Response or Comment
Mitogen-activated protein kinase (MAPK) cascades process myriads of stimuli, generating receptor-specific cellular outcomes. New work exploits emergent mathematics of network inference to reveal distinct feedback designs of the RAF/MEK/ERK cascade induced by two different growth factors. It shows that response specificity can arise from differential signal-induced wiring of overlapping protein networks.
Kholodenko, Boris N. PhD, DSci, "Untangling the signalling wires" (2007). Department of Pathology, Anatomy, and Cell Biology Faculty Papers. Paper 17.