Document Type

Response or Comment

Publication Date

March 2007


This article has been peer reviewed. It is the author's final version prior to publication in Nature Cell Biology 9(3):247-249, March 2007. The published version is available at, copyright © 2007 by Nature Publishing Group.

It is a comment on Santos SD, Verveer PJ, Bastiaens PI. Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nature Cell Biology 9(3):324-30, March 2007.


Mitogen-activated protein kinase (MAPK) cascades process myriads of stimuli, generating receptor-specific cellular outcomes. New work exploits emergent mathematics of network inference to reveal distinct feedback designs of the RAF/MEK/ERK cascade induced by two different growth factors. It shows that response specificity can arise from differential signal-induced wiring of overlapping protein networks.