The influence of axial myopia on optic disc characteristics of glaucoma eyes.

Authors

Jasmin Rezapour, Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0946, USA; Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Christopher Bowd, Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0946, USA.
Jade Dohleman, Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0946, USA.
Akram Belghith, Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0946, USA.
James A Proudfoot, Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0946, USA.
Mark Christopher, Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0946, USA.
Leslie Hyman, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.Follow
Jost B Jonas, Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Massimo A Fazio, Department of Ophthalmology and Vision Science, School of Medicine, The University of Alabama At Birmingham, Birmingham, AL, USA.; Department of Biomedical Engineering, School of Engineering, The University of Alabama At Birmingham, Birmingham, AL, USA.
Robert N Weinreb, Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0946, USA.
Linda M Zangwill, Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0946, USA.

Document Type

Article

Publication Date

4-23-2021

Comments

This article is the author's final published version in Scientific Reports, 2021 Apr 23;11(1):8854.

The published version is available at https://doi.org/10.1038/s41598-021-88406-1

Copyright © 2021, The Author(s).

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Abstract

This study characterizes differences in glaucomatous eyes with and without high axial myopia using custom automated analysis of OCT images. 452 eyes of 277 glaucoma patients were stratified into non (n = 145 eyes), mild (n = 214 eyes), and high axial myopia (axial length (AL) > 26 mm, n = 93 eyes). Optic disc ovality index, tilt and rotation angle of Bruch´s membrane opening (BMO) and peripapillary choroidal thickness (PCT) were calculated using automated and deep learning strategies. High myopic optic discs were more oval and had larger BMO tilt than mild and non-myopic discs (both p < 0.001). Mean PCT was thinnest in high myopic eyes followed by mild and non-myopic eyes (p < 0.001). BMO rotation angle, global retinal nerve fiber layer (RNFL) thickness and BMO-minimum rim width (MRW) were similar among groups. Temporal RNFL was thicker and supranasal BMO-MRW was thinner in high myopic eyes. BMO tilt and PCT showed moderate and temporal RNFL and nasal BMO-MRW showed weak but significant associations with AL in multivariable analyses (all p < 0.05). Large BMO tilt angle and thin PCT are characteristics of highly myopic discs and were not associated with severity of glaucoma. Caution should be exercised when using sectoral BMO-MRW and RNFL thickness for glaucoma management decisions in myopic eyes.

Recommended Citation

Rezapour, Jasmin; Bowd, Christopher; Dohleman, Jade; Belghith, Akram; Proudfoot, James A; Christopher, Mark; Hyman, Leslie; Jonas, Jost B; Fazio, Massimo A; Weinreb, Robert N; and Zangwill, Linda M, "The influence of axial myopia on optic disc characteristics of glaucoma eyes." (2021). Wills Eye Hospital Papers. Paper 124.
https://jdc.jefferson.edu/willsfp/124

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

33893383

Language

English