Document Type
Article
Publication Date
8-16-2024
Abstract
Vagal innervation is well known to be crucial to the maintenance of cardiac health, and to protect and recover the heart from injury. Only recently has this role been shown to depend on the activity of the underappreciated dorsal motor nucleus of the vagus (DMV). By combining neural tracing, transcriptomics, and anatomical mapping in male and female Sprague-Dawley rats, we characterize cardiac-specific neuronal phenotypes in the DMV. We find that the DMV cardiac-projecting neurons differentially express pituitary adenylate cyclase-activating polypeptide (PACAP), cocaine- and amphetamine-regulated transcript (CART), and synucleins, as well as evidence that they participate in neuromodulatory co-expression involving catecholamines. The significance of these findings is enhanced by previous knowledge of the role of PACAP at the heart and of the other neuromodulators in peripheral vagal targets.
Recommended Citation
Hornung, Eden; Robbins, Shaina; Srivastava, Ankita; Achanta, Sirisha; Chen, Jin; Cheng, Zixi Jack; Schwaber, James; and Vadigepalli, Rajanikanth, "Neuromodulatory Co-expression in Cardiac Vagal Motor Neurons of the Dorsal Motor Nucleus of the Vagus" (2024). Department of Pathology, Anatomy, and Cell Biology Faculty Papers. Paper 421.
https://jdc.jefferson.edu/pacbfp/421
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Language
English
Comments
This article is the author's final published version in iScience, Volume 27, Issue 8, August 2024, Article number 110549.
The published version is available at https://doi.org/10.1016/j.isci.2024.110549.
Copyright © 2024 The Authors. Published by Elsevier Inc.