Document Type
Article
Publication Date
9-30-2024
Abstract
PURPOSE: Recent research has highlighted the mechanotransducer PIEZO2 as a crucial factor in lower urinary tract function, demonstrating associations with bladder compliance (BC), bladder wall thickening, and elevated bladder pressure. We explored the hypothesis that PIEZO2 expression may be associated with lower urinary tract dysfunction in men with bladder outlet obstruction (BOO) due to benign prostatic hyperplasia (BPH).
METHODS: The study included a consecutive series of patients undergoing open prostatectomy for BPH at our hospital between September 2014 and January 2016. All participants underwent comprehensive preoperative evaluations, including urodynamic assessments. During prostatectomy, a full-thickness fragment of the bladder wall was obtained for subsequent PIEZO2 gene expression analysis. Cadaveric organ donors served as the control group.
RESULTS: PIEZO2 expression was downregulated in the detrusor muscle of men with BPH compared to the control group. Among patients with BPH, those experiencing urinary retention and requiring an indwelling catheter exhibited significantly lower PIEZO2 messenger RNA (mRNA) expression than patients capable of spontaneous voiding. PIEZO2 mRNA expression was similar in men with and without detrusor overactivity. Additionally, a positive correlation was found between PIEZO2 mRNA expression levels and BC.
CONCLUSION: Our findings indicate that PIEZO2 is downregulated in the detrusor muscle of men with BPH, particularly in those experiencing urinary retention and those with reduced BC. These results suggest a potential role for PIEZO2 in BOOinduced bladder dysfunction. Further research is required to clarify the role of PIEZO mechanotransducers in the bladder and to explore their therapeutic implications.
Recommended Citation
Bellucci, Carlos Henrique Suzuki; Hemerly, Thiago Souto; Tenório de Albuquerque, Luisa Resende; Pimenta, Ruan; Schreiter, Vanessa Guimaraes; dos Reis, Sabrina Thalita; de Bessa, Jose Jr; Leite, Katia Ramos Moreira; Antunes, Alberto; Ettickan, Boopathi; Nahas, William C.; and Gomes, Cristiano Mendes, "Downregulation of PIEZO2 in the Detrusor of Men With Bladder Outlet Obstruction and Its Association With Urinary Retention and Decreased Bladder Compliance" (2024). Center for Translational Medicine Faculty Papers. Paper 123.
https://jdc.jefferson.edu/transmedfp/123
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
PubMed ID
39363413
Language
English
Comments
This article is the author's final published version in International Neurourology Journal, Volume 28, Issue 3, September 2024, Pages 225 - 231.
The published version is available at https://doi.org/10.5213/inj.2448298.149. Copyright © 2024 Korean Continence Society.