Document Type
Article
Publication Date
7-1-2016
Abstract
Purpose: To determine the sensitivity of the combination of optical coherence tomography angiography (OCTA) and structural optical coherence tomography (OCT) for detecting type 1 neovascularization (NV) and to determine significant factors that preclude visualization of type 1 NV using OCTA.
Methods: Multicenter, retrospective cohort study of 115 eyes from 100 patients with type 1 NV. A retrospective review of fluorescein (FA), OCT, and OCTA imaging was performed on a consecutive series of eyes with type 1 NV from five institutions. Unmasked graders utilized FA and structural OCT data to determine the diagnosis of type 1 NV. Masked graders evaluated FA data alone, en face OCTA data alone and combined en face OCTA and structural OCT data to determine the presence of type 1 NV. Sensitivity analyses were performed using combined FA and OCT data as the reference standard.
Results: A total of 105 eyes were diagnosed with type 1 NV using the reference. Of these, 90 (85.7%) could be detected using en face OCTA and structural OCT. The sensitivities of FA data alone and en face OCTA data alone for visualizing type 1 NV were the same (66.7%). Significant factors that precluded visualization of NV using en face OCTA included the height of pigment epithelial detachment, low signal strength, and treatment-naïve disease (P < 0.05, respectively).
Conclusions: En face OCTA and structural OCT showed better detection of type 1 NV than either FA alone or en face OCTA alone. Combining en face OCTA and structural OCT information may therefore be a useful way to noninvasively diagnose and monitor the treatment of type 1 NV.
Recommended Citation
Inoue, Maiko; Jung, Jesse J.; Balaratnasingam, Chandrakumar; Dansingani, Kunal K.; Dhrami-Gavazi, Elona; Suzuki, Mihoko; de Carlo, Talisa E.; Shahlaee, Abtin; Klufas, Michael A.; El Maftouhi, Adil; Duker, Jay S.; Ho, Allen C.; Maftouhi, Maddalena Quaranta-El; Sarraf, David; and Freund, K. Bailey, "A Comparison Between Optical Coherence Tomography Angiography and Fluorescein Angiography for the Imaging of Type 1 Neovascularization." (2016). Wills Eye Hospital Papers. Paper 58.
https://jdc.jefferson.edu/willsfp/58
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
PubMed ID
27409488
Comments
This article has been peer reviewed. It is the author’s final published version in Investigative Ophthalmology and Visual Science
Volume 57, Issue 9, July 2016, Pages OCT314-OCT323.
The published version is available at DOI: 10.1167/iovs.15-18900 Copyright © Association for Research in Vision and Ophthalmology Inc.