Document Type
Article
Publication Date
6-1-2019
Abstract
Purpose: To assess features and outcomes of Coats disease over 5-decades.
Methods: Retrospective review of Coats disease patients at a single center. Features and outcomes were compared based on decade of presentation.
Results: There were 351 patients with Coats disease. The presenting median age (6 years), male sex (84%), and unilaterality (100%) did not change per decade. Coats disease classification did not change per decade with Stage 1 (1%), Stage 2 (21%), Stage 3 (68%), Stage 4 (6%), and Stage 5 (1%). Clinical features that changed per decade (1970s vs. 1980s vs. 1990s vs. 2000s vs. 2010s) included 1980s features of more eyes with exudation in all 4 quadrants (22% vs. 58% vs. 44% vs. 33% vs. 27, P = 0.01) and total exudative retinal detachment (33% vs. 53% vs. 39% vs. 27% vs. 21%, P < 0.001). Imaging features that changed per decade included 2010s greater fluorescein angiographic extent of retinal non-perfusion in mean clock hours (4 vs. 4 vs. 3 vs. 5 vs. 6, P = 0.003), and 1980s greater mean height of retinal detachment ultrasonographically (5 vs. 12 vs. 5 vs. 5 vs. 4 mm, P < 0.001). Treatment features that changed per decade included 1980s greater primary enucleation (11% vs. 16% vs. 3% vs. 4% vs. 1%, P = 0.001), and 2010s greater use of laser photocoagulation (55% vs. 33% vs. 38% vs. 40% vs. 72%, P < 0.001), sub-Tenon corticosteroid (0% vs. 4% vs. 5% vs. 8% vs. 29%, P < 0.001), and intravitreal anti-VEGF) (0% vs. 4% vs. 2% vs. 13% vs. 18%, P = 0.003). Outcomes that changed per decade included 2010s findings of more complete resolution of subretinal fluid (64% vs. 59% vs. 38% vs. 58% vs. 72%, P = 0.01) and less need for primary/secondary enucleation (17% vs. 27% vs. 14% vs. 13% vs. 6%, P = 0.04).
Conclusion: Eyes with Coats disease in the 1980s demonstrated more advanced findings, often requiring enucleation. Over the decades, greater use of laser photocoagulation and injections has led to improved disease resolution with greater globe salvage.
Recommended Citation
Shields, Carol L.; Udyaver, Sanika; Dalvin, Lauren A.; Lim, Li-Anne S.; Atalay, Hatice T; Khoo, Chloe T.L.; Mazloumi, Mehdi; and Shields, Jerry A., "Coats disease in 351 eyes: Analysis of features and outcomes over 45 years (by decade) at a single center." (2019). Wills Eye Hospital Papers. Paper 96.
https://jdc.jefferson.edu/willsfp/96
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.
PubMed ID
31124485
Language
English
Comments
This article has been peer reviewed. It is the author’s final published version in Indian Journal of Ophthalmology, Volume 67, Issue 6, June 2019, Pages 772-783.
The published version is available at https://doi.org/10.4103/ijo.IJO_449_19. Copyright © Shields et al.