In this issue of Cancer Cell, Hydbring and colleagues define a novel class of microRNAs (miRNAs), deemed "cell-cycle-targeting miRNAs," that target several cyclins/CDKs, reduce tumor cell growth, and induce apoptosis. These miRNAs effectively suppressed chemoresistant patient-derived xenograft growth in vivo, and efficacy could be prospectively predicted with an expression-based algorithm.
Schiewer, Matthew J. and Knudsen, Karen E., "Not So Fast: Cultivating miRs as Kinks in the Chain of the Cell Cycle." (2017). Department of Cancer Biology Faculty Papers. Paper 132.