Prostate cancer (PrCa) cells crosstalk with the tumour microenvironment by releasing small extracellular vesicles (sEVs). sEVs, as well as large extracellular vesicles (LEVs), isolated via iodixanol density gradients from PrCa cell culture media, express the epithelial-specific αvβ6 integrin, which is known to be induced in cancer. In this study, we show sEV-mediated protein transfer of αvβ6 integrin to microvascular endothelial cells (human microvascular endothelial cells 1 - HMEC1) and demonstrate that
Recommended CitationKrishn, Shiv Ram; Salem, Israa; Quaglia, Fabio; Naranjo, Nicole M; Agarwal, Ekta; Liu, Qin; Sarker, Srawasti; Kopenhaver, Jessica; McCue, Peter A; Weinreb, Paul H; Violette, Shelia M; Altieri, Dario C; and Languino, Lucia R, "The αvβ6 integrin in cancer cell-derived small extracellular vesicles enhances angiogenesis." (2020). Department of Cancer Biology Faculty Papers. Paper 167.
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