Document Type
Article
Publication Date
December 2007
Abstract
The need for self-protecting polymer or alloy implants resistant to a broad spectrum of bacterial challenges led us to investigate covalent bonding of minocycline (MIN), a tetracycline derivative, to polystyrene beads and to titanium alloy foils by oligoethylene glycol spacers. 9-Hydrazino-acetyl-amido-MIN, and simpler glycylcycline derivatives, retained minimum inhibitory concentration (MIC) against Staphylococcus aureus comparable to MIN. However, PEG-glycyl-amido-MIN showed very low activity. Hence, we coupled 9-hydrazino-acetyl-amido-MIN to the aldehyde termini of oligoethylene glycol spacers bonded to polystyrene and titanium alloy surfaces to form acid-releasable hydrazone linkages. 9-Hydrazino-acetyl-amido-MIN was released from the monolayers more rapidly at pH 5.0 than at pH 7.4.
Recommended Citation
Chen, Chang-po; Zeiger, Allen R.; and Wickstrom, Dr. Eric, "Bactericidal activity of extended 9-glycyl-amido-minocyclines" (2007). Department of Biochemistry and Molecular Biology Faculty Papers. Paper 16.
https://jdc.jefferson.edu/bmpfp/16
Comments
This article has been peer reviewed. It is the authors' final version prior to publication in Bioorganic & Medicinal Chemistry Letters 17(23):6558-6562, December 2007. The published version is available at http://dx.doi.org/10.1016/j.bmcl.2007.09.077; copyright © 2007 Elsevier, Ltd.