Conversion of Intermediate LIRADS Categories to Hepatocellular Carcinoma in patients with Chronic Hepatitis B: Korean Immigrant Experience
Kofi-Buaku Atsina, MD; Zhenteng Li, MD; and Sandeep Deshmukh, MD
Introduction and Objective
The Liver Imaging Reporting and Data System (LIRADS) was created to standardize the reporting and data collection of MR imaging for hepatocellular carcinoma (HCC) in high risk patients. The major categories for LIRADS have the following descriptors:
LI-RADS 1 = Definitely benign
LI-RADS 2 = Probably benign
LI-RADS 3 = Intermediate probability for HCC
LI-RADS 4 = Probably HCC
LI-RADS 5 = Definitely HCC
LI-RADS 5V = Definitely HCC with tumor in vein
LI-RADS M = Probable malignancy, not specific for HCC
LI-RADS T = Treated Observation
However, there is a paucity of quantitative evidence for the progression of LIRADS 2, 3 and 4, (hereafter defined as intermediate LIRADS categories) to LIRADS 5. Our objective was to investigate the conversion of intermediate LIRADS categories to definite hepatocellular carcinoma (LIRADS 5) to help inform management decisions regarding treatment and better stratify imaging follow up for high-risk patients with intermediate LIRADS categories.
Poster presented at: SCBT-MR in Salt Lake City, Utah.
Annemarie Daecher, Flemming Forsberg, and John R. Eisenbrey
Many infectious diseases are most transmittable when the carrier is presenting with fever. We propose a disposable face mask that changes color as an indicator of fever to provide hospitals with a quick and inexpensive method for triaging infected patients while limiting exposure to others. Two blue thermochromatic dyes which transition to white at 89°F and 92°F were mixed with white paint and applied to 5 types of disposable face masks. During trials, a wearer either sat at rest or ran on a treadmill for 20 minutes and images were obtained every 5 minutes with a thermal camera to record surface body temperature. At rest there was no change in body temperature or in mask color. After 20 minutes of running, a 5°F increase in surface body temperature was measured. Only the mask created with the 89°F dye showed a color transition with large white areas apparent post-run. This indicates the ability of thermochromatic masks to measure body temperature and potentially identify febrile patients.
Pulse Shaping for Improved Diagnosis of Portal Hypertension Using Subharmonic Aided Pressure Estimation
Ipshita Gupta, John R. Eisenbrey, Maria Stanczak, Anush Sridharan, Jaydev K. Dave, Ji-Bin Liu, Christopher Hazard, Colette Shaw, Susan Shamini-Noori, Jonathan M. Fenkel, Michael Soluen, Chandra Sehgal, Kirk Wallace, and Flemming Forsberg
Subharmonic aided pressure estimation (SHAPE) is based on the inverse relationship between the subharmonic amplitude of contrast microbubbles (obtained by transmitting at the fundamental frequency fo and receiving at fo/2) and the ambient pressure (see fig.1).
A noninvasive ultrasound based pressure estimation procedure would be a major development in the diagnosis of portal hypertension and less invasive than the current catheter-based hepatic venous pressure gradient (HVPG) measurement.
The hypothesis of this study was that portal vein pressures can be monitored and quantified noninvasively in humans using SHAPE.
First selected waveforms were optimized in vitro and in canines, then SHAPE was correlated with measured HVPG in patients undergoing a transjugular liver biopsy (TJLB).
Four-Dimensional (4D) Subharmonic Aided Pressure Estimation for Monitoring Neoadjuvant Chemotherapy Response of Breast Cancer
Kibo Nam, Maria Stanczak, Anush Sridharan, Adam C. Berger, Tiffany Avery, John R. Eisenbrey, and Flemming Forsberg
Neoadjuvant chemotherapy is a well-established treatment option for patients with non-metastatic breast cancer. The patient response is correlated with survival. However, the optimal method for monitoring neoadjuvant therapy response has not been established. One factor that may affect the response of neoadjuvant therapy is the interstitial fluid pressure (IFP). Increased IFP prevents an effective delivery of therapeutic agents and reduces the efficacy of the therapy. Recently, subharmonic-aided pressure estimation (SHAPE) using contrast-enhanced ultrasound (CEUS) has been developed and its potential was demonstrated in animals as a non-invasive technique for IFP measurements. The SHAPE method estimates IFP based on the inverse relationship between the subharmonic signal magnitude from CEUS and IFP. The purpose of this study was to determine if 4D SHAPE can predict the response of breast cancer to neoadjuvant chemotherapy.
Poster presented at International Ultrasonics Symposium in Tours France.