Can Low-Dose Radiation Therapy (LD-RT) Aid in Chronic Subdural Hematoma (cSDH) Management? Literature Review and Proposed Clinical Trial Design

Authors

Ryan Shah, BS, Thomas Jefferson UniversityFollow
Nilanjan Haldar, MD, Thomas Jefferson UniversityFollow
Debanjan Haldar, MD, Thomas Jefferson UniversityFollow
Keenan Piper, MD, Thomas Jefferson UniversityFollow
Wenyin Shi, MD, PhD, Thomas Jefferson UniversityFollow
Pascal Jabbour, MD, Thomas Jefferson UniversityFollow

Files

Description

Introduction + Methods

• Chronic subdural hematoma (cSDH) is a common neurosurgical condition, complicated by high rates of hematoma recurrence.
• There is growing interest in less invasive management options for primary and adjunctive treatment, such as middle meningeal artery embolization (MMAE).
• Low-dose radiation therapy (LD-RT) is an emerging noninvasive treatment for a range of inflammatory conditions, raising the question of whether LD-RT could benefit cSDH patients.
• Literature review was conducted to describe cSDH pathophysiology, the therapeutic mechanisms of LD-RT, and any clinical evidence supporting the efficacy of LD-RT for cSDH.
• Based on these findings, a randomized controlled trial design and LD-RT regimen were proposed to evaluate safety and efficacy.

Publication Date

9-9-2025

Keywords

radiation, chronic subdural hematoma

Disciplines

Medicine and Health Sciences | Oncology

Comments

Presented at the 2025 Department of Radiation Oncology Research Symposium.

Recommended Citation

Shah, BS, Ryan; Haldar, MD, Nilanjan; Haldar, MD, Debanjan; Piper, MD, Keenan; Shi, MD, PhD, Wenyin; and Jabbour, MD, Pascal, "Can Low-Dose Radiation Therapy (LD-RT) Aid in Chronic Subdural Hematoma (cSDH) Management? Literature Review and Proposed Clinical Trial Design" (2025). Department of Radiation Oncology Posters. 6.
https://jdc.jefferson.edu/radoncposters/6