Document Type
Article
Publication Date
6-2-2023
Abstract
BACKGROUND: Data regarding outcomes among patients with cancer and co-morbid cardiovascular disease (CVD)/cardiovascular risk factors (CVRF) after SARS-CoV-2 infection are limited.
OBJECTIVES: To compare Coronavirus disease 2019 (COVID-19) related complications among cancer patients with and without co-morbid CVD/CVRF.
METHODS: Retrospective cohort study of patients with cancer and laboratory-confirmed SARS-CoV-2, reported to the COVID-19 and Cancer Consortium (CCC19) registry from 03/17/2020 to 12/31/2021. CVD/CVRF was defined as established CVD
RESULTS: Among 10,876 SARS-CoV-2 infected patients with cancer (median age 65 [IQR 54-74] years, 53% female, 52% White), 6253 patients (57%) had co-morbid CVD/CVRF. Co-morbid CVD/CVRF was associated with higher COVID-19 severity (adjusted OR: 1.25 [95% CI 1.11-1.40]). Adverse CV events were significantly higher in patients with CVD/CVRF (all
CONCLUSIONS: Co-morbid CVD/CVRF is associated with higher COVID-19 severity among patients with cancer, particularly those not receiving active cancer therapy. While infrequent, COVID-19 related CV complications were higher in patients with comorbid CVD/CVRF. (COVID-19 and Cancer Consortium Registry [CCC19]; NCT04354701).
Recommended Citation
Moey, Melissa Y.Y.; Hennessy, Cassandra; French, Benjamin; Warner, Jeremy L.; Tucker, Matthew D.; Hausrath, Daniel J.; Shah, Dimpy P.; DeCara, Jeanne M.; Bakouny, Ziad; Labaki, Chris; Choueiri, Toni K.; Dent, Susan; Akhter, Nausheen; Ismail-Khan, Roohi; Tachiki, Lisa; Slosky, David; Polonsky, Tamar S.; Awosika, Joy A.; Crago, Audrey; Wise-Draper, Trisha; Balanchivadze, Nino; Hwang, Clara; Fecher, Leslie A.; Gomez, Cyndi Gonzalez; Hayes-Lattin, Brandon; Glover, Michael J.; Shah, Sumit A.; Gopalakrishnan, Dharmesh; Griffiths, Elizabeth A.; Kwon, Daniel H.; Koshkin, Vadim S.; Mahmood, Sana; Bashir, Babar; Nonato, Taylor; Razavi, Pedram; McKay, Rana R.; Nagaraj, Gayathri; Oligino, Eric; Puc, Matthew; Tregubenko, Polina; Wulff-Burchfield, Elizabeth M.; Xie, Zhuoer; Halfdanarson, Thorvardur R.; Farmakiotis, Dimitrios; Klein, Elizabeth J.; Robilotti, Elizabeth V.; Riely, Gregory J.; Durand, Jean-Bernard; Hayek, Salim S.; Kondapalli, Lavanya; Berg, Stephanie; O'Connor, Timothy E.; Bilen, Mehmet A.; Castellano, Cecilia; Accordino, Melissa K.; Sibel, Blau; Weissmann, Lisa B.; Jani, Chinmay; Flora, Daniel B.; Rudski, Lawrence; Dutra, Miriam Santos; Nathaniel, Bouganim; Ruíz-García, Erika; Vilar-Compte, Diana; Gupta, Shilpa; Morgans, Alicia; and Nohria, Anju, "COVID-19 Severity and Cardiovascular Outcomes in SARS-CoV-2-Infected Patients With Cancer and Cardiovascular Disease" (2023). Kimmel Cancer Center Faculty Papers. Paper 107.
https://jdc.jefferson.edu/kimmelccfp/107
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
PubMed ID
37302348
Language
English
Comments
This article is the author's final published version in Translational Oncology, Volume 34, August 2023, Article number 101709.
The published version is available at https://doi.org/10.1016/j.tranon.2023.101709. Copyright © 2023 Published by Elsevier Inc.