Obesity-induced Endoplasmic Reticulum Stress Causes Lung Endothelial Dysfunction and Promotes Acute Lung Injury

Authors

Dilip Shah, Thomas Jefferson UniversityFollow
Freddy Romero, Thomas Jefferson UniversityFollow
Zhi Guo, Thomas Jefferson University
Jianxin Sun, Thomas Jefferson UniversityFollow
Jonathan C. Li, Thomas Jefferson UniversityFollow
Caleb Kallen, Thomas Jefferson UniversityFollow
Ulhas P. Naik, Thomas Jefferson UniversityFollow
Ross Summer, Thomas Jefferson UniversityFollow

Document Type

Poster

Publication Date

4-17-2017

Comments

Presented at the 2017 AOA Research Symposium

Abstract

Conclusion

• Lung endothelial dysfunction in DIO mice coincides with increased endoplasmic reticulum (ER) stress.
• Fatty acids in obese serum induce ER stress in the pulmonary endothelium leading to pulmonary endothelial cell dysfunction.
• Reducing protein load in the endoplasmic reticulum of pulmonary endothelial cells might protect against ARDS in obese individuals.

Recommended Citation

Shah, Dilip; Romero, Freddy; Guo, Zhi; Sun, Jianxin; Li, Jonathan C.; Kallen, Caleb; Naik, Ulhas P.; and Summer, Ross, "Obesity-induced Endoplasmic Reticulum Stress Causes Lung Endothelial Dysfunction and Promotes Acute Lung Injury" (2017). Center for Translational Medicine Faculty Papers. Paper 53.
https://jdc.jefferson.edu/transmedfp/53

Language

English