-Wei Shen, Sulbha Choudhari, Yuliya Kriga, Kris Ylaya, Andrew C Warner, Elijah F Edmondson, Marshonna Forgues, Tim F Greten, and Xin Wei Wang
Systemic Anticancer Therapy and Thromboembolic Outcomes in Hospitalized Patients With Cancer and COVID-19, Shuchi Gulati, Chih-Yuan Hsu, Surbhi Shah, Pankil K. Shah, Rebecca Zon, Susan Alsamarai, Joy Awosika, Ziad El-Bakouny, Babar Bashir, Alicia Beeghly, Stephanie Berg, Daniel de-la-Rosa-Martinez, Deborah B. Doroshow, Pamela C. Egan, Joshua Fein, Daniel B. Flora, Christopher R. Friese, Ariel Fromowitz, Elizabeth A. Griffiths, Clara Hwang, Chinmay Jani, Monika Joshi, Hina Khan, Elizabeth J. Klein, Natalie Knox Heater, Vadim S. Koshkin, Daniel H. Kwon, Chris Labaki, Tahir Latif, Rana R. McKay, Gayathri Nagaraj, Elizabeth S. Nakasone, Taylor Nonato, Hyma V. Polimera, Matthew Puc, Pedram Razavi, Erika Ruiz-Garcia, Renee Maria Saliby, Aditi Shastri, Sunny R.K. Singh, Vicky Tagalakis, Diana Vilar-Compte, Lisa B. Weissmann, Cy R. Wilkins, Trisha M. Wise-Draper, Michael T. Wotman, James J. Yoon, Sanjay Mishra, Petros Grivas, Yu Shyr, Jeremy L. Warner, Jean M. Connors, Dimpy P. Shah, and Rachel P. Rosovsky
Preclinical Evaluation of Anti-CD38 Therapy in Mature T-cell Neoplasms, Colleen Isabelle, William Johnson, Kathleen McConnell, Ashley Vogel, Jonathan Brammer, Amy Boles, Robyn Keller, Paola Sindaco, Liam Nisenfeld, Guldeep Uppal, Neda Nikbakht, Bruno Calabretta, Patrizia Porazzi, Jerald Gong, Nitin Chakravarti, Pierluigi Porcu, and Anjali Mishra
Relative Burden of Cancer and Noncancer Mortality Among Long-Term Survivors of Breast, Prostate, and Colorectal Cancer in the US, Madhav Kc, Jane Fan, Terry Hyslop, Sirad Hassan, Michael Cecchini, Shi-Yi Wang, Andrea Silber, Michael S. Leapman, Ira Leeds, Stephanie B. Wheeler, Lisa P. Spees, Cary P. Gross, Maryam Lustberg, Rachel A. Greenup, Amy C. Justice, Kevin C. Oeffinger, and Michaela A. Dinan
Xaluritamig, a STEAP1 × CD3 XmAb 2+1 Immune Therapy for Metastatic Castration-Resistant Prostate Cancer: Results from Dose Exploration in a First-in-Human Study, William K. Kelly, Daniel C. Danila, Chia-Chi Lin, Jae-Lyun Lee, Nobuaki Matsubara, Patrick J. Ward, Andrew J. Armstrong, David Pook, Miso Kim, Tanya B. Dorff, Stefanie Fischer, Yung-Chang Lin, Lisa G. Horvath, Christopher Sumey, Zhao Yang, Gabor Jurida, Kristen M. Smith, Jamie N. Connarn, Hweixian L. Penny, Julia Stieglmaier, and Leonard J. Appleman
PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis, Jason Kirkbride, Garbo Nilsson, Jee In Kim, Kosuke Takeya, Yoshinori Tanaka, Hiroshi Tokumitsu, Futoshi Suizu, and Masumi Eto
PARP Inhibitors for the Treatment of BRCA1/2-Mutated Metastatic Breast Cancer: A Systematic Review and Meta-analysis, Ranju Kunwor, Daniel P. Silver, and Maysa Abu-Khalaf
Kruppel-Like Factor 8 Regulates Triple Negative Breast Cancer Stem Cell-Like Activity, Giang Le Minh, Emily M Esquea, Tejsi T Dhameliya, Jessica Merzy, Mi-Hye Lee, Lauren E Ball, and Mauricio J Reginato
Cabozantinib plus atezolizumab in previously untreated advanced hepatocellular carcinoma and previously treated gastric cancer and gastroesophageal junction adenocarcinoma: results from two expansion cohorts of a multicentre, open-label, phase 1b trial (COSMIC-021)., Daneng Li, Yohann Loriot, Adam Burgoyne, James Cleary, Armando Santoro, Daniel Lin, Santiago Ponce Aix, Ignacio Garrido-Laguna, Ramu Sudhagoni, Xiang Guo, Svetlana Andrianova, and Scott Paulson
Population Pharmacokinetics and Exposure–Response Analysis for the Phase 3 COSMIC-311 Trial of Cabozantinib for Radioiodine-Refractory Differentiated Thyroid Cancer, Neang S. Ly, Jing Li, Raffaella Faggioni, Lorin K. Roskos, and Marcia S Brose
A Rare Metastatic Mesenteric Malignant PEComa with TSC2 Mutation Treated with Palliative Surgical Resection and Nab-Sirolimus: A Case Report, Luke Meredith; Timothy Chao; Avinoam Nevler; Atrayee Basu Mallick; Rajan Singla; Peter McCue; Wilbur Bowne; and Wei Jiang, MD, PhD
"Keep Your Chin Up, and Keep Eating": Perceptions of Barriers and Facilitators to Healthful Dietary Behaviors Among Individuals With Gastrointestinal Cancer and Caregivers, Brandy-Joe Milliron, Cynthia Klobodu, Jonathan Deutsch, Karon Martyn, Dan Dychtwald, Emily Riahi, Shawn Carro, Taylor Hisek, Natalie Darcy, and Ann C. Klassen
COVID-19 Severity and Cardiovascular Outcomes in SARS-CoV-2-Infected Patients With Cancer and Cardiovascular Disease, Melissa Y.Y. Moey, Cassandra Hennessy, Benjamin French, Jeremy L. Warner, Matthew D. Tucker, Daniel J. Hausrath, Dimpy P. Shah, Jeanne M. DeCara, Ziad Bakouny, Chris Labaki, Toni K. Choueiri, Susan Dent, Nausheen Akhter, Roohi Ismail-Khan, Lisa Tachiki, David Slosky, Tamar S. Polonsky, Joy A. Awosika, Audrey Crago, Trisha Wise-Draper, Nino Balanchivadze, Clara Hwang, Leslie A. Fecher, Cyndi Gonzalez Gomez, Brandon Hayes-Lattin, Michael J. Glover, Sumit A. Shah, Dharmesh Gopalakrishnan, Elizabeth A. Griffiths, Daniel H. Kwon, Vadim S. Koshkin, Sana Mahmood, Babar Bashir, Taylor Nonato, Pedram Razavi, Rana R. McKay, Gayathri Nagaraj, Eric Oligino, Matthew Puc, Polina Tregubenko, Elizabeth M. Wulff-Burchfield, Zhuoer Xie, Thorvardur R. Halfdanarson, Dimitrios Farmakiotis, Elizabeth J. Klein, Elizabeth V. Robilotti, Gregory J. Riely, Jean-Bernard Durand, Salim S. Hayek, Lavanya Kondapalli, Stephanie Berg, Timothy E. O'Connor, Mehmet A. Bilen, Cecilia Castellano, Melissa K. Accordino, Blau Sibel, Lisa B. Weissmann, Chinmay Jani, Daniel B. Flora, Lawrence Rudski, Miriam Santos Dutra, Bouganim Nathaniel, Erika Ruíz-García, Diana Vilar-Compte, Shilpa Gupta, Alicia Morgans, and Anju Nohria
IDO1 and Inflammatory Neovascularization: Bringing New Blood to Tumor-Promoting Inflammation, Alexander J. Muller, Arpita Mondal, Souvik Dey, and George C Prendergast
How I Read an Article That Uses Machine Learning Methods, Aziz Nazha, Olivier Elemento, Shannon McWeeney, Moses Miles, and Torsten Haferlach
Exploring Breast Cancer Systemic Drug Therapy Patterns in Real-World Data, Julia O'Rourke, Jeff Warnick, John Doole, Luc De Keyser, Zuzanna Drebert, Olivia Wan, Courtney N Thompson, Jack W. London, Karen Fairchild, and Matvey B. Palchuk
Hepatitis B Virus and B-cell Lymphoma: Evidence, Unmet Need, Clinical Impact, and Opportunities, Maya Rosenberg, Maria Poluch, Colin Thomas, Paola Sindaco, Alan Khoo, and Pierluigi Porcu
The Role of Interleukin-15 in the Development and Treatment of Hematological Malignancies, Paola Sindaco, Hritisha Pandey, Colleen Isabelle, Nitin Chakravarti, Jonathan Edward Brammer, Pierluigi Porcu, and Anjali Mishra
Submissions from 2022
Epigenetic Mechanisms Influencing Therapeutic Response in Breast Cancer., Amaia Arruabarrena-Aristorena and Eneda Toska
Astronauts Plasma-Derived Exosomes Induced Aberrant EZH2-Mediated H3K27me3 Epigenetic Regulation of the Vitamin D Receptor, Malik Bisserier, Agnieszka Brojakowska, Nathaniel Saffran, Amit Kumar Rai, Brooke Lee, Matthew Coleman, Aimy Sebastian, Angela Evans, Paul J Mills, Sankar Addya, Arsen Arakelyan, Venkata Naga Srikanth Garikipati, Lahouaria Hadri, and David A Goukassian
Assessment of Regional Variability in COVID-19 Outcomes Among Patients With Cancer in the United States., Jessica E Hawley, Tianyi Sun, David D Chism, Narjust Duma, Julie C Fu, Na Tosha N Gatson, Sanjay Mishra, Ryan H Nguyen, Sonya A Reid, Oscar K Serrano, Sunny R K Singh, Neeta K Venepalli, Ziad Bakouny, Babar Bashir, Mehmet A Bilen, Paolo F Caimi, Toni K Choueiri, Scott J Dawsey, Leslie A Fecher, Daniel B Flora, Christopher R Friese, Michael J Glover, Cyndi J Gonzalez, Sharad Goyal, Thorvardur R Halfdanarson, Dawn L Hershman, Hina Khan, Chris Labaki, Mark A Lewis, Rana R McKay, Ian Messing, Nathan A Pennell, Matthew Puc, Deepak Ravindranathan, Terence D Rhodes, Andrea V Rivera, John Roller, Gary K Schwartz, Sumit A Shah, Justin A Shaya, Mitrianna Streckfuss, Michael A Thompson, Elizabeth M Wulff-Burchfield, Zhuoer Xie, Peter Paul Yu, Jeremy L Warner, Dimpy P Shah, Benjamin French, and Clara Hwang
Creating and Implementing a Principal Investigator Tool Kit for Enhancing Accrual to Late Phase Clinical Trials: Development and Usability Study., Kristin A Higgins, Alexandra Thomas, Nancy Soto, Rebecca Paulus, Thomas J George, Thomas B Julian, Sharon Hartson Stine, Merry Jennifer Markham, and Maria Werner-Wasik
Assessing the Coverage of US Cancer Center Primary Catchment Areas., Amy E Leader, Christopher McNair, Christina Yurick, Matthew Huesser, Elizabeth Schade, Emily E Stimmel, Caryn Lerman, and Karen E Knudsen
Uremic Myopathy and Mitochondrial Dysfunction in Kidney Disease, Eurico Serrano, Diana Whitaker-Menezes, Zhao Lin, Megan Roche, and Maria Paula Martinez Cantarin
ROS and miRNA Dysregulation in Ovarian Cancer Development, Angiogenesis and Therapeutic Resistance, David C Stieg, Yifang Wang, Ling-Zhi Liu, and Bing-Hua Jiang
Impact of homologous recombination status and responses with veliparib combined with first-line chemotherapy in ovarian cancer in the Phase 3 VELIA/GOG-3005 study, Elizabeth M Swisher, Carol Aghajanian, David M O'Malley, Gini F Fleming, Scott H Kaufmann, Douglas A Levine, Michael J Birrer, Kathleen N Moore, Nick M Spirtos, Mark S Shahin, Thomas J Reid, Michael Friedlander, Karina Dahl Steffensen, Aikou Okamoto, Vasudha Sehgal, Peter J Ansell, Minh H Dinh, Michael A Bookman, and Robert L Coleman
Efficacy and safety of larotrectinib in patients with TRK fusion-positive thyroid carcinoma, Steven G Waguespack, Alexander Drilon, Jessica J Lin, Marcia S Brose, Ray McDermott, Mohammed Almubarak, Jessica Bauman, Michela Casanova, Anuradha Krishnamurthy, Shivaani Kummar, Serge Leyvraz, Do-Youn Oh, Keunchil Park, Davendra Sohal, Eric Sherman, Ricarda Norenberg, Josh D Silvertown, Nicoletta Brega, David S Hong, and Maria E Cabanillas
Submissions from 2021
Global gene expression analysis of systemic sclerosis myofibroblasts demonstrates a marked increase in the expression of multiple NBPF genes, Giuseppina Abignano, Heidi Hermes, Sonsoles Piera-Velazquez, Sankar Addya, Francesco Del Galdo, and Sergio A. Jimenez
Long-Term Effects of Very Low Dose Particle Radiation on Gene Expression in the Heart: Degenerative Disease Risks, Venkata Naga Srikanth Garikipati, Arsen Arakelyan, Eleanor A Blakely, Polly Y Chang, May M Truongcao, Maria Cimini, Vandana Malaredy, Anamika Bajpai, Sankar Addya, Malik Bisserier, Agnieszka Brojakowska, Abrisham Eskandari, Mary K Khlgatian, Lahouaria Hadri, Kenneth M Fish, Raj Kishore, and David A Goukassian
Therapeutic resistance in pancreatic ductal adenocarcinoma: Current challenges and future opportunities, Aditi Jain, PhD and Vikas Bhardwaj
Association Between Sex and Immune Checkpoint Inhibitor Outcomes for Patients With Melanoma., Se Ryeong Jang, Nikita Nikita, Joshua Banks, Scott W. Keith, Jennifer M. Johnson, Melissa Wilson, and Grace Lu-Yao
Digital Literacy at an Urban Cancer Center: Implications for Technology Use and Vulnerable Patients, Amy Leader; Lisa M. Capparella; L. Waldman, BA; Rebecca Cammy; Alison Petok; Rebecca Dean; Ayako Shimada; Liana Yocavitch; Kristin L. Rising; Gregory Garber; Brooke Worster; and Adam Dicker
Macrophage and adipocyte interaction as a source of inflammation in kidney disease, Cristina Martos-Rus, Goni Katz-Greenberg, Zhao Lin, Eurico Serrano, Diana Whitaker Menezes, Marina Domingo-Vidal, Megan Roche, Kavitha Ramaswamy, D. Craig Hooper, Bonita Falkner, and Maria P Martinez Cantarin
Returning to Sport: Female Athletes Living with and beyond Cancer., Anna L. Schwartz and Christopher Terry
Potential Immunomodulatory Properties of Biologically Active Components of Spices Against SARS-CoV-2 and Pan β-Coronaviruses, Sourodip Sengupta, Debina Bhattacharyya, Grishma Kasle, Souvik Karmakar, Omkar Sahu, Anirban Ganguly, Sankar Addya, and Jayasri Das Sarma
Cancer Vaccines and Immunotherapy for Tumor Prevention and Treatment, Jagmohan Singh, Wilbur Bowne, and Adam E. Snook
Lack of Interferon (IFN) Regulatory Factor 8 Associated with Restricted IFN-γ Response Augmented Japanese Encephalitis Virus Replication in the Mouse Brain, Aarti Tripathi, Bhupendra Singh Rawat, Sankar Addya, Milan Surjit, Prafullakumar Tailor, Sudhanshu Vrati, and Arup Banerjee
Submissions from 2020
Treating Hematologic Malignancies During a Pandemic: Utilizing Telehealth and Digital Technology to Optimize Care, Adam Binder, Nathan Handley, Lindsay Wilde, Neil D. Palmisiano, and Ana Maria Lopez
Targeting homologous recombination addicted tumors: Challenges and opportunities, Talia Golan and Jonathan Brody, MD
Virtual Connectivity During Quarantine: The Role of Social Media for Radiation Oncology During COVID-19, Miriam A Knoll, Mudit Chowdhary, Adam Dicker, and Thomas Eichler
iSeqQC: a tool for expression-based quality control in RNA sequencing., Gaurav Kumar, Adam Ertel, George Feldman, Joan Kupper, and Paolo Fortina
Expression of Tryptophan 2,3-Dioxygenase in Metastatic Uveal Melanoma, Mizue Terai, Eric R Londin, Ankit Rochani, Emma Link, Bao Lam, Gagan Kaushal, Alok Bhushan, Marlana Orloff, and Takami Sato
Epidemiology of non-alcoholic fatty liver disease and risk of hepatocellular carcinoma progression, Krishna Chaitanya Thandra, Adam Barsouk, Kalyan Saginala, John Sukumar Aluru, Prashanth Rawla, and Alexander Barsouk
Utilizing Digital Health to Collect Electronic Patient-Reported Outcomes in Prostate Cancer: Single-Arm Pilot Trial, Christine Tran, MS; Adam Dicker, MD, PhD; Benjamin Leiby, PhD; Eric Gressen, MD; Noelle Williams, MD; and Heather Jim, PhD
Epigenomic profiling of neuroblastoma cell lines., Kristen Upton, Apexa Modi, Khushbu Patel, Nathan M Kendsersky, Karina L Conkrite, Robyn T Sussman, Gregory P Way, Rebecca N Adams, Gregory I Sacks, Paolo Fortina, Sharon J Diskin, John M Maris, and Jo Lynne Rokita
Announcing the ISEV2020 special achievement award recipients: Andrew Hill and Edit Buzás; and the recipient of the ISEV2020 special education award: Carolina Soekmadji., Kenneth W Witwer, Lucia R Languino, Alissa M Weaver, and Marca H Wauben
Is Host Metabolism the Missing Link to Improving Cancer Outcomes?, Christopher M Wright, Anuradha A. Shastri, Emily K Bongiorno, Ajay Palagani, Ulrich Rodeck, and Nicole L Simone
Health Insurance Coverage Disruptions and Cancer Care and Outcomes: Systematic Review of Published Research, K Robin Yabroff, Katherine Reeder-Hayes, Jingxuan Zhao, Michael T Halpern, Ana Maria Lopez, Leon Bernal-Mizrachi, Anderson B Collier, Joan Neuner, Jonathan Phillips, William Blackstock, and Manali Patel
Submissions from 2017
Editorial: Murine models of leukemia and lymphoma, Christine E. Cutucache and Pierluigi Porcu
Submissions from 2016
HIV-1 Genetic Variation Resulting in the Development of New Quasispecies Continues to Be Encountered in the Peripheral Blood of Well-Suppressed Patients., Will Dampier, Michael R Nonnemacher, Joshua Mell, Joshua Earl, Garth D Ehrlich, Vanessa Pirrone, Benjamas Aiamkitsumrit, Wen Zhong, Katherine Kercher, Shendra Passic, Jean W Williams, Jeffrey M Jacobson, and Brian Wigdahl
Antimetabolite TTL-315 selectively kills glucose-deprived cancer cells and enhances responses to cytotoxic chemotherapy in preclinical models of cancer., James DuHadaway and George C Prendergast
Romidepsin for the treatment of relapsed/refractory peripheral T cell lymphoma: prolonged stable disease provides clinical benefits for patients in the pivotal trial., Francine Foss, Steven Horwitz, Barbara Pro, H Miles Prince, Lubomir Sokol, Barbara Balser, Julie Wolfson, and Bertrand Coiffier
Insights from HuR biology point to potential improvement for second-line ovarian cancer therapy., Yu-Hung Huang; Weidan Peng; Narumi Furuuchi; James B DuHadaway; Masaya Jimbo; Andrea Pirritano; Charles J Dunton; Gary S Daum; Benjamin E Leiby; Jonathan Brody, MD; and Janet A Sawicki
Analysis of tumor template from multiple compartments in a blood sample provides complementary access to peripheral tumor biomarkers., William M Strauss, Chris Carter, Jill Simmons, Erich Klem, Nathan Goodman, Behrad Vahidi, Juan Romero, Michael Masterman-Smith, Ruth O'Regan, Keerthi Gogineni, Lee Schwartzberg, Laura Austin, Paul W Dempsey, and Massimo Cristofanilli
Submissions from 2015
Kinase independent oncogenic cyclin D1., Mathew C Casimiro, Andrew Arnold, and Richard Pestell
Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells: Understanding WNT/FGF-driven anabolic signaling., Rebecca Lamb, Gloria Bonuccelli, Béla Ozsvári, Maria Peiris-Pagès, Marco Fiorillo, Duncan L Smith, Generoso Bevilacqua, Chiara Maria Mazzanti, Liam A McDonnell, Antonio Giuseppe Naccarato, Maybo Chiu, Luke Wynne, Ubaldo E Martinez-Outschoorn, Federica Sotgia, and Michael P. Lisanti
Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy., Rebecca Lamb; Marco Fiorillo; Amy Chadwick; Bela Ozsvari; Kimberly J Reeves; Duncan L Smith; Robert B Clarke; Sacha J Howell; Anna Rita Cappello; Ubaldo E. Martinez-Outshoorn, MD; Maria Peiris-Pagès; Federica Sotgia; and Michael P Lisanti
Targeting tumor-initiating cells: Eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction., Rebecca Lamb; Hannah Harrison; Duncan L Smith; Paul A Townsend; Thomas Jackson; Bela Ozsvari; Ubaldo E. Martinez-Outshoorn, MD; Richard Pestell; Anthony Howell; Michael P. Lisanti; and Federica Sotgia
Dissecting tumor metabolic heterogeneity: Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells., Rebecca Lamb; Bela Ozsvari; Gloria Bonuccelli; Duncan L Smith; Richard Pestell; Ubaldo E. Martinez-Outshoorn, MD; Robert B Clarke; Federica Sotgia; and Michael P Lisanti
Biology of advanced uveal melanoma and next steps for clinical therapeutics., Jason J Luke, Pierre L Triozzi, Kyle C McKenna, Erwin G Van Meir, Jeffrey E Gershenwald, Boris C Bastian, J Silvio Gutkind, Anne M Bowcock, Howard Z Streicher, Poulam M Patel, Takami Sato, Jeffery A Sossman, Mario Sznol, Jack Welch, Magdalena Thurin, Sara Selig, Keith T Flaherty, and Richard D Carvajal
Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses., Roberta Malaguarnera, Maria Luisa Nicolosi, Antonella Sacco, Alaide Morcavallo, Veronica Vella, Concetta Voci, Michela Spatuzza, Shi-Qiong Xu, Renato V Iozzo, Riccardo Vigneri, Andrea Morrione, and Antonino Belfiore
IGF-I induces upregulation of DDR1 collagen receptor in breast cancer cells by suppressing MIR-199a-5p through the PI3K/AKT pathway., Roberta Matà, Chiara Palladino, Maria Luisa Nicolosi, Anna Rita Lo Presti, Roberta Malaguarnera, Marco Ragusa, Daniela Sciortino, Andrea Morrione, Marcello Maggiolini, Veronica Vella, and Antonino Belfiore
Change in PSA velocity is a predictor of overall survival in men with biochemically-recurrent prostate cancer treated with nonhormonal agents: combined analysis of four phase-2 trials., D L Suzman, X C Zhou, M L Zahurak, Jianqing Lin MD, and E S Antonarakis
Submissions from 2014
Identification of a developmental gene expression signature, including HOX genes, for the normal human colonic crypt stem cell niche: overexpression of the signature parallels stem cell overpopulation during colon tumorigenesis., Seema Bhatlekar, Sankar Addya, Moreh Salunek, Christopher R Orr, Saul Surrey, Steven E. McKenzie, Jeremy Z Fields, and Bruce M Boman
Classification of current anticancer immunotherapies., Lorenzo Galluzzi, Erika Vacchelli, José-Manuel Bravo-San Pedro, Aitziber Buqué, Laura Senovilla, Elisa Elena Baracco, Norma Bloy, Francesca Castoldi, Jean-Pierre Abastado, Patrizia Agostinis, Ron N Apte, Fernando Aranda, Maha Ayyoub, Philipp Beckhove, Jean-Yves Blay, Laura Bracci, Anne Caignard, Chiara Castelli, Federica Cavallo, Estaban Celis, Vincenzo Cerundolo, Aled Clayton, Mario P Colombo, Lisa Coussens, Madhav V Dhodapkar, Alexander M Eggermont, Douglas T Fearon, Wolf H Fridman, Jitka Fučíková, Dmitry I Gabrilovich, Jérôme Galon, Abhishek Garg, François Ghiringhelli, Giuseppe Giaccone, Eli Gilboa, Sacha Gnjatic, Axel Hoos, Anne Hosmalin, Dirk Jäger, Pawel Kalinski, Klas Kärre, Oliver Kepp, Rolf Kiessling, John M Kirkwood, Eva Klein, Alexander Knuth, Claire E Lewis, Roland Liblau, Michael T Lotze, Enrico Lugli, Jean-Pierre Mach, Fabrizio Mattei, Domenico Mavilio, Ignacio Melero, Cornelis J Melief, Elizabeth A Mittendorf, Lorenzo Moretta, Adekunke Odunsi, Hideho Okada, Anna Karolina Palucka, Marcus E Peter, Kenneth J Pienta, Angel Porgador, George C Prendergast, Gabriel A Rabinovich, Nicholas P Restifo, Naiyer Rizvi, Catherine Sautès-Fridman, Hans Schreiber, Barbara Seliger, Hiroshi Shiku, Bruno Silva-Santos, Mark J Smyth, Daniel E Speiser, Radek Spisek, Pramod K Srivastava, James E Talmadge, Eric Tartour, Sjoerd H Van Der Burg, Benoît J Van Den Eynde, Richard Vile, Hermann Wagner, Jeffrey S Weber, Theresa L Whiteside, Jedd D Wolchok, Laurence Zitvogel, Weiping Zou, and Guido Kroemer
The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells., Lymor Ringer, Paul Sirajuddin, Lucas Tricoli, Sarah Waye, Muhammad Umer Choudhry, Erika Parasido, Angiela Sivakumar, Mary Heckler, Aisha Naeem, Iman Abdelgawad, Xuefeng Liu, Adam S Feldman, Richard J Lee, Chin-Lee Wu, Venkata Yenugonda, Bhaskar Kallakury, Anatoly Dritschilo, John Lynch, Richard Schlegel, Olga Rodriguez, Richard Pestell, Maria Laura Avantaggiati, and Chris Albanese
CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines., Daniela Sicoli, Xuanmao Jiao, Xiaoming Ju, Marco Velasco-Velazquez, Adam Ertel, Sankar Addya, Z Li, Sebastiano Andò, Alessandro Fatatis, Bishnuhari Paudyal, Massimo Cristofanilli, Mathew L. Thakur, Michael P. Lisanti, and Richard Pestell
Submissions from 2013
Glutamine supplementation alleviates vasculopathy and corrects metabolic profile in an in vivo model of endothelial cell dysfunction., Francesco Addabbo, Qiuying Chen, Dhara P Patel, May Rabadi, Brian Ratliff, Frank Zhang, Jean-Francois Jasmin, Michael Wolin, Michael Lisanti, Steven S Gross, and Michael S Goligorsky
An APC:WNT Counter-Current-Like Mechanism Regulates Cell Division Along the Human Colonic Crypt Axis: A Mechanism That Explains How APC Mutations Induce Proliferative Abnormalities That Drive Colon Cancer Development., Bruce M Boman and Jeremy Z Fields
Landscape of the mitochondrial Hsp90 metabolome in tumours., Young Chan Chae, Alessia Angelin, Sofia Lisanti, Andrew V Kossenkov, Kaye D Speicher, Huan Wang, James F Powers, Arthur S Tischler, Karel Pacak, Stephanie Fliedner, Ryan D Michalek, Edward D Karoly, Douglas C Wallace, Lucia R Languino, David W Speicher, and Dario C Altieri
A phase 1b study of humanized KS-interleukin-2 (huKS-IL2) immunocytokine with cyclophosphamide in patients with EpCAM-positive advanced solid tumors., Joseph P Connor, Mihaela C Cristea, Nancy L Lewis, Lionel D Lewis, Philip B Komarnitsky, Maria R Mattiacci, Mildred Felder, Sarah Stewart, Josephine Harter, Jean Henslee-Downey, Daniel Kramer, Roland Neugebauer, and Roger Stupp
Circulating tumor DNA to monitor metastatic breast cancer., Massimo Cristofanilli and Paolo Fortina
Insulin promotes glucose consumption via regulation of miR-99a/mTOR/PKM2 pathway., Wei Li, Jing Wang, Qiu-Dan Chen, Xu Qian, Qi Li, Yu Yin, Zhu-Mei Shi, Lin Wang, Jie Lin, Ling-Zhi Liu, and Bing-Hua Jiang
Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFκB target stromal MCT4., Ubaldo E. Martinez-Outshoorn, MD; Joseph Curry, MD; Ying-Hui Ko, MD; Zhao Lin, MD; Madalina Tuluc, MD; David Cognetti, MD; Ruth Birbe, MD; Edmund A. Pribitkin, MD; Alessandro Bombonati; Richard Pestell, MD; Anthony Howell; Federica Sotgia; and Michael P. Lisanti, MD
Caloric restriction augments radiation efficacy in breast cancer., Anthony D Saleh, Brittany A Simone, Juan Palazzo, Jason E Savage, Yuri Sano, Tu Dan, Lianjin Jin, Colin E Champ, Shuping Zhao, Meng Lim, Frederica Sotgia, Kevin Camphausen, Richard G Pestell, James B Mitchell, Michael P Lisanti, and Nicole L Simone
Peripheral T-cell lymphomas: a review of current approaches and hopes for the future., Alan P Skarbnik, Meher Burki, and Barbara Pro
Cancer metabolism: new validated targets for drug discovery., Federica Sotgia; Ubaldo E. Martinez-Outshoorn, MD; and Michael P. Lisanti
The CCL5/CCR5 axis promotes metastasis in basal breast cancer., Marco Velasco-Velázquez and Richard G Pestell
Submissions from 2012
Lymph node ratio is an important and independent prognostic factor for patients with stage III melanoma, Adam C. Berger, Michael Fierro, John C. Kairys, David Berd, Takami Sato, Jocelyn Andrel, Terry Hyslop, and Michael J. Mastrangelo
ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice., Mathew C Casimiro, Marco Crosariol, Emanuele Loro, Adam Ertel, Zuoren Yu, William Dampier, Elizabeth A Saria, Alex Papanikolaou, Timothy J Stanek, Zhiping Li, Chenguang Wang, Paolo Fortina, Sankar Addya, Aydin Tozeren, Erik S Knudsen, Andrew Arnold, and Richard G Pestell
Genetic Polymorphism in a VEGF-Independent Angiogenesis Gene ANGPT1 and Overall Survival of Colorectal Cancer Patients after Surgical Resection, Jingyao Dai, Shaogui Wan, Feng Zhou, Ronald E. Myers, Xu Guo, Bingshan Li, Xiaoying Fu, Juan P. Palazzo, Kefeng Dou, Hushan Yang, and Jinliang Xing
Hyccin, the Molecule Mutated in the Leukodystrophy Hypomyelination and Congenital Cataract (HCC), Is a Neuronal Protein., Elisabetta Gazzerro, Simona Baldassari, Caterina Giacomini, Veronica Musante, Floriana Fruscione, Veronica La Padula, Roberta Biancheri, Sonia Scarfì, Valeria Prada, Federica Sotgia, Ian D Duncan, Federico Zara, Hauke B Werner, Michael P Lisanti, Lucilla Nobbio, Anna Corradi, and Carlo Minetti
The Quest for the Perfect Prostate Biopsy Continues, Leonard G. Gomella
Enteric alpha defensins in norm and pathology., Nikolai A Lisitsyn, Yulia A Bukurova, Inna G Nikitina, George S Krasnov, Yuri Sykulev, and Sergey F Beresten
MiR-128 Inhibits Tumor Growth and Angiogenesis by Targeting p70S6K1., Zhu-Mei Shi, Jing Wang, Zhiping Yan, Yong-Ping You, Chong-Yong Li, Xu Qian, Yu Yin, Peng Zhao, Ying-Ying Wang, Xie-Feng Wang, Ming-Na Li, Ling-Zhi Liu, Ning Liu, and Bing-Hua Jiang
Quantifying the CDK inhibitor VMY-1-103's activity and tissue levels in an in vivo tumor model by LC-MS/MS and by MRI., Paul Sirajuddin, Sudeep Das, Lymor Ringer, Olga C Rodriguez, Angiela Sivakumar, Yi-Chien Lee, Aykut Üren, Stanley T Fricke, Brian Rood, Alpay Ozcan, Sean S Wang, Sana Karam, Venkata Yenugonda, Patricia Salinas, Emanuel Petricoin, Michael Pishvaian, Michael P Lisanti, Yue Wang, Richard Schlegel, Bahram Moasser, and Chris Albanese
Increase in muscle mitochondrial biogenesis does not prevent muscle loss but increased tumor size in a mouse model of acute cancer-induced cachexia., Xiao Wang, Alicia M Pickrell, Teresa A Zimmers, and Carlos T Moraes
Identification of Functionally Distinct TRAF Proinflammatory and PI3K/MEK Transforming Activities Emanating from the RET/PTC Fusion Oncoprotein, Josephine H.F. Wixted, Jay L. Rothstein, and Laurence C. Eisenlohr
Submissions from 2011
Prolactin-induced mouse mammary carcinomas model estrogen resistant luminal breast cancer., Lisa M Arendt, Debra E Rugowski, Tara A Grafwallner-Huseth, Maria Jose Garcia-Barchino, Hallgeir Rui, and Linda A Schuler
Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells., Matteo Fassan, Domenico D'Arca, Juraj Letko, Andrea Vecchione, Marina P Gardiman, Peter McCue, Bernadette Wildemore, Massimo Rugge, Dolores Shupp-Byrne, Leonard G Gomella, Andrea Morrione, Renato V Iozzo, and Raffaele Baffa
Regulation of the androgen receptor by SET9-mediated methylation., Luke Gaughan, Jacqueline Stockley, Nan Wang, Stuart R C McCracken, Achim Treumann, Kelly Armstrong, Fadhel Shaheen, Kate Watt, Iain J McEwan, Chenguang Wang, Richard Pestell, and Craig N Robson
New insights into the androgen-targeted therapies and epigenetic therapies in prostate cancer., Abhijit M Godbole and Vincent C O Njar
A meta-analysis of array-CGH studies implicates antiviral immunity pathways in the development of hepatocellular carcinoma., Xu Guo, Yanna Ba, Xi Ma, Jiaze An, Yukui Shang, Qichao Huang, Hushan Yang, Zhinan Chen, and Jinliang Xing
A tale of three PKCs: epsilon emerges as a driver of pre-neoplastic phenotypes., Karen E Knudsen
