The Mitochondrial Ca(2+) Uniporter: Structure, Function, and Pharmacology.

Authors

Jyotsna Mishra, Thomas Jefferson UniversityFollow
Bong Sook Jhun, Warren Alpert Medical School of Brown UniversityFollow
Stephen Hurst, Thomas Jefferson UniversityFollow
Jin O-Uchi, Warren Alpert Medical School of Brown University
György Csordás, Thomas Jefferson UniversityFollow
Shey-Shing Sheu, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

1-1-2017

Comments

This article has been peer reviewed. It is the authors' final version prior to publication in Handbook of Experimental Pharmacology

Volume 240, February 2017

The published version is available at DOI: 10.1007/164_2017_1 Copyright © Springer International Publishing Switzerland

Abstract

Mitochondrial Ca(2+) uptake is crucial for an array of cellular functions while an imbalance can elicit cell death. In this chapter, we briefly reviewed the various modes of mitochondrial Ca(2+) uptake and our current understanding of mitochondrial Ca(2+) homeostasis in regards to cell physiology and pathophysiology. Further, this chapter focuses on the molecular identities, intracellular regulators as well as the pharmacology of mitochondrial Ca(2+) uniporter complex.

Recommended Citation

Mishra, Jyotsna; Jhun, Bong Sook; Hurst, Stephen; O-Uchi, Jin; Csordás, György; and Sheu, Shey-Shing, "The Mitochondrial Ca(2+) Uniporter: Structure, Function, and Pharmacology." (2017). Center for Translational Medicine Faculty Papers. Paper 44.
https://jdc.jefferson.edu/transmedfp/44

PubMed ID

28194521