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This article has been peer reviewed. It is the author’s final published version in Frontiers in Endocrinology

Volume 7, July 2016, Article number 100.

The published version is available at DOI: 10.3389/fendo.2016.00100. Copyright © Tanimoto, Lu, Xu, Buraschi, Belfiore, Iozzo and Morrione.


The growth factor progranulin has emerged in recent years as a critical regulator of transformation in several cancer models, including breast cancer, glioblastomas, leukemias, and hepatocellular carcinomas. Several laboratories, including ours, have also demonstrated an important role of progranulin in several genitourinary cancers, including ovarian, endometrial, cervical, prostate, and bladder tumors, where progranulin acts as an autocrine growth factor thereby modulating motility and invasion of transformed cells. In this review, we will focus on the mechanisms of action and regulation of progranulin signaling in genitourinary cancers with a special emphasis on prostate and bladder tumors.

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Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

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