Document Type
Article
Publication Date
12-2-2024
Abstract
BACKGROUND: The role of adult adiposity in young-onset breast cancer (YOBC) subtype risk is not well understood.
METHODS: In this population-based case (n = 1812)-control (n = 1,381) study of invasive YOBC (ages <50 >years), cases were identified from the Los Angeles County and Metropolitan Detroit Surveillance, Epidemiology, and End Results registries, 2010 to 2015. Area-based, frequency-matched controls were sampled from the 2010 Census. General adiposity [body mass index (BMI)] and central adiposity (waist circumference and waist-to-height ratio) across adulthood and covariates were collected from in-person interviews and measurements. ORs and 95% confidence intervals (CI) for adiposity and YOBC tumor subtypes [i.e., luminal A, luminal B, HER2+, and triple negative (TN)] were calculated, overall and by parity, using multivariable weighted logistic regression.
RESULTS: Obese young adult BMI was inversely associated with luminal A YOBC (OR = 0.35, 95% CI, 0.16-0.79); other subtype associations were nonsignificant. Similarly, adult overweight and obese BMIs were inversely associated with luminal A (OR = 0.66, 95% CI, 0.48-0.91 and OR = 0.59, 95% CI, 0.46-0.87, respectively), but not other subtypes. Conversely, larger waist circumference was associated with higher odds of luminal B and TN YOBC (OR = 1.48, 95% CI, 1.01-2.15 and OR = 2.48, 95% CI, 1.52-3.88, respectively), but not other subtypes (with similar results for weight-to-height ratio); highest odds were among parous women.
CONCLUSIONS: Findings show greater general adult adiposity is associated with reduced odds of luminal A YOBC, whereas greater central adiposity is associated with increased odds of luminal B and TN YOBC, particularly among parous women.
IMPACT: Additional studies of central adiposity and YOBC subtype risk, especially incorporating pregnancy history, are warranted.
Recommended Citation
Marcus Post, Lydia; Pathak, Dorothy R.; Hamilton, Ann S.; Hirko, Kelly A.; Houang, Richard T.; Guseman, Emily H.; Sanfelippo, Dan; Bohme Carnegie, Nicole; Olson, L. Karl; Rui, Hallgeir; Schwartz, Ann G.; and Velie, Ellen M., "Adiposity throughout Adulthood and Risk of Young-Onset Breast Cancer Tumor Subtypes in the Young Women's Health History Study" (2024). Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers. Paper 30.
https://jdc.jefferson.edu/ppcbfp/30
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
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Language
English
Included in
Biochemical Phenomena, Metabolism, and Nutrition Commons, Cancer Biology Commons, Neoplasms Commons, Women's Health Commons
Comments
This article is the author's final published version in Cancer Epidemiology Biomarkers and Prevention, Volume 33, Issue 12, December 2024, Pages 1659 - 1670.
The published version is available at https://doi.org/10.1158/1055-9965.EPI-24-1067.
Copyright © 2024 The Authors