Mitochondrial Ca(2+) uptake is crucial for an array of cellular functions while an imbalance can elicit cell death. In this chapter, we briefly reviewed the various modes of mitochondrial Ca(2+) uptake and our current understanding of mitochondrial Ca(2+) homeostasis in regards to cell physiology and pathophysiology. Further, this chapter focuses on the molecular identities, intracellular regulators as well as the pharmacology of mitochondrial Ca(2+) uniporter complex.
Recommended CitationMishra, Jyotsna; Jhun, Bong Sook; Hurst, Stephen; O-Uchi, Jin; Csordás, György; and Sheu, Shey-Shing, "The Mitochondrial Ca(2+) Uniporter: Structure, Function, and Pharmacology." (2017). Center for Translational Medicine Faculty Papers. Paper 44.