Four-Dimensional (4D) Subharmonic Aided Pressure Estimation for Monitoring Neoadjuvant Chemotherapy Response of Breast Cancer

Authors

Kibo Nam, Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107Follow
Maria Stanczak, Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107Follow
Anush Sridharan, Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107Follow
Adam C. Berger, Department of Surgery, Thomas Jefferson UniversityFollow
Tiffany Avery, Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107Follow
John R. Eisenbrey, Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USAFollow
Flemming Forsberg, Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USAFollow

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Description

Introduction

Neoadjuvant chemotherapy is a well-established treatment option for patients with non-metastatic breast cancer. The patient response is correlated with survival. However, the optimal method for monitoring neoadjuvant therapy response has not been established. One factor that may affect the response of neoadjuvant therapy is the interstitial fluid pressure (IFP). Increased IFP prevents an effective delivery of therapeutic agents and reduces the efficacy of the therapy. Recently, subharmonic-aided pressure estimation (SHAPE) using contrast-enhanced ultrasound (CEUS) has been developed and its potential was demonstrated in animals as a non-invasive technique for IFP measurements. The SHAPE method estimates IFP based on the inverse relationship between the subharmonic signal magnitude from CEUS and IFP. The purpose of this study was to determine if 4D SHAPE can predict the response of breast cancer to neoadjuvant chemotherapy.

Poster presented at International Ultrasonics Symposium in Tours France.

Publication Date

9-19-2016

Keywords

Four-Dimensional (4D) Subharmonic Aided Pressure Estimation for Monitoring Neoadjuvant Chemotherapy Response of Breast Cancer

Disciplines

Oncology | Radiology | Surgery

Recommended Citation

Nam, Kibo; Stanczak, Maria; Sridharan, Anush; Berger, Adam C.; Avery, Tiffany; Eisenbrey, John R.; and Forsberg, Flemming, "Four-Dimensional (4D) Subharmonic Aided Pressure Estimation for Monitoring Neoadjuvant Chemotherapy Response of Breast Cancer" (2016). Department of Radiology Posters. 2.
https://jdc.jefferson.edu/radiologyposters/2