Pulse Shaping for Improved Diagnosis of Portal Hypertension Using Subharmonic Aided Pressure Estimation

Authors

Ipshita Gupta, Thomas Jefferson UniversityFollow
John R. Eisenbrey, Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USAFollow
Maria Stanczak, Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107Follow
Anush Sridharan, Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107Follow
Jaydev K. Dave, Thomas Jefferson UniversityFollow
Ji-Bin Liu, Thomas Jefferson UniversityFollow
Christopher Hazard, University of Pennsylvania
Colette Shaw, Thomas Jefferson UniversityFollow
Susan Shamini-Noori, Thomas Jefferson UniversityFollow
Jonathan M. Fenkel, Thomas Jefferson UniversityFollow
Michael Soluen, Thomas Jefferson University
Chandra Sehgal, University of Pennsylvania
Kirk Wallace, GE Global Research, Niskayuna, NYFollow
Flemming Forsberg, Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USAFollow

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Description

Subharmonic aided pressure estimation (SHAPE) is based on the inverse relationship between the subharmonic amplitude of contrast microbubbles (obtained by transmitting at the fundamental frequency fo and receiving at fo/2) and the ambient pressure (see fig.1).

A noninvasive ultrasound based pressure estimation procedure would be a major development in the diagnosis of portal hypertension and less invasive than the current catheter-based hepatic venous pressure gradient (HVPG) measurement.

The hypothesis of this study was that portal vein pressures can be monitored and quantified noninvasively in humans using SHAPE.

First selected waveforms were optimized in vitro and in canines, then SHAPE was correlated with measured HVPG in patients undergoing a transjugular liver biopsy (TJLB).

Publication Date

10-28-2016

Disciplines

Gastroenterology | Medicine and Health Sciences | Radiology

Comments

Poster presented at 6th Regional Translational Research inMitochondria, Aging, and Disease (TriMAD2016) in Philadelphia PA.

Recommended Citation

Gupta, Ipshita; Eisenbrey, John R.; Stanczak, Maria; Sridharan, Anush; Dave, Jaydev K.; Liu, Ji-Bin; Hazard, Christopher; Shaw, Colette; Shamini-Noori, Susan; Fenkel, Jonathan M.; Soluen, Michael; Sehgal, Chandra; Wallace, Kirk; and Forsberg, Flemming, "Pulse Shaping for Improved Diagnosis of Portal Hypertension Using Subharmonic Aided Pressure Estimation" (2016). Department of Radiology Posters. 4.
https://jdc.jefferson.edu/radiologyposters/4