Document Type
Article
Publication Date
6-27-2018
Abstract
We developed an innovative biomaterial-based approach to repair the critical neural circuitry that controls diaphragm activation by locally delivering brain-derived neurotrophic factor (BDNF) to injured cervical spinal cord. BDNF can be used to restore respiratory function via a number of potential repair mechanisms; however, widespread BDNF biodistribution resulting from delivery methods such as systemic injection or lumbar puncture can lead to inefficient drug delivery and adverse side effects. As a viable alternative, we developed a novel hydrogel-based system loaded with polysaccharide-BDNF particles self-assembled by electrostatic interactions that can be safely implanted in the intrathecal space for achieving local BDNF delivery with controlled dosing and duration. Implantation of BDNF hydrogel after C4/C5 contusion-type spinal cord injury (SCI) in female rats robustly preserved diaphragm function, as assessed by
Recommended Citation
Ghosh, Biswarup; Wang, Zhicheng; Nong, Jia; Urban, Mark W.; Zhang, Zhiling; Trovillion, Victoria A.; Wright, Megan C.; Zhong, Yinghui; and Lepore, Angelo C., "Local BDNF Delivery to the Injured Cervical Spinal Cord using an Engineered Hydrogel Enhances Diaphragmatic Respiratory Function." (2018). Farber Institute for Neuroscience Faculty Papers. Paper 30.
https://jdc.jefferson.edu/farberneursofp/30
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
PubMed ID
29891731
Language
English
Comments
This article has been peer reviewed. It is the author’s final published version in Journal of Neuroscience, Volume 38, Issue 26, June 2018, Pages 5982-5995.
The published version is available at https://doi.org/10.1523/JNEUROSCI.3084-17.2018. Copyright © Ghosh et al.