Document Type
Article
Publication Date
12-25-2018
Abstract
Young female cancer survival rates significantly increased due to the great progress of cancer therapy. In fact, cryostorage and transplantation of ovarian tissue have already resulted in the birth of healthy babies. Follicle in vitro growth (IVG) has the great potential of restoring fertility by achieving functional oocytes from the most immature stages to maturation. This is suitable for a wide range of patients, from pubertal to perimenopause women. Notable achievements have been achieved in human follicle IVG in the past decade. Mature oocytes have been successfully collected from long-term sequential follicle IVG. However, it is still a major challenge to establish a stable and efficient follicle IVG system able to generate mature and competent oocytes. Hereby, we review the approaches being taken so far using ovarian tissue to support follicle growth at different stages in vitro. © 2019 Reproductve and Developmental Medicine | Published by Wolters Kluwer - Medknow.
Recommended Citation
Marin, Diego; Yang, Min; and Wang, Tianren, "In Vitro growth of human ovarian follicles for fertility preservation" (2018). Department of Biochemistry and Molecular Biology Faculty Papers. Paper 155.
https://jdc.jefferson.edu/bmpfp/155
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.
Language
English
Comments
This article has been peer reviewed. It is the author’s final published version in Reproductive and Developmental Medicine, Volume 2, Issue 4, December 2018, Pages 230-236.
The published version is available at https://doi.org/10.4103/2096-2924.249892. Copyright © Marin et al.