Inducing Accelerated Lung Toxicity in Mice Using a Partial Arc SBRT Technique

Authors

Andrew Gerry, Thomas Jefferson UniversityFollow
Charita Kunta, Thomas Jefferson University
Noelle Francois, Thomas Jefferson UniversityFollow
Tiziana DeAngelis, Thomas Jefferson University
Anuradha Shastri, Thomas Jefferson UniversityFollow
Nicole Simone, Thomas Jefferson UniversityFollow
Reza Taleei, Thomas Jefferson UniversityFollow

Files

Description

Background

• Radiation-induced pulmonary fibrosis (RIPF) is a frequent outcome of thoracic radiation therapy, constraining safe tumor radiation dosage. Various animal models, such as mice, rats, and pigs, have been devised to study RIPF
• Current methods for inducing lung fibrosis in mice involve whole lung irradiation with doses between 2-20 Gy. These methods used fixed anterior and posterior (AP/PA) x-ray beams at 0º and 180º with analysis typically commencing 24 to 52 weeks post-radiation
• Current methods are unrepresentative of modern radiation therapy techniques and are limited by the associated long latency of RIPF

Publication Date

8-28-2023

Keywords

accelerated lung toxicity, radiation

Disciplines

Medicine and Health Sciences | Oncology | Radiation Medicine

Comments

Presented at the 2023 17th International Congress for Radiation Research.

Recommended Citation

Gerry, Andrew; Kunta, Charita; Francois, Noelle; DeAngelis, Tiziana; Shastri, Anuradha; Simone, Nicole; and Taleei, Reza, "Inducing Accelerated Lung Toxicity in Mice Using a Partial Arc SBRT Technique" (2023). Department of Radiation Oncology Posters. 1.
https://jdc.jefferson.edu/radoncposters/1