- Lung endothelial dysfunction in DIO mice coincides with increased endoplasmic reticulum (ER) stress.
- Fatty acids in obese serum induce ER stress in the pulmonary endothelium leading to pulmonary endothelial cell dysfunction.
- Reducing protein load in the endoplasmic reticulum of pulmonary endothelial cells might protect against ARDS in obese individuals.
Shah, Dilip; Romero, Freddy; Guo, Zhi; Sun, Jianxin; Li, Jonathan C.; Kallen, Caleb; Naik, Ulhas P.; and Summer, Ross, "Obesity-induced Endoplasmic Reticulum Stress Causes Lung Endothelial Dysfunction and Promotes Acute Lung Injury" (2017). Center for Translational Medicine Faculty Papers. Paper 53.