Integrating Ki-67 and Treatment Strategies to Guide Prognosis in High-Grade Meningiomas: A Multivariable Analysis of Prognostic Factors in WHO Grade II/III Meningiomas

Authors

Anthony Chen, Thomas Jefferson UniversityFollow
Aneesh Reddy, Thomas Jefferson UniversityFollow
Toren Ikea-Mario, Thomas Jefferson UniversityFollow
Shray Jain, Thomas Jefferson UniversityFollow
Zhenghao Xiao, Thomas Jefferson UniversityFollow
Nilanjan Haldar, MD, Thomas Jefferson UniversityFollow
James J. Evans, MD, Thomas Jefferson UniversityFollow
Wenyin Shi, MD, PhD, Thomas Jefferson UniversityFollow

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Description

Introduction

• High-grade meningiomas (WHO Grade II/III) are associated with high recurrence rates and poor survival despite aggressive therapy
• Adjuvant radiotherapy’s (RT) benefit after gross total resection (GTR) remains uncertain and histopathologic markers such as Ki-67 may further refine risk stratification and inform postoperative management
• AIM: to identify the role of RT and clinicopathologic predictors of local failure-free survival (LFFS) and overall survival (OS) in high-grade meningiomas

Publication Date

9-9-2025

Keywords

meningioma, stereotactic radiosurgery, adjuvant radiotherapy, neurosurgery, radiation oncology

Disciplines

Medicine and Health Sciences | Oncology

Comments

Presented at the 2025 Department of Radiation Oncology Research Symposium.

Recommended Citation

Chen, Anthony; Reddy, Aneesh; Ikea-Mario, Toren; Jain, Shray; Xiao, Zhenghao; Haldar, MD, Nilanjan; Evans, MD, James J.; and Shi, MD, PhD, Wenyin, "Integrating Ki-67 and Treatment Strategies to Guide Prognosis in High-Grade Meningiomas: A Multivariable Analysis of Prognostic Factors in WHO Grade II/III Meningiomas" (2025). Department of Radiation Oncology Posters. 5.
https://jdc.jefferson.edu/radoncposters/5