Mechanisms of Progranulin Action and Regulation in Genitourinary Cancers.

Authors

Ryuta Tanimoto, Thomas Jefferson UniversityFollow
Kuojung G Lu, Thomas Jefferson UniversityFollow
Shi-Qiong Xu, Thomas Jefferson UniversityFollow
Simone Buraschi, Thomas Jefferson UniversityFollow
Antonino Belfiore, University Magna Graecia of CatanzaroFollow
Renato V. Iozzo, Thomas Jefferson UniversityFollow
Andrea Morrione, Thomas Jefferson UniversityFollow

Document Type

Article

Publication Date

7-27-2016

Comments

This article has been peer reviewed. It is the author’s final published version in Frontiers in Endocrinology

Volume 7, July 2016, Article number 100.

The published version is available at DOI: 10.3389/fendo.2016.00100. Copyright © Tanimoto, Lu, Xu, Buraschi, Belfiore, Iozzo and Morrione.

Abstract

The growth factor progranulin has emerged in recent years as a critical regulator of transformation in several cancer models, including breast cancer, glioblastomas, leukemias, and hepatocellular carcinomas. Several laboratories, including ours, have also demonstrated an important role of progranulin in several genitourinary cancers, including ovarian, endometrial, cervical, prostate, and bladder tumors, where progranulin acts as an autocrine growth factor thereby modulating motility and invasion of transformed cells. In this review, we will focus on the mechanisms of action and regulation of progranulin signaling in genitourinary cancers with a special emphasis on prostate and bladder tumors.

Recommended Citation

Tanimoto, Ryuta; Lu, Kuojung G; Xu, Shi-Qiong; Buraschi, Simone; Belfiore, Antonino; Iozzo, Renato V.; and Morrione, Andrea, "Mechanisms of Progranulin Action and Regulation in Genitourinary Cancers." (2016). Department of Urology Faculty Papers. Paper 33.
https://jdc.jefferson.edu/urologyfp/33

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.

PubMed ID

27512385