Start Date
4-16-2024 3:45 PM
End Date
4-16-2024 4:45 PM
Description
Abstract
The healing of a bone fracture is a complex, multistage process consisting of inflammation in the local tissue, angiogenesis, callus formation, and eventually, remodeling and restoration of the bone to its original morphology. It is estimated that 5-10% of fractures do not heal properly and exhibit non-union of the fractured bone segments, with long-term complications compared to properly healed fractures. There is great clinical benefit in the ability to have early detection of impending non-union fractures, and diagnostic ultrasound can be used to image formation of the callus in a healing fracture through the use of different imaging modes. Superb microvascular imaging (SMI) is a new microvascular flow imaging mode and represents this information as a color overlay image or as a grayscale map of flow, named cSMI and mSMI, respectively. Shear wave elastography (SWE) is a technique for measuring tissue stiffness noninvasively. X-ray imaging is the standard for imaging fractures, and dual-energy X-ray absorptiometry (DXA) measures bone mineral density. This study investigated methods of evaluating the bone fracture healing process using Doppler flow imaging, cSMI, mSMI, and SWE, relative to X-ray, DXA and CD-31 stains in a rabbit model. The standard of care for evaluation of fracture healing is based solely on callus formation, but ultrasound has the ability to document inflammation and angiogenesis to predict patients at risk for delayed or non-union healing.
Included in
Evaluating Bone Fracture Healing Utilizing Doppler Imaging Modes, Shear Wave Elastography, X-Ray and Dual-Energy X-Ray Absorptiometry in a Rabbit Model
Abstract
The healing of a bone fracture is a complex, multistage process consisting of inflammation in the local tissue, angiogenesis, callus formation, and eventually, remodeling and restoration of the bone to its original morphology. It is estimated that 5-10% of fractures do not heal properly and exhibit non-union of the fractured bone segments, with long-term complications compared to properly healed fractures. There is great clinical benefit in the ability to have early detection of impending non-union fractures, and diagnostic ultrasound can be used to image formation of the callus in a healing fracture through the use of different imaging modes. Superb microvascular imaging (SMI) is a new microvascular flow imaging mode and represents this information as a color overlay image or as a grayscale map of flow, named cSMI and mSMI, respectively. Shear wave elastography (SWE) is a technique for measuring tissue stiffness noninvasively. X-ray imaging is the standard for imaging fractures, and dual-energy X-ray absorptiometry (DXA) measures bone mineral density. This study investigated methods of evaluating the bone fracture healing process using Doppler flow imaging, cSMI, mSMI, and SWE, relative to X-ray, DXA and CD-31 stains in a rabbit model. The standard of care for evaluation of fracture healing is based solely on callus formation, but ultrasound has the ability to document inflammation and angiogenesis to predict patients at risk for delayed or non-union healing.
