Document Type
Article
Publication Date
4-20-2023
Abstract
Cytokines are a vital component of the immune system that controls the activation and growth of blood cells. However, chronic overexpression of cytokines can trigger cellular events leading to malignant transformation. The cytokine interleukin-15 (IL-15) is of particular interest, which has been shown to contribute to the development and progression of various hematological malignancies. This review will provide an overview of the impact of the immunopathogenic function of IL-15 by studying its role in cell survival, proliferation, inflammation, and treatment resistance. We will also review therapeutic approaches for inhibiting IL-15 in blood cancers.
Recommended Citation
Sindaco, Paola; Pandey, Hritisha; Isabelle, Colleen; Chakravarti, Nitin; Brammer, Jonathan Edward; Porcu, Pierluigi; and Mishra, Anjali, "The Role of Interleukin-15 in the Development and Treatment of Hematological Malignancies" (2023). Kimmel Cancer Center Faculty Papers. Paper 101.
https://jdc.jefferson.edu/kimmelccfp/101
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
37153603
Language
English
Comments
This article, first published by Frontiers Media, is the author's final published version in Frontiers in Immunology, Volume 14, 2023, Pages 1141208.
The published version is available at https://doi.org/10.3389/fimmu.2023.1141208.
Copyright © 2023 Sindaco, Pandey, Isabelle, Chakravarti, Brammer, Porcu and Mishra
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