Phylogenetic Tree Construction and “Truncal Loss” Analysis Reveal Hidden Associations Between Loss of Protein Expression in SWI/SNF Complex Components and Tumor Stage and Survival in Clear Cell Renal Cell Carcinoma (CCRCC)

Authors

Wei Jiang, MD, PhD, Thomas Jefferson UniversityFollow
Essel Dulaimi, Fox Chase Cancer Center/Temple UniversityFollow
Karthik Devarajan, ox Chase Cancer Center/Temple UniversityFollow
Qiong Wang, Thomas Jefferson UniversityFollow
Raymond O'Neill, Thomas Jefferson UniversityFollow
Charalambos C. Solomides, MD, Thomas Jefferson University HospitalFollow
Stephen C Peiper, PhD, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of AmericaFollow
Robert Uzzo, Fox Chase Cancer Center/Temple UniversityFollow
Joseph R. Testa, 2Fox Chase Cancer Center/Temple UniversityFollow
Haifeng Yang, PhD, Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of AmericaFollow

Document Type

Poster

Publication Date

4-20-2015

Abstract

Background

Polybromo-1 (PBRM1), a targeting subunit of the SWI/SNF chromatin remodeling complex, is mutated at a rate of ~40% in clear cell Renal Cell Carcinoma (ccRCC), second only to VHL. Whether its mutation is correlated with tumor stage is controversial. As other components of the SWI/SNF complex were also reported to be mutated in ccRCC, we aim to examine the protein expression patterns of PBRM1, ARID1A, BRG1, and BRM in ccRCC, and to investigate possible association between their loss of expression and tumor stage, as well as survival. We also included a histone modifier, SETD2, which is recently discovered to be mutated in ~15% of ccRCC.

Recommended Citation

Jiang, MD, PhD, Wei; Dulaimi, Essel; Devarajan, Karthik; Wang, Qiong; O'Neill, Raymond; Solomides, MD, Charalambos C.; Peiper, PhD, Stephen C; Uzzo, Robert; Testa, Joseph R.; and Yang, PhD, Haifeng, "Phylogenetic Tree Construction and “Truncal Loss” Analysis Reveal Hidden Associations Between Loss of Protein Expression in SWI/SNF Complex Components and Tumor Stage and Survival in Clear Cell Renal Cell Carcinoma (CCRCC)" (2015). Department of Pathology, Anatomy, and Cell Biology Faculty Papers. Paper 160.
https://jdc.jefferson.edu/pacbfp/160