Andrew Gerry, Charita Kunta, Noelle Francois, Tiziana DeAngelis, Anuradha Shastri, Nicole Simone, and Reza Taleei
- Radiation-induced pulmonary fibrosis (RIPF) is a frequent outcome of thoracic radiation therapy, constraining safe tumor radiation dosage. Various animal models, such as mice, rats, and pigs, have been devised to study RIPF
- Current methods for inducing lung fibrosis in mice involve whole lung irradiation with doses between 2-20 Gy. These methods used fixed anterior and posterior (AP/PA) x-ray beams at 0º and 180º with analysis typically commencing 24 to 52 weeks post-radiation
- Current methods are unrepresentative of modern radiation therapy techniques and are limited by the associated long latency of RIPF
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