Document Type
Article
Publication Date
4-1-2021
Abstract
The persistence of latent HIV provirus pools in different resting CD4+ cell subsets remains the greatest obstacle in the current efforts to treat and cure HIV infection. Recent efforts to purge out latently infected memory CD4+ T-cells using latency-reversing agents have failed in clinical trials. This review discusses the epigenetic and non-epigenetic mechanisms of HIV latency control, major limitations of the current approaches of using latency-reversing agents to reactivate HIV latency in resting CD4+ T-cells, and potential solutions to these limitations.
Recommended Citation
Hokello, Joseph; Sharma, Adhikarimayum Lakhikumar; and Tyagi, Mudit, "Combinatorial use of both epigenetic and non-epigenetic mechanisms to efficiently reactivate hiv latency" (2021). Center for Translational Medicine Faculty Papers. Paper 82.
https://jdc.jefferson.edu/transmedfp/82
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Language
English
Comments
This article is the author’s final published version in International Journal of Molecular Sciences, Volume 22, Issue 7, April 2021, Article number 3697.
The published version is available at https://doi.org/10.3390/ijms22073697. Copyright © Hokello et al.